Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a BAC-based DNA library: application to the detection of mycobacteria

ABSTRACT

A method for isolating a polynucleotide of interest that is present in the genome of and/or expressed by a first mycobacterium strain that is also absent or altered in the genome of and/or not expressed by a second mycobacterium strain. The method includes contacting the genomic DNA of the first strain under hybridizing conditions with the DNA of at least one clone belonging to a bacterial artificial chromosome (BAC) genomic DNA library of the second strain and isolating the polynucleotide of interest that does not hybridize with the DNA of the second strain. This invention further pertains to a  Mycobacterium tuberculosis  strain H37Rv genomic DNA library, a  Mycobacterium bovis  BCG strain Pasteur genomic DNA library, and the recombinant BAC vectors belonging to those genomic DNA libraries. This invention also relates to mycobacterial nucleic acids, and methods and kits for using these nucleic acids to detect mycobacteria in a biological sample.

I. BACKGROUND OF THE INVENTION

The present invention pertains to a method for isolating a polynucleotide of interest that is present in the genome of a mycobacterium strain and/or is expressed by said mycobacterium strain and that is absent or altered in the genome of a different mycobacterium strain and/or is not expressed in said different mycobacterium strain, said method comprising the use of at least one clone belonging to a genomic DNA library of a given mycobaterium strain, said DNA library being cloned in a bacterial artificial chromosome (BAC). The invention concerns also polynucleotides identified by the above method, as well as detection methods for mycobacteria, particularly Mycobacterium tuberculosis, and kits using said polynucleotides as primers or probes. Finally, the invention deals with BAC-based mycobacterium DNA libraries used in the method according to the invention and particularly BAC-based Mycobacterium tuberculosis and Mycobacterium bovis BCG DNA libraries.

Radical measures are required to prevent the grim predictions of the World Health Organisation for the evolution of the global tuberculosis epidemic in the next century becoming a tragic reality. The powerful combination of genomics and bioinformatics is providing a wealth of information about the etiologic agent, Mycobacterium tuberculosis, that will facilitate the conception and development of new therapies. The start point for genome sequencing was the integrated map of the 4.4 Mb circular chromosome of the widely-used, virulent reference strain, M. tuberculosis H37Rv and appropriate cosmids were subjected to systematic shotgun sequence analysis at the Sanger Centre.

Cosmid clones (Balasubramanian et al., 1996; Pavelka et al., 1996) have played a crucial role in the M. tuberculosis H37Rv genome sequencing project. However, problems such as under-representation of certain regions of the chromosome, unstable inserts and the relatively small insert size complicated the production of a comprehensive set of canonical cosmids representing the entire genome.

II. SUMMARY OF THE INVENTION

In order to avoid the numerous technical constraints encountered in the state of the art, as decribed hereabove, when using genomic mycobacterial DNA libraries constructed in cosmid clones, the inventors have attempted to realize genomic mycobacterial DNA libraries in an alternative type of vectors, namely Bacterial Artificial Chromosome (BAC) vectors.

The success of this approach depended on whether the resulting BAC clones could maintain large mycobacterial DNA inserts. There are various reports describing the successful construction of a BAC library for eucaryotic organisms (Cai et al., 1995; Kim et al., 1996; Misumi et al., 1997; Woo et al., 1994; Zimmer et al., 1997) where inserts up to 725 kb (Zimmer et al., 1997) were cloned and stably maintained in the E. coli host strain.

Here, it is shown that, surprisingly, the BAC system can also be used for mycobacterial DNA, as 70% of the clones contained inserts in the size of 25 to 104 kb.

This is the first time that bacterial, and specifically mycobacterial, DNA is cloned in such BAC vectors.

In an attempt to obtain complete coverage of the genome with a minimal overlapping set of clones, a Bacterial Artificial Chromosome (BAC) library of M. tuberculosis was constructed, using the vector pBeloBAC11 (Kim et al., 1996) which combines a simple phenotypic screen for recombinant clones with the stable propagation of large inserts (Shizuya et al., 1992). The BAC cloning system is based on the E. coli F-factor, whose replication is strictly controlled and thus ensures stable maintenance of large constructs (Willets et al., 1987). BACs have been widely used for cloning of DNA from various eucaryotic species (Cat et al., 1995; Kim et al., 1996; Misumi et al., 1997; Woo et al., 1994; Zimmer et al., 1997). In contrast, to our knowledge this report describes the first attempt to use the BAC system for cloning bacterial DNA.

A central advantage of the BAC cloning system over cosmid vectors used in prior art is that the F-plasmid is present in only one or a maximum of two copies per cell, reducing the potential for recombination between DNA fragments and, more importantly, avoiding the lethal overexpression of cloned bacterial genes. However, the presence of the BAC as just a single copy means that plasmid DNA has to be extracted from a large volume of culture to obtain sufficient DNA for sequencing and it is described here in the examples a simplified protocol to achieve this.

Further, the stability and fidelity of maintenance of the clones in the BAC library represent ideal characteristics for the identification of genomic differences possibly responsible for phenotypic variations in different mycobacterial species.

As it will be shown herein, BACs can be allied with conventional hybridization techniques for refined analyses of genomes and transcriptional activity from different mycobacterial species.

Having established a reliable procedure to screen for genomic polymorphisms, it is now possible to conduct these comparisons on a more systematic basis than in prior art using representative BACs throughout the chromosome and genomic DNA from a variety of mycobacterial species.

As another approach to display genomic polymorphisms, the inventors have also started to use selected H37Rv BACs for “molecular combing” experiments in combination with fluorescent in situ hybridization (Bensimon et al., 1994; Michalet et al., 1997). With such technique the one skilled in the art is enabled to explore the genome of mycobacteria in general and of M. tuberculosis in particular for further polymorphic regions.

The availability of BAC-based genomic mycobacterial DNA libraries constructed by the inventors have allowed them to design methods and means both useful to identify genomic regions of interest of pathogenic mycobacteria, such as Mycobacterium tuberculosis, that have no counterpart in the corresponding non-pathogenic strains, such as Mycobacterium bovis BCG, and useful to detect the presence of polynucleotides belonging to a specific mycobacterium strain in a biological sample.

By a biological sample according to the present invention, it is notably intended a biological fluid, such as plasma, blood, urine or saliva, or a tissue, such as a biopsy.

Thus, a first object of the invention consists of a method for isolating a polynucleotide of interest that is present in the genome of a mycobacterium strain and/or is expressed by said mycobacterium strain and that is absent or altered in the genome of a different mycobacterium strain and/or is not expressed in said different mycobacterium strain, said method comprising the use of at least one clone belonging to a genomic DNA library of a given mycobaterium strain, said DNA library being cloned in a bacterial artificial chromosome (BAC).

The invention is also directed to a polynucleotide of interest that has been isolated according to the above method and in partoular a polynucleotide containing one or several Open Reading Frames (ORFs), for example ORFs encoding either a polypeptide involved in the pathogenicity of a mycobacterium strain or ORFs encoding Polymorphic Glycine Rich Sequences (PGRS).

Such polynucleotides of interest may serve as probes or primers in order to detect the presence of a specific myobacterium strain in a biological sample or to detect the expression of specific genes in a particular mycobacterial strain of interest.

The BAC-based genomic mycobacterial DNA libraries generated by the present inventors are also part of the invention, as well as each of the recombinant BAC clones and the DNA insert contained in each of said recombinant BAC clones.

The invention also pertains to methods and kits for detecting a specific mycobacterium in a biological sample using either at least one recombinant BAC clone or at least one polynucleotide according to the invention, as well as to methods and kits to detect the expression of one or several specific genes of a given mycobacterial strain present in a biological sample.

III. BRIEF DESCRIPTION OF THE FIGURES

In order to better understand the present invention, reference will be made to the appended figures which depicted specific embodiments to which the present invention is in no case limited in scope with.

FIG. 1: PCR-screening for unique BAC clones with specific primers for 2 selected genomic regions of the H37Rv chromosome, using 21 pools representating 2016 BACs (Panel A) and sets of 20 subpools from selected positive pools (Panel B).

FIG. 2: Pulsed-field gel electrophoresis gel of DraI-cleaved BAC clones used for estimating the insert sizes of BACs.

FIG. 3: Minimal overlapping BAC map of M. tuberculosis H37Rv superimposed on the integrated physical and genetic map established by Philipp et al. (18). Y- and I-numbers show pYUB328 (2) and pYUB412 (16) cosmids which were shotgun sequenced during the H37Rv genome sequencing project. Y-cosmids marked with * were shown in the integrated physical and genetic map (18). Rv numbers show the position of representative BAC clones relative to sequenced Y- and I-clones. Squared Rv numbers show BACs which were shotgun sequenced at the Sanger Centre.

FIG. 4: Ethidium bromide stained gel (Panel A) and corresponding Southern blot (Panel B) of EcoRI and PvuII digested Rv58 DNA hybridized with ³²P labeled genomic DNA preparations from M. tuberculosis H37Rv, M. bovis ATCC 19210 and M. bovis BCG Pasteur.

FIG. 5: Organisation of the ORFs in the 12.7 kb genomic region present in M. tuberculosis H37Rv but not present in M. bovis ATCC 19210 and M. bovis BCG Pasteur. Arrows show the direction of transcription of the putative genes. Positions of EcoRI and PvuII restriction sites are shown. Vertical dashes represent stop codons. The 11 ORFs correspond to the ORFs MTCY277.28 to MTCY277.38/accession number Z79701-EMBL Nucleotide Sequence Data Library. The junction sequences flanking the polymorphic region are shown.

FIG. 6: Variation in the C-terminal part of a PE-PGRS open reading frame in M. tuberculosis strain H37Rv relative to M. bovis BCG strain Pasteur.

The numbers on the right side of the Figure denote the position of the end nucleotides, taking as the reference the M. tuberculosis genome.

FIG. 7: Polynucleotide sequence next to the HindIII cloning site in the BAC vector pBeloBAC11 (Kim et al., 1996) used to clone the inserts of the BAC-based myobacterial genomic DNA library according to the invention.

-   NotI: location of the NotI restriction sites. -   Primer T7-BAC1: nucleotide region recognized by the T7-BAC 1 primer     shown in Table 1. -   T7 promoter: location of the T7 promoter region on the pBeloBac11     vector. -   Primer T7-Belo2: nucleotide region recognized by the T7-Belo2 pimer     shown in Table 1. -   Hind III: the HindIII cloning site used to clone the genomic inserts     in the pBeloBAC11 vector. -   SP6-Mid primer: nucleotide region recognized by the SP6 Mid primer     shown in Table 1. -   SP6-BAC1 primer: nucleotide region recognized by the SP6 BAC1 primer     shown in Table 1. -   SP6 promoter location of the SP6 promoter region on the pBeloBac11     vector.

IV. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

As already mentioned hereinbefore, the present invention is directed to a method for isolating a polynucleotide of interest that is present in the genome of a mycobacterium strain and/or is expressed by said mycobacterium strain and that is absent or altered in the genome of a different mycobacterium strain and/or is not expressed in said different mycobacterium strain, said method comprising the use of at least one clone belonging to a genomic DNA library of a given mycobaterium strain, said DNA library being cloned in a bacterial artificial chromosome (BAC).

For this purpose, the inventors have constructed several BAC-based mycobacterial genomic DNA libraries that may be used in order to perform the above described method.

Because it is the first time that mycobacterial genomic DNA has been successfully cloned in BAC type vectors, and because these DNA libraries are then novel and nonobvious, an object of the present invention consists in a myobacterial genomic DNA library cloned in such a BAC type vector.

As an illustrative example, a BAC-based DNA library of Mycobacterium tuberculosis has been realized. Forty-seven cosmids chosen from the integrated map of the 4.4 Mb circular chromosome (Philipp et al., 1996a) were shotgun-sequenced during the initial phase of the H37Rv genome sequence project. The sequences of these clones were used as landmarks in the construction of a minimally overlapping BAC map. Comparison of the sequence data from the termini of 420 BAC clones allowed us to establish a minimal overlapping BAC map and to fill in the existing gaps between the sequence of cosmids. As well as using the BAC library for genomic mapping and sequencing, we also tested the system in comparative genomic experiments in order to uncover differences between two closely related mycobacterial species. As shown in a previous study (Philipp et al., 1996b), M. tuberculosis, M. bovis and M. bovis BCG, specifically BCG Pasteur strain, exhibit a high level of global genomic conservation, but certain polymorphic regions were also detected. Therefore, it was of great interest to find a reliable, easy and rapid way to exactly localize polymorphic regions in mycobacterial genomes using selected BAC clones. This approach was validated by determining the exact size and location of the polymorphisms in the genomic region of DraI fragment Z4 (Philipp et al., 1996b), taking advantage of the availability of an appropriate BAC clone covering the polymorphic region and the H37Rv genome sequence data. This region is located approximately 1.7 Mb from the origin of replication.

The Bacterial Artificial Chromosome (BAC) cloning system is capable of stably propagating large, complex DNA inserts in Escherichia coli. As part of the Mycobacterium tuberculosis H37Rv genome sequencing project, a BAC library was constructed in the pBeloBAC11 vector and used for genome mapping, confirmation of sequence assembly, and sequencing. The library contains about 5000 BAC clones, with inserts ranging in size from 25 to 104 kb, representing theoretically a 70 fold coverage of the M. tuberculosis genome (4.4 Mb). A total of 840 sequences from the T7 and SP6 termini of 420 BACs were determined and compared to those of a partial genomic database. These sequences showed excellent correlation between the estimated sizes and positions of the BAC clones and the sizes and positions of previously sequenced cosmids and the resulting contigs. Many BAC clones represent linking clones between sequenced cosmids, allowing fall-coverage of the H37Rv chromosome, and they are now being shotgun-sequenced in the framework of the H37Rv sequencing project. Also, no chimeric, deleted or rearranged BAC clones were detected, which was of major importance for the correct mapping and assembly of the H37Rv sequence. The minimal overlapping set contains 68 unique BAC clones and spans the whole H37Rv chromosome with the exception of a single gap of ˜150 kb. As a post-genomic application, the canonical BAC set was used in a comparative study to reveal chromosomal polymorphisms between M. tuberculosis, M. bovis and M. bovis BCG Pasteur, and a novel 12.7 kb segment present in M. tuberculosis but absent from M. bovis and M. bovis BCG was characterized. This region contains a set of genes whose products show low similarity to proteins involved in polysaccharide biosynthesis. The H37Rv BAC library therefore provides the one skilled in the art with a powerful tool both for the generation and confirmation of sequence data as well as for comparative genomics and a plurality of post-genomic applications.

The above described BAC-based Mycobacterium tuberculosis genomic DNA library is part of the present invention and has been deposited in the Collection Nationale de Cultures de Microorganismes (CNCM) on Nov. 19, 1997 under the accession number I-1945.

Another BAC-based DNA library has been constructed with the genomic DNA of Mycobacterium bovis BCG, Pasteur strain, and said DNA library has been deposited in the Collection Nationale de Cultures de Microorganismes (CNCM) on XX XX, 1998 under the accession number I-XXXX.

Thus, as a specific embodiment of the above described method for isolating a polynucleotide of interest said method makes use of at least one BAC-based DNA library that has beeen constructed from the genomic DNA of Mycobacterium tuberculosis, more specifically of the H37Rv strain and particularly of the DNA library deposited in the accession number I-1945.

In another specific embodiment of the above described method for isolating a polynucleotide of interest said method makes use of at least one BAC-based DNA library has beeen constructed from the genomic DNA of Mycobacterium bovis BCG, more specifically of the Pasteur strain and particularly of the DNA library deposited in the accession number I-XXXX.

In more details, the method according to the invention for isolating a polynucleotide of interest may comprise the following steps:

-   -   a) Isolating at least one polynucleotide contained in a clone of         a BAC-based DNA library of mycobacterial origin;     -   b) Isolating:         -   at least one genomic or cDNA polynucleotide from a             mycobacterium, said mycobacterium belonging to a strain             different from the strain used to construct the BAC-based             DNA library of step a); or alternatively         -   at least one polynucleotide contained in a clone of a             BAC-based DNA library prepared from the genome of a             mycobacterium that is different from the mycobacterium used             to construct the BAC-based DNA library of step a);     -   c) Hybridizing the at least one polynucleotide of step a) to the         at least one polynucleotide of step b);     -   d) Selecting the at least one polynucleotide of step a) that has         not formed a hybrid complex with the at least one polynucleotide         of step b);     -   e) Characterizing the selected polynucleotide.

Following the above procedure, the at least one polynucleotide of step a) may be prepared as follows:

-   -   1) Digesting at least one recombinant BAC clone by an         appropriate resctriction endonuclease in order to isolate the         polynucleotide insert of interest from the vector genetic         material;     -   2) Optionally amplifying the resulting polynucleotide insert;     -   3) Optionally digesting the polynucleotide insert of step 1) or         step 2) with at least one restriction endonuclease.

The above method of the invention allows the one skilled in the art to perform comparative genomics between different strains or species of mycobacteria cells, for example between pathogenic strains or species and their non pathogenic strains or species counterparts, as it is the illustrative case for the genomic comparison between Mycobacterium tuberculosis and Mycobacterium bovis BCG that is described herein in the examples.

Restriction digests of a given clone of a BAC library according to the invention may be blotted to membranes, and then probed with radiolabeled DNA form another strain or another species of mycobacteria, allowing the one skilled in the art to identify, characterize and isolate a polynucleotide of interest that may be involved in important metabolical and/or physiological pathways of the mycobacterium under testing, such as a polynucleotide functionally involved in the pathogenicity of said given mycobacteria for its host organism.

More specifically, the inventors have shown in Example 6 that when restriction digests of a given clone of the BAC library identified by the CNCM accession number I-1945 are blotted to membranes and then probed with radiolabeled total genomic DNA from, for example, Mycobacterium bovis BCG Pasteur, it is observed that restriction fragments that fail to hybridize with the M. bovis BCG Pasteur DNA are absent from its genome, hence identifying polymorphic regions between M. bovis BCG Pasteur and M. tuberculosis H37Rv.

Thus, a further object of the present invention consists in a polynucleotide of interest that has been isolated according to the method described herein before.

In Example 6, a polynucleotide of approximately 12.7 kilobases has been isolated that is present in the genome of M. tuberculosis but is absent of the genome of M, bovis BCG. This polynucleotide of interest contains 11 ORFs that may be involved in polysaccharide biosynthesis. In particular, two of said ORFs are of particular interest, namely ORF6 (MTCY277.33; Rv1511) that encodes a protein that shares significant homology with bacterial GDP-D-mannose dehydratases, whereas the protein encoded by ORF7 (MTCY277.34; Rv1512) shares significant homology with a nucleotide sugar epimerase. As polysaccharide is a major constituent of the mycobacterial cell wall these deleted genes may cause the cell wall of M. bovis BCG to differ from that of M. tuberculosis, a fact that may have important consequences for both the immune response to M. bovis BCG and virulence. Detection of such a polysaccharide is of diagnostic interest and possibly useful in the design of tuberculosis vaccines.

Consequently, the polynucleotide of interest obtained following the method according to the invention may contain at least one ORF, said ORF preferably encoding all or part of a polypeptide involved in an important metabolical and/or physiological pathway of the mycobacteria under testing and more specifically all or part of a polypeptide that is involved in the pathogenicity of the mycobacteria under testing, such as for example Mycobacterium tuberculosis, and more generally mycobacteria belonging to the Mycobacterium tuberculosis complex.

The Mycobacterium tuberculosis complex has its usual meaning, i.e. the complex of mycobacteria causing tuberculosis which are Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium africanum, Mycobacterium microti and the vaccine strain Mycobacterium bovis BCG.

An illustrative polynucleotide of interest according to the present invention comprises all or part of the polynucleotide of approximately 12.7 kilobases that is present in the genome of M. tuberculosis but is absent from the genome of M. bovis BCG disclosed hereinbefore. This polynucleotide is contained in clone Rv58 of the BAC DNA library I-1945.

Generally, the invention also pertains to a purified polynucleotide comprising the DNA insert contained in a recombinant BAC vector belonging to a BAC-based mycobacterial genomic DNA library, such as for example the I-1945 BAC DNA library.

Advantageously, such a polynucleotide has been identified according to the method of the invention.

Such a polynucleotide of interest may be used as a probe or a primer useful for specifically detecting a given mycobacterium of interest, such as Mycobacterium tuberculosis or Mycobacterium bovis BCG.

More specifically, the invention then deals with a purified polynucleotide useful as probe or a primer comprising all or part of the nucleotide sequence SEQ ID N^(o)1: ACCTGCGCTT GCAGAGATCA AATAGGGCGC ATGGGTCAGC 60 ATAGTACAGG TCGTCGCGCA TCTTTGATGC ATCGGAATAA GATGTCAGGC AATTAAAAGA 120 GAAGCCACGG CGACTCGCGG CATTCAGCAT GTCGAGCGTC GCTTCGATGT GAGCGCACCA 180 TTCCGTGTCC AACGATTTCA GACGAACATT GAATATTCCA CTCGCGACGC TATAGTCCGC 240 CTCCCGATCT ATGCGCGCCG CGCAGATGAA GTCTGCGTTC GCCCGACCTT CGAAACGTAG 300 TGCGGCCGCG CGCACCATTT CGGGGGAGAC GTCGATGCCG GTGTAATCAG TTTTGAAGCC 360 ACGCGCATCT AGGTAGTCCA GTAGAGCCCC ATAGCCACAG CCTAGATCGT TGATCGAAAA 420 TGGGTCCGCC GCATTGACAA TGCGCACCAG CTGGTCAAAG CGCAACGCCT GCCCGGCTTC 480 GCCGTTCCAA TCGACGCCGC GCGGGTGCCG TGTGCTTCGA GTTTCGATGC GTAGTAACGG 540 GCCACGTCAG CGAGCATGGT CGTTGCGTCT TCCGCCATGA AGCTGCCTCA CGATTTGTGT 600 GTGTGGGCGT CGGTGCGTGG GTCCGAGACT ATACCTTCAA CAGTTGCATG CCGAGGCTGC 660 GGCGGGCAAT GACCCAAAAA CCCGCCGGCA CGGTTCGCCG AGCAAGGAAG CGTGGAGACG 720 ATAGATAATT TCACTGGCGA CAGTACCTCA AATAGTCCGG AGCCTCGGCT CCGACGTTAA 780 AGAGCAGATC CAGAATCGAC ACGGCGGGCT CGAACCCTCC CCACAATTGC TTATAATCGC 840 GGTAGCCGTC ATAATCGAAC CAAGTTACCC GGATGCTAAG TTCGTCGAAC ACGCGCTCAT 900 CGACATACGA ACGGGCTGAG GGGCCAGAGA CATATTCGGT CGCTGCGGCC TGTTGGCAGA 960 GGTTGGCCAG TCTCTCGGTC TTGCCGTCGG CTAATTCGTA GTCCCACGAA TTTGCCAGTC 1020 GCGTGCTGAT ACCGAGATAA CTGCAAATCG CATTCAATAG ACGCCTGTTG AGTAAGGAAA 1080 GATTCGTGTG CTGTTCTTCG AGGTAAATCG GCGCGAGCCA GTCAGCGATC TCCGCAAAAT 1140 GAGCGGCCGC GCTGTAGTTG AATTCTAGTG CCCGCCAGTG CGCTTTCGCC CAATCGGTGC 1200 CGTCGATCAG CGTCTCACGT ATCTTTTGAT GGAAACGTCC CTTCACCTGG ACGGGAACAG 1260 TTATCCACTG TAACCCCTGG CTCGTTTTGA TCCGATTTCT GTTTCGCCAA TCACGCTTGG 1320 TATATTGCAT GTCATCATAG ATGATGAATT CATCGACGAA TGCAATCAGG TCAAAATATC 1380 CTCGCCAAGG TATGTAATTT GATTGAACAA TCGCGACTTT CTTCAACGCG GTGTCTCCAA 1440 TTTAGAATAA CAAATACGTC GCGCCCGCGA CAGCTCCGCT GGAGCGAGTT CAAGCGATTC 1500 TGCGACATAT TCAATATGGT GCTCGGGAAG GCCAGGATGG GCCGCGACCC GGGGCGTCCG 1560 GTGCGCGATG AACGTCGCAT CGTCTCCTGT GAGATAATTG CATCCGATCA TATAGGGCTG 1620 GCTGCGGCTA GGTTGCTGGC AAAAAGATAT CGCGGCCGAT CCGTTTCTGG TTTTGTCTTG 1680 ATGATCAAAT CCGCTTCCGT TCACGAGATC GATTCCTGGT CTTCCCCCAG CGTCGCGATG 1740 TCGATAGGTG TCGCGCTTTG TTCGTACCCG CACTACGCGG CGGCGAGAAC CTCGCCACCG 1800 AATCGGGATT GGGGGGAGGA TACCACTCGG TCGAGGCCCG TCACCGGCCT TCTAGCGGGT 1860 TGACCATCAG TGTTTGCAGG GCCCTATCCC GGTATGGCGC ACCACGGGAT CGGCAGCGTT 1920 CCGGTTGCTG GCGTGGTACC TCGTTGTGGC GCCGTGGTCC ATGTCGATTG AGTGCGTGGA 1980 TCAGTGTAAA CCGTTGCGCG CCATGTTCTG TAGGCACTGG TTCGGGTTGT GGTTAGGCTG 2040 CACGGTTGGC AGGTTACCAA CCACTGAGCC CCTGGGCGGA TGTGAGCTCG GACTCCGCCT 2100 ATGGGGTGTA ATTTTGGCAG ATTGGGCCGG GTCCCCGTGG TGAGGACTCC TCAACCGGAT 2160 TGGGTAAGCA TGAGGTGGTG CTGGCAGCGG TGTCCTGGTC GCTCTCCCGA GTAGGCCCGT 2220 TGTGACTGTC ATGTGGGCGA GCGGGTTTGC GCGCGTAGGA GACGATGATT ACTACGCACG 2280 TGACCAACCA CAAGAACGGT GCCCATGTCA CCGTGGTGAA AACGAGTGGC GTGGTACCGA 2340 CTACCCCTTT GGCTCCCAGC TGTCCATAGA GCGGCACGTA GAACGGCTGG CCCGGGACCG 2400 CGACGTTGAC GATGCTCAGC GCCACGGCCA AACTCACGCA GACGCCGACC GCGCGGCGGC 2460 GGTCTCCATG GGCTGCGAGT TGGTCGAATA TCCCAGCACC AGGAGGCCCG TTGGGCTCTC 2520 GGGCTACCAG TGCAGCGATT GGCAAGACGA AAACGAGATA GTAGAAGGCG ACGTCCGCGG 2580 GGGAGAAGGT GGCGGTGGCG AGCAACACAA TCCCCACCAT GACAGGCGGG ATACGGCGTC 2640 CGAGCGCCAG CACGGCGACC ACGACTATGA CTAGGACAGC AAACCCGATC TGCGTTCGCG 2700 GACCAGTGAG GAAACCCTCT GGGATCTTGC CCGATTGATA GTTCTTGATG CTATCGGGGA 2760 TCAGCAGGAG TGCCTTGCCA AAGGACACGT TCCGCGGGTC TCGAAGCCCT CCGAACGAAC 2820 TATTGAACTT GATGATGCCG TGGATCGACT GTGCGATCGT CCCCGGGAAG CCTCGTGGCC 2880 ACAACAGAAA GGCTGCGATA TTGGACACCA CCACGCCGGT GATCCCGATA CCAGCCCACC 2940 GCCATTGTCG AGCCGCCAAC AACACCACGC CGAGAACGAC GAACTGCGGC TTTACCAGGA 3000 CGGCCAAGAT CACCGTGATG GTGGCGAGGC CCCACCGCTG TCGGGACAAC GCCACGAAGT 3060 AAGCCAGCGC GATCGGTACC ACGAACCCTG TCGAGTTGCC TCGATCGATG ACCCCCCACG 3120 CCGGGATGGC CGCGGCGCCC AGTGTCACGA AGATGACCAC TCGCTCCAGA CCACGTGCCC 3180 CCCGGGCCGC CCAGATGGCG GGAGATATGA CCGCCATCGT TAGGGCGACC AGGTAACAGA 3240 TCAGCCCCAA GCGCGGCGCA CCCAGCCAAT GGCTGGGTAG TCCGAAAATC GCATACGGTA 3300 TGCGGGCGGG GGCCCATGCA GCAACCGCGG TCGGCTGGTA ATCGGCGGGT AGCGAGATCA 3360 GGTAGTCCGC GGGATTGGGT TGAATCCCGG CGGCGGCGAC CATGGCGTAG TCGCTGAAGC 3420 AGTGCCGACC GATATTCATG CCCCAATCAA GCCAACAGTC CCCAGGGACT ACCAAAAGAG 3480 TGGAAAAGAC GTCGACCGCG TACCACTGAC TGAGGGCGTA CGCCGTCGCC GCCGAAATCA 3540 CCGACGCCAG CAGGATGGTG CCGAGCATGA GGGTGCGCTC GGATTGGGAG CCGATCGCCC 3600 AGAGCCGCTC CCGGCTCGCG GTCACGGCAC CGCGCAACAC CTCCGGGGGT CGCTTCATCT 3660 GGATTCTCCT CGGTTCTGCG CGAAACGGTA GCAGAGCGCC ATGGTTGCCA ACGCGGTCGC 3720 CGGGCAGTCT AGACCGGATC TTCCTCCTGG CAACCGACAA CAGGACGTCG TTGCCGAAAG 3780 GGCGCTGGGC ACCGACATCT AGGATGAACC CACAGCCACG CCCCGACGTT ATGCCATGGC 3840 GAAGAGCGAC CGGCAGGAGC GGGAACCCAG TGAAGCGAGC GCTCATCACC GGAATCACAG 3900 GACCGGACGG CTCGTATCTC GCTAAGCTCC CGCTGAAGGG ATATGTGCCC GCTGGTAGCC 3960 CGGCCGAGGT CTATTTCTGC TGGGCGACAC GGAATTATCG CGAATTGTAT GGCTTGCTCG 4020 CGGTCAACAG CATCTGGTTC AATCACGAAT CACCGCGTCA CGGCGAGACA TTCATGACTC 4080 GTAATCCTGC ACCATATCGC GGTCGGCAAC GAGGCGCTGA TCGATGCGCA GACGCTGATG 4140 CGCCCGCCCA CCCGGATAGG TATCAGTATT GGGGCGTTCC GGCCAGCGTA CGAGGCGTGA 4200 TCGACCGCGC AATGGGTGTT TGCGTTGAGT AATAATCTGA ACCGTGTGAA CGCATGCATG 4260 GATGCATTCC TTGCCCGTAT CCGCTCACAT GTTGATGCGC ACGCGCCAGA ATTGCGTTCA 4320 CTGTTCGATA CGATGGCGGC CGAGGCCCGA TTTGCACGCG ACTGGCTGTC CGAGGACCTC 4380 GCGCGGTTGC CTGTCGGTGC AGCATTGCTG GAAGTGGGCG GGGGGGTACT TCTGCTCAGC 4440 TGTCAACTGG CGGCGGAGGG ATTTGACATC ACCGCCATCG AGCCGACGGG TGAAGGTTTT 4500 GGCAAGTTCA GACAGCTTGG CGACATCGTG CTGGAATTGG CTGCAGCACG ACCCACCATC 4560 GCGCCATGCA AGGCGGAAGA CTTTATTTCC GAGAAGCGGT TCGACTTCGC CTTCTCGCTG 4620 AATGTGATGG AGCACATCGA CCTTCCGGAT GAGGCAGTCA GGCGGGTATC GGAAGTGCTG 4680 AAACCCGGGG CCAGTTACCA CTTCCTGTGC CCGAATTACG TATTCCCGTA CGAACCGCAT 4740 TTCAATATCC CAACATTCTT CACCAAAGAG CTGACATGCC GGGTGATGCG ACATCGCATC 4800 GAGGGCAATA CGGGCATGGA TGACCCGAAG GGAGTCTGGC GTTCGCTCAA CTGGATTACG 4860 GTTCCCAAGG TGAAACGCTT TGCGGCGAAG GATGCGACGC TGACCTTGCG CTTCCACCGT 4920 GCAATGTTGG TATGGATGCT GGAACGCGCG CTGACGGATA AGGAATTCGC TGGTCGCCGG 4980 GCACAATGGA TGGTCGCTGC TATTCGCTCG GCGGTGAAAT TGCGTGTGCA TCATCTGGCA 5040 GGCTATGTTC CCGCTACGCT GCAGCCCATC ATGGATGTGC GGCTAACGAA GAGGTAATGA 5100 CATGGCGCAA GCGACATCGG GCATTCGCGC GGCACTTTCG CAACCTGCTG TGTATGAGGC 5160 GTATCAGCGG ATTGCGGGCG CTAAAAGCGG GCTTGCGTGG ATCACAACCG ACCCCATCCA 5220 GTCGTTGCCA GGCATGCGTA CTCTCGACCT CGGTTGCTGG CCAGCGGTGA TACACAGCTC 5280 CCCGCCAGTG GACGTGACAT GTACGAGAGA CGGCATGAGC GCGGAATGTG CGACCGTGCC 5340 GTCGAGATGA CCGACGTCGG CGCTACGGCA GCCCCCACCG GACCTATCGC GCGGGGCAGC 5400 GTCGCTCGGG TCGGCGCGGC GACCGCGTTG GCCGTTGCCT GCGTCTACAC GGTCATCTAT 5460 CTGGCGGCCC GCGACCTACC CCCGGCTTGT TTTTCGATAT TCGCGGTGTT TTGGGGGGCG 5520 CTCGGCATTG CCACCGGCGC CACCCACGGC CTCCTGCAAG AAACGACCCG CGAGGTCCGC 5580 TGGGTGCGCT CCACCCAAAT AGTTGCGGGC CATCGTACCC ATCCGCTGCG GGTGGCCGGG 5640 ATGATTGGCA CCGTCGCGGC CGTCGTAATT GCGGGTAGCT CACCGCTGTG GAGCCGACAG 5700 CTATTCGTCG AGGGGCGCTG GCTGTCCGTG GGGCTACTCA GCGTTGGGGT GGCCGGGTTC 5760 TGCGCGCAGG CGACCCTGCT GGGCGCGCTG GCCGGCGTCG ACCGGTGGAC ACAGTACGGG 5820 TCACTGATGG TGACCGACGC GGTCATCCGG TTGGCGGTCG CCGCGGCAGC GGTTGTGATC 5880 GGATGGGGTC TGGCCGGGTA CTTGTGGGCC GCCACCGCGG GAGCGGTGGC GTGGCTGCTC 5940 ATGCTGATGG CCTCGCCCAC CGCGCGCAGC GCGGCCAGCC TGCTGACGCC CGGGGGAATC 6000 GCCACGTTCG TGCGCGGTGC CGCTCATTCG ATAACCGCCG CGCGTGCCAG CGCGATTCTG 6060 GTAATGGGTT TCCCAGTGTT GCTCAAAGTG ACCTCCGACC AGTTAGGGGC AAAGGGCGGA 6120 GCGGTCATCC TGGCTGTGAC CTTGACGCGT GCGCCGCTTC TGGTCCCACT GAGCGCGATG 6180 CAAGGCAACC TGATCGCGCA TTTCGTCGAC CGGCGCACCC AACGGCTTCG GGCGCTGATC 6240 GCACCGGCGC TGGTCGTCGG CGGCATCGGT GCGGTCGGGA TGTTGGCCGC AGGGCTTACC 6300 GGTCCCTGGT TGCTGCGTGT TGGATTCGGC CCCGACTACC AAACTGGCGG GGCGTTGCTG 6360 GCCTGGTTGA CGGCAGCGGC GGTAGCTATC GCCATGCTGA CGCTGACCGG CGCCGCCGCG 6420 GTCGCGGCCG CACTGCACCG GGCGTATTTG CTGGGCTGGG TCAGCGCGAC GGTGGCGTCG 6480 ACGCTGTTGC TGCTGCTGCC GATGCCGCTG GAGACGCGCA CCGTGATCGC GCTGTTGTTC 6540 GGTCCAACGG TGGGAATCGC CATCCATGTG GCCGCGTTGG CGCGGCGACC CGACTGATTT 6600 GTGCCCCAGG TCGACAAATC ACGCCGTCTC GTCAGTGAGC ACTCCGTCCT CGGGTCCGAT 6660 CCTTCCAGGA GACGTTGCAA CCTGATTTGG CTCAAATTGG TGCGCACCGA GGGTCGGGCA 6720 CATCGTAGGG TCGCAACAGT CACATGTGTC ACTGCACCGG GCGACACCCG ATGTCCCGGC 6780 TCTCAGCGAC AGCTGTCTGA CCTGTGGTTT TGTTCCCAAG TTGGTCGTGG CTGTGCGGGA 6840 TTGGAGGTGG CGTGGGGGTC GCGTCGTATG GATTCTCCTC CTCGGTTCCG CGCGAAACGG 6900 CCGCAGGCGC AATGGTCACC AACTTGGCCG CGGTGGAGTC TAGCCTCACA TTTTCCTGGT 6960 CGCCCCCGAC AACCAGGAGG TCGCTGCAGA ACGGGCGTTC CCTACCCACA TCTACTATGA 7020 AGCGACAGCG GCGCCCCGCT GTGATGGCTG AGCATGACCG ACAGAGGCGG GAAGACAGTG 7080 AAGCGAGCGC TCATCACCGG AATCACCGGC CAGGACGGCT CGTATCTCGC CGAACTGCTG 7140 CTGGCCAAGG GGTATGAGGT TCACGGGCTC ATCCGGCGCG CTTCGACGTT CAACACCTCG 7200 CGGATCGATC ACCTCTACGT CGACCCGCAC CAACCGGGCG CGCGGCTGTT TCTGCACTAT 7260 GGTGACCTGA TCGACGGAAC CCGGTTGGTG ACCCTGCTGA GCACCATCGA ACCCGACGAG 7320 GTGTACAACC TGGCGGCGCA GTCACACGTG CGGGTGAGCT TCGACGAACC CGTGCACACC 7380 GGTGACACCA CCGGCATGGG ATCCATGCGA CTGCTGGAAG CCGTTCGGCT CTCTCGGGTG 7440 CACTGCCGCT TCTATCAGGC GTCCTCGTCG GAGATGTTCG GCGCCTCGCC GCCACCGCAG 7500 AACGAGCTGA CGCCGTTCTA CCCGCGGTCA CCGTATGGCG CCGCCAAGGT CTATTCCTAC 7560 TGGGCGACCC GCAATTATCG CGAAGCGTAC GGATTGTTCG CCGTTAACGG CATCTTGTTC 7620 AATCACGAAT CACCGCGGCG CGGTGAGACG TTCGTGACCC GAAAGATCAC CAGGGCCGTG 7680 GCACGCATCA AGGCCGGTAT CCAGTCCGAG GTCTATATGG GCAATCTGGA TGCGGTCCGC 7740 GACTGGGGGT ACGCGCCCGA ATACGTCGAA GGCATGTGGC GGATGCTGCA GACCGACGAG 7800 CCCGACGACT TCGTTTTCGC GACCGGGCGC GGTTTCACCG TGCGTGAGTT CGCGCGGGCC 7860 GCGTTCGAGC ATGCCGGTTT GGACTGGCAG CAGTACGTGA AATTCGACCA ACGCTATCTG 7920 CGGCCCACCG AGGTGGATTC GCTGATCGGC GACGCGACCA AGGCTGCCGA ATTGCTGGGC 7980 TGGAGGGCTT CGGTGCACAC TGACGAGTTG GCTCGGATCA TGGTCGACGC GGACATGGCG 8040 GCGCTGGAGT GCGAAGGCAA GCCGTGGATC GACAAGCCGA TGATCGCCGG CCGGACATGA 8100 ACGCGCACAC CTCGGTCGGC CCGCTTGACC GCGCGGCCCG GGTCTACATC GCCGGGCATC 8160 GCGGCCTGGT CGGGTCCGCG CTGCTACGCA CGTTTGCGGG CGCGGGGTTC ACCAACCTGC 8220 TGGTGCGGTC ACGCGCCGAG CTTGATCTGA CGGATCGGGC CGCGACGTTC GACTTCGTTC 8280 TCGAGTCGAG GCCGCAGGTC GTCATCGACG CGGCGGCCCG GGTCGGCGGC ATCCTGGCCA 8340 ACGACACCTA CCCGGCCGAT TTCCTGTCGG AAAACCTCCA GATCCAGGTC AACCTGCTGG 8400 ATGCCGCCGT GGCGGCGCGG GTGCCGCGGC TGCTGTTCCT GGGCTCGTCG TGCATCTACC 8460 CGAAACTCGC CCCGCAGCCG ATCCCGGAGA GCGCGCTGCT CACCGGTCCG TTGGAGCCGA 8520 CCAACGACGC GTACGCGATC GCCAAAATCG CCGGCATCCT TGCGGTCCAG GCGGTGCGCC 8580 GCCAACATGG CCTGCCGTGG ATCTCGGCGA TGCCCACCAA CCTGTACGGG CCAGGCGACA 8640 ACTTTTCGCC GTCCGGCTCG CATCTGCTGC CGGCACTCAT CCGCCGCTAT GACGAGGCCA 8700 AAGCCAGTGG CGCGCCCAAC GTGACCAACT GGGGCACCGG CACGCCCCGA CGGGAGTTGC 8760 TGCACGTCGA CGACCTGGCG AGCGCATGCC TGTATCTGCT GGAACATTTC CACGGGCCGA 8820 CCCATGTCAA CGTGGGAACC GGCATCGACC ACACCATCGG CGAGATCGCC GAGATGGTCG 8880 CCTCGGCGGT AGGCTATAGC GGCGAAACCC GCTGGGATCC AAGCAAACCG GACGGAACAC 8940 CACGCAAACT GCTGGATGTT TCGGTGCTAC GGGAGGCGGG ATGGCGGCCT TCGATCGCGC 9000 TGCGCGACGG CATCGAGGCG ACGGTGGCGT GGTATCGCGA GCACGCGGGA ACGGTTCGGC 9060 AATGAGGCTG GCCCGTCGCG CTCGGAACAT CTTGCGTCGC AACGGCATCG ACGTGTCGCG 9120 CTACTTTGCC GAACTGGACT GGGAACGCAA TTTCTTGCGC CAACTGCAAT CCCATCGGGT 9180 CAGTGCCGTG CTCGATGTCG GGGCCAATTC GGGGCAGTAC GCCAGGGGTC TGCGCGGCGC 9240 GGGCTTCGCG GGCCGCATCG TCTCGTTCGA GCCGCTGCCC GGGCCCTTTG CCGTCTTGCA 9300 GCGCAGCGCC TCCACGGACC CGTTGTGGGA ATGCCGGCGC TGTGCGCTGG GCGATGTCGA 9360 TGGAACCATC TCGATCAACG TCGCCGGCAA CGAGGGCGCC AGCAGTTCCG TCTTGCCGAT 9420 GTTGAAACGA CATCAGGACG CCTTTCCACC AGCCAACTAC GTGGGCGCCC AACGGGTGCC 9480 GATACATCGA CTCGATTCCG TGGCTGCAGA CGTTCTGCGG CCCAACGATA TTGCGTTCTT 9540 GAAGATCGAC GTTCAAGGAT TCGAGAAGCA GGTGATCGCG GGTGGCGATT CAACGGTGCA 9600 CGACCGATGC GTCGGCATGC AGCTCGAGCT GTCTTTCCAG CCGTTGTACG AGGGTGGCAT 9660 GCTCATCCGC GAGGCGCTCG ATCTCGTGGA TTCGTTGGGC TTTACGCTCT CGGGATTGCA 9720 ACCCGGTTTC ACCGACCCCC GCAACGGTCG AATGCTGCAG GCCGATGGCA TCTTCTTCCG 9780 GGGCAGCGAT TGACGCGCCG GCGCGTCAAT CTATTTCGAC ATTCGCGTGA AGACGTTTTC 9840 CCAGAATCGA CTGTTGTAGG CGTAGAACTC CCGGCCGCGT AGGTAGGCAT GTGATATTCG 9900 CCTTCCCCCG AACGGGTAGC GGCGATGAAG GTCGCCCATG CGGCGCAGAT CACCGAAGAC 9960 CGCGCTTGGT TCCCGGTGCG AGCCGACGCC CGTGGTGTCG AACTCGCACA GCACACACCG 10020 AATCGTGACC GGCTCGCATA CCAGCGCGGC CCGCAATATG AATTCCTGGT CGGCGGCGAT 10080 CCCGAAATCA AGGTCGTAGC CACCGATCTT GGCCACCAGC GATGATCCGA AGAACGATGC 10140 TTGATGCGGA ACAACCTGCT TGCCGGCCAG GAATTTGCGC AGGCTGAAAG GTATCGGGCC 10200 GCGCACCCGA TCGAGCCCGA CGAGACGATC CATCCCGAAG CCCCACAATT CGGACACCGG 10260 TCCCTTGCCG GATAGCGCCT CCACGGCCTG GGOTACCACG TCGGGCCCGG AAAAACGATC 10320 GGCGGAGTGC AAGAACCACA ACAGATCACC CGATGCGTGC GCGATGCCCT GGTTCATCGC 10380 GTCGTACCGC CCGCCGTCGG GCTCGGACTG CCAATACGCG AAGCCTGGTT CACACCCGGA 10440 CAGGTATGCC ACCACGTCGT CGCCGCTGCC ACCGTCGATT ACGATGTGCT CGATGCGTCC 10500 CCGGTAGCGT TGCGCCCGCA CACTTTTCAC CGTGCGCTGC AACCCGTCGA GGTCGTTGAA 10560 CGAGATCGTT ATCACCGAGA CGGTCGGAGC AGACGTCACC GAGTTCCCCT AGGTTGCTGG 10620 CGGCGATTGT GGATCACCGG GTCTTGATAC CGATGAAGGT GCCTCGAAGA TTCGCCGCAT 10680 AGGAACCTCC GAGCAACGAC TCGGCGATGC TTGGTTCCAA GTTGTCGTAC TCCTCCATCA 10740 CCAGGTCGAC GCCGACGTCT TTGATGGCCT GAAGTAGGTG CTCGCGTTGA ATCCAGAATG 10800 ACCGGCGATT GTCCCAGGAC GCCCATTTTG CGGTGTCGCG CTGGCCAAAC GAGCGGTCGT 10860 CGGAAAACTC GGTAAACCAC CTACCGGGAA GTCCCTCATG TTCGGTGGGC GCCGAGAGCA 10920 TGAACTTCAC CGGCGCCGGC CGCCGCAGCA ACCGATCGGT CAATTGTCGT GCCGTCGTGG 10980 GCAACCGGAG CCATTTATCG CTCCGGTTGA TGATCGAGAA GTGCGTCTGG AGAATCAGCA 11040 GCTTGTTCGT TACCGACGAG AGGGTTTCCA GGTATTGCTT CGGATTCTCC AGGTGGTAGA 11100 AGAGGCCGCA GCAGAAGACG GTATCGAAGA GCCCGTGGTT GGCGATGTTG AGGGCGTTGT 11160 CGTGGACGAA CCGGAGATTC GGCAGGTTGG TCTTCGATTT GATGTAGTTG CAGGCCGCCA 11220 TGTTCAGCTC GCGAACCTCG ATCCCGAGGA CCTGAAATCC CATGCGCGCG AACCCGACCG 11280 CGTACCCGCC TTCCAAGCAG CCGACATCGG CCAGGCGTAG GTGGCTCTTG TCCCCGGGAA 11340 AGACGGTTTC CAGAATCCCG CGCGCCGAGA TGAACCAGGA CGATTCGTCT AACGTGCGCG 11400 AGGACTCCGG TATCGTCAAG GTTCCGTCGT CGAGGCGAAC GTTGTGGGCG GTGAATTGTA 11460 CCGCGCCGGC CGAATGTTCC TGTGCCATCA CTTGGTTAGC CCCTTCGGCT GGTCCTGGGT 11520 TTGTCGACAT GGTCAGGCTC GACAGCCGCG TCGGAGCCGG GAGGGCCACA CATCCACGAG 11580 CCCCCTGCGG CTCGGCGTCG CGGCGGCGAG CTTGCGCCAC TGGGTCTTGA GCCGCCGCGC 11640 GGGTGTCGCC CCGCGGTGCT GCAGCGCCAG CATGGCGATC CGGGGATGGC GCGCGATGGT 11700 TTCCTGCAGC GCGGCGCGCC CCTCCGGGCC TGGAACGTTG GCGATCTGGC GAAGGATCCA 11760 GTCGGCCATG ACGGCGATGA GCTCCTCGCG CGCGGGGTCT CCCGGGAACA GGTCGAGCAT 11820 CGCGTCAAAC GTCGCCGCAT GCCCCGGACC CTGCGTCAAC CAGAACTTTG GCGGGTCCAC 11880 CACCTGGTTG TGCCACATGC CTTGGGCGTG GCGGCGATAC ACGGCCATGG TGTCGGGCAA 11940 CATGGCGATG TCGCCATGCA CCGCGTGCCG GACGTGCAGA TACCAGTCCA GGGGCATGAC 12000 GTCGGCAGGA ATGTCGTCGT AGCGCTCGAG GCGACGGTAC ACGGCCGAGT TGGTCTGGAT 12060 GAAGTTCATC AAGATCAACG CATCCAGGCT CAAGTTGCCC CGCACCCGAA CCGGGGGGAA 12120 CTTCGAGTCC TTGGCATGGC CGTCCTCCCA TATCACTCGG ACGGGATGGA AGCACACCGT 12180 CGTCTTGGGG TGCCGGTCGA GGAATGCGAC CTGTTTGCTT AGCTTCAGCG GATCGATCCA 12240 GTAGTCGTCC GCCTCGCACA ACGCGACGTA CTCGCCGCGA GCGGCCGACA GGGCGCCGGT 12300 CAGGTTCCCA TTGAGGCCGA GGTTTTCGGT CCTGAAGATC GGCCGGAACA CGTGCGGGTA 12360 CCGCTCGGCG TACTCACGGA TGATCGCCGG GGTGGCATCG GTCGACGCGT CGTCGGCGAC 12420 GATGATCTCC ACCGGGAAGT CGGTTTGCTG GTCGAGAAAG CTGTCGAAGG CCTGACGGGC 12480 GTAGCCCGCC TGGTTGTGAG TGGTCGAGAC GATGCTCACC TTGGGGCAAA GCTGGGGACT 12540 CACCGTCGGC CCTTTTCCTG CGCGGCCGCA AGGGTATTGC GATGGCGAAC GTGAATCGCC 12600 TGTGCCCGCC GGCCGTCGGC CGTCGTGGCC TGGTGGTCGG CGGACGTACG GCACACGCTG 12660 GCGAAGTATA GCGAGGGTGC ACTGACGTTG GGCTCGAACC GCGTGGCGCG CGGTGTGGGC 12720 CCACCGTCTC GAGTCGGTGC TGGTTGGCTC GC 12732

The location, on the Mycobacterium tuberculosis chromosome, of the above polynucleotide of sequence SEQ ID N^(o)1 has now been ascribed to begin, at its 5′end at nucleotide at position nt 1696015 and to end, at its 3′end, at nucleotide at position nt 1708746.

For diagnostic purposes, this 12.7 kb deletion should allow a rapid PCR screening of tubercle isolates to identify whether they are bovine or human strains. The primers listed in Table 1 are flanking the deleted region and give a 722 bp amplicon in M. bovis or M. bovis BCG strains, but a fragment of 13,453 bp in M. tuberculosis that is practically impossible to amplify under the same PCR conditions. More importantly, assuming that some of the gene products from this region represent proteins with antigenic properties, it could be possible to develop a test that can reliably distinguish between the immune response induced by vaccination with M. bovis BCG vaccine strains and infection with M. tuberculosis or that the products (e.g. polysaccharides) are specific immunogens.

The invention also provides for a purified polynucleotide useful as a probe or as a primer, said polynucleotide being chosen in the following group of polynucleotides:

-   a) a polynucleotide comprising at least 8 consecutive nucleotides of     the sequence SEQ ID N^(o)1. -   b) a polynucleotide whose sequence is fully complementary to the     sequence of the polynucleotide defined in a); -   c) a polynucleotide that hybridizes under stringent hybridization     conditions with the polynucleotide defined in a) or with the     polynucleotide defined in b).

For the purpose of defining a polynucleotide or oligonucleotide hybridizing under stringent hybridization conditions, such as above, it is intended a polynucleotide that hybridizes with a reference polynucleotide under the following hybridization conditions:

The hybridization step is realized at 65° C. in the presence of 6×SSC buffer, 5× Denhardt's solution, 0.5% SDS and 100 μg/ml of salmon sperm DNA.

For technical information, 1×SSC corresponds to 0.15 M NaCl and 0.05M sodium citrate; 1× Denhardt's solution corresponds to 0.02% Ficoll, 0.02% polyvinylpyrrolidone and 0.02% bovine serum albumin.

The hybridization step is followed by four washing steps:

-   -   two washings during 5 min, preferably at 65° C. in a 2×SSC and         0.1% SDS buffer;     -   one washing during 30 min, preferably at 65° C. in a 2×SSC and         0.1% SDS buffer,     -   one washing during 10 min, preferably at 65° C. in a 0.1×SSC and         0.1% SDS buffer

A first illustrative useful polynucleotide that is included in the polynucleotide of sequence SEQ ID N^(o)1 is the following polynucleotide of sequence SEQ ID N^(o)2 that corresponds to the Sp6 endsequence of SEQ ID N^(o)1: ATACTCAAGC TTGCCGCAAT CGAAACCAAC CTGTTTGTGC 60 CGCAAGAAAT TACGCCGTGG CCCGGCGCCG ATCAAGAAAC GCCCCGGCGC GCGGCGGTGT 120 CGTCGTATGG CATGACGGGC ACCAATGTGC ACGCCATTGT CGAGCAGGCA CCGGTGCCAG 180 CCCCCGAATC CGGTGCACCA GGCGACACCC CGGCCACACC CGGTATCGAC GGCGCGCTGC 240 TGTTCGCGCT GTCGGCCAGC TCGCAGGACG CGCTGCGGCA AACCGCCGCG CGGCTGGCCG 289 ATTGGGTCT

A second illustrative useful polynucleotide that is included in the polynucleotide of sequence SEQ ID N^(o)1 is the following polynucleotide of sequence SEQ ID N^(o)3 that corresponds to the T7 endsequence of SEQ ID N^(o)1, located on the opposite strand: TTGGCGGGTT GGCCACACAC CCGCCGGTGA CGGCGACGAT 60 GCTGGGCTGG TTGCGGCCCT GCGCCACCGC GGCTTGCATG CTGGTTGGCT GTCTTGGGAC 120 GATCCCGAAA TAGTCCACGC GGATCTGGTG ATTTTGCGGG CTACCCGCGA TTACCCCGCG 180 CGGCTCGACG AGTTTTTGGC CTGGACTACC CGCGTGGCCA ATCTGCTGAA CTCGCGGCCG 240 GTGGTGGCCT GGAATGTCCA CGCCGTTCAC CTACGTGACC TTGATGGGAT 278 CCGGGGGT

The polynucleotide of sequence SEQ ID N^(o)1 contains 11 ORFs, the respective locations of which, taking into account the orientation of each ORF on the chromosome, on the sequence of the Mycobacterium tuberculosis chromosome, is given hereafter:

-   -   The location of ORF1 is comprised between nucleotide at position         nt 1695944 and nucleotide at position nt1696441.     -   The location of ORF2 is comprised between nucleotide at position         nt 1696728 and nucleotide at position nt1697420.     -   The location of ORF3 is comprised between nucleotide at position         nt 1698096 and nucleotide at position nt1699892. ORF3 probably         encodes a protein having the characteristics of a membrane         protein.     -   The location of ORF4 is comprised between nucleotide at position         nt 1700210 and nucleotide at position nt1701088.     -   The location of ORF5 is comprised between nucleotide at position         nt 1701293 and nucleotide at position nt1702588. ORF5 encodes a         protein having the characteristics of a membrane protein.     -   The location of ORF6 is comprised between nucleotide at position         nt 1703072 and nucleotide at position nt1704091. ORF6 encodes a         protein having the characteristics of a GDP-D-mannose         dehydratase.     -   The location of ORF7 is comprised between nucleotide at position         nt 1704091 and nucleotide at position nt1705056. ORF7 encodes a         protein having the characteristics of a nucleotide sugar         epimerase involved in colanic acid biosynthesis.     -   The location of ORF8 is comprised between nucleotide at position         nt 1705056 and nucleotide at position nt1705784.     -   The location of ORF9 is comprised between nucleotide at position         nt 1705808 and nucleotide at position nt1706593. ORF9 encodes a         protein having the characteristics of colanic acid biosynthesis         glycosyl transferase.     -   The location of ORF10 is comprised between nucleotide at         position nt 1706631 and nucleotide at position nt1707524.

The location of ORF11 is comprised between nucleotide at position nt 1707530 and nucleotide at position nt1708648. ORF11 encodes a protein similar to a spore coat polysaccharide biosynthesis.

A polynucleotide of interest obtained by the above-disclosed method according to the invention may also contain at least one ORF that encodes all or part of acidic, glycine-rich proteins, belonging to the PE and PPE families, whose genes are often clustered and based on multiple copies of the polymorphic repetitive sequences. The names PE and PPE derive from the fact that the motifs ProGlu (PE, positions 8, 9) and ProProGlu (PPE, positions 7 to 9) are found near the N-terminus in almost all cases. The PE protein family all have a highly conserved N-terminal domain of ˜110 amino acid residues, that is predicted to have a globular structure, followed by a C-terminal segment which varies in size, sequence and repeat copy number. Phylogenetic analysis separated the PE family into several groups, the larger of which is the highly repetitive PGRS class containing 55 members whereas the other groups share very limited sequence similarity in their C-terminal domains. The predicted molecular weights of the PE proteins vary considerably as a few members only contain the ˜110 amino acid N-terminal domain while the majority have C-terminal extensions ranging in size from 100 up to >1400 residues. A striking feature of the PGRS proteins is their exceptional glycine content (up to 50%) due to the presence of multiple tandem repetitions of GlyGlyAla or GlyGlyAsn motifs or variations thereof.

Like the PE family, the PPE protein family also has a conserved N-terminal domain that comprises ˜180 amino acid residues followed by C-terminal segments that vary considerably in sequence and length. These proteins fall into at least three groups, one of which constitutes the MPTR class characterised by the presence of multiple, tandem copies of the motif AsnXGlyXGlyAsnXGly. The second subgroup contains a characteristic, well-conserved motif around position 350 (GlyXXSerValProXXTrp), whereas the other group contains proteins that are unrelated except for the presence of the common 180-residue PPE domain. C-terminal extensions may range in size from 00 up to 3500 residues.

One member of the PGRS sub-family, the WHO antigen 22T (Abou-Zeid et al., 1991), a 55 kD protein capable of binding fibronectin, is produced during disease and elicits a variable antibody response suggesting either that individuals mount different immune responses or that this PGRS-protein may not be produced in this form by all strains of M. tuberculosis. In other words, at least some PE_PGRS coding sequences encode for proteins that are involved in the recognition of M. tuberculosis by the immune system of the infected host. Therefore, differences in the PGRS sequences could represent the principal source of antigenic variation in the otherwise genetically and antigenically homogeneous bacterium.

By performing the method of the invention using the M tuberculosis BAC based DNA library I-1945, the inventors have discovered the occurence of sequence differences between a given PGRS encoding ORF (ORF reference on the genomic sequence of M. tuberculosis Rv0746) of M. tuberculosis and its counterpart sequence in the genome of M. bovis BCG.

More precisely, the inventors have determined that one ORF contained in BAC vector N^(o) Rv418 of the M. tuberculosis BCG I-1945 DNA library carries both base additions and base deletions when compared with the corresponding ORF in the genome of M. bovis BCG that is contained in the BAC vector N^(o) X0175 of the M. bovis BCG I-XXXX DNA libary. The variations observed in the base sequences correspond to variations in the C-terminal part of the aminoacid sequence of the PGRS ORF translation product.

As shown in FIG. 6, an amino acid stretch of 9 residues in length is present in this M. tuberculosis PGRS (ORf reference Rv0746) and is absent from the ORF counterpart of M. bovis BCG, namely the following amino acid sequence: NH₂-GGAGGAGGSSAGGGGAGGAGGAGGWLLGD-COOH.

Furthermore, FIG. 6 shows also that an amino acid stretch of 45 residues in length is absent from this M. tuberculosis PGRS and is present in the ORF counterpart of M. bovis BCG, namely following amino acid sequence: NH₂-GAGGIGGIGGNANGGAGGNGGTGGQLWGSGGAGVEGGAALSVGDT- COOH.

Similar observations were made with PPE ORF Rv0442, which showed a 5 codon deletion relative to a M. bovis amino acid sequence.

Given that the polymorphism associated with the PE-PGRS or PEE ORFS resulted in extensive antigenic variability or reduced antigen presentation, this would be of immense significance for vaccine design, for understanding protective immunity in tuberculosis and, possibly, explain the varied responses seen in different BCG vaccination programmes.

There are several striking parallels between the PGRS proteins and the Epstein-Barr virus-encoded nuclear antigens (EBNA). Both polypeptide families are glycine-rich, contain Gly-Ala repeats that represent more than one third of the molecule, and display variation in the length of the repeat region between different isolates. The Gly-Ala repeat region of EBNA1 has been shown to function as a cis-acting inhibitor of antigen processing and MHC class I-restricted antigen presentation (Levitskaya et al., 1995). The fact that MHC class I knock-out mice are extremely suscepible to M. tuberculosis underlines the importance of MHC class I antigen presentation in protection against tuberculosis. Therefore, it is possible that the PE/PPE protein family also play some role in inhibiting antigen presentation, allowing the bacillus to hide from the host's immune system.

As such the novel and nonobvious PGRS polynucleotide from M. bovis which is homolog to the M. tuberculosis ORF Rv0746, and which is contained in the BAC clone N^(o) X0175 (See Table 4 for SP6 and T7 endsequences of clone n^(o) X0175) of the I-XXXX M. bovis BCG BAC DNA library is part of the present invention, as it represents a starting material in order to define specific probes or primers useful for detection of antigenic variability in mycobacterial strains, possible inhibition of antigen processing as well as to differentiate M. tuberculosis from M. bovis BCG.

Thus, a further object of the invention consists in a polynucleotide comprising the following sequence SEQ ID N^(o)4: CCGACCCAGA CACTGACCGG GCGACCGCTG ATCGGCAACG 60 GCACCCCCGG GGCGGTCCGC AGCGGGGCCA CCGGGGCCCC CGGTGGGTGG CTGCTCGGCG 120 ACGGCGGGGC CGGCGGGTCC GGCGCGGCGG GCTCGGGCGC GCCCGGCGGG GCGGGCGGGG 180 CTGCCGGGCT GTGGGGTACC GGCGGGGCCG GCGGGATCGG CGGAGCCAGC ACCGTACTCG 240 GCGGCACCGG CGGGGGAGGC GGGGTCGGTG GGCTGTGGGG CGCCGGTGGG GCCGGCGGGG 300 CCGGTGGAAC CGGCCTTGTT GGTGGCGACG GCGGGGCCGG TGGGGCCGGC GGGACCGGCG 360 GACTGCTGGC CGGGCTGATC GGTGCCGGCG GAGGTCACGG CGGGACCGGC GGGCTCAGCA 420 CTAATGGCGA CGGCGGGGTT GGCGGGGCCG GCGGGAATGC CGGAATGCTC GCCGGGCCGG 480 GCGGCGCCGG CGGAGCCGGC GGTGACGGCG AAAACCTGGA CACCGGTGGG GACGGCGGGG 540 CCGGCGGTAG CGCAGGGCTG CTGTTCGGCA GCGGCGGCGC CGGCGGCGCC GGCGGATTTG 600 GTTTCCTCGG TGGGGACGGC GGGGCCGGTG GCAACGCCGG GCTGCTGTTG TCCAGCGGCG 660 GGGCCGGCGG GTTCGGCGGG TTCGGCACCG CCGGTGGGGT CGGTGGGGCC GGCGGCAATG 720 CCGGCTGGCT GGGCTTCGGC GGGGCCGGGG GCATCGGCGG AATCGGCGGT AACGCTAACG 780 GGGGCGCCGG TGGGAACGGC GGCACCGGCG GTCAGTTATG GGGTAGCGGC GGCGCCGGCG 840 TCGAAGGCGG CGCAGCCTTA AGCGTCGGCG ACACCGGCGG GGCCGGTGGC GTCGGCGGCA 900 GCGCCGGGCT GATCGGCACC GGCGGCAACG GCGGCAACGG CGGCACCGGC GCCAACGCCG 960 GCAGCCCCGG AACCGGCGGC GCCGGCGGGT TGCTGCTGGG CCAAAACGGG CTCAACGGGT 1020 TGCCGTAGCC GGGCGGCACG GCATGGCTTC CGGGCGTCAA CCACTCGCCG GTGATGCAGA 1080 TCGGCTGCGG AGCGGGCCGC CAAAATGGGG GCCGCCGCGC CAGGTATCTC GGCGAAGATC 1140 CCCGGCGCTC GAGCGCTTTG TCAGAGGCCC GTCGCGGGTC GTCGTGACGA CGGCTATCCG 1200 GGCGGTGCGG GTTTCGCGGC GCGCCCTGTG CCCGGCACCG CCGCCCGTTT GTCGGCAACG 1260 CCGCCGCGAC CCGTGAGCCG TCCAGCAGCT GGCGCCTGCG 1280

Polynucleotides of interest have been defined by the inventors as useful detection tools in order to differentiate M. tuberculosis from M. bovis BCG. Such polynucleotides are contained in the 45 aminoacid length coding sequence that is present in M. bovis BCG but absent from M. tuberculosis. This polynucleotide has a sequence beginning (5′end) at the nucleotide at position nt 729 of the sequence SEQ ID N^(o)4 and ending (3′end) at the nucleotide in position nt 863 of the sequence SEQ ID N^(o)4.

Thus, part of the present invention is also a polynucleotide which is chosen among the following group of polynucleotides:

a) A polynucleotide comprising at least 8 consecutive nucleotides the following nucleotide sequence SEQ ID N^(o)5: GGGCATCGGC GGAATCGGCG GTAACGCTAA CGGGGGCGCC 60 GGTGGGAACG GCGGCACCGG CGGTCAGTTA TGGGGTAGCG GCGGCGCCGG CGTCGAAGGC 120 GGCGCAGCCT TAAGCGTCGG CGACACC 127

-   b) A polynucleotide which sequence is fully complementary to the     sequence of the polynucleotide defined in a); -   c) A polynucleotide that hybridizes under stringent hybridization     conditions with the polynucleotide defined in a) or with the     polynucleotide defined in b).

The stringent hybridization conditions for the purpose of defining the above disclosed polynucleotide are defined herein before in the specification.

The invention also provides for a BAC-based Mycobacterium tuberculosis strain H37Rv genomic DNA library that has been deposited in the Collection Nationale de Cultures de Microorganismes on Nov. 19, 1997 under the accession number I-1945.

A further object of the invention consists in a recombinant BAC vector which is choosen among the group consisting of the recombinant BAC vectors belonging to the BAC-based DNA library I-1945.

Generally, a recombinant BAC vector of interest may be choosen among the following set or group of BAC vectors contained in the BAC-based DNA library I-1945:

Rv101; Rv102; Rv103; Rv104; Rv105; Rv106; Rv107; Rv108; Rv109; Rv10; Rv110; Rv111; Rv112; Rv113; Rv114; Rv115; Rv116; Rv117; Rv118; Rv119; Rv11; Rv120; Rv121; Rv122; Rv123; Rv124; Rv126; Rv127; Rv128; Rv129; Rv130; Rv132; Rv134; Rv135; Rv136; Rv137; Rv138; Rv139; Rv13; Rv140; Rv141; Rv142; Rv143; Rv144; Rv145; Rv146; Rv147; Rv148; Rv149; Rv14; Rv150; Rv151; Rv152; Rv153; Rv154; Rv155; Rv156; Rv157; Rv159; Rv15; Rv160; Rv161; Rv162; Rv163; Rv164; Rv165; Rv166; Rv167; Rv169; Rv16; Rv170; Rv171; Rv172; Rv173; Rv174; Rv175; Rv176; Rv177; Rv178; Rv179; Rv17; Rv180; Rv181; Rv182; Rv183; Rv184; Rv185; Rv186; Rv187; Rv188; Rv18; Rv190; Rv191; Rv192; Rv193; Rv194; Rv195; Rv196; Rv19; Rv1; Rv201; Rv204; Rv205; Rv207; Rv209; Rv20; Rv214; Rv215; Rv217; Rv218; Rv219; Rv21; Rv220; Rv221; Rv222; Rv223; Rv224; Rv225; Rv226; Rv227; Rv228; Rv229; Rv22; Rv230; Rv231; Rv232; Rv233; Rv234; Rv235; Rv237; Rv240; Rv241; Rv243; Rv244; Rv245; Rv246; Rv247; Rv249; Rv24; Rv251; Rv252; Rv253; Rv254; Rv255; Rv257; Rv258; Rv259; Rv25; Rv260; Rv261; Rv262; Rv263; Rv264; Rv265; Rv266; Rv267; Rv268; Rv269; Rv26; Rv270; Rv271; Rv272; Rv273; Rv274; Rv275; Rv276; Rv277; Rv278; Rv279; Rv27; Rv280; Rv281; Rv282; Rv283; Rv284; Rv285; Rv286; Rv287; Rv288; Rv289; Rv28; Rv290; Rv291; Rv292; Rv293; Rv294; Rv295; Rv296; Rv29; Rv2; Rv301; Rv302; Rv303; Rv304; Rv306; Rv307; Rv308; Rv309; Rv30; Rv310; Rv311; Rv312; Rv313; Rv314; Rv315; Rv316; Rv317; Rv318; Rv319; Rv31; Rv32; Rv322; Rv327; Rv328; Rv329; Rv32; Rv330; Rv331; Rv333; Rv334; Rv335; Rv336; Rv337; Rv338; Rv339; Rv33; Rv340; Rv341; Rv343; Rv344; Rv346; Rv347; Rv348; Rv349; Rv34; Rv350; Rv351; Rv352; Rv353; Rv354; Rv355; Rv356; Rv357; Rv358; Rv359; Rv35; Rv360; Rv361; Rv363; Rv364; Rv365; Rv366; Rv367; Rv368; Rv369; Rv36; Rv370; Rv371; Rv373; Rv374; Rv375; Rv376; Rv377; Rv378; Rv379; Rv37; Rv381; Rv382; Rv383; Rv384; Rv385; Rv386; Rv387; Rv388; Rv389; Rv38; Rv390; Rv391; Rv392; Rv393; Rv396; Rv39; Rv3; Rv40; Rv412; Rv413; Rv414; Rv415; Rv416; Rv417; Rv418; Rv419; Rv41; Rv42; Rv43; Rv44; Rv45; Rv46; Rv47; Rv48; Rv49; Rv4; Rv50; Rv51; Rv52; Rv53; Rv54; Rv55; Rv56; Rv57; Rv58; Rv59; Rv5; Rv60; Rv61; Rv62; Rv63; Rv64; Rv65; Rv66; Rv67; Rv68; Rv69; Rv6; Rv70; Rv71; Rv72; Rv73; Rv74; Rv75; Rv76; Rv77; Rv78; Rv79; Rv7; Rv80; Rv81; Rv82; Rv83; Rv84; Rv85; Rv86; Rv87; Rv88; Rv89; Rv8; Rv90; Rv91; Rv92; Rv94; Rv95; Rv96; Rv9.

The end sequences of the polynucleotide inserts of each of the above clones corresponding respectively to the sequences adjacent to the T7 promoter and to the Sp6 promoter on the BAC vector are shown in Table 3.

It has been shown by the inventors that the minimal overlapping set of BAC vectors of the BAC-based DNA library I-1945 contains 68 unique BAC clones and practically spans almost the whole H37Rv chromosome with the exception of a single gap of approximately 150 kb.

More specifically, a recombinant BAC vector of interest is choosen among the following set or group of BAC vectors from the BAC-based DNA library I-1945, the location of which vector DNA inserts on the chromosome of M. tuberculosis is shown in FIG. 3:

Rv234; Rv351; Rv166; Rv35; Rv415; Rv404; Rv209; Rv272; Rv30; Rv228; Rv233; Rb38; Rv280; Rv177; Rv48; Rv374; Rv151; Rv238; Rv156; Rv92; Rv3; Rv403; Rv322; Rv243; Rv330; Rv285; Rv233; Rv219; Rv416; Rv67; Rv222; Rv149; Rv279; Rv87; Rv273; Rv266; Rv25; Rv136; Rv414; Rv13; Rv289; Rv60; Rv104; Rv5; Rv165; Rv215; Rv329; Rv240; Rv19; Rv74; Rv411; Rv167; Rv56; Rv80; Rv164; Rv59; Rv313; Rv265; Rv308; Rv220; Rv258; Rv339; Rv121; Rv419; Rv418; Rv45; Rv217; Rv134; Rv17; Rv103; Rv21; Rv22; Rv2; Rv270; Rv267; Rv174; Rv257; Rv44; Rv71; Rv7; Rv27; Rv191; Rv230; Rv128; Rv407; Rv106; Rv39; Rv255; Rv74; Rv355; Rv268; Rv58; Rv173; Rv264; Rv417; Rv401; Rv144; Rv302; Rv81; Rv163; Rv281; Rv221; Rv420; Rv175; Rv86; Rv412; Rv73; Rv269; Rv214; Rv287; Rv42; Rv143.

The polynucleotides disclosed in Table 3 may be used as probes in order to select a given clone of the BAC DNA library I-1945 for further use.

The invention also provides for a BAC-based Mycobacterium bovis strain Pasteur genomic DNA library that has been deposited in the Collection Nationale de Cultures de Microorganismes on XXXX XX, 1998 under the accession number I-XXXX.

A further object of the invention consists in a recombinant BAC vector which is chosen among the group consisting of the recombinant BAC vectors belonging to the BAC-based DNA library I-XXXX. This DNA library contains approximately 1600 clones. The average insert size is estimated to be ˜80 kb.

Generally, a recombinant BAC vector of interest may be chosen among the following set or group of BAC vectors contained in the BAC-based DNA library I-XXXX:

X0001; X0002; X0003; X0004; X0006; X0007; X0008; X0009; X0010; X0012; X0013; X0014; X0015; X0016; X0017; X0018; X0019; X0020; X0021; X0175.

The end sequences of the polynucleotide inserts of each of the above clones corresponding respectively to the sequences adjacent to the T7 promoter and to the Sp6 promoter on the BAC vector are shown in Table 4.

The polynucleotides disclosed in Table 4 may be used as probes in order to select a given clone of the BAC DNA library I-XXXX for further use.

Are also part of the invention the polynucleotide inserts that are contained in the above described BAC vectors, that are useful as primers or probes.

These polynucleotides and nucleic acid fragments may be used as primers for use in amplification reactions, or as nucleic probes.

PCR is described in the U.S. Pat. No. 4,683,202. The amplified fragments may be identified by an agarose or a polyacrylamide gel electrophoresis, or by a capillary electrophoresis or alternatively by a chromatography technique (gel filtration, hydrophobic chromatography or ion exchange chromatography). The specificity of the amplification may be ensured by a molecular hybridization using, for example, one of the initial primers as nucleic probes.

Amplified nucleotide fragments are used as probes in hybridization reactions in order to detect the presence of one polynucleotide according to the present invention or in order to detect mutations in the genome of the given mycobacterium of interest, specifically a mycobacterium belonging to the Mycobacterium tuberculosis complex and more specifically Mycobacterium tuberculosis and Mycobacterium bovis BCG.

Are also part of the present invention the amplified nucleic fragments (

amplicons

) defined herein above.

These probes and amplicons may be radioactively or non-radioactively labeled, using for example enzymes or fluorescent compounds.

Other techniques related to nucleic acid amplification may also be used and are generally preferred to the PCR technique.

The Strand Displacement Amplification (SDA) technique (Walker et al., 1992) is an isothermal amplification technique based on the ability of a restriction enzyme to cleave one of the strands at his recogntion site (which is under a hemiphosphorothioate form) and on the property of a DNA polymerase to initiate the synthesis of a new strand from the 3′OH end generated by the restriction enzyme and on the property of this DNA polymerase to displace the previously synthesized strand being localized downstream. The SDA method comprises two main steps:

-   a) The synthesis, in the presence of dCTP-alpha-S, of DNA molecules     that are flanked by the restriction sites that may be cleaved by an     appropriate enzyme. -   b) The exponential amplification of these DNA molecules modified as     such, by ezyme cleavage, strand displacement and copying of the     displaced strands. The steps of cleavage, strand displacement and     copy are repeated a sufficient number of times in order to obtain an     accurate sensitivity of the assay.

The SDA technique was initially realized using the restriction endonuclease HincII but is now generally practised with an endonuclease from Bacillus stearothermophilus (BSOBI) and a fragment of a DNA polymerase which is devoid of any 5′→3′exonuclease activity isolated from Bacilllus cladotenax (exo-Bca) [=exo-minus-Bca]. Both enzymes are able to operate at 60° C. and the system is now optimized in order to allow the use of dUTP and the decontamination by UDG. When unsing this technique, as described by Spargo et al. in 1996, the doubling time of the target DNA is of 26 seconds and the amplification rate is of 10¹⁰ after an incubation time of 15 min at 60° C.

The SDA amplification technique is more easy to perform than PCR (a single thermostated waterbath device is necessary) and is faster thant the other amplification methods.

Thus, another object of the present invention consists in using the nucleic acid fragments according to the invention (primers) in a method of DNA or RNA amplification according to the SDA technique. For performing SDA, two pairs of primers are used: a pair of external primers (B1, B2) consisting of a sequence specific for the target polynucleotide of interest and a pair of internal primers (S1, S2) consisting of a fusion oligonucleotide carrying a site that is recognized by a restriction endonuclease, for exemple the enzyme BSOBI.

The operating conditions to perform SDA with such primers are described in Spargo et al. 1996.

The polynucleotides of the invention and their above described fragments, especially the primers according to the invention, are useful as technical means for performing different target nucleic acid amplification methods such as:

-   -   TAS (Transcription-based Amplification System), described by         Kwoh et al. in 1989;     -   SR (Self-Sustained Sequence Replication), described by Guatelli         et al. in 1990.     -   NASBA (Nucleic acid Sequence Based Amplification), described by         Kievitis et al. in 1991.     -   TMA (Transcription Mediated Amplification).

The polynucleotides according to the invention are also useful as technical means for performing methods for amplification or modification of a nucleic acid used as a probe, such as:

-   -   LCR (Ligase Chain Reaction), described by Landegren et al. in         1988 and improved by Barany et al. in 1991 who employ a         thermostable ligase.     -   RCR (Repair Chain Reaction) described by Segev et al. in 1992.     -   CPR (Cycling Probe Reaction), described by Duck et al. in 1990.     -   Q-beta replicase reaction, described by Miele et al. in 1983 and         improved by Chu et al. in 1986, Lizardi et al. in 1988 and by         Burg et al. and Stone et al. in 1996.

When the target polynucleotide to be detected is a RNA, for example a mRNA, a reverse transcriptase enzyme will be used before the amplification reaction in order to obtain a cDNA from the RNA contained in the biological sample. The generated cDNA is subsequently used as the nucleic acid target for the primers or the probes used in an amplification process or a detection process according to the present invention.

The non-labeled polynucleotides or oligonucleotides of the invention may be directly used as probes. Nevertheless, the polynucleotides or oligonucleotides are generally labeled with a radioactive element (³²P, ³⁵S, ³H, ¹²⁵I) or by a non-isotopic molecule (for example, biotin, acetylaminofluorene, digoxigenin, 5-bromodesoxyuridin, fluorescein) in order to generate probes that are useful for numerous applications.

Examples of non-radioactive labeling of nucleic acid fragments are described in the french patent N^(o) FR-7810975 or by Urdea et al. or Sanchez-Pescador et al., 1988.

In the latter case, other labeling techniques may be also used such as those described in the french patents FR-2,422,956 and 2,518,755. The hybridization step may be performed in diffrent ways (Matthews et al., 1988). The more general method consists of immobilizing the nucleic acid that has been extracted from the biological sample onto a substrate (nitrocellulose, nylon, polystyrene) and then to incubate, in defined conditions, the target nucleic acid with the probe. Subsequently to the hybridization step, the excess amount of the specific probe is discarded and the hybrid molecules formed are detected by an appropriate method (radioactivity, fluorescence or enzyme activity measurement).

Advantageously, the probes according to the present invention may have structural characteristics such that they allow the signal amplification, such structural characteristics being, for example, branched DNA probes as those described by Urdea et al. in 1991 or in the European patent N^(o) EP-0225,807 (Chiron). In another advantageous embodiment of the probes according to the present invention, the latters may be used as

capture probes

, and are for this purpose immobilized on a substrate in order to capture the target nucleic acid contained in a biological sample. The captured target nucleic acid is subsequently detected with a second probe which recognizes a sequence of the target nucleic acid which is different from the sequence recognized by the capture probe.

The oligonucleotide probes according to the present invention may also be used in a detection device comprising a matrix library of probes immobilized on a substrate, the sequence of each probe of a given length being localized in a shift of one or several bases, one from the other, each probe of the matrix library thus being complementary to a distinct sequence of the target nucleic acid. Optionally, the substrate of the matrix may be a material able to act as an electron donor, the detection of the matrix poisitons in which an hybridization has occurred being subsequently determined by an electronic device. Such matrix libraries of probes and methods of specific detection of a targer nucleic acid is described in the European patent application N^(o) EP-0713,016 (Affymax technologies) and also in the U.S. Pat. No. 5,202,231 (Drmanac).

Since almost the whole length of a mycobacterial chromososme is covered by a BAC-based genomic DNA libraries according to the present invention (i.e. 97% of the M. tuberculosis chromosome is covered by the BAC library I-1945), these DNA libraries will play an important role in a plurality of post-genomic applications, such as in mycobacterial gene expression studies where the canonical set of BACs could be used as a matrix for hybridization studies. Probing such matrices with cDNA probes prepared from total mRNA will uncover genetic loci induced or repressed under different physiological conditions (Chuang et al., 1993; Trieselmann et al., 1992). As such, the H37Rv BAC library represents a fundamental resource for present and future genomics investigations.

The BAC vectors or the polynucleotide inserts contained therein may be directly used as probes, for example when immobilized on a substrate such as described herein before.

The BAC vectors or their polynucleotide inserts may be directly asdorbed on a nitrocellulose membrane, at predetermined locations on which one or several polynucleotides to be tested are then put to hybridize therewith.

Preferably, a collection of BAC vectors that spans the whole genome of the mycobacterium under testing will be immobilized, such as, for example, the set of 68 BAC vectors of the I-1945 DNA library that is described elsewhere in the specification and shown in FIG. 3.

The immobilization and hybridization steps may be performed as described in the present Materials and Methods Section.

As another illustrative embodiment of the use of the BAC vectors of the invention as polynucleotide probes, these vectors may be useful to perform a transcriptional activity analysis of mycobacteria growing in different environmental conditions, for example under conditions in which a stress response is expected, as it is the case at an elevated temperature, for example 40° C.

In this specific embodiment of the invention, Genescreen membranes may be used to immobilize the restriction endonuclease digests (HindIII digests for the BAC DNA library I-1945) of the BAC vectors by tranfer from a gel (Trieselmann et al., 1992).

Alternatively, the BAC vectors may be immobilized for dot blot experiments as follows. First, the DNA concentration of each BAC clone is determined by hybridization of blots of clone DNAs and of a BAC vector concentration standard with a BAC vector specific DNA probe. Hybridization is quantified by the Betascope 603 blot analyzer (Betagen Corp.), which colects beta particles directly from the blot with high efficiency. Then, 0.5 μg of each clone DNA is incubated in 0.25 M NaOH and 10 mM EDTA at 65° C. for 60 min to denature the DNA and degrade residual RNA contaminants. By using a manifold filtration system (21 by 21 wells), each clone DNA is blotted onto a GeneScreen Plus nylon membrane in the alkaline solution. After neutralization, the blots are baked at 85° C. for 2 h under vacuum. Positive and negative controls are added when necessary. In order to perform this procedure, it may be referred to the article of Chuang et al. (1993).

For RNA extractions, cells grown in a suitable volume of culture medium may, for example, be immediately mixed with an equal volume of crushed ice at −70° C. and spun at 4° C. in a 50 ml centrifugation tube. The cell pellet is then suspended in 0.6 ml of ice-cold buffer (10 mM KCl, 5 mM MgCl, 10 mM Tris; pH 7.4) and then immediately added to 0.6 ml of hot lysis buffer (0.4 M NaCl, 40 mM EDTA, 1% beta-mercaptoethanol 1% SDS, 20 mM Tris; pH 7.4) containing 100 μl of water saturated phenol. This mixture is incubated in a boiling water bath for 40 s. The debris are removed by centrifugation. The supernatant is extracted with phenol-chloroform five times, ethanol precipitated, and dried. The dried RNA pellet is dissolved in water before use.

Then labeled total cDNA may be prepared by the following method. The reaction mixture contains 15 μg of the previously prepared total RNA, 5 μg of pd(N₆) (random hexamers from Pharmacia Inc.), 0.5 mM dATP, 0.5 mM dGTP and 0.5 mM DTTP, 5 μM dCTP, 100 μCi of [α-³²P]dCTP (3,000 Ci/mmol), 50 mM Tris-HCl (pH 8.3), 6 mM MgCl₂, 40 mM Kcl, 0.5 U of avian myeloblastosis virus reverse transcriptase (Life Science Inc.) in a total volume of 50 μl. The reaction is allowed to continue overnight at room temperature. EDTA and NaOH are then added to final concentrations of 50 mM and 0.25 M, respectively, and the mixture is incubated at 65° C. for 30 min to degrade the RNA templates. The cDNA is then ready to use after neutralization by adding Hcl and Tris buffer.

The hybridization step may be performed as described by Chuang et al. (1993) and briefly disclosed hereinafter. The DNA dot blot is hybridized to ³²P-labeled total cDNA in a solution containing 0.1% polyvinylpyrrolidone, 0.1% Ficoll, 0.1% sodium Pp_(i), 0.1% bovine serum albumin, 0.5% SDS, 100 mM NaCl, and 0.1 mM sodium citrate, pH 7.2, at 65° C. for 2 days and then washed with a solution containing 0.1% SDS, 100 mM NaCl, and 10 mM Na-citrate, pH 7.2. The same dot blot is used for hybridization with both control and experimental cDNAs, with an alkaline probe stripping procedure (soaked twice in 0.25M NaOH-0.75 M NaCl at room temperature, 30 min each, neutralized, and completely dried at 65° C. for at least 30 min) between the two hybridizations. Quantification may be done with the Betascope 603 blot analyzer (Betagen Corp.).

As it flows from the above technical teachings, another object of the invention consists in a method for detecting the presence of mycobateria in a biological sample comprising the steps of:

-   a) bringing into contact the recombinant BAC vector or a purified     polynucleotide according to the invention with a biological sample. -   b) detecting the hybrid nucleic acid molecule formed between said     purified polynucleotide and the nucleic acid molecules contained     within the biological sample.

The invention further deals with a method for detecting the presence of mycobacteria in a biological sample comprising the steps of:

-   a) Bringing into contact the recombinant BAC vector or a purified     polynucleotide according to the invention that has been immobilized     onto a substrate with a biological sample. -   b) Bringing into contact the hybrid nucleic acid molecule formed     between said purified polynucleotide and the nucleic acid contained     in the biological sample with a labeled recombinant BAC vector or a     polynucleotide according to the invention, provided that said     polynucleotide and polynucleotide of step a) have non-overlapping     sequences.

Another object of the invention consists in a method for detecting the presence of mycobacteria in a biological sample comprising the steps of:

-   a) Bringing into contact the nucleic acid molecules contained in the     biological sample with a pair of primers according to the invention. -   b) Amplifying said nucleic acid molecules; -   d) detecting the nucleic acid fragments that have been amplified,     for example by gel electrophoresis or with a labeled polynucleotide     according to the invention.

In one specific embodiment of the above detection and/or amplification methods, said methods comprise an additional step wherein before step a), the nucleic acid molecules of the biological sample have been made available to a hybridization reaction.

In another specific embodiment of the above detection methods, said methods comprise an additional step, wherein, before the detection step, the nucleic acid molecules that are not hybridized with the immobilized purified polynucleotide are removed.

Also part of the invention is a kit for detecting mycobacteria in a biological sample comprising:

-   a) A recombinant BAC vector or a purified polynucleotide according     to the invention; -   b) Reagents necessary to perform a nucleic acid hybridization     reaction.

The invention also pertains to a kit for detecting a mycobacteria in a biological sample comprising:

-   a) A recombinant BAC vector or a purified polynucleotide according     to the invention that is immobilized onto a substrate. -   b) Reagents necessary to perform a nucleic acid hybridization     reaction. -   c) A purified polynucleotide according to the invention which is     radioactively or non-radioactively labeled, provided that said     polynucleotide and the polynucleotide of step a) have     non-overlapping sequences.

Moreover, the invention provides for a kit for detecting mycobacteria in a biological sample comprising:

-   a) A pair of purified primers according to the invention; -   b) Reagents necessary to perform a nucleic acid amplification     reaction; -   c) Optionally, a purified polynucleotide according to the invention     useful as a probe.

The invention embraces also a method for detecting the presence of a genomic DNA, a cDNA or a mRNA of mycobacteria in a biological sample, comprising the steps of:

-   a) Bringing into contact the biological sample with a plurality of     BAC vectors according to the invention or purified polynucleotides     according to the invention, that are immobilized on a substrate; -   b) Detecting the hybrid complexes formed.

The invention also provides a kit for detecting the presence of genomic DNA, cDNA or mRNA of a mycobacterium in a biological sample, comprising:

-   a) A substrate on which a plurality of BAC vectors according to the     invention or purified polynucleotides according to the invention     have been immobilized; -   b) Optionally, the reagents necessary to perform the hybridization     reaction.

Additionally, the recombinant BAC vectors according to the invention and the polynucleotide inserts contained therein may be used for performing detection methods based on

molecular combing

. Said methods consist in methods for aligning macromolecules, especially DNA and are applied to processes for detecting, for measuring intramolecular distance, for separating and/or for assaying a macromolecule, especially DNA in a sample.

These

molecular combing

methods are simple methods, where the triple line S/A/B (meniscus) resulting form the contact between a solvent A and the surface S and a medium B is caused to move on the said surface S, the said macromolecules (i.e. DNA) having a part, especially an end, anchored on the surface S, the other part, especially the other end, being in solution in the solvent A. These methods are particularly fully described in the PCT Application No. PCT/FR 95/00165 files on Feb. 11, 1994 (Bensimon et al.).

When performing the

molecular combing

method with the recombinant BAC vectors according to the inventions or their polynucleotide inserts, the latters may be immobilized (

anchored

) on a suitable substrate and aligned as described in the PCT Application No. PCT/FR 95/00165, the whole teachings of this PCT Application being herien incorporated by reference. Then, polynucleotides to be tested, preferably under the form of radioactively or non radioactively labeled polynucleotides, that may consist of fragments of genomic DNA, cDNA etc. are brought into contact with the previously aligned polynucleotides according to the present invention and then their hybridization position on the aligned DNA molecules is determined using any suitable means including a microscope or a suitable camera device.

Thus, the present invention is also directed to a method for the detection of the presence of a polynucleotide of mycobacterial origin in a biological sample and/or for physical mapping of a polynucleotide on a genomic DNA, said method comprising:

-   a) Aligning at least one polynucleotide contained in a recombinant     BAC vector according to the invention on the surface of a substrate; -   b) Bringing into contact at least one polynucleotide to be tested     with the substrate on which the at least one polynucleotide of     step a) has been aligned; -   c) detecting the presence and/or the location of the tested     polynucleotide on the at least one aligned polynucleotide of step     a).

The invention finally provides for a kit for performing the above method, comprising:

-   a) a substrate whose surface has at least one polynucleotide     contained in a recombinant BAC vector according to the invention; -   b) optionally, reagents necessary for labeling DNA; -   c) optionnally, reagents necessary for performing a hybridization     reaction.

In conclusion, it may be underlined that the alliance of such BAC-based approaches such as described in the present specification to the advances in comparative genomics by the availability of an increased number of complete genomes, and the rapid increase of well-characterized gene products in the public databases, will allow the one skilled in the art an exhaustive analysis of the mycobacterial genome.

Materials and Methods

1. DNA-preparation. Preparation of M. tuberculosis H37Rv DNA in agarose plugs was conducted as previously described (Canard et al., 1989; Philipp et al., 1996b). Plugs were stored in 0.2 M EDTA at 4° C. and washed 3 times in 0.1% Triton X-100 buffer prior to use.

2. BAC vector preparation. pBeloBAC11 was kindly provided by Dr. Shizuya, Department of Biology, California Institute of Technology (Pasadena, Calif.). The preparation followed the description of Woo et al., 1994 (Woo et al., 1994).

3. Partial digestion with HindIII. Partial digestion was carried out on plugs, each containing approximately 10 μg of high molecular weight DNA, after three one hour equilibration steps in 50 ml of HindIII 1× digestion buffer (Boehringer Mannheim, Mannheim, Germany) plus 0.1% Triton X-100. The buffer was then removed and replaced by 1 ml/plug of ice-cold HindIII enzyme buffer containing 20 units of HindIII (Boehringer). After two hours incubation on ice, the plugs were transferred to a 37° C. water bath for 30 minutes. Digestions were stopped by adding 500 μl of 50 mM EDTA (pH 8.0).

4. Size selection. The partially digested DNA was subjected to contour-clamped homogenous electric field (CHEF) electrophoresis on a 1% agarose gel using a BioRad DR III apparatus (BioRad, Hercules, Calif.) in 1×TAE buffer at 13° C., with a ramp from 3 to 15 seconds at 6 V/cm for 16 hours. Agarose slices from 25 to 75 kb, 75 to 120 kb and 120 to 180 kb were excised from the gel and stored in TE at 4° C.

5. Ligation and transformation. Agarose-slices containing fractions from 25 to 75 kb, 75 to 120 kb and 120 to 180 kb were melted at 65° C. for 10 minutes and digested with Gelase (Epicentre Technologies, Madison, Wis.), using 1 unit per 100 μl gel-slice. 25-100 ng of the size-selected DNA was then ligated to 10 ng of HindIII digested, dephosphorylated pBeloBAC11 in a 1:10 molar ratio using 10 units of T4 DNA ligase (New England Biolabs, Beverly, Mass.) at 16° C. for 20 hours. Ligation mixtures were heated at 65° C. for 15 minutes, then drop-dialysed against TE using Millipore VS 0.025 mM membranes (Millipore, Bedford, Mass.). Fresh electrocompetent E. coli DH10B cells (Sheng et al., 1995) were harvested from 200 ml of a mid-log (OD₅₅₀=0.5) culture grown in SOB medium. Cells were washed three times in ice-cold water, and finally resuspended in ice-cold water to a cell density of 10¹¹ cells/ml (OD₅₅₀=150). 1 μl of the ligation-mix was used for electroporation of 30 μl of electrocompetent DH10B E. coli using a Eurogentec Easyject Plus electroporator (Eurogentec, Seraing, Belgium), with settings of 2.5 kV, 25 μF, and 99½, in 2 mm wide electroporation cuvettes. After electroporation, cells were resuspended in 600 μl of SOC medium, allowed to recover for 45 minutes at 37° C. with gentle shaking, and then plated on LB agar containing 12.5 μg/ml chloramphenicol (CM), 50 μg/ml X-gal, and 25 μg/ml IPTG. The plates were incubated overnight and recombinants (white colonies) were picked manually to 96 well plates. Each clone was inoculated 3 times (2×200 μl and 1×100 μl of 2YT/12.5 μg/ml CM per clone) and incubated overnight. One of the microtiter plates, containing 100 μl culture per well, was maintained as a master plate at −80° C. after 100 ml of 80% glycerol were added to each well while minipreps (Sambrook et al., 1989) were prepared from the remaining two plates to check for the presence of inserts. Clones containing inserts were then designated “Rv” clones, repicked from the master plate to a second set of plates for storage of the library at −80° C.

6. Preparation of DNA for sizing, direct sequencing and comparative genomics. A modified Birnboim and Doly protocol (Birnboim et al., 1979) was used for extraction of plasmid DNA for sequencing purposes. Each Rv clone was inoculated into a 50 ml Falcon polypropylene tube containing 40 ml of 2YT medium with 12.5 μg/ml of CM and grown overnight at 37° C. with shaking. Cells were harvested by centrifugation and stored at −20° C. The frozen pellet was resuspended in 4 ml of Solution A (50 mM glucose, 10 mM EDTA, 25 mM Tris, pH 8.0) and 4 ml of freshly prepared solution B (0.2 M NaOH, 0.2% SDS) was then added. The solution was gently mixed and kept at room temperature for 5 minutes before adding 4 ml of ice-cold solution C (3M Sodium Acetate, pH 4.7). Tubes were kept on ice for 15 min, and centrifuged at 10,000 rpm for 15 min. After isopropanol precipitation, the DNA pellet was dissolved in 600 μl RNase solution (15 mM Tris HCl pH 8.0, 10 μg/ml RNase A). After 30 minutes at 37° C. the DNA solution was extracted with chloroform:isoamylalcohol (24:1) and precipitated from the aqueous phase using isopropanol. The DNA pellet was then rinsed with 70% ethanol air-dried and dissolved in 30 μl distilled water. In general, DNA prepared by this method was clean and concentrated enough to give good quality results by automatic sequencing (at least 300 bp of sequence). For a few DNA preparations, an additional polyethylene glycol (PEG) precipitation step was necessary, which was performed as follows. The 30 μl of DNA solution were diluted to 64 μl, mixed gently and precipitated using 16 μl 4M NaCl and 80 μl of 13% PEG 8000. After 30 min on ice the tubes were centrifuged at 4° C., the pellet carefully rinsed with 70% ethanol, air-dried and diluted in 20 μl of distilled water.

7. Sizing of inserts. Insert sizes were determined by pulsed-field gel electrophoresis (PFGE) after cleavage with DraI (Promega). 100-200 ng of DNA was DraI-cleaved in 20 μl total reaction volume, following the manufacturer's recommendations, then loaded onto a 1% agarose gel and migrated using a pulse of 4 s for 15 h at 6.25 V/cm at 10° C. on an LKB-Pharmacia CHEF apparatus. Mid-range and low-range PFGE markers (New England Biolabs) were used as size standards. Insert sizes were estimated after ethidium bromide staining of gels.

8. Direct sequencing. For each sequencing reaction 7 μl BAC DNA (300-500 ng), 2 μl primer (2 μM), 8 μl reaction mix of the Taq DyeDeoxy Terminator cycle sequencing kit (Applied Biosystems) and 3 μl distilled water were used. After 26 cycles (96° C. for 30 sec; 56° C. for 15 sec; 60° C. for 4 min) in a thermocycler (MJ-research Inc., Watertown, Mass.) DNA was precipitated using 70 μl of 70% ethanol/0.5 mM MgCl₂, centrifuged, rinsed with 70% ethanol, dried and dissolved in 2 μl of formamide/EDTA buffer. SP6 and T7 samples of 32 BAC clones were loaded onto 64 lane, 6% polyacrylamide gels and electrophoresis was performed on a Model 373A automatic DNA sequencer (Applied Biosystems) for 12 to 16 hours. The sequences of oligonucleotides used as primers are shown in Table 1.

9. DOP-PCR. As an alternate procedure we used partially degenerate oligonucleotides in combination with vector-specific (SP6 or T7) primers to amplify insert ends of BAC clones, following a previously published protocol for P1 clones (Liu et al., 1995). The degenerate primers Deg2, Deg3, Deg4, Deg6 (Table 1) gave the best results for selected amplification of insert termini. TABLE 1 Primers used for PCRs and sequencing Vector specific Primers for DOP PCR- first amplification step: SP6-BAC1: AGT TAG CTC ACT CAT TAG GCA T7-BAC1: GGA TGT GCT GCA AGG CGA TTA Vector specific Primers (direct sequencing, nested primer for second PCR step) SP6 Mid: AAA CAG CTA TGA CCA TGA TTA CGC CAA T7-Belo2: TCC TCT AGA GTC GAC CTG CAG GCA Degenerate Primers: Deg2: TCT AGA NNN NNN TCC GGC Deg3: TCT AGA NNN NNN GGG CCC Deg4: CGT TTA AAN NNN NWA GGC CG Deg6: GGT ACT AGT NNN NNW TCC GGC Primers used for the amplification of M. bovis DNA in polymorphic chromosomal region of Rv58: Primer 1: ACG ACC TCA TAT TCC GAA TCC C Primer 2: GCA TCT GTT GAG TAC GCA CTT CC

10. Screening by pooled PCR. To identify particular clones in the library which could not be detected by random end-sequencing of the 400 BAC clones, PCR-screening of DNA pools was performed. Primers were designed for regions of the chromosome where no BAC coverage was appearent using cosmid-or H37Rv whole genome shotgun sequences. Primers were designed to amplify approximately 400-500 bp. Ninety-six-well plates containing 200 μl 2YT/12.5 μg/ml CM per well were inoculated with 5 μl of −80° C. glycerol stock cultures each from the master plates and incubated overnight. The 96 clones of each plate were pooled by taking 20 μl of culture from each well and this procedure was repeated for 31 plates. Pooled cultures were centrifuged, the pellets were resuspended in sterile water, boiled for 5 minutes, centrifuged and the supernatants kept for PCRs. As an initial screening step, the 31 pools of a total of 2976 BACs, representing about two thirds of the library were tested for the presence of a specific clone using appropriate PCR primers. PCR was performed using 10 μl of supernatant, 5 μl of assay buffer (100 mM b-mercaptoethanol, 600 mM Tris HCl (pH 8.8), 20 mM MgCl₂, 170 mM (NH₄)₂SO₄), 5 μl of Dimethylsulfoxide (DMSO), 5 μl of dNTPs (20 mM), 5 μl of water, 10 μl primer (2 μM), 10 μl inverse primer (2 μM) and 0.2 units of Taq DNA polymerase (Boehringer). 32 cycles of PCR (95° C. for 30 s, 55° C. for 1 min 30 s, 72° C. for 2 min) were performed after an initial denaturation at 95° C. for 1 min. An extension step at 72° C. for 5 min finished the PCR-If a pool of 96 clones yielded an appropriate PCR product (FIG. 1A), subpools were made to identify the specific clone. Subpools representative for lane A of a 96 well plate were made by pooling clones 1 to 12 from lane A into a separate tube. Subpools for lanes B to H were made in the same way. In addition, subpools of each of the 12 rows (containing 8 clones each) were made, so that for one 96 well plate, 20 subpools were obtained. PCR with these 20 subpools identified the specific clone (FIG. 1B, lower gel portion). If more than one specific clone was present among the 96 clones of one plate (FIG. 1B, upper gel portion), additional PCR reactions had to be performed with the possible candidates (data not shown).

11. Genomic comparisons. DNA from the BAC clone Rv58 was digested with the restriction endonucleases EcoRI and PvuII, and resolved by agarose gel electrophoresis at low voltage overnight (1.5 V/cm). DNA was transferred via the method of Southern to nitrocellulose membranes (Hybond C extra, Amersham) following standard protocols (Sambrook et al., 1989), then fixed to the membranes at 80° C. for 2 hours. The blot was hybridized with ³²P labelled total genomic DNA from M. tuberculosis H37Rv, M. bovis type strain (ATCC 19210) or M. bovis BCG Pasteur. Hybridization was performed at 37° C. overnight in 50% formamide hybridization buffer as previously described (Philipp et al., 1996b). Results were interpreted from the autoradiograms.

12. Computer analysis. Sequence data from the automated sequencer ABI373A were transferred as binary data to a Digital Alpha 200 station or Sun SparcII station and analysed using TED, a sequence analysis program from the Staden software package (Dear et al., 1991). Proof-read sequences were compared using the BLAST programs (Altschul et al., 1990) to the M. tuberculosis H37Rv sequence databases of the Sanger Centre, containing the collected cosmid sequences (TB.dbs) and whole-genome shotgun reads (TB_shotgun_all.dbs) (http://www.sanger.ac.uk/). In addition, local databases containing 1520 cosmid endsequences and the accumulating BAC endsequences were used to determine the exact location of end-sequenced BACs on the physical and genetic map. MycDB (Bergh et al., 1994) and public databases (EMBL, Genbank) were also used to compare new sequences, but to a lesser extent. The organization of the open reading frames (ORFs) in the polymorphic region of clone Rv58 was determined using the DIANA software established at the Sanger Centre.

EXAMPLES Example 1 Construction of a pBeloBAC11 Library of M. tuberculosis H37Rv

Partial HindIII fragments of H37Rv DNA in the size range of 25 to 180 kb were ligated into pBeloBAC11 and electroporated into strain E. coli DH10B. While cloning of fractions I (25 to 75 kb) and 11 (75 to 120 kb)-gave approximately 4×10⁴ transformants (white colonies), cloning of fraction m (120 to 180 kb) repeatedly resulted in empty clones. Parallel cloning experiments using partial HindIII digests of human DNA resulted in stable inserts for all three fractions (data not shown), suggesting that the maximum size of large inserts in BAC clones is strongly dependent on the source of the DNA. Analysis of the clones for the presence of inserts revealed that 70% of the clones had an insert of the appropriate size while the remaining 30% of white colonies represented empty or lacZ′-mutated clones. Size determination of randomly selected, DraI-cleaved BACs via PFGE showed that the insert sizes ranged for the majority of the clones between 40 kb and 100 kb with an average size of 70 kb. Clones with inserts of appropriate size were designated with “Rv” numbers, recultured and stored at −80° C. for further use.

Example 2 Direct DNA Sequence Analysis of BACs

To characterize the BAC clones, they were systematically subjected to insert termini sequencing. Two approaches, direct sequencing of BAC DNA and PCR with degenerate oligonucleotide primers (DOP), adapted to the high G+C content of mycobacterial DNA, were used. In a first screening phase, 50 BAC clones designated Rv1 to Rv50 were analysed using both methods in parallel. Except for two clones, where the sequences diverged significantly, the sequences obtained by the two methods only differed in length. Sequences obtained directly were on average about 350 bp long and for 95% of the clones both the SP6 and T7 endsequences were obtained at the first attempt. Sequences obtained by DOP-PCR were mostly shorter than 300 bp. For 40% of the BACs we obtained only very short amplicons of 50 to 100 base pairs from one end. In two cases the sequence obtained with the DOP-PCR differed from the sequences obtained by direct sequencing, and in these cases E. coli or vector sequences were amplified (data not shown). Taking the advantages and disadvantages of both methods into account, we decided to use direct termini sequencing for the systematic determination of the SP6 and T7 end-sequences.

Example 3 Representativity of the Library

After having determined the end-sequences of 400 BACs a certain redundancy was seen; The majority of clones were represented at least 3 to 4 times. Maximum redundancy was seen in the vicinity of the unique rrn operon, as 2.5% of the clones carried identical fragments that bridge the cosmids Y50 and Y130 (FIG. 3, approximate position at 1440 kb). The majority of clones with identical inserts appeared as two variants, corresponding to both possible orientations of the HindIII fragment in pBeloBAC11. This suggests that the redundancy was not the result of amplification during library construction, but due to the limited number of possible combinations of partial HindIII fragments in the given size-range of 25 to 120 kb. To detect rare BAC clones, a pooled PCR protocol was used. Primers were designed on the basis of the existing cosmid sequences and used to screen 31 pools of 96 BAC clones. When positive PCR products of the correct size were obtained, smaller subpools (of 8 or 12 clones each) of the corresponding pool were subsequently used to identify the corresponding clone (FIG. 1). With this approach 20 additional BACs (Rv401-Rv420) were found for the regions where no BACs were found with the initial systematic sequencing approach. The endsequences of these BACs (Rv401-420) were determined by direct sequencing, which confirmed the predicted location of the clones on the chromosome. A 97% coverage of the genome of H37Rv with BAC clones was obtained. Only one region of ˜150 kb was apparently not represented in the BAC library as screening of all pools with several sets of specific primers did not reveal the corresponding clone. This was probably due to the fact that HindIII fragments of mycobacterial DNA larger than 110 kb are very difficult to establish in E. coli and that a HindIII fragment of ˜120 kb is present in this region of the chromosome (data not shown).

Example 4 Establishing a BAC Map

Using all endsequence and shotgun-sequence data from the H37Rv genome sequencing project, most of the BAC clones could then be localized by sequence comparison on the integrated map of the chromosome of M. tuberculosis strain H37Rv (Philipp et al., 1996b) and an ordered physical map of the BAC-clones was established. PCR with primers from the termini sequences of selected BACs were used for chromosomal walking and confirmation of overlapping BACs (data not shown). The correct order of BACs on the map was also confirmed more recently, using 40,000 whole genome shotgun reads established at the Sanger Centre. In addition, pulsed-field gel electrophoresis of DraI digests of selected BACs was performed (FIG. 2) in order to see if the approximate fragment size and the presence or absence of DraI cleavage sites in the insert were consistent with the location of the BACs on the physical map (FIG. 3). Comparison of the sequence-based BAC-map with the physical and genetic map, established by PFGE and hybridization experiments (Philipp et al., 1996b), showed that the two maps were in good agreement. The positions of 8 genetic markers previously shown on the physical and genetic map were directly confirmed by BAC-endsequence data (Table 2, FIG. 3). The position of 43 from 47 Y-clones (91%) shown on the physical and genetic map, which were later shotgun sequenced, was confirmed by the BAC endsequences and shotgun sequence data. Four clones (Y63, Y180, Y251, and Y253) were located to different positions than previously thought and this was found to be due to book keeping errors or to chimeric inserts. Their present approximate location relative to the oriC is shown in FIG. 3: Y63 at 380 kb, Y63A at 2300 kb, Y180 at 2160 kb, Y251 at 100 kb, and Y253 at 2700 kb. A total of 48 BACs, covering regions of the chromosome, not represented by cosmids were then shotgun sequenced (Cole et al., 1997), and these are squared in FIG. 3. No chimeric BACs were found, which is consistent with the observations of other research groups for other BAC libraries (Cai et al., 1995; Zimmer et al; 1997). The absence of chimeric BACs was of particular importance for the correct assembly of the M. tuberculosis H37Rv sequence. The exact position of the BAC termini sequences on the chromosome will be available via the world wide web http://www.pasteur.fr/MycDB). TABLE 2 Identities of genetic markers previously shown on the integrated and genetic map of H37Rv (Phlipp et al., 1996b) wich showed perfect sequence homology with BAC ens. sequences. BAC GenBank end Description of Accession Locus sequence genetic marker Organism n° apa Rv163SP6 Secreted M. tuberculosis X80268 alanine-proline- rich antigen dnaJ, dnaK Rv164T7 DnaJ hsp M. leprae M95576 fop-A Rv136T7 Fibronectin M. tuberculosis M27616 binding protein pa/A Rv401T7 DNA polymerase M. tuberculosis L11920 I ponA Rv273T7 Penicillin binding M. leprae S82044 protein pstC Rv103T7 Putative M. tuberculosis Z48057 phosphate transport receptor recA Rv415SP6 Homologous M. tuberculosis X58485 recombination wag9 Rv35SP6 35-kDa antigen M. tuberculosis M69187

Example 5 Repetitive Endsequences

Repetitive sequences can seriously confound mapping and sequence assembly. In the case of the BAC endsequences, no particular problems with repetitive sequences were observed. Although nine clones with one end in an IS1081 (Collins et al., 1991) sequence were identified, it was possible to correctly locate their position on the map using the sequence of the second terminus. Moreover, these BACs were used to determine the exact locations of IS1081 sequences on the map. Five copies of this insertion sequence, which harbors a HindIII cleavage site, were mapped on the previous physical and genetic map. In contrast, BAC endsequence data revealed an additional copy of IS1081 on the M. tuberculosis H37Rv chromosome. The additional copy was identified by six clones (Rv27, Rv118, Rv142, Rv160, Rv190, Rv371) which harbored an identical fragment linking Y50 to 1364 (FIG. 3, at ˜1380 kb). This copy of IS1081 was not found by previous hybridization experiments probably because it is located near another copy of IS1081, localized on the same DraI fragment Z7 and AsnI fragment U (FIG. 3, at ˜1140 kb). Furthermore, the position of a copy of IS1081 previously shown in DraI fragment Y1 (FIG. 3, at ˜1840 kb) had to be changed to the region of Y349 (FIG. 3, at ˜3340 kb) according to the endsequences of BAC Rv223. The positions of the four other IS1081 copies were confirmed by the sequence data and therefore remained unchanged. In total 6 copies of IS1081 were identified in the H37Rv genome in agreement with the findings of others (Collins et al., 1991).

In addition, a sequence of 1165 bp in length containing a HindIII site was found in two copies in the genome of H37Rv in different regions. The endsequences of BAC clones Rv48 and Rv374, covering cosmid Y164, as well as Rv419 and Rv45, that cover cosmid Y92, had perfect identity with the corresponding parts of this 1165 bp sequence (FIG. 3, at ˜3480 kb and ˜900 kb). Analysis of the sequence did not reveal any homology with insertion sequences or other repetitive elements. However, as each of the two locations showed appropriate BAC coverage, chimerism of the sequenced cosmids Y164 and Y92 can be ruled out as the probable cause.

Example 6 Using BAC Clones in Comparative Genomics

The minimal overlapping set of BAC clones represents a powerful tool for comparative genomics. For example, with each BAC clone containing on average an insert of 70 kb, it should be possible to cover a 1 Mb section of the chromosome with 15 BAC clones. Restriction digests of overlapping clones can then be blotted to membranes, and probed with radiolabelled total genomic DNA from, for example, M. bovis BCG Pasteur. Restriction fragments that fail to hybridize with the M. bovis BCG Pasteur DNA must be absent from its genome, hence identifying polymorphic regions between M. bovis BCG Pasteur and M. tuberculosis H37Rv. The results of such an analysis with clone Rv58 (FIG. 3, at −1680 kb) are shown here. This clone covers a previously described polymorphic genomic region between M. tuberculosis and M. bovis BCG strains (Philipp et al., 1996a). EcoRI and PvuII digests from clone Rv58, fixed on nitrocellulose membranes, were hybridized with ³²P-labelled total genomic DNA from M. tuberculosis H37Rv, M. bovis (ATCC 19120), and M. bovis BCG Pasteur. FIG. 4 presents the results of this analysis, where it is clear that several restriction fragments from clone Rv58 failed to hybridize with genomic DNA from either M. bovis or M. bovis BCG Pasteur. On the basis of the various missing restriction fragments, a restriction map of the polymorphic region was established and compared to the H37Rv sequence data. The localization of the polymorphism could therefore be estimated, and appropriate oligonucleotide primers (Table 1) were selected for the amplification and sequencing of the corresponding region in M. bovis. The alignment of M. bovis and M. tuberculosis H37Rv sequences showed that 12,732 bp were absent from the chromosomal region of the M. bovis type strain and M. bovis BCG Pasteur strain. The G+C content of the polymorphic region is 62.3 mol %, which is the same as the average genome G+C content of the M. tuberculosis genome, hence indicating that this region is not a prophage or other such insertion. Subsequent PCR studies revealed that this segment was also absent from the Danish, Russian, and Glaxo substrains of M. bovis BCG, suggesting that this polymorphism can be used to distinguish M. bovis from M. tuberculosis. Analysis of this sequence showed that 11 putative open reading frames (ORFs) are present in M. tuberculosis, corresponding to ORFs MTCY277.28 to MTCY277.38/accession number Z79701-EMBL Nucleotide Sequence Data Library (FIG. 5). FASTA searches against the protein and nucleic acid databases revealed that the genes of this region may be involved in polysaccharide biosynthesis. Among these putative genes, the highest score was seen with ORF 6 (MTCY277.33), whose putative product shows a 51.9% identity with GDP-D-Mannose dehydratase from Pseudomonas aeruginosa (accession number U18320—EMBL Nucleotide Sequence Data Library) in a 320 amino acid overlap. The novel M. bovis sequence of the polymorphic region was deposited under accession number AJ003103 in the EMBL Nucleotide Sequence Data Library.

As it appears from the teachings of the specification, the invention is not limited in scope to one or several of the above detailed embodiments; the present invention also embraces all the alternatives that can be performed by one skilled in the same technical field, without deviating from the subject or from the scope of the instant invention. TABLE 3 End sequences of the polynucleotide inserts cloned in the named recombinant BAC vectors contained in the I-1945 M. tuberculosis H37Rv genomic DNA library. RvXXXSP6 corresponds to the SP6 endsequence of the clone RvXXX; RvXXXT7 corresponds to the T7 endsequence of the clone RvXXX. RvXXXIS 1081 corresponds to a region located close to a copy of the IS1081 repetitive sequence (Insertion element) The character << - >> denotes an uncertain base residue. Clone Rv101 :::::::::::::::Rv101SP6.seq:::::::::::::: AATACTCAAGCTTGCCCAGCCGTCGATGACAAGAAATATGTCCGCAAAAGACTCAGCGGCCGACTTTGCTCGCAGCTGGCGGTACCGCGCCACCGATTCTATGCCG TGGTCGCGGAAAAATGCCTCCCGAAATCGCACGGCCGACTCCAGTTCGGCGAGCATCCGCGATGCCAGCTGCGGCTGCGCCCTGCCGGCCACGGCACCCTCATGCG GCAGTTCGTCCACCTGGGCCAGCGCCCCGCCGCCGAATTCCAAACAATAGAACTGCACCCGGCCCGCATCGTGGGTAACAGCCAACGGCATGATCAGCGTCGGCAG CGCGGTTGACTTGCCCGTTTGCGGTGCACCTACGAACGCGACATTGCCTGCGGCCCCGGACAAGTCGATCGTGCGCGGCACCCGTGACTGCTCTAACGGGCGATTG AAATTCCGAT :::::::::::::::Rv101T7.seq::::::::::::::: CCACCCGTGTAATTTGGGATGGGCAAAAAGGCGAAGCACCGCGTGGCCACGAACGCCGGGAGGGACAATCTCGGGCGGTTAGGGCTTCTCGCGGGAAGGCCCGAAC GTACGGCGTTTCAACACCTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGCTGGCACCCTGGCCGGGCGATGATCTGCAGCGTCGCCGCGGG TAGTCGCCGCCCGGGCGGCTACACTCTGAAACGCGATGACCATCGATGTGTGGATGCAGCATCCCGACGCAACGGTTCCTACACCGCGATATGTTCGGCTCGCTGC CCCGGTGGACCGGT Clone Rv102 :::::::::::::::Rv102SP6.seq::::::::::::::: AATACTCAAGCTTTCCGCCGATACCCGCCATGTCGCGCACATCCAGGACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAAGTGCGGATGATCGGGCCGCC TACGTCGTGGTGTACCTCGTCGGTAACAACGAAACCGAAGCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGCCACCGCACGGGGTGAAGG CCTATGTCACCGGTCCGGCAGCACTCAATGCCGACCAGGCCGAGGGCGGAGACAAAAGTATCGCTAAGGTCACCGCGATCACCAACATGGTGATCGCAGCAATGTT GCTAGTGATCTATCGCTCCGTAATTACCGCGGTTCT :::::::::::::::Rv102T7.seq::::::::::::::: GTGCCGTTCCAACCCGAATTGGCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACCTCGATGCTGCCGCCATGG ACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGGATCGCGGTGATCGTGGA TGACGGCATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCGATCGGCCCAGACGACATC GTGGCGAGATTCGCCGGGTACGCCGATGAGGTGGT Clone Rv103 :::::::::::::::Rv103SP6.seq::::::::::::::: AATACTCAAGCTTTCGGCGGAAACGGACACACATTGAATATTGATGACAAAATAAAAATCATTGATGGTTTGAGTCACCAGGCCGATCAAGCCTTCGCCGAGCCAA ATTCCAATCAAGAGGCCCAAGCCCGTACCAATCAGCCCGGCAACGAGGGATTCCGTCATTATCAGCCAAAATAACTGCTCTCGGGTTACACCCAAACAGCGCAATA TGGCGAAAAACGGTCGCCGTTGCACGACATTAAATGTCACGGTATTGTAGATTAAAAAGATACCCAC :::::::::::::::Rv103T7.seq::::::::::::::: TGCTCCCGAAACCTGGGGGTGTGCCTGCTCTGTATGCACGGCATACGGACATCCTTCCCCTGAGACCCGCGGTCGAACCAGCCACGTGTCCATCATAGNGGGTCAA CCCCGGCCAAGGGCGACGGCACGCCAAGTTCGCCGACCGTTAACCTAGTGCTGTTAGCTTCATTTGCTGCGATCAAAACAGCTGGTCGGCCGTTAGGAACTGAATT GAAACTCAACCGATTTGGTGCCGCCGTAGGTGTCCTGGCTGCGGGTGCGCTGGTGTTGTCGGCGTGTGGTAACGACGACAATGTGACCGGGGGAGGTGCAACCACT GGCCAGGCGTCGGCAAAGGTCGATTGCGGGGGGAAGAAGACACTCAAAGCCAGTGGGT Clone Rv104 :::::::::::::::Rv104SP6.seq::::::::::::::: ATACTCAAGCTTTGCCGACGAGCGGGCGATGTTGATGACGGGAAACCCCAGCGCACAACCGACGATTTTGGCGTAGCCGGCGGACGTCTGCTCGATTCCGATCACG TCGGCGCTCGCATCGAGCATGGCGCCGGCGACGGCTAGCAGCGATCCGCCGTCGTCGAGAAGCACGACACGAGCCGTACGCCCGGCCGTAAGCCGCGCCCAGGATT CGGCGAAAAACCGTTCTACGTGGCGGGTGTACTGGGTGTCGAATGATTCGTGGGGTGCGTAGGCGTCGCTGCAATCGTCGACATAGATGCCGTCGGGCCGCATCGC GTCGACAACTCCGGGTGAGTGCAATAGCACTTGCCGATCACCGCGACGTTGCGCGGATGAGGCCGAACCCGAATA :::::::::::::::Rv104T7.seq::::::::::::::: TCCTATGTCCCTGCCGAGCANGTGATCGAACGCGGTGACAGATTTGTCTATCCTGGACCTGACGGTGAGGTCGAAGTTTTCCAGGAATTCGGCAAAATCGGTAAGA GCCTGAAGAATTCGGTATCGCCGGACGAAATCTGCGACGCATACGGGGGCATATACGCTTCGGGTTTACGAGATGTCGATGGGGCCGCTGGAGGCTTCACGTCCAT GGGCCACAAAGGATGTTGTCGGCGCGTACCGTTTTCTGCAGCGGGTGTGGCGCTTGGTCG Clone Rv105 :::::::::::::::Rv105SP6.seq::::::::::::::: ATACTCAAGCTTGATTCCGCCGAAACCGACCGTGAGCACCCCGCCAGCCACCACGCTCGGGTCGGGCGCCGGGCCCGGGCCGCCAGGCTGCTCCGCTCGGTGATGG CACGCCACCGCGACACCACCCGGCTGCGCTACGTCTAACCATTCCAGGCGGAGCTACATCAGCTCGGCCGCCCAGTGTTCGGGGCCTCTTTCCAGGTCGAAGTCTA TACCGATATGCGCATCCGCAGCCGCCACCCTGGAGAACAGAACGATGCCCTACTAATGCTTGTCTGGCGGGGCC :::::::::::::::Rv105T7.seq::::::::::::::: GGTACGCTTCGGTCGCAGTCTGCGAGTGATGCATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTCAGTTGCTCACCGGAATCCAACCGGTA GAAGGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCAGCACTCCGCAGGCTTCGTCGGGGTGGTCGCGA CGCGCATGGGCCACCATCGCATTCACCAGGTCTGCGCGAATCACCAGCACGTAGACGGTTCCTTTCCTAAGCAACACCGAAGTTTCAGGACCCGAATGCTCCGGGA AACATGTCACGGTAGGTCGGTATTCCGGCTACCGGCTGA Clone Rv106 :::::::::::::::Rv106SP6.seq::::::::::::::: GGCGTCAACGGTGTCGGAACCCGCGTCAAGCAATTGGTAGGCCTGCAGTCTGTGAATCAGGCCGACGCTGTGGCCGCCGCGGC :::::::::::::::Rv106T7.seq::::::::::::::: GGCTNGCGTACCCGGTACCGGCCGCGGGCCTACCACGTGCCGGAACTGGAAGCGCAGTAAGCCCTCAACGCGCCACCGCTTTGGCCCGGGGGCCCGGCGTAGGCGC ATCGGCGGTGGCCGTGGGGCGGCGCACTGCGACCTCACCAGCGGCTTTCGAGCTTTGTTCGATCAACCGGCCAGCATGGTCGANGATGCATTCGAGACCATATTCG AAATTGGTTTCATCGGGGGCCCCGATCCGATGCCCCCTCCCAGTTGCGTGAGCAANCAGCGGAGTCNTCGCGGGATCGATGGCCACGGGGTGTTCAATGGCGGATG GTCCGCTGCCCGCCGACTGGCTCTTGCGGGAGAACCGATCTAGCACCACCGATCCGCGCACGTNG Clone Rv107 :::::::::::::::Rv107T7D4.seq::::::::::::::: CGTAATNTCGCGCACANCCANGACTTCTGGGGGGATCNGCTGACAGTGGTNGGATCCCAAATTGCGGATGATCGGGCCGCCNACGTCGTTGTGTACCTCNTCNGTC ACAACNAANCCGAANCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGCCACCGCNCGGGGTGAAGGCCTATGTCACCGGTCCGGCAACACT CAATGCCGACCAGGCCGANGCCGGACACNANAGTATCNCTAACGTCACCGCGATCACGAGCATGGTGATCGNNCAATGTTNCTANTGATCTATCGCTCCGTAATTA CCGCGGTTCTCGTCTTGATCATGGTCGCANCGAACTCCGGCGCAATCCGCGGATTCATCGNCTTGCTCGCCGATCACATATTTTCAGCCTTTCACATTGCAACNAA CCTGCTCGTCTCATGGNGATGCGGCGACACGGACTACCGATATCATGCTCGCCGTTACACAATCNCGCCACGCCGCGAAGACNGGAAACGCTTCTACACAATNTTC NCGGGACGCCACTNAACTTGGTTCNGGTTTGACATTGCCGCGCATGTNTGCCCAGCTTTGCCGGCTCCCCTTA Clone Rv108 :::::::::::::::Rv108T7D4.seq::::::::::::::: TGAATTTCCCGATCCCACAATCTCGGTTCAGATACAGGTCGCCATACCCCTTACTTCGGCAACGCTGGGCGGATTGGGGCTGCNGCTGCAGCANACCATCGACGCC ATCGAATTGCCGGCAATCTCGTTCAGCCAATCCATACCCATCGACATTCCGCCGATCGACATCCCGGCCTTCNCCCTTTAACGG Clone Rv109 :::::::::::::::Rv109SP6.seq::::::::::::::: AACAGCTATGACCATGNTTACGCCAAGCTATTTAGGTAACACTATANAATACTCAAGCTTTTACGGTGATCGCGCATCACCTGGTTCATGAACTGGAAGCAGCGCA NCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCCGCGGTCNGGTGCAGGTGCTCGGGCAGCTCGGCCGCGACAGCCGCCTGACCCTGAAACCAGCTTCC ATATCCCGCGACNAACNACNCCAGTCCGCTACGTAACCCCTCCGCGACTGTCCATGGACAACAGCGCGTTCTCCACCGACCGGGCCCGGGTGTGGGGTGTTTGGGC GACCGGCAGCCAGGTGGTCCACACTGCCGACGGGCGCCGCGAGCCGTTCACCGACCAAGCCGCCGAACAAGTCCGCCCGATCGCATACTCCAACCGGTTGCGGTAC TGCAGGTCAGCTGGCGTACCTCCTCNTCNCGCTCGGCGAAGTCTTGCTCCANCACGTCGCAGAACGGCAAGGAACACGTTCA :::::::::::::::Rv109T7seq::::::::::::::: GACCGNNCCATGTTTCCACAATGTGGTGCCAGTNCGGNGGCTACGTGCCATCNANACACTGGCGCAGGCTATCGCACCCGTTATCNGCTACGAACAAATCNCGGTA TGCGTTCTTTANCATGAGTCGGCGACCGNCGATCATGGTCGACACCCACGACNGAAATACGCAGATCGCCNTCNAGCNTGTGTGCCGCGGATTATCANGACTGACC TCCTGGCTGACCGGNNTGTNTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGNTCGTGGTCGGCTCGGATAGCGAAGTCAGCTAATTCTCGTGGCAGCTCGAAAGGG TCCTGCCGGTGCCGGTCTTTGCGCAAACCATGCNCATGTTACGGTCCCTCGGGTGCGGCCTGGCGGCGGC Clone Rv10 :::::::::::::::Rv10SP602.seq::::::::::::::: GGGATGGGCGGGCCCGCTAAACTCTTCGTGTTCCACTAACTCCGGGAGGGNCAATCTCGGGCCGTTATGGCTCACGTCGCGTCGCCCTCCGACCGCGAACATTCGG AGTTGGCAGCAACCTGGTAGCACCCTGGCCGG :::::::::::::::Rv107TD4.seq::::::::::::::: NCCGTCGTTGACAAGTAAATATGTCCGCAAAAGTCTCAGCGGCCGACTTTGCTCGCAGGTGGCGGTACCGCGCCACCGAGTCGATGCCGTGGTCGCGGAAGAATGC CTCCCGAAATCGCACGGCCTTCCCNNTTTAAACGGA Clone Rv110 :::::::::::::::Rv110SP6.seq::::::::::::::: TTTAGGTGACACTATAGAATACTCAAGCTTTTGGTCTAGCCGGCCGAGCACGATACGGGTGTCATTGGCCACCGGCGGCGGCTGTCCGGGAAATGGCGGGTCCCCG GTGGTTTTGCTGATGAGTGCTGAACCGTANTCGAAGTGGGCGGCGTCAGACTCCACCCANCCAGCAGGCAGCGCGAAGCTGAATCCTCCAACCGGGTTGTCNATCC GGACAAGTTGGGGTGCGTTTGGGGCAATGACAGGTGGCNGCGGTGCGTTCGGGTCCGCCGGCCGGAAGTGCTGCGTTGGATCNCCCGCTGGGCATTGGGCNTTTTT GCGGCGGCCGGTGGTNGGGGGGCAACAGGTNTCCCNGTGCGGGTGGCGCTCAACGGTCNACGGCGCAAGCCGCCGTTGTTGGTACCNGGGGCGCTGGCTCCGGATC GCGTTGGCGGTCNCCGG :::::::::::::::Rv110T7.seq::::::::::::::: CTACACCATCGAATACGACGGCGTCGCCNACTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTAC TTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGCACGGANAACCTGCCGCTGC TAGAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAANGTGATTGTTAACCTGGGCTACNGCGACCCGGCCTATGG TTATTCNACCTCNCCGCCCAATGTTGCGACTCCGTTCGGGTTGTTCCCANAAGTCNNCCCGGTCGTCATCGCCGAANCTCTCNTCCCGGGACCCACAGGGAATCNG CNATTTCNCCTACAAATCANCCACCTCCA Clone Rv111 :::::::::::::::Rv111T7.seq::::::::::::::: GCATGATCGGCCACCTTTCGGGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGCGGGTAATCGCCGACGGTGCCGGTTCGCGAGCCGAAGGT GACGACTCTGATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCACCAACGGCGCGAGCTCAACGACGTCAATCNCGTTGTCGCTTTCTACGGTCACCGACCCTGGT GACCGTATGGCNCCCG Clone Rv112 :::::::::::::::Rv112SP6.seq::::::::::::::: GACACTATAGAATACTCAAGCTTGCCAACCGCCAGCCTGCATCCGGCGGCGANCACTGCTCCGCCGACCNGTACGAACCAACCTGCGGTGCCCAGGCCATTGACGA TGTGCTGGTCGGCGCCCGCGAGTCCGCGCACCATCAACGCCGCGGGCACCACCANGGCGGCCCCACCCTGCACGGCGACGATCATTCCGGCGCCGCTCACGGCGGG CGGGGCTCGAACANGCACAGCATCAACGTNGTCACCCGGCCGTGACCGGCCCGCATCGTCACACCACCCAAGCCCATTGCCGTCCTCCTCAACNGGGCGACCCGGC CCGCATCGTCACACGGNCTAAGGCCATTGCCGTCCTCCT :::::::::::::::Rv112T7.seq::::::::::::::: TCGGCGCCATCGGCACCTTCGAGGACCTGTATTTCGACGCCGTGGCCNACCTGAGGTTGGCGGTGGACNAAGTGTGCACCCGGTTGATTGGCTCGGCCTTGCCGGA TGCCACCCNGCGCCTGGTGGTCGATCCGCNAANAGACAANTTGTGGTGGANGCTTCTGCTGCCTGCGACACCCACNACGTGGTGGCACCGGGCAGCTTTAGCTGGC ATGTCCTGACCGCGCTGGCCGACNACTCCAGACNTTCCACNAANGGTCGCCNNCCCAATGTNCCGNANTGTCTCCGGNTCCCTTTACCNCCCAATGGGCNGNTTCC ACNGGTTACGGGCCCCNTNCCGGCGGGTCTNCCTCCCAANCTACCAAATACGCCCGACNTTCCGGA Clone Rv113 :::::::::::::::Rv113SP6.seq::::::::::::::: ATACTCAAGCTTTTATGGTGATCGCGCATCACCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCG GGTGCAGGTGCTCGGGCAGCTCGGCCGCGAACAGCCCGGCTTGAACCCTGAAAACCNGCTTTCCATATCCCGCGACGAAAGAACGCCAGTTCCGCTACTTAAGCCC TCCGCGAACCGTCCATGGACAACAGCGCGTTCTCCACCAACCGGGCCCGGGTGT :::::::::::::::Rv113T7.seq::::::::::::::: TCGGCTCAGGCCGCGCTGCTGGTAGAGTCGCTGACCGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGCGCAGGCTATCG CACCCGTTATCGGCTACGAAGCAAATCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGATCGCCGTCA AGCATGTGTGCCGCGGATTATCAGGACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGGTCGTGGTCGGCTCGGATAGCGA GGTCAGCGAATTCTCGTGGCAGCTCGAAAGGGTCCTGCCGGTGCCGGTCTTTGCGCAAACAATAGCGCAGGTTACGGTCGCGCGGGGTGCGGCCTGGCGGCGGCC Clone Rv114 :::::::::::::::Rv114SP6.seq::::::::::::::: CAAGCTATTTAGGTGACACTATAGAATACTCAAGCTTCGCGTCTACGCCGGCCCGGAGCATCCGCACAGCGCTCAGCAGCCGGTTCCGTACGANCTCAAGCAGGTG GCGCAATGACCGAAACCACCCCAGCCCCGCAAACCCCGGCGGCCCCGGCCGGGCCCGCACAATCGTTCGTGTTGGAGCGGCCCATCCANACCGTTGGGCGCCGTAA GGANGCCGTGGTACGAATGCGGCTGGTGCCCGGCACCGGCAAGTTCGACCTCAACGGCCGCAGCTTGGANGACTACTTCCCAAACAAGGTGCACCAGCAGTTGATC AAGGCACCCCTGGTCACCGTGGATCGGGTGGAAAGTTTCGACATCTTTGCCCACCTGGGCGGCGGCGGCCGTCCGGTCAGGCCGGGCCTGCCCTGGGTATCGCCCG GGCATTGATTCTGGTATCCCCNGAAGAACCG :::::::::::::::Rv114T7.seq::::::::::::::: CGGTTGGCCACCGCTTCTGCGGTGCCGCCGCCGTCGACAATGACCGTGTCGTCCTTGCTGACCACCACGCGTCGGGCCGAGCCCAGCACCTCCAAGCCCACCTCGC GCAGCACCATGCCGGCGTCGGGGTTGACCACCTGGCCACCCGTCACCACCGCCAGGTCCTCAAGGAAACGCCTTACGGCGGTCACCGAMGTACGGCCCCTTGACCG CGACCGCTTTCAACGTCTTGCGAATCGCGTTGACGACCAGCGTCGCCAACGCTTCGCCCTCCACGTCTTCAGCCACGATCAGTAGTGGCTTACCCGTTCCTGCAAC CTTTTCCAGCAATGGCAACAGATCGGGAAGCGANCTGATCTTGTCTTGGTGCN Clone Rv115 :::::::::::::::Rv115SP6.seq::::::::::::::: CCAAGCTATTTAGGTGACACTATAGAATACTCAAGCTTTTGGCTGGGTCGCCTTCGAATTCNGCGTGCACCGCTATGGGTTGCANCAGCGGCTGGCGCCGCACACC CCACTGGCCCGGGTGTTTTCGCCCCGAACCCGGATCATGGTGAGCGAAAAGGANATTCNCCTGTTCGATGCTGGATTCGCCACGCCAAGGCATCTANACGATTACT CTCCNCGGGGTGGGAAAAGTGCCCAATCCCCCTCCCTCCAACTTTCCNAACAATCATTCCGGTTCCNCCNTCCGGTTGGNGGTAACCNNCCAATAAAACCCCTGCC CG :::::::::::::::Rv115T7.seq::::::::::::::: GCCCGCNCATGGCCAATCCCCGAAGACATCATTGGCCAGTGGCCGGGCGCTAACAGGTTCCAGCCCCCCACCANTGCCGCTCGAACATGCGGTGCAACCCATTCGC AGGCCGGCAGGGAAAGCACCGCGGAAGCCGCAAAGGGCTGCAGTTCCGCGCCCAATAATGTCGTCCGCAACCAGATGCGCTCNAAAACCNCNCCGGCAGTCAGCGC ACCCGACGCGANGTCGAAAGACGTCNTCAGCGCGCCCACATGGGGTGCCAATCGGCACGGCAGGTATGCCGCGCGCAACCCGAGCGCGTGGTGCATGCCCACGGTC CGCANGANGCGCANCACCCGCCAATGCCGAANCCCACGAAACATCGGGCGCATCCACCTTCAACC Clone Rv116 :::::::::::::::Rv116SP6.seq::::::::::::::: ATACTCAAGCTTGCCCAGCCGTCGATGACAAGAAATATGTCCGCAAAAGACTCAGCGGCCGACTTTGCTCGCAGCTGGCGGTACCGCGCCACCGAGTCGATGCCGT GGTCGCGGAAGAATGCCTCCCGAATTCGCACGGCCAATTCCATTCCGGGAAGCATCCGCAATGCCAGCTGCGGTTGCCCCCTGCCGGCCACGGCACCCACTTGCGG CATTGCGTCCACCTGGGCCAGCGCCCCGCCGCCAAATTCCAAACAATAAAAATTGCACCCGGC :::::::::::::::Rv116T7.seq::::::::::::::: CCACCCGTGTATTTTGGGATGGGCAAAAAGGCGAAGCACCGCGTGGCCACGAACGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGAAC GTACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGGTAGCACCCTGGCCGGGCGATGATCTGCAGCGTCGCCGCGGG TAGTCGCCGCCCGGGCGGCTACAGTCTGAAACGCGATGACCATCGATGTGTGGATGCAGCATCCGACGCAACGGTTCCTACACGGCGATATGTTCGCCTCCCTGCC CCGT Clone Rv117 :::::::::::::::Rv117SP602.seq::::::::::::::: CTGCCCATGTTTGGGGACGCCCGACCAGCCGATGCTGGAGGCCTACACGGCCCTTGGTGCGCTGGCCACGGCGACCGAGCGGCTGCAACTGGGCGCGTTGGTGACC GGCAATACCTACCGCAGCCNGACCCCTNTCNCAANAGGATNTTGTTCGCCGGACCCCNCTC :::::::::::::::Rv117T7D4.seq::::::::::::::: CCGACTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGA CGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATC GTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCTACGCGACCGCCTTT Clone Rv118 :::::::::::::::Rv118SP6.seq::::::::::::::: ATACTCAAGCTTTGTCACACCAAGTGTTTCGACCAGGCGCTCCATCCGGCGAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGGGCGTTCA GCTCGCTTGCGGCGCTGCAGCAGCCATTCGGGGAAATACCTGCCCTGGCGCAGCTGGGGGATCCCAACTTCAATGGTTGCGGCACGGGTGTCAAATTCACGGTGGC GGTAGCCGTTGCCCTAATTGGACCGCTCATCGCTGCTTTCGCGGTACCCCGCCCCGCACAGGGCTTCGGCTTCAGCCCCCATCAGGGCGGCAATAAACTTCAAGAG CACC :::::::::::::::Rv118T7.seq::::::::::::::: GAGGCAGCTTCGCCGGCAATTCTACTAGCGAGAAGTCTGGCCCGATACGGATCTGACCGAAGTCGCTGCGGTGCAGCCCACCCTCATTGGCGATGGCGCCGACGAT GGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGCGACGCGGTAGGTGGTCAAGTCCGGTCTACGCTTGGGCCTTTGCGGACGGTCCCGACGCTGGTCGCGGTTG CGCCGCGAAAGCGGCGGGTCGGGTGCCATCAGGAATGCCTCACCGCCGCGGCACTGCACGGCCAGTGCCGCGGCGATGTCAGCCATCGGGACATCATGCTCGGGTT CATACTCCTCGACCAGTCGGCGGAACAGCTCGATTCCCGGACCGCCCAGCGCATTGGTGATGGAATCGGCGAACTTGGCCACCCGCTGGGTGTTGACATCCTCGAC GGTGGGCAATTGCGCCTCGGTAAGCTTTGCCGCGTAGCCTTTTCATC Clone Rv119 :::::::::::::::Rv119SP6.seq::::::::::::::: ATACTCAAGCTTCACTGACAAGGGACGAATTCGTCGGCCGCCTGTTCGACTGGGTGGTGGCCGAGCTGGTCGCCACCACTCAGGCCGCGGTCACGGCGGTACCGGC GCGGGAGCAAACTCGCGCGGGCATGGCCAACTTCTTGCGGACCATCACCGCAGACGCCCGCTTCGGACCCCTGCTGTCCACCACACAGTTGGCCAACGCATTAATC ACCCGCAAGCTTGCGGAATCCACCGCCCTGTTCGC :::::::::::::::Rv119T7.seq::::::::::::::: TCCATCACCCGATGTGGCNGGAGCACTGCCATGTCGATCTCAACTACCACCTCCGGCCGTGGCGGTTGCGCGCCCCGGGGGGTCCGCGCGAACTCGACGAGGCGGT CGGAGAAATCGCCANCACCCCGCTGAACCGCGACCACCCGCTGTGGGAGATGTACTTCGTTGAGGGGCTTGCCAACCACCGGATGCGGTGGTTGCCAAAAATTCAC CATGCGTTGGCTGACGGTGTTGCCTCGGCAAACATGATGGCACGGGGGATGGATCTGCCGCCGGGACCGGAGGTCGGCCGCTATGTGCCTGACCCCGCTCCTACCA AGCGGCA Clone Rv11 :::::::::::::::Rv11SP6.seq::::::::::::::: AGCTTTGCAGTTGCTGAGTAATGTCGGCCAACGTCACCACAACCGCGATGAATTCAATCATGCCGCCCAGGGCGGCCAACCCAATGGTGGCCGCGAGCGGCAGCTC GATCGCAGCGCGGAGGTTGCCGGCCGCCAGTTGATTCACGAACAGGGTGAGGTCATAGGCGGGCAGGATAGTGACGAAGGCAAGACCTCCATCTGCCGTCGGAAGA AGTATCGAG :::::::::::::::Rv11T7.seq::::::::::::::: AGCTTCAGAACAGGCCTGTTGTGGGCGCACCCGGCTCGCCGAGTTCTGCACGCACCGCCTCAAGTGCGGCCCGCACCGCCGGCATCTCCCGGTCAGGCAGGGCCGC GGCCCGCGCCGCAGCGACGGCGTGTTCGCGCAGTTCGCCGTCAATGATGCTGACCTGATCGGCCACCCGGGCGTTCTCGGCGTCGTCGCGTTCACTAATCGCGGTG CTCAGCAGCGTCTCGACAGCCACCACCCGAGTGGCGACCAGCTGCTCCACCACGGACCGCAGCGATGCCCGTC Clone Rv120 :::::::::::::::Rv120SP6.seq::::::::::::::: ATACTCAAGCTTCAGTTCCTCCACGACGCGTTCCCAAATGAATTTCCCGATCCCACAATCTCGGTTCAGATACAGGTCGCCATACCCCTTACTTCGGCAACGCTGG GCGGATTGGCCCTGCCGCTGCACCAAACCATCAACGCCTTCAAATTGCCGGCAATCTCGTTCAGCCAATCCAT :::::::::::::::Rv120T7.seq::::::::::::::: GCTCTACGCCGCCTACGGGTCGAACATGCATCCCGAGCAGATGCTCGAGCGCGCACCCCACTCGCCGATGGCCGGAACCGGCTGGTTACCCGGGTGGCGGCTGACG TTCGGCGGCGAGGACATCNGCTGGGAAGGGGCGCTTGCCACCGTCGTCNAAGACCCAAATTCGAAGGTGTTCGTCGTGCTCTACGACATGACCCCGGCGGACGAGA AGAACCTTGACCGGTGGGAAGGCTCCGAGTTCGGTATCCACCAGAAGATCCGATGCCGCGTGGAGCGCATTTCCTCGGACACCACAACGGGATCCCGTCCTCG Clone Rv121 :::::::::::::::Rv121SP6.seq::::::::::::::: ATACTCAAGCTTGCCAAAGAGACCTCGTCCACCAAGCAGGACGCGACCGTCGAGGTGGCGATCCGGCTTGGCGTCGACCCGCGTAAGGCAAACCAGATGGTTCGCG GCACGGTCAACCTGCCCACACCGGCACTGGTTAAGAACTGCCCGCGTCGCGGTTTTCGCGGTTGGTGAAAAGGCCAATGCCTGCGTTTGCCGTGGGGGCGGATGTT GTCGGGAGTGACAATCTGATCAAAAGGATTCAGGGCGGTTGGCTGGAATTCAATGCCGCAATCGCGACACCGG :::::::::::::::Rv121T7.seq::::::::::::::: CCACGGCGTGGATCAAGGTACCGGCCGGGATGTTGCGCAATGGCAGGTTGTTGCCCGGCTTGATGTCGGCGTTAGCGCCGGATTCCACCACATCCCCTTGCGAAAG TCCGTTGGGTGCAATGATGTAGCGCTTCTCCCCATCGAGATAGTGGAGCAACGCAATCCGTGCGGTACGGTTCGGGTCGTACTCGATGTGCGCGACCTTGGCGTTG ACACCATCTTTGTCATTGCGGCGAAAGTCGATCATCCGGTAAGCGCGCTTATGACCGCCGCCTTTGTGCCGGGTGGTAATCCGGCCATGCGCGTTGCGTCCACCGC GACGTGCAGCGGGCGCACCAGCGACTTCTCCGGGGTTGACCGGGTNATCTC Clone Rv122 :::::::::::::::Rv122SP6D2.seq::::::::::::::: GCAGCATGACGGCGGTAGCGAACACCGCCGGATGCAGCGCAAGTAGCGTCGATGTGCTCACGGAATCGCCCCGGCACCGCGATCTCGANGATCACCAGTGCCACCC CCTGCAGCGCNACACCGACGATTCCGTACACCGCCACGCCGATCAGGCCCTGGGCCATCTGATTGGAGCTGGCGTANATGGCGGCGATGGTGACGATGGCCAGCGC CACATACATTGTGGCGGCCAGAACCACGGCGTTGGGGCGGCGGTCGATGAACACTAGGCGACGCAGATCGCCCGGGGTCAACAGGTTGACCATCAGAAAGCCTGCG ACTAGCACGGCGGCGCCACTAGGAAGTACAAGAANGTGGCCACCACCCCATGCAGGATCGGGGTAAGGCTGATGGTCCCGAAATCGACTCCGGCCTAATACATGAC TCTCTCCTTTGCGTCATCGCCTTACTTGTGCGCGGAA Clone Rv :::::::::::::::Rv123SP6D2.seq::::::::::::::: GGGACACACCTCGATGCTGCCGCNATGGACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACGCATCCCGTT GACCGGCCGGANCNCTCTCTA :::::::::::::::Rv123T7D4.seq::::::::::::::: TGGGCGCCTCTTTCGGCCTTCCCNNTTTAAACGNAGCANGACATTCTGGGTATCGAGTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCCTGGCGGTGG GATCCGACTACAATCTGCTGCTGATTTCCCGGTTGAAAGAGGAAATTGGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGGAGTGGTGAC GGCTGCCGGCATGGTGTTCGCCGTTACCATGTCGTTGTTTGTGTTCAGCGATTTGCGAATTATTGGTCAGATCGGTACCACCATCGCCTTCCC Clone Rv124 :::::::::::::::Rv124SP6D2.seq::::::::::::::: CCGATCGGCGCCGCANCTGGTTGGTGTTNCGGATGAATCCGCAGCGAAAATGTAGCTGCGGTGGCGTGTCGTGACTCGTNGGCGTCGACGCTCGTGGCAGCCACCG ANCGGTTGGTCCAGGATCTGGATGGGCAAAGTTGTGCGGCCCGGCCGGTGACGGCCGATGAGCTGACCGAGGTCGACAGCGCCGTGTTGGCTGACTTGGAACCGAC ATGGAGTCGCCCCGGTTGGCGTCACCTCAAGCATTTCAATGGTTATGCGACCAGTTTTTGGGTTACGCCGTCAGACATCACGTCGGAGACTTGGATGAGCTGTGTC TGCCAGATAGCCCCGAATCGGGACGACCGTGGTCACGGTGCGTCTGACCACTCGGGTCGGGTCGCCCGCGCTATCGGCATGGGTGCGTNATCACAGCGACACGCGC CTGCCCAAGGANGTNCGGNCGGACC :::::::::::::::Rv124T7D4.seq::::::::::::::: CGGGTTGCGGATCCACGCGTGCGGGTTGTCAGCAGCTACGGCACTGAACCGCGGCCACAGCTCGCCGATCCGCTTTCGGTGGTTCTCGATCGACTCGCCGTAGGCG ATGCGCAGCGCCTGCTCGAATATCGGGTACACGTAGGCCGGCCTTCCCNCTTTA Clone Rv126 :::::::::::::::Rv126SP6.seq::::::::::::::: CTTGATTTTGATCATCATGACGATCATCACCCTAATTTTGCTACCCGCACTGGTTATCGTGGGTACCGTCGTGCTTTCCATGGGCGCCTCTTTCGGGCTTTCGGTA TTGGTCTGGCAGGACATTCTGGGTATCGATTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCCTGGCGGTGGGATCCGACTACAATCTGCTGCTGATTT CCCGGTTGAAAAAGGAAATTGGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGGAGTGGTGACGGCTGCCGGCATGGTGT :::::::::::::::Rv126T7.seq::::::::::::::: GGGGATCCCTAGATCGACCTGCAGGCATGCAAGCTTGGCGTGTCGTTCCAACCCGAATTGGCTTTCGGCGCCATCGGTGAGGCGGGACACACCTCGATGCTGCCGC CATGGACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGGATCGCGGTGATC GTCGATGACGGCATCGCCACCGGAGCNACTGTCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCGATCGGCCCAGACG ACATCGTGGCGAGATTCGNCGGGTACGCCGATGAGGTGGTGTGTTTGGCGACGCCGGCGTNGTTCTTCGCCGNCGGGCANGGTTACCGCAACTTCACCCAGACCTC CGACGACGAGGTGGTGGCGTCTCCTGGATCGTGCTC Clone Rv127 :::::::::::::::Rv127SP6.seq::::::::::::::: AAGGCTGCAGGTCGAAGCGGNTGGTTACGACTCCCTGTGTGTGATGGACCAGTTCTACTATCTGCGTCTACACGGCCCTTGGTGCGCTGGCCACGGCGACCGAGCG GCTGCAACTGGGCGCGTTGGTGACCGGCAATACCTACCGCAGCCCCGACCCTGCTGGCAAAGATNATCACCACGCTCGACGTGGTTAGCGCCGGTCGAGCGATCCT CGGCATTGGAGCCGGCGGGTTTGAACTGGAACACCGCCAGCTCGGCTTCGAGTCCGGCACTTCCAGTGACCGGTTCAACCGGCTCGA :::::::::::::::Rv127T7.seq::::::::::::::: CTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCN GCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTACAGCCACTGCGATCGGTGCCGATCGTGG GGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCTACGGCGACCCGGCCTATGGTTATTCGACCTCGCCGNCCAATGTTGCGAC TCCGTTCGGGTTGTTCCAGANGTCAGCCCGGTCGTCATCGCCGACGCTCTCGTCN Clone Rv128 :::::::::::::::Rv128SP6.seq::::::::::::::: CGGTCATAGCCCTCGGGTCCGGCCAGCACTCCGCAGGCTTCGTCGGGGTGGTCGCGACGCGCATGGGCCACCATCGCATTCACCAGGTCTGCGCGAATCACCAGCA CGTAGACGGTTCCTTTCCTAAGCAACACCGAAGTTTCACGACCCGAATGCTCCGGGAAACATGTCACGGTAGGTCGGTATTCCGGCTACCGGCTGAGCATTGAGCA CGCCGGCCAGCACCGCACGAGCCAGGCAATCAGCCGCCGCCGCACCGATCGCGGTGACCAGCTGAGTCTCCGGAGACAATGCGGCCGGCACGCCGGNCTCCGGCGG CACCGCTACNGCGCCCGGTGG :::::::::::::::Rv128T7.seq::::::::::::::: GTGATGGCACGCCACCGCGACACCACCCGGCTGCGCTACNTCGAGCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCGAGGTCG AGGTCGATACCGATTTGCGCATCCGCANCCGCNCCCTGGACGACAGAACCGTGCCCTACGAGTGCTTGTCGGGCGGGGCCAAAGAACAGCTTGGCATCCTGGCGCG ATTGGCCGGCGCGGCGCTGGTCGCCAAGGACGACGCCGTTCCGGTGCTGATCGACGACGCGCTGGGGTTCACCGATCCGGAGCGACTATCAAGATGGGGGAGGTCT CTGACACCATCGGCCCCNACGGACATGTGATCGTGCCGACGTGCAGTCCCACCCCG Clone Rv129 :::::::::::::::Rv129SP6.seq::::::::::::::: GCGAAAGTCCGTTGGGTGCAATGATGTAGCGCTTCTCCCCATCGAGATAGTGGAGCAACGCAATCCGTGCGGTACGGTTCGGGTCGTACTCGATGTGCGCGACCTT GGCGTTGACACCATCTTTGTCATTGCGGCGAAAGTCGATCATCCGGTNNGCGCGCTTATGACCGCCGCCTTTGTGCCGGGTGGTAATCCGGCCATGCGCGTTGCGT CCACCGCGACCGTGCAGCGGGCGCACCAGCGACTTCTCCGGGGTTGACCGGGTGATCTCGGCGAAATCAGATACGCTGGCGCCGCGACGACCAGGCGTCGTGGGCT TGTNCTTGCGAATTGNCATGTCTAATCANGTCTTTCTCTCACGCTCTCGTCGCCGGGCTAGGCCGCATTGCCCTGCTCCTCCTCATCGCTTCGCTCTGCATCGTCC CCGGGCTAAGCCCGTGCCCCGAAA :::::::::::::::Rv129T7.seq::::::::::::::: GATGGTTCGCGGCACGGTCAACCTGCCACACGGCACTGGTAAGACTGCCCGCGTCGCGGTATTCGCGGTTGGTGAAAAGGCCGATGCTGCCGTTGCCGCGGGGGCG GATGTTGTCGGGAGTGACGATCTGATCGAGAGGATTCAGGGCGGCTGGCTGGAATTCGATGCCGCGATCGCGAACACCGGATCAGAATGGCCAAAGTCGGTCGCAT CGCTCGGGTGCTGGGTCCGCGCGGCCTGATGCCCAACCCGAAAACCGGCACCGTCACCGCCGACTCCCCATGGCGTCCCGGATATCAAGGGCCGGCAAATCAACTT CCCGGTTGATCAGCAAGGCAACCTGCCTCCNCCTCCGG Clone Rv130 :::::::::::::::Rv130SP6.seq::::::::::::::: ATACTCAAGCTTCGTCATAAGACCATGGTGCGCTTTCTTTCACCCGTCCAGAGTCGGGGGCATCCGCACCGGCTCGCATCGCATCATCCTCCCACGACGGGCCGCT CATCAGCTTGGGCCATTTCAATGTACTTGATACCCCGCGCTGCGGGTAGGCCACTGCGACAATTCAAACACGGTGTCACACGGTGAATAGTGTCGAGATGGGCTCT GATCAACCGTCGCAAACCCGGTTTCGCATCAATAGCGGAATCCCACCGGGTTGCATGGAGGCTGCTGACCTTGGAAAACAAAATTTTTTCATTACAACAAAACAAC CGCCNCGGAAACTTTGCA :::::::::::::::Rv130T7.seq::::::::::::::: CGAATTCGGCGTGCACCGCTATGGGTTGCAGCAGCGGCTGGCGCCGCACACCCCACTGGCCCGGGTGTTTTCGCCCCGAAGCCGGATCATGGTGAGCGAAAAGGAG ATTCGCCTGTTCGATGCTGGGATTCGCCACCGCGAGGCCATCGACCGATTACTCGCCACCGGGGTGCGAGAGGTGCCGCAGTCCCGCTCCGTCGACGTCTCCGACG ATCCATCCGGCTTCCGCCGTCGGGTGGCGGTAGCCGTCGATGAAATCGCTGCCGGCCGCTACCTGCAAGGTGATTCTGTCCCGTTGTGTCGAAGTGCCTTTCGCGA TCGACTTTCCGTTGACCTACCGGCTGGGCGTCGGCACAACACCCCGGTGAAGGTCGTTTTTGTTGCAGTTGGGCGGAATCCGTGCTCTGGGTTACAGCCCCGAACT CGTCACGGCGGTGCGCGCCGACGGAGTTGTTATCACCGATCCGTTGGCCGTACCGCGCCTTGGGC Clone Rv132 :::::::::::::::Rv132SP6.seq::::::::::::::: TCAGACTCCACCCAGCCAGCAGGCAGCGCGAAGCTGAATCCTCCAACCGGGTTGTCGATCCGGACAGGTTGGGGTGCGTTTGGGGCAATGACAGGTGGCGGCGGTG CGTTCGGGTCGGCCGGCGGAGGTGCTGCGTTGGATCGCCCGGCTGGCATTCNGCGTGTTGGCGCGGCCGGTGGTGGGGGGCAACACAGGTGTCGGCCGGTGCAGGG TGGCGCTGCAGCGGTCGACGGCGGCGAAGCGGCCGTTGTGGGTACCGGGGGCGCTGGCTCCGGATCGGCGTTGGCGGTCGCGGGCACCGCAACGGTCACCAAGCTG GCGCTGGCCATCGCCGCGATAGCCAGTGCCGCCAATCGTCCCTTGCGACGTGTCAAGTNGGGGTCCACCTGATGCATGGCCAAAGAACCTACCGTGTTAACGGCNC AACNCAAGGACCGCGCCGGTCGCN :::::::::::::::Rv132T7seq::::::::::::::: TTTCCGCGGTACCCGCTCAACTTTGTGTCNACCCTCAACGGCATTGCCGGCACCTACTACGTNCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAG CGGGTCCGCTGAACAATTCGGTCCGTCCCACGAAAGAACCAGTTTTNCNTCTTTCNCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGG GGAACCCACTGGCGAACCTGTGTTTCAACCAACACTTAGAGTGTAATTGTAAACCTGGGCTAGGGGAAACCGGCTCTAGTTTTTCCACCNTCTCCGCCCCNTGTTT CGAATACTCCGTTCGGGTTGTCCCCAAA Clone Rv132 :::::::::::::::Rv134SP6.seq::::::::::::::: GCTTCCGGCTCGTATGTTGTGTGGAATTGTGACCGGATACCAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTAGTTAGGTGACACTATACAATA CTCAAGCTTGCCGGCTGGTGGGCCGACCACTTCGATGGCACGACCCGTGAACTGCTGCCCGGCCAATTCTTCTTGGTCGCCCGGACCGATGGACCGCGGCTGGGAT TCCAGAAGGTGCCCGATCCCGCCCCTGGGAAAAACCGCGTGCACCTCTACTTCACGACCAACGAC :::::::::::::::Rv134T7.seq::::::::::::::: CCGATCGACTGATGCGCCGACAACCACGCCCCAACAACTGGAATGAACCGTCGTGACCATCATCAGCACGCGGTTGTAGGCGACTTGCGACATGTTCAACCCGCCG TACTCGGACGGAATCTTCAAACCGAAACAGCCCAGCTCGGCCAGGCCTTTCACGTACTCGTCGGGGATCTGGGCACCACGCTCGAGGACGCTGCCGTCCACGGTGT CTAGGAATTCCCGCAGTTTGACCAGAAACGCCTCGGTTCGGGCCTCCTCGGCGTCCGACGGCTTGGGAAATGGGTGTATGAGCCCTACGGGAAACCGGCCCACAAA GAGTTCTTTGGCGAAGGACGGTTTATCCCAACCACTTTCGCGAGATTCCTCGGCAAGGGCCCGCGCTTGCTCCTCGGTGACCTGAGTTTGCTGTGCCATCGCCGCC TCCTCCCTGA Clone Rv135 :::::::::::::::Rv135SP6.seq::::::::::::::: TGCATCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAAT ACTCAAGCTTTTACGGTGATCGCGCATCACCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCGGG TGCAGGTGCTCGGGCAGCTCGGCCGCGACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACGAACGACGCCAGTCCGCTACGTAACCCCTCCGCGACTG TCCATGGACAACAGCGCGTTCTCCACCGACCGGGCCCGGGTGTGGGGTGTTTCGGCGACCGGCAGCCAGGTGGTCCACACTGCCGACGGGCGCCGCGAGCCGTTCA CCGACCAGGCCGCCGAGCAAGTCCGCCCGATCGCATACTCC :::::::::::::::Rv135T7.seq::::::::::::::: GGGGGCGCTGCTGGTATAGTCGCTGACCGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGCCAGGCTATCGCACCCGGTT ATCGGCTACGAGCAAATCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGATCGCCGTCAAGCATGTGT GCCGCGGATTATCAGGACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGGTCGTGGTCGGCTCGGATAGGCAGGTCAGCGA ATTCTCGTGGCAGCTCGAAAGGGTCCTGCCGGTGCCGGTCTTTGCGCAAACGATGGCGCAGGTTACGGTCGCGCGGGGTGCGGCCTGGCGGCGGCCAGAGCAGGAG TTCACCGATGCGCAGCTAGTGGCGACAGCGTCAGCCAAC Clone Rv136 :::::::::::::::Rv136SP6.seq::::::::::::::: TGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAAT ACTCAAGCTTCCGTACAGGTCGCCTCCAACACGGCGGGGAAGCGACACCAGCCTACCGAGCTTGGAGTCCAGGACGCCAGCGGCGGCGTCGGTCTGCGTCGTGGTG CCGCCGGGGTGGCGTTGGCTGGCAACGATCTCCACCCAGCCGGTCGGGTTACCCACGATCTCGGCATAGACGCGGGCCGAGGCCGGTGCGATACCGTATTGCGTCA ATTGGGACGCGGTTGTGCATTCGGCTAGCTCGGTTGCCACACCCGTCAGGGGTTCGACGTTGGCGGGTTCGGCGGGCCCCAGCACCGCTGTCACCATGCCCGCCAA GCCGACCTGCGGCGCCACCAACT :::::::::::::::Rv136T7.seq::::::::::::::: CGGCATGACCACCGACAGGCCCGACTGGTCGTACCACTCGAACGCCGGGGTGTTGATGTCCCAGCCGCTGAAGTCGTCCTGCGCGCGCGGCCGTCGAAGCAGGTAC AGGGCGGGCGAGTTGGCACCACCACTTTGGAATTGGACCTTGATGTCACGGCCCATCGACGGCGACGGCACCTGCAGGTACTCCACCGGCAAGCCCGGCCGGGAAA ATGCCCCCGCGGTCGCCGTGCCACCGACGGCGCCGACCAGACCCGACACTAGGGCCGCGCCGACGGCCCGGACCACGAGTCGACGCGACATACCCGTGACGGCGCC ACGAACCCTGTCAACAAGCTGCATTCTTGCTTCCCTCATCCTCATCTCAACGCATCCATGCATGTTTGGGCGCATCCTGAATTANGTCAGACTGCAGGCGCTGGGC CGGCAGTGCTCGTGTATCAACCACAACTTCGGGCGT Clone Rv137 :::::::::::::::Rv137SP6.seq::::::::::::::: TTCCAACCCTAATTGGCTTTCGGCCCCATCCGTGAGGACGGGGTGCGGGTGCTCAACAACAACGTCGTCCGCGGGACACACCTCTATGCTGCGGCCATGGACGCGG TCCAACGCAAGCAGCTGATCGAGCTACAACCCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGGATCGCGGTGATCGTCGATGACGG CATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCACGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCGGATCGGCCCAAACGACATCGTGGCG AGATTCGCCGGGTACGCCGATGAGGTGGTGTGTCTGGCGACGCCGGCGTTGTTCTTCGCCCTCGGGCAGGGTTACCGCAACTTCAC :::::::::::::::Rv137T7.seq::::::::::::::: CAGGCATGCAAGCTTTCCGCCGATACCCGCCATGTCGCGCACATCCAGGACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAAGTGCGGATGATCGGGCCG CCTACGTCGTGGTGTACCTCGTCGGTAACAACGAAACCGAAGCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGCCACCGCACGGGGTGAA GGCCTATGTCACCGGTCCGGCAGCACTCAATGCCGACCAGCCGAGGCCGGAGACAAAAGTATCGCTAAGGTCACCGCCGATCAACNAGCATGGTGATCGCAGCAAT GTTGCTAGTGATCTATCGCTCCGTAATTACCGCGGTTCTCGTCTTGATCATGGTCGGCATCGACTCGGCCAATCCGCGGATTCATCGCCTTGCTCGCCGAACACAA CATTTTCACCTTTCACATTTGCACCAACCTGCTCTTCTCAT Clone Rv138 :::::::::::::::Rv138SP6.seq::::::::::::::: CACTACTCAAGCTCTCTCNTCATTACCACCCCTGTAATTTGGGATGGGCAAAAGGCGAAGCACCGCTTGGCCACNAACGCCGGGACGGGACAATCTCGGGCGGCTA TGGCTTCTCCCGGAAAGGCCCCAACGTACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATTGGCACCAACCTGNTACCACCCTGGCCGG GCGATGATCTGCAGCGTCGCCGCGGGTAGTCCCCGCCCGGGCGGCTACAGTCTGAAACCCCGATGACCATCGATGTGTGGATGCAGCATCCGACGCAACGGTTCCT ACACGGCGGATATGTTCTCCTCGCTGCGCCGGTGGACCGGTGGGTATATCCCCTGAAACCGACATCCCN :::::::::::::::Rv138T7.seq::::::::::::::: CAGGCATGCAAGCTTTCGTCAGTTCATTGCGCCAGCAGACCAACAAGAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGA CGGCGCGAACGACGCCAGCGACCACATTCAGCAGATGGCCAGCGCGTGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGGCGTGATCGACATC GTCACCGCCGCACCACTGCCCGGCCTCGGGTTCACGCAGCCGTTGCCGCCCGCAGCGGACGATCACATCGCCGCGATCGCCCTGTTCGGGAATCCCTCGGGCCGCG CTGGCGGGCTGATGAGCGCCCTGACCCCTCAATTCGGGTCCAAGAACATCAACCTCTGCAACAACGGCGACCCATTTGTTCGGACGGCAACCGGTGGCAACGCACC TAAGCTACTTGCCCGGGATGA Clone Rv139 :::::::::::::::Rv139SP6.seq::::::::::::::: GTTTATGCACTGGTTAGGTGTTTCCATGAGTTTCATTCTGAACATCCTTTAATCATTGCTTTGCGTTTTTTTATTAAATCTTGCAATTTACTGCAAAGCAACAACA AAATCGCAAAGTCATCAAAAAACCGCAAAGTTGTTTAAAATAAGAGCAACACGTACACAAGGAGATAAGAAGAGCACATACCTCAGTCACTTATTATCACTAGCGC CCGCCGCAGCCGTGTAACCGAGCATAGCGAGCGAACTGGCGAGGAAGCAAAGAAGAACTGTTCTGTCAGATAGCTCTTACGCTCAGCGCAAGAAGAAATATCCACC GTGGGGAAAAACTCCAGGTAGAGGTAC Clone Rv13 :::::::::::::::Rv13SP6.seq::::::::::::::: ATACTCAAGCTTGGGTGTAGCCGATCACCGGAAGTCNCATGATCAGCCACGTTCCGCGCCGCCCGGCATACGGTGGTGTACCGATCTCCGCGTCATACACCCGCGG GTAATCGCCGACGGTGCCGGTTCGCGAGCCGAA :::::::::::::::Rv13T7.seq::::::::::::::: AGCTTTATCGAAAGCGCGAACAGCTCGCGGCGGCCCACGACGTGCTGCGTCGGATTGCCGGCGGCGAGATCAATTCCAGGCAGCTCCCGGACAATGCGGCTCTGCT GGCCCGCAACGAAGGACTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGCTTGATGCCCGGTCGGCAAG CCCGGCAGTTGCCAAACCCATCGTGATCAGGCTCGGCTCGCGAGTTCGGCGAAGAAATGGTTCGCCTGATCACCTACCATCGGCCA Clone Rv140 :::::::::::::::Rv140SP6.seq::::::::::::::: TCAACACGCCGCCAGCCACCACGCGCGGGTCGGGCGCCGGGCCCGGGCCTCCAGGCTNCTCCGCTCGGTGATGGCACGCCACCGCGACACCACCCGGCTGCGCTAC GTCGAGCCATACCGGGCGGAGCTACATCGGCCCGGCCGCCCAGTGTTCGGGCCCTCTCGCCCAGGTCGAGGTCGACACCGATTTGCGCATCCGCAGCCGCACCCTG CGACGACAGAACCGCGGCCCTACCCACTGCTTGTCGGGCGGGGGCCAAAGAACCAGCTTGACATCCTGCCACAATTGGCCGGCGCCCG :::::::::::::::Rv140T7.seq::::::::::::::: CAGGCATGCAAGCTTCACGTCCGTACGGCTCGGGTACGCTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCAC ACCTTCAGTTGCTCACCGGAATCCAACCGGTAGAAGGTCGGCCAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCA GCACTCCGCAGGCTTCGTCGGGGTGGTCGCGACGCGCATGGGCCACCATCGCATTCACCAGGTCTGCGCGAATCACCAGCACGTAGACGGTTCCTTTCCTAAGCAA CAC Clone Rv141 :::::::::::::::Rv141SP6.seq::::::::::::::: AATATTCAAGCTTTCGGCGGAAACGGACNCCTTGCGAACATTGATAACAAAATAGAAATCATTGATGGTTTGAGTCACCAGGCCGATCAAGCCTTCGCCGAGCCAA ATTCCAATCAAGAGGCCCAAGCCCGTACCAATCAGCCCGGCAACGAGGGATTCCGTCNTTATCAGCCNAAATAACTGCTCTCGGGTACCACCCAAACAGCGCAATA TGGCGAAAAACGGTCGCCGTTGCACAACATTAAATGTCTCGGTATTGTTGATTAAAAAGATACCCACCACCAGGGCAATCCAACTGAGAGGGGTTAAATTGACCGT AAAAACCTCCCGTCATCTGTTT :::::::::::::::Rv141T7.seq::::::::::::::: CAGGCATGCAAGCTTGCTGCATCTTCCTGTGACTGCTCCCGAAACCTGGGGGTGTGCCTGCTGTGTATGCACGGCATACGGACATCCTTCCCCTGATACCCGCGGT CGAACCAGCCACGTGTCCATCATCAGGGGTCAACCCCGGCCAAGGGCGACGGCACGCCAAGTTCGCCGACCGTTAACCTAGTGCTGTTAGCTTCATTTGCTGCGAG CAAAACAGCTGGTCGGCCGTTAGGAACTGAATTGAAACTCAACCGATTTGGTGCCGCCGTAAGTGTCCTGTCTGCGGGTGCGCTGGTGTTGTCCGCGTGTGGTAAC GACGACAATGTGACCGGGGGAGGTGCAACCACTGGCCAGGCGTCCGCGAAAGTCCATTGCNGGGGGAAGAAGACAC Clone Rv142 :::::::::::::::Rv142IS1081.seq::::::::::::::: GAAAGTGCCCCAAGGTGTTGGTGAAACTCGCTGGACGGTCCCCAGGATGTTGGCAGCACATTCACCGGACATGACCGGAGCAAGACCGGACATCCTCCCATACCGT CGTCGCCGTGTACATCCGTAGCCCGTCCTGGCAGGTGCTGGGTTGAACAAAATCAGCCCAACACCTGCCACGACGAAGAAGCGGGTTGCGCTGGCATGTCTTGTCG GCTCGGCGATCGAATTCTACGAATTCCTTATCTACGGGACCGCTGCGGCGCTGGTGTTTCCCACCGTGTTCTTCCCACACCTGGATCCCACGGTGGCCGCCGTGGC CTCCAAGGGGACATTTGCTGTGGCGTTCCTATCCCGGCCGTTCGGCGCGGCCGTCTTTGGATACTTTGGAGACCGCCTCGGCCGCCAGAAGACCCTGGTCGCCACA CTGTTGATCATGGGCCTGGCAACCGTGACTGTTGGGCTGGTTCCACGACAGTGGCCATCGCGC :::::::::::::::Rv142SP6.seq::::::::::::::: ATATTCAAGCTTTGTCACACCAAGTGTTCCGACCAANCGCTCCATCCGGCGAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCGCGTTCA TCTCGCTTGCGGCGCTGCAGCAGCCAGTCCGGGAAATAGCTGCCCTGGCGCAGCTTGGGGATCGCGACGTCGATGGTTGCGGCACGGGTGTCGAAATCACGGTGGC GGTAGCCGTTGCGCTGATTGGACCGCTCATCGCTGCGTTCGCGGTAGCCCNCCCCGCACAGGGCGTCGGCTTCAGCCCCCATCCAAGGCGGCGATGAACGTCGAGA GCAGCCCGCGCAGCAAATCCGGGCTCGCCTGTGCGAGTTGGTCAGCCAGAAGCTGCTCGGTGTCATAAGATGAGAAGAGGTCAGTGCGTCCTTTCCTTCG :::::::::::::::Rv142T7.seq::::::::::::::: CAGGCATGCAAGCTTTTTGAGCGTCTCGCGGGGCAGCTTCGCCGGCAATTCTACTAGCGAGAAGTCTGGCCCGATACGGATCTGACCGAAGTCGCTGCGGTGCAGC CCACCCTCATTGGCGATGGCGCCGACGATGGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGCGACGCGGTAGGTGGTCAAGTCCGGTCTACGCTTGGGGCTTT GCGGACGGTCCCGACGCTGGTCGCGGTTGCGCCGCCAAAGCGGCGGGTCGGGTGCCATCATGAATGCCTCACCGCCGCCGCACTGCACGGGCAGTGCCCGGGCGAT GTCAGCCATCGGGACATCATGCTCGCGTTCATACTCCTCGACCAGTCCGCGGAACAGCTCCATTCCCGGACCGCCCAACGC Clone Rv143 :::::::::::::::Rv143SP6.seq::::::::::::::: ATACTCAAGCTTTTGGCTGGGTCGCCTTCCAATTCAGCGTGCACCGCTATGGGTTGCAGCAGCGGCTGGCNCCGCACACCCCACTGGCCCGGGTGTTTTCGCCCCG AACCCGGATCATGGTGAGCGAAAAGGAGATTCNCCTGTTCGATGCTGGGATTCGCCACCGCGAGGCCATCGACCGATTACTCGCCACCGGGGTGCGAGAGGTGCCG CAGTCCCGCTCCGTCGACGTCTCCGACGATCCATCCGGCTTCCGCCGTCGGGTGGCGGTAGCCGTCGATGAAATCGCTGCCGGCCGCTACCACAAGGTGATTCTGT CCCGTTGTGTCCAAGTGCCTTTCGCGATCGACTTTCCGTTGACCTACCGGCTGGGGCGTCGGCACAACAGCCCGGTGAGGTCGTTTTTGTTGCAGTTGGGCGGAAT CCGTGCTCTGGGTTACAGCCCCGAACTCGTCACGGCGGTGCGCCGCCGAC :::::::::::::::Rv143T7.seq::::::::::::::: CAGGCATGCAAGCTTCAACCTATTGACGCATTGTGCGAACTGACGGCGCCCGCGCATGGCCAATCCGGAAGACCATCATTGGCCAGTGGCCGGGCGCTAACAGGTT CCAGCCCCCCACCAGTGCCGCTCGAACATGCGGTGCAACCCATTCGCAGGCCGGCAGGGAAAGCACCGCGGAAGCCGCAAAGGGCTGCAGTTCCGCGCCCAATAGT GTCGTCCGCAACCAGATGCGCTCGAAAACCGCCGCCGGCAGTCAGCGCACCCGACGCGAGGTCGAGAGACGTCGTCAGCGCGCCCACATGGGGTGCCAATCGGCAC GGCAGGTAGGCCGCGCGCAACCCCAACGCGTGGTGCATGCCACGGTCCGCAGGAGGCCACCACCC Clone Rv144 :::::::::::::::Rv144SP6.seq::::::::::::::: ATACTCAAGCTTCCCGGCCGCAGGTGACGGCGCGGCCTAGCGCCACTTGATGCCGCACCCGATCGACGGNCGTTGGTCGGGGTTGACTGGGGGCCCGGCGAGCAGG GCGTCAACCGCGGCCCGGACGTCGGCGGCCGTCACCGGTCGGCCATTGCCCGGGCGGGAGTCGTCGAGCTGACCACGGTAGACAAGTCGGCGCTGGCCGTCGAAGA CAAACGTGTCGGGTGTGCAGGCCGCGGAGAAGGCGCMGGCGACGTCTCGGGTTTCGTCGTAGAGATACGGGAACGTCCAGCCGTGGCGGCGGGCCTCGGCGACCAT CTGATCGGGCCCGTCCTGCGGGTAGGTGACCACGTCCTTACTGGAGATACCGACCATCGGGACCCTTTGATCGGCGAGGTCCCGGCCGACCGTGGCCAATCCGGCG GCGACGTGTCGCCCGTACCGGCCAGTGGTTC :::::::::::::::Rv144T7.seq::::::::::::::: CAGGCATGCAAGCTTTANCANCATCAACCCCGCCCCGCACCAGCACCGACACGATGTCGATGCCATCGAGGTGAATGTCGAACTGGCNCAAACCATCTGGCGACCG CGACCACCGGCAACATGGGTACCGGCGATTTCCGGTGCCAATGCCGACCCGACGGGCCGCTCTCACCGCAGGTGACCTCGATCACCGAGACCAGCCGGCCGTTATA CTCACGCACCCCTACCGTGTCACGCCCAAAACGGCGCTGGTGGTCGATTGCCGGAGTGCACCCCGCACCCAGTGTCGTGCCCGGATCCGCCGACCAATCCCGCACC CACGTCGCCAAACCCGAAATCACCGTGATGCCGTGGTAACTGACCACCGACAGTAACGTCACTACGGCCGCCACGCCGACGCCGAACCACCACGCACATGATGATC GGCTG Clone Rv145 :::::::::::::::Rv145SP6.seq::::::::::::::: ATATTCAACCTTGCACACATTGACGATACCTTGGTCACGAGACCCCAAAAGCTGGCCTCCACCGCGCGCCGGGGACCACGGTCATACCTTGANNCNGCTTTCGATC GTTGATGCTGCGTCTTGGTCCGCGGAAACCGCAGGCTGGCATATGCACGTGGGCGCACTGGCGATCTGCGATCCCCACCGATTCGCCCGAATACAGCTTTCAGCGG CTCCCCAAGTTGATCATCGACCGGCTGCCGGATATCCCGCACTTGCGGTGGCGGGTCACCGGCGCCCCGCTCGGACTGGACCGGCCGTGGTTCGTCGAGGACCACG AAC :::::::::::::::Rv145T7.seq::::::::::::::: CAGGCATGCAAGCTTCATGCCCGCGGCATGATAGCCACATGCACGCAATCGAACTCAGCGAAACCGGCGGGCCAGGCGTCTTACGCCACCTCACCAGCGCGCAACC TCAACCCGGCCACGGAGACCTCCTGATC Clone Rv146 :::::::::::::::Rv146SP6.seq::::::::::::::: ATACTCAAGCTTGATTTTGATCATCATGATGATCATCACCCGAATTGTGGTAGCCGCAGTGGTTATCGTGGGTACCGTCGTGCTTTCCATGGGCGCCTCTTTCGGG CTTTCCGTATTGGTCTGGCAGGACATTCTGGGTATCGAGTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCNTGGCGGTGGGATCCGACTACAATCTGC TGCTGATTTCCCGGTTGAAAGAGGAAATTGGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGGAGTGGTGACGGCTGCCGGCATGGTGTT CGCCGTTACCATGTCGTTGTTTGTGTTCAGCGATTTGCGAATTATTGGTCAGATCGGTACCACCATCGGCTGGGCTTGCTGTTCGACAGCCTCGTCGTGCCTCGT TCATGAAACCGTCCATTGCTGCCCTGCTGGGACCTGGTTCTGGTGGCCGCTACGGGTGCGCCCGCGCCCGGCAGTCAAATCTTCCGCCG :::::::::::::::Rv146T7.seq::::::::::::::: CAGGCATGCAAGCTTGGCGTGCCGTTCCAACCCGAATTGGCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACC TCGATGCTGCCGCCATGGACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCG GATCGCGGTGATCGTCGATGACGGCATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAACTTGGTGCTGGCGGTCCCC ATCGGCCCAGACGACATCGTGGCGAGA Clone Rv147 :::::::::::::::Rv147SP6.seq::::::::::::::: ATACTCAAGCTTTTACGGTGATCGCGCATCACCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCG GGTGCAGGTGCTCGGGCAGCTCGGCCGCGACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACGAACGACGCCAGTCCGCTACGTAACCCCTCCGCGAC TGTCCATGGACAACAGCGCGTTCTCCACCGACCGGGCCCGGGTGTGGGGTGTTTCGGCGACCGGCAGCCANGTGGTCCACACTGCCGAAG :::::::::::::::Rv147T7.seq::::::::::::::: TAGTCGCTGACCGGTGCAGGTTTCGACNATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGCGCAGGCTATCGCACCCGTTATCGGCTACGAGCAAA TCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGATCGCCGTCTANCNTGTGTGCCGCGGATTATCAGG ACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGGTCGTGGTCGGCTCGG Clone Rv148 :::::::::::::::Rv148SP6.seq::::::::::::::: ATACTCAAGCTTTCCGCCGATACCCGCCATGTCGCGCACATCCAGAACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAAGTGCGGATGATCGGGCCGCCT ACGTCGTGGTGTACCTCGTCGGTAACAACGAAACCGAAGCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGCCACCGCACGGGGTGAAGGC CTATGTCACCGGTCCGGCAGCACTCAATGCCGACCAGGCCGAGGCCGGAGACAAAAGTATCGCTAAGGTCACCGCGATCACGAGCATGGTGATCGCAGCAATGTTG CTAGTGATCTATCGCCCCGTAATTACCGCGGTTCTCGTCTTGATCATGGTCGGCATCGACCTCGGCGCAATCCGCGGATTCNTCGCCTTGCTCGCCGACCACAACA TTTTCAGCCTTTCAACATTTGCGACAACCTGCTCGTTCTCATGGCGATTGCNGCGAAC :::::::::::::::Rv148T7.seq::::::::::::::: CAGGCATGCAAGCTTGGCGTGCCGTTCCAACCCGAATTGGCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCTGGACACACC TCGATGCTGCCGCCATGGACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGTTCCGCCGCGGGGCGTGACCGCATCCCGTTGACCGGGCG GATCGCGGTGATCGTCGATGCGGCATCGCCACCGGAGCGACCGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCG ATCGGCCCAGACGACATCGTGGCGAGATTCGCCGGGTACGCCGATGAAGTGGTGTTGTTGGCGACCCGGCGTTGTT Clone Rv149 :::::::::::::::Rv149SP6.seq::::::::::::::: ATACTCAAGCTTTGGCATTGTGCACATTTTCCACCCGTGCTCTATTAATGCTGAGCCGCTAATTGTGACCCCAGTCGGGAAACACGCGGAGCACCAAATTCACCGC AGCGGCCGGGGCGGTTCAACTCACCATGGATCGCTCTCGTCGTCTGGTGCTGGACAATCGTCGCTGTAGCGCGTCGCGAACACCTCAGCTTCTGCTGCCGCGGCTT CTTCCGGCGATGGTAACCCCCAGGTTTCGCCCACGGTCTTACGTAGCAGTGCGACGCGGTGTTCATCTGCATCGACCTGTTGACTCATCCTGTCAAGGATGAAGGC GTACTGGGCCGACTGCGCCTTCTGCCGCGCCAGGTCGGCAATCACCAGGATCTCAGAAACGAGCTGCGACTCACTCTTCCAGGCCACCCTGGCCGAAAGCTCGACA TGGTCAATCCGGCCG :::::::::::::::Rv149T7.seq::::::::::::::: CAGGCATGCAAGCTTGCGGGCCGGAGTGGTTTCGACGGCCGCTCGCTTCTCGGCATCGGTTTGGGCTGTCACCAGCAGTTGGTAGTTCTTCACGTACTGTTGTTCG AGCGTCGAGCCGCCGCGCGTGTCGAGGTCGCCGGACGCGTATCCCGCCAGGCCGGTCAGGGTGCCCTTCCAGTCCACGCCGCTGTGGTCGGCGAACCGCTTATCTT CAATCGAGACGATCGCCAGCTTCATCGTGTTGGCGATCTTGTCCGAGGGCACCTCGAACCGGCGCTGCGAGTACAGCCACGCGATCGTGTTGCCCTTCGCGTCGAC CATCGTCGATACCGCAGGCACTTGCCCCTC Clone Rv14 :::::::::::::::Rv14SP6.seq::::::::::::::: ATACTCAAGCTTCCCGGCGGCCAGTACCGAAAGCGCGAACAGCTGGCGGCAGCCCACGACGTGCTGCGTCGGATTGCCGGCGGCGAAATCAATTCCAGGCAGCTCC CGGACAATGCGGCTCTGCTGGCCCGCAACGAAGGACTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGC TTGATGCCCGGTCGGCAAGCCCGGCAGTTGCCAAACCCAGCGTGATCAGGCTCGGCTCGCGAGTTCGGCGAAGAAGTGGCTCGCCTGATCACCTACCATCGGCCAG GATCTGCGTGTCATCACAACGCTCGCCAAGGAGGTTGTTGTGGTGCTATCGACGGCCTTTAGCCAGATGTTCGGAATCGACTATCCGATAGTGTCCGCGCCAATGG ACTTGATCGCCG :::::::::::::::Rv14T7.seq::::::::::::::: AGCTTCGGTGTAGCCGATCACCGGAAGCCGCATGATCAGCCACGTTTCGCGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGCGGGTAATCG CCGACGGTGCCGGTTCGCGAGCCGAAGGTGACGACGCTGATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCAGCAACGGCGCGAGCTCAACGACGTCAATCACGT TGTCGCTTTCTACGGTCACCGACCCGGTGACCGTAGTCGCCCGGTGCGCTCGGCCGAGAAGTTGCACCGCCACCACCGCGACACCGTCTTGCACGCGGACGCCACC CCCGGATCGGTTGTTGGCCAAGGTAATTGGGTCATTCCATTTGACGGGACGCCGACCCCGCAGCCCCAGTACCGCCCACGACCACGCCGGCTGACCCACCACTGTA CGAACACCAAGGCGACGCCGA Clone Rv15 :::::::::::::::Rv150SP6.seq::::::::::::::: ATACTCAAGCTTCGGTGGCTTCGCCCGCCCTGCCGGGTGGACTTCATGACAACGCGGGGGCGATTACCCCCGCTACCGCCAGCAGCATGACGGCGGTACCTAACAC CGCCCGGATGCCTCGCACGTGCCTCGATGTGCTCACGGAATCGCCCCGGCACCGCGATCTCGAGGATCACCAGCGTTACCCCCGGCAGCGCGACACCGACAATTCC GTACACCGCCACGCCGATCCGGCCCTGGGCCAGCTGATTGGAGCTGGCG :::::::::::::::Rv150T7.seq::::::::::::::: CAGGCATGCAAGCTTCCACATGTACGGATCCACGAACATCCCGTTGAACTGACAGGTGCGGCCCGGCTCGATCAGGCCGGCCACTTGTTCTACGCGGTTACCGAAG ATCTCTTCGGTGACCTGCCCGCCGCCGGCCAGCTCGGCCCAGTGCCCGGCGTTGGCCGCCGCGGCGACGATCTTGGCGTCCACGGTGGTCCGGGTCTTGCCCGCTA GCACGATCCGCGAGTCGGCCGGTCACCCGGGT Clone Rv151 :::::::::::::::Rv151SP6.seq::::::::::::::: ATACTCAAGCTTTCCAAGTCCCAAGTGTCGATCATGGCCAAAGAGCTCGACAAAGCCGTAGAGGCGTTTCGGACCCGCCCGCTCGATGCCGGCCCGTATACCTTCC TCGCCGCCGACGCCCTGGTGCTCAAGGTGCGCGAGGCAGGCCGCGTCGTCGGGGTGCACACCTTGATCGCCACCGGCGTCAACGCCGAGGGCTACCGAAAGATCCT GGGCATCCAGGTCACCTCCGCCGAAGACGGGGCCGGCTGGCTGGCGTTCTTCCGCGACCTGGTCGCCCGCGGCCTGTCCGGGGTCGCGCTGGTCACCAGCGACGCC CACGCCGGCCTGGTGGCCGCGATCGGGGCCACCCTGCCCGCAGCGGCCTGGCAGCGCT :::::::::::::::Rv151T7.seq::::::::::::::: CAGGCATGCAAGCTTCACACGTAGGCGCCGTCGATAAATGACTCCGCCGCGCTTCGCACATCCTCGTAGCGATCCTTGGCGAGCAGGTCAACCGGGCGCTGCCCGT CGAGGAGCCGGTTTTTGGCGTGCAGCCACTGGCCGACACCTCGGGGGGTAAGCGAATCCGAGAGCAGGAGGACGAGGTCACGAAGCTGCGCCAGCCGGTCGTACCG CTCAGGGCGGATGTCGCCGGTCCGCCACCCGCGTACCGCCCGATCGGACACCTGTATGACCGCGGCGACGTC Clone Rv152 :::::::::::::::Rv152SP6.seq::::::::::::::: CGCGGCGGCGCATTACCCCCGCTACCGTCAGCAGCTTGACGGCGGTAGCGAACACCGCCGGATGCAGCGCAGGTGCGTCTATGTGCACACGGAATCGCCCCGGCAC CGCGATCTCGAGGATCACCAGTGCCCGCCCCCTG :::::::::::::::Rv152T7.seq::::::::::::::: GGGATCGAGGAACAGCGCGTTGAACTGATAGGTGCGGCCCGGCTCGAGCAGGCCGGCCATTTGTTCGATGCGGTTACCGAAGATCTCTTCGGTGACCTGCCCGCCG CCGGCCAGCTCGGCCCAGTGCCCGGCGTTGGCCGCCGCGGCGACGATCTTGGCGTCCACGGTGGTCGGGGTCATGCCCGCGAGCAGGATCGGCGAGCGGCCGGTCA GCCGGGTGAACTTCGTCGAGAGCTTGACCCTGCCGTCGGGGAGGCGAACCACGGTCGGTGCGTATCTCGACCAGGCCCGGGCAACCTCGGGGGTGGCGCCGACGGT GAACAGGTTGCGCTGGCCACCGCGGGTAGCCGCCGGCACTATGCCGATGCCCAGGCCGCGGATCACCGGTGCGGTCAGTCGGGTCAGGATGTCGCCCGGCCCCAGG TCGAAGATCCAGCGGGCGCCGGCCGCGTGGACACNGGTGATCTCGTCCACCATCGACTTTCTGATCA Clone Rv153 :::::::::::::::Rv153SP6.seq::::::::::::::: TAACTCAAGGCTTGCGTTGAGGCCCCAGGCCCATCGACGGTTTGGCGGCCTTAAATGCACTGAGGTCGTCAATTGACCCCACAGCGGAAATGCCGACTATTCGCAG GCCTCCTTCGCCTTGGCTGCCGGAGAGGGGCTCCGCGGGAACCGCATGCAGGTATATGACCTCGGTTTCTCGGGTGCTACCGCGTGCCTTGTCGAGGATGAACTCG GCGTTGGAATTGTCCAGCCGGCCCAATTCATCGAGCGCAGATTCGTACACATGGCCGGCGGCGACATACGCTTCACCGTGGATCTGCTCCACACGGACCGCCCTGT CGGGATCCTGCTCACGGGTAAAGGAACTTACNTGGCNCTCGGTGCC :::::::::::::::Rv153T7.seq::::::::::::::: CCTTCTGCGCCACCCACACCGTCAACGCCCGCGAAGTCGACGTCGTCCAGGCCATCGGCGGCCTCACGGATGGATTCGGCGCGGACGTGGTGATCGACGCCGTCGG CCGACCGGAAACCTACCAGCAGGCCTTCTACGCCCGCGATCTCGCCGGAACCGTTGTGCTGGTGGGTGTGCCGACGCCCGACATGCGCCTGGACATGCCGCTGGTC GACTTCTTCTCTCACGGCGGTGCGCTGAAGTCGTCGTGGTACGGCGATTGCCTGCCCGAAAGCGACTTCCCCACGCTGATCGACCTTGACCTGCATGGCCGGCTGC CGCTGCAGCGGTTCGTTTCCGAACGCATCGGGCTCGAAGACGTCGAGGAGGCGTTCCACAAGATGCATGGCGGCAAGGTATTGCGTTCGGTGGTGATGTTGTGATG GCCGCCATCGAGCGCGTCTCACCCCACGG Clone Rv154 :::::::::::::::Rv154SP6.seq::::::::::::::: ATACTCAAGCTTGATTTTGATCATCATGATGATCATCACCCGAAGTGTGGTAGCCGCAGTGGTTATCGTGGGTACCGTCGTGCTTTCCATGGGCGCCTCTTTCGGG CTTTCCGTATTGGTCTGGCAGGACATTCTGGGTATCGAGTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCCTGGCGGTGGGATCCGACTACAATCTGC TGCTGATTTCCCGGTTGAAAAAAGAAATTGGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGGAGTGGTTACCGCTGCCGGCATGGTGTT CGCCGTTACCA :::::::::::::::Rv154T7.seq::::::::::::::: ATTGNCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACCTCGATGCTGCCGCCATGGACGCGGTCGAACGCAAG CAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGGATCGCGGTGATCGTCGATGACGGCATCGCCACCG GAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCGATCGGCCCAGACGACATCGTGGCGAGATTCGCCGG GTACGCCGATGAGGTGGTGTGTTTGGCGACGCCGGCGTTGTTCTTCGCCGTCGGGCAGGGTTACCGCAACTTCACCCAGACCTCCGACGAAGAAGTGGTGGCGTTT TCTGGATCGTGCTC Clone Rv155 :::::::::::::::Rv155SP6.seq::::::::::::::: ATACTCAAGCTTTTCCCGTCCGTCATCGCCCAAGCGCGTGAGGCCGAAGCGGCTGGTTACGACTCCCTGTTTGTGATGGACCACTTCTACCAACTGCCCATGTTGG GGACGCCCGACCAGCCGATGCTGGAGGCCTACACGGCCCTTGGTGCGCTGGCCACGGCGACCGAGCGGCTGCAACTGGGCGCGTTGGTGACCGGCAATACCTACCG CAGCCCGACCCTGCTGGCAAAGATCATCACCACGCTCGACGTGGTTAGCGCCGGTCGAGCGATCCTCGGCATTGGAGCCGGTTGGTTTGAGCTGGAACACCGCCAG CTCGGCTTCGAGTTCGGCACTTTCAGTGACCGGTTCAACCGGCTCGAANAGGCGCTACAGATCCTCGAGCCAATGGTCAAGGGTGAGCGCCAACGTTTTTCGGCGA TTGGTACCCACCGA :::::::::::::::Rv155T7.seq::::::::::::::: CGGCCACCGGGGCCACTCCGCACAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTGTGTCGAC CCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACG ATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACT TGAAGGTGATTGTTAACCTGGGCTACGGCGACCCGGCCTATGGTTATTCGACCTCGCCGCCCAATGTTGCGACTCCGTTCGGGTTGTTCCCAGAGGTCAGCCCGGT CGTCATCGCCGACGCTCTCGTCGCCGGGACCAGCAGGGAATCGGCGATTTCGCCTACA Rv156 :::::::::::::::Rv156SP6.seq::::::::::::::: ATACTCAAGCTTGGGGTGGCGCTGTCGGTCGGTGTGCTTGGCGGCGTCGGTATCAACACCGCCCACGAAATGGGGCACAAGAAGGATTCGCTGGAGCGGTGGCTGT CCAAAATCACCCTCGCCCAGACCTGCTACGGGCACTTCTACATCGAGCACAACCGTGGCCATCACNTCCGGGTGTCCACACCGGAGGACCCGGGGTCGGCGCGGTT CGGCGAAACGTTGTGGGAGTTCCTGCCCCGCAGTGTTATCGGCGGCTTGCGCTCGGCCGTTCATTTGGAGGCCCAACGGCTGCGTCGGCTCGGCGTCAGCCCCTGG AATCCCATGACGTATCTGCGCAACGACGTGCNCAACNCGTGGCTGATGTCNGTGGTGTTGTGGGGTGGGC :::::::::::::::Rv156T7.seq::::::::::::::: TCGCCACCGCACCGCGGCGAACGCTCAAAGGCACCTACTGGCACCAAGGCCCCACACGTCACCCTGTGACCTCCTGCGCCGACCCCGCCCGAGGTCCTGGCCGTTA CCACCGAACGGGCGAGCCGGGAGTCTGGTACGCATCGAACAAAGAGCAAGGTGCATGGGCGGAGTTGTTCCGCCACTTCGTCGATGACGGGGTCGATCCATTCGAG GTCCGTCGCCGCGTCGGTCGAGTGGCGGTCACACTCCAGGTACTCGACCTCACAGACGAGAGGACTCGATCCCATCTAGGTGTGGACGAAACAGATCTTCTGTCCG ACGACTACACCACCACCCAGGCCATCGCCGCCGCCCGCGATGCCAACTTCGACGCCGTACTGGCCCCGGCGGCGGCGCTCCCCGGTTGTCAAACACTTTGCCGTGT TCGTTCACGCACTGCCCAACATCGAGCCCGA Clone Rv157 :::::::::::::::Rv157SP6.seq::::::::::::::: ATGAAATAAGAAGAGCACATCCCTCAGTCGGTTATCATCACTAGCGCTCGCCGCACCCGTGTAACCGATCATAGCGAGCGAACTGGCGAGGAAGCAAAGAATATCT GTTCTGTCAGATAGCTCTTACGCTCAGCGCAAGAAGAAATATCCCCCGCGGGAACAACTCCAGGTAGAGGTACACACGCGGATAGCCAATTCAGAGTAATAAACTG TGACACTCACACCCTCATCAATGATGACGAACTACACCCCGATATCCGGTCACATGACGAAGGGAAAGAGAAGGATATCATCTGTGACAAACTGCCCTCAAATTTG GCTTCCTTAA Clone Rv159 :::::::::::::::Rv159SP6.seq::::::::::::::: ATACTCAAGCTTGTCGAACTCCTTCTTGAATACCGGCCGGCCATCCACAGATGCCCGGAAGAACTTCCAGGTACCCATGGCGGCTGGATCAGGGGGCGGCACAGTT GGTCTTGTCCTGCCTCGAGTGGCGTCGTTGTCCGGCTTGGACGGGGCTCCGACGGTACCGGAGGGCAGCGACAAAACACTTATGCACTTGGGCGACCCGCCGAGAC GGTGCGACACCCATCCCGACGGCACAAGCTCAGCCGCGGCCGCTCTTGTTCTTCGTCGGATCGACATTCACCCACTTCTGACCGGGCTTGGGCGAAGGAAGCAGAA :::::::::::::::Rv159T7.seq::::::::::::::: GGTATAGTCGCTGACCGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGCGCAGGCTATCGCACCCGTTATCGGCTACGAG CAAATCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCTGCGTCATGGTCGACACCCACGACGGAAAGACGCAGATCGCCGTCAAGCATGTGTGCCGCGGATTAT CAGGACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGGTCGTGGTCGGCTCGGATAGCGAGGTCAGCGAATTCTCGTGGCA GCTCGAAAGGGTCCTGCCGGTGCCGGTCTTTGCGCAAACGATGGCGCAGGTTACGGTCGCGCGGGGTGCGGCCCTGGCGGCGGCCCA Clone Rv15 :::::::::::::::Rv15SP6D2.seq::::::::::::::: GACACTATATNATACTCAAGCTTCAGGTCAATGTGCGCCAAGCCCTGACGCTGGCCGACCAGGCCACCGCCGCCGGANCCCTNTCTAGA :::::::::::::::Rv15T7.seq::::::::::::::: CTGTAGCCACCTGTTGCCATCCCCGTCATGCCCGACTCTGGTCATCTCGGATCCGCTGACACCCCGCTAAGGCTGCTCCTCTCGGTGCATTACCTCACCGACCGCG AACNCCCCCAGCTTTACGACTATCCGGATGACGGCACCTGGTTGCCGGCTAACTTCACCGTCAGCTTGGACGGCGGCGCTACCGTCGATGGCGCCAGGGGGGCGAT GGCCGGGCCCGGCGACCGATTCGTCNTCANCCTGTCGCGTGAACTTGCCGACGTCATCGTGGTCGGTGTGGGCACCGTGCGCATTGAGGGCTACTCCGGCGTCCGG ATGGGTGTCGTCAAGCGCCCGCACCGGCAGGCCCGA Clone Rv160 :::::::::::::::Rv160SP6.seq::::::::::::::: ATACTCAAGCTTCGCACGCTCGGCGCGCGCGGTACCGCCCAGGTCGCCCAACAGATCGTCGATGTTCGCGTCGTCCGCCTCGCGCACGTGGTCTGTCACCAGTCAA CGTTAACGCCGCCGCACATGTCCTGCGGCCGGGCAAAAACGTGAAAAACGAGCGGGCGACTGCNATGTCATGACAGCGACGGCCGCCGATGGGCCCAGGGTCTGGC AAATTCGATCTGTGCGGCCAGTGCCAGCAGCGTCGCCTCGTCATACGGCCGGCCGACGAGTTGAACCGACATGGGCAGGCCGTCGCCGTCGAAGTCCCACGGCACC ACGGGCGCGGGCTGGCCGGTCAGATTCCAAAATTGAAAGTACGGAACCGCTGCACCACCAA :::::::::::::::Rv160T7.seq::::::::::::::: ATCGTTTCGACCAGGCGCTCCATCCGGCGAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCGGGTTCAGCTGGCTTGCGGCGCTGCAGCA GCCAGTCCGGGAAATAGCTGCCCTGGCGCAGCTTGGGGATCGCGACGTCGATGGTTGCGGCACGGGTGTCGAAATCACGGTGGCGGTAGCCGTTGCGCTGATTGGA CCGCTCATCGCTGCGTTCGCGGTAGCCCGCCCCGCACAGGGCGTCGGCTTCAGCCCCCATCAAGGCGGCGATGAACGTCGAGAGCAGCCCGCGCAGCAGATCCGGG CTCGCCTGTGCGAGTTGGTCAGCCAGAAGCTGCTCGGTGTCGATAAGATGANAAGAAGTCATTGCGTTATTTCCT Clone Rv161 :::::::::::::::Rv161SP6.seq::::::::::::::: ATACTCAAGCTTGGGTGTTGCCGATCACCGGAAGCCGCATGATCAGCCACGTTTCGCGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGCGG GTAATCGCCGACGGTGCCGGTTCGCGAGCCGAAGGTGACGACGCTGATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCAGCAACGGCGCGAGCTCAACNACGTCA ATCACGTTGTCGCTTTCTACGGTCACCGACCCGGTGACCGTAGTCGCCCGGTGCGCTCGGCCGAGAAGTTGCACCGCCACCACCGCGACAACGTCTTGCACGCGGA CGCCACCCCCCGGAT :::::::::::::::Rv161T7.seq::::::::::::::: GCGCMAACAGCTCGCGGCAGCCCACGACGTGCTGCGTCGGATTGCCGGCGGCGAGATCAATTCCAGGCAGCTCCCGGACAATGCGGCTCTGCTGGCCCGCAACGAA GGACTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGCTTGATGCCCGGTCGGCAAGCCCGGCAGTTGCC AAACCCAGCGTGATCAGGCTCGGCTCGCGAGTTCGGCGAAAAAGTGGCTCGCCTGATCACCTACCATCGGCCAGGATCTGCGTGTCATCACGACGCTCGCCAAGGA GGTTGTTGTGGTGCTATCGACGGCCTTTAGCCAGATGTTCGGAATCGACTATCCGATAGTGTCCGCGCCAATGGACTTGATCGCCGGCGGTGAGCTGGCTGCCGCN GT Clone Rv162 :::::::::::::::Rv162SP6.seq::::::::::::::: ATACTCAAGCTTTCTCCGATACCCGCCATGTCGCGCACATCCAGGACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAAGTGCGGATGATCGGGCCGCCTA CGTCGTGGTGTACCTCGTCGGTAACAACGAAACCGAAGCGTATGACTCGGTGCACGCGGTGCGGCACATGGTGGACACCACACCGCCACCGCACGGGGTGAAGGCC TATGTCACCGGTCCGGCAGCACTCAATGCCGACCAGGCCGAGGCCGGAAACAAAAGTATCGCTAAGGTCAGCGCGATCACGAACATGGTGATCGCAGCAATGTTGC TAGTGATCTATCGCTCCG :::::::::::::::Rv162T7.seq::::::::::::::: CCATGAGCACCGCCAGCCGAGCACGAGGCCAAACTCCGCCGACGCAGGCCGGTTGGACTTGTCGTGCTGGACAAGGGGTTTAGCCGCCGAAGCAGTGACGTACATC GGCGAAGAGCAGTTCGCCTGTCGACCGACGGCGCAAACCGTGAGGCTAGGGAAGCGAGGAGCACATGGCCGCCGACCCGCAATGTACACGCTGCAAGCAAACCATC GAACCCGGATGGCTATACATCACCGCCCATCGCCGCCGGTCAAGCCGGGATCGTCGATGACGGCGCAGTACTGATTCACGTGCCCGGTGAATGCCGCAGCCGGGGA GCACTTTCCGCCAAAACTAACCCGGTTGG Clone Rv163 :::::::::::::::Rv163SP6.seq::::::::::::::: CGGGTGTCATTGGGCCACCGGCGGCGGCTGTCCGGGAAATGGCGGGTCCCCGGTGGTTTTGCTGAGGAGTGCTGAACCGTAGTCGAAGTGGCGGCGTCAGACTCCA CCCAGCCAGCAGGCAGCGCGAANCTGAATCCTCCAACCGGGTTGTCNATCCGGACAGGTTGGGGTGCGTTTGGGGCAATNACAGGTGGCGGCGGTGCGTTCGGGTC GGCCGGCGGAGGTGCTGCNTTGGATCCCCGGCTGGGCATTCGGCNTGTTGGCGGCGGCCGGTGGTGGGGGGGGCAACACGTGTCNGCGGTGCGGGTGGCCCT :::::::::::::::Rv163T7.seq::::::::::::::: CCAAGATCTACACCATCGAATCGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACGCCCATTGCCGGCACCTACTACGTGCACTC CAACTACTTCATCCTGACGCCGGAACAANTTGACGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGCACGGAGAACCTG CCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGGANACCCACTGGCGAACCTGGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCTACGGCGACCC GGCCTATGGTTATTCGACCTCGCCGCCCAAATGTTG Clone Rv164 :::::::::::::::Rv165SP6.seq::::::::::::::: AGCTTCCCGAGTTCGGCTTTGGATCAAGACCCCAGTCCGCGGGCGCGATCCGGCBGCTCGGTGACTACATCAAGCCACAAATCGACGGCTTTCGGGGTGCCGATAC CGATGACGTGGCGGATGTCGAGTGTTGAGTTCTCGGCGGGGCGGATGCTCACCTGGCGATCACCTGCCTCTCGTTGACGATCGATCGTCTATGCCGCCGTCTCTGC GGGAACAGGCCNCCAGTACATCGCCACAGACGGGATCCACCCGCATTTCGGCTACGGTTGCTCGTTTCGGTGTTCGGACTAGTCGGTCCTGGTGACGTGCCGGTGA TGCGGACCGGTCCTAGCACTGACCAATGGCCAAAATGCGGGC :::::::::::::::Rv164T7.seq::::::::::::::: CGGGGGGCCTCTTAATAGTGTAGGAAAGAAGCTCTACATATTCAGGAGGATTCACCATGGCTCGTGCGGTCGGGATCGACCTCGGGACCACCAACTCCGTCGTCTC GGTTCTGGAAGGTGGCGACCCGGTCGTCGTCGCCAACTCCGAGGGCTCCAGGACCACCCCGTCAATTGTCGCGTTCGCCCGCAACGGTGAGGTGCTGGTCTGCCAG CCCGCCAAGAACCAGGCAGTGACCAACGTCGATCGCACCGTGCGCTCGGTCAAGCGACACATGGGCAGCGACTGGTCCATAGAGATTGACGGCAAGAAATACACCG CGCCGGAGATCAGCGCCCGCATTCTGATGAAGCTGAAGCGCGACGCCGAGGCCTACCTCGGTGAGGACATTACCGACGCGGTTATCACGACGCCCGCCTACTTCAA TGACGCCCAGCGTCAGGCCACCAAGGACCCGGCCAGATCGCCGGTCTCACGTGCTGCGG Clone Rv165 :::::::::::::::Rv165SP6.seq::::::::::::::: ATACTCAAGCTTCATAACAGGCCTGTTGTGGGCGCACCCGGCTCGCCGAGTTCTGCACGCACCGCCTCAAGTGCGGCCCGCACCGCCGGCATCTCCCGGTCACGCA GGGCCGCGGCCCGCGCCGCAGCGACGGCGTGTTCGCGCAGTTCGCCGTCAATGATGCTGACCTGATCGGCCACCCGGGCGTTCTCGGCGTCTTCGCGTTCACTAAT CGCGGTGCTCAGCAGCGTCTCGACAGCCACCACCCGAGTGGCGACCAGCTGCTCCACCACGGACCGCAGCGATGCCGTCACCTCACCCGTCCAGCGGTCCACCACG ACACGGTCGTGCACCAGCGCGCGGGCATTCACCACCCAGGCGGTCACCGCCAGGCCGATCGCCACACCCGCCACCATCCCCGATGCAGCCAGGCCGGGAGTAAGA :::::::::::::::Rv165T7.seq::::::::::::::: CTGGTGCTGGACGGAGCCTAGTACAACTTCCTCTCCAATGCTCTTGCCCCGATCGCGGCGACCAGGATGACCCAGGACATCCTGCCGCCCGAAGTACTGGAAAAGC TCACACCCGAGTTCGTCGCACCGGTGGTGGCCTACCTGTGCACCGAGGAGTGTGCCGACAACCCATCGGTGTACGTCGTCAGTGGTGGTTAGGTGCAGCGAGTTGC GCTGTTTGGCAACGACGGCGCCAACTTCGACAAACCGCCGTCNGTACAAGATGTTGCGGCGCGGTGGGCCGAGATCNCCGATCTGTCCGGTGCGAAAATTGCTGGA TTCAAGTTGTAGAACTAAAT Clone Rv166 :::::::::::::::Rv166SP6.seq::::::::::::::: ATACTCAAGCTTTTCCGGCGTCGTCCACCTGACCCAAAAAGCGCAGGTGCGCCGCCAAACGGCCCGCCTGGCCGCGCAACTGGTCGGCGTCGCCGTGGCCGACAAT CAGTAGCTGGACATCCGGAAACCGCTGCACCACCTTCGGCAGCGCGTCAAGCAAAAACGGCCATTCC :::::::::::::::Rv166T.seq::::::::::::::: TTTCAGATCTCATTTTTATGACATGACTGGAGATCTGTCTAGATTGCAGCTCCTGTGAGCGTGGGTACCGGATTCAAGCCGGTCGGTCACGCCGCGGTGGTACCGG CTTTGCGGCAGTGCTCGGCCTCGAGTTCGGCGATCGCGCGCGAAGTGCGTTTCGCGCACCAAGATCGCGGCCTAATGGCCGGCGATGACCGCGATGACCAGCGCGA TCCAGGAAAAACCGTTCCAACCAGTGCTGGGCGGCCATCCCCG Clone Rv167 :::::::::::::::Rv167SP6.seq::::::::::::::: ATACTCAAGCTTCCCGACCACAAGTTGAACAGCACCGATTTCGGCGAGCACTTCGTCAACTTCCAGGGTGCCCGCACCAAGTATTTCGACAAGTATTTCCGTCGGG CCGCCGCCGCCGGCGCGCGGCAGGTGGTCATCCTGGCGGCGGGGCTGGACTCCCGCGCGTACCGGCTGCCTTGGCCCGACGGGACCACGGTTTTTGAGCTGGACCG CCCGCAGGTCCTTGATTTCAAGCGCGAGGTGCTCGCCAGCCACGGTGCCCAACCGCGCGCCCTGCGCCCGCGA :::::::::::::::Rv167T7.seq::::::::::::::: GTGTGCTGTCAATTCAGAGCTGAGCCTGATGCACTCAACTTACTGAGCATGCTAACGCTGGTCGTGCGGGTCTTGTTCCCGCGTGTCGGCAGGGCACACGCTCGGG GCGTAGCTGGGAGAGGCCCCGGTCAAGCCCGGAGAGCAGTGCTCAGTCCGCCAGCTTGACCGACTTTCGATGAGAACGCGCTTCTCGCCGTATTGAACTGGCGTGC TGACGGTCGCTGAGCAGCGCTCGCCGAGTGCGGCCGCTGATTCTTTCATCGAGCCAGGAGGCGCATTCGTGTTCGGCCGCCTGCGGGTCGGCCCCATCGTCGACGC GATCCGTCACCCACTCCTCGATCAGGTCTGCCTCATCGAACGGGCCAACGGTGCTGTCGGAGTATGTGTGCGTGGGCACGGCGAGCCGGGTGCTGTGGTACACCCA CCGTTGCATGACCAAGTTGACGCCTGACTGGCTGAGCACCGCGATCCGCTCACAGGTCGGAACGTTGGTG Clone Rv169 :::::::::::::::Rv169SP6.seq::::::::::::::: ATACTCAAGCTTTTGGTCTAGCCGGCCGAGCCCGATACAGGTGTCATTGGCCACCGGCGGCGGCTGTCCGGGAAATGGCGGGTCCCCGGTGGTTTTGCTGAGGAGT GCTGAACCGTATGCGAAGTGGGCGGCGTCAGACTCCACCCAGCCAGCAGGCAGCGCGAAACTGAATCCTCCAACCGGGTTGTCGATCCGGACAGGTTGGGGTGCGT TTGGGGCAATGACAGGTGGCGGCGGTGCGTCCGGGTCGGCCGGCGGAAGTGCTGCGTTGGGATCGCCCGGCTGGGCATTCTGCGTGTTGGCGGCGGCCGGTGGTGG GGGGGCAACAGGTGTCTCCGGTGCGGGTGGCGCTGCACC :::::::::::::::Rv169T7.seq::::::::::::::: GGGGCCACTCCGCACAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACG CCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCA GTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTG ATTGTTAACCTGGGCTACGGCGACCCGGCCTATGGTTATTCGACCTCGCCGCCCAATGTTGCGACTCCGTTCGGGTTGTTCCCAGAGGTCAGCCCGGTCGTCATCG CCGACGCTCTCGTCGCCGGGACCCAGCACGGAAT Clone Rv16 :::::::::::::::Rv16SP6.seq::::::::::::::: TTCTNTCTTCCCNNATTCGTNNNTCTCNTACTACCNGGGCCNCAAAACACCTTGGCNAACGCTCAAAGGCGNTACNGGCACCAAGGCCCCACACGTCACCCTGTGA CCTCCTGCGCCGACCCCGCCCGAGGTCCTGGCCGTTACCACTGAACGGGCGAGCCGGGAGTCTGGTACGCATCGAACAAAGAGCAAGGTGCATGGGCGGAGTTGTT CCGCCNCTTTTTTTATGACGGGGTCGATCCATTCGAGGTCCGTCGCCGCGTCGGTCGAGTGGCGGTCACACTCCAGGTACTCGACCTCNCAGACGAGAGGACTCGA TCCCATCTANGTGTGGACNAAACAGATCTTCTGTCCGACGACTACACACCACCCAGGCCATCGCCGCCGCCCGCGATGCCAACTTCNACNCCGTNCTGGCCCCGGC GGCGGCGCTCCCCGGTTGTCAAACACCTGCCGTGTTCGTTCACNCACTGCCCAACATCNAGCCCGANCNATCCNAGGTCCGTCCAACGCCTCCGCGGCTCNCCAAC CTNCTCCCNCTGATCNTCCGCACCAAACACATGCCCGACTCCNTGCNCCNATTGCTTGNATCCCT :::::::::::::::Rv16T7.seq::::::::::::::: CCGCTATCGGTCGGTGTGCTTGGCGGCGTCGGTATCAACACCGCCCACGAAATGGGGCACAAGAAGGATTCGCTGGAGCGGTGGCTGTCCAAGATCACCCTCGCCC AGACCTGCTACGGGCACTTCTACATCGAGCACAACCGTGGCCATCACGTCCGGGTGTCCACACCGGAGGACCCGGCGTCGGCGCGGTTCGGCGAAGAGTTGTGGGA GTTCCTGCCCCGCAGTGTTATCGGCGGCTTGCGCTCGGCCGTTCATTTGGAGGCCCAACGGCTGCGTCGGCTCGGCGTCAGCCCCTGGAATCCCATGACGTATCTG CGCAACGACGTGCTCAACGCGTGGCTGATGTCGGTGGTGTTGTGGGGTGGGCTGATCGCGGTCTTCGGCCCGGCGCTGATCCCGTTCGTCATCATCCAGGCAGTCT TCGGCTTCAG Clone Rv170 :::::::::::::::Rv170SP6.seq::::::::::::::: ATACTCATGCTTGCCGAAGTTCCGATGGGTCGCGCCGGCGANCCCAGCGAAGTCGCTAGCGTGGCCGTGTTCTTGGCTTCGGATCTATCCTCGTACATGACCGGCA CCGTGTTGGACGTGACTGGCGGCCGGTTCATATGACACCGAGATCATTGCCACGGTACGGCAATTCGTCAAGAAGGAAATCTTTCCCAATGCACCGGCCCTCGAAC GTGGCAACAGCTACCCGCAAGAAATCGTCGATCGGCTGGGTGTTATTGGCTTGCTCGGTCGCCGGCTGCAAGGGTATCGACACCACCGAGTTCATTCTCCGGGCGT GCC :::::::::::::::Rv170T7.seq::::::::::::::: GGCGTCAACGGTGTCGGCACCGGCGTCCTGCAGTTGGTAGGCCTGCAGTTTGTGCATCAGGCCGATGCCGCGGCCCTCGTGGCCACGCATGTACAGCACCACGCCG CGCCCCTCACGGGCGACCATCGCCAGCGCGGCGTCCAGCTGAGGCCCGCAATCGCAGCGGCGTGACCCAAACACATCGCCGGTCAAGCACTCCGAATGCACCCGGA CCAGCACGTCGTCACCGTCGGCGTTGGGCCCGGCGATCTCGCCGCGGACCAGCGCGACATGTTGCACGTCCTCGTAGATGCTGGTGTAGCCGATGGCGCGAATCTC CCATGACGAGTCGGAATCCGCGCCTCGGCG Clone Rv171 :::::::::::::::Rv171SP6.seq::::::::::::::: ATACTCAAGCTTCGGCCTCGCTGCAGGAGTGGGAGCCGCAGGGCTGGAAATCCGAAAAACGAGCCCGGTGATCGCACTGTCGCCGATCGGGGCCGCACCTGGTGGT GTTACCGATGAATCCGCACCCAAAATGTGGCTGCGGTGGCGTTTCTTGACTCCTTGGCGTCGACTCTTGTGGCAGCCACCGAGCGGTTGGTCCAGGATCTGGATGG GCAAAGTTGTGCGGCCCGGCCGGTGACGGCCGATGAGCTGACCGAGGTCGACAGCGCCCGTGTTGGCTGACTTGGAACCGACATGGATCGCCCCGGTTGGCGTCAC CTCAAGCATTTCAATGGTTAT :::::::::::::::Rv171T7.seq::::::::::::::: ATGCGTCACCCCGATGCGCCCAGATCGGGGCTTCGCAAATAAAGCACGAACAGGCGGGCAAAACGTCTATCTCGGAGCCGGAAGGGCAATCAGCCGACCGTCGACG AACGACACCGGCGATAACCACTTAGGCGTTGAACGGCCGGCCCAAACATTACGCCTCCGTTGATAGGCTTTCGGTCTCTTCCCCGGTCATCCCAAGCACCTTTGCG GCAAATTTGAACGCTTTCCTGTCCGGGCACCGGCCCCGGGCTTTGGGGTCCNTCCGA Clone Rv172 :::::::::::::::Rv172SP6.seq::::::::::::::: ATACTCAAGCTTCAATCGCGCCGCCACAATCCAAATATGCGTCTAGCGTCTCGATGAGCGTCGGTCCGGCATCGGCTAGGGGCCGCATCACGTCGGTATGCAGGGC CACGATCGCCCAAGGCGTCGCCCATCAAGGGCGCGTTCGGGCAAAAATTCCCCTATCCAGCACGGGCCGCGGCGCTCCGCNCCAGCCGGCGACGGCGTTCATCCCG GAGATCGCCTCGCTAGCGCTGCGGTGCGCCGCGGTCAGCATGGGCGCCGTGGGGCCGATGACCACCGGGGCGT :::::::::::::::Rv172T7.seq::::::::::::::: TTCGGCGGGTCTGTAGATTGCGGTCGGCCACCCCACAGGCACTCATGAACCGCAGCCCACGATCGATCTCGGTGG Clone Rv173 :::::::::::::::Rv173SP6.seq::::::::::::::: GCGCACCATCGCCAGTAGGTGCCCGTGGTCGGGCGCGTCGAGCCACCCGAGCGGAAACGCGAGTCCGAACAGCAACAGCAGGACGGGCGCAACCAGGGCGGTGACC ATGCCCCCGGCGCTGAACATCAACCACAGGAAGGGCTCCGCCGAGCGTCCGCGCGACC :::::::::::::::Rv173T7.seq::::::::::::::: CATCGTCGAACTTCGGTCCGGGTTGNTAGNACCGCAGCACCAAACGCACCCACCGACCCCCACGCTTCACGCCAACCCTTTAGTTCATTGGCGTGAACAGCAGCGT AGCCGGTTGCCCCGATATATGTGGAAAAATCGTTCGGACGTACAAAAAAAGTTCCTGACGCTGGCGTCAACTCGAAACTGCCTCGGAAGTCAATGATGATCCATCA GTCAATATTAAAGTCG Clone Rv174 :::::::::::::::Rv174SP6.seq::::::::::::::: ATACTCAAGCTTGTCTGCTGCCTCAGCGTATGCATGCAACAGCGCATCGCGATCAACGATCAGGCGCGCCGATTTCGGGCCGCGGGCAGTGGCACTGGCCAGATGG CCGTTTTTTTCGAGAAACTTCAACGCCTGAGCGCTGCTTCCCATCGAGAGACCGGTGGCCTCTACAACCGATGCGACAGTTGGACCGGCGATGTTCGCCAGCAGCG CTTCACATACGGCAAGTNTGGCGCGG :::::::::::::::Rv174T7.seq::::::::::::::: TTGTCCAGGCGGGGAATCGGGCAGGGAGACGACACCTTCGTTCGGTTCGATCGTCGCGAACGGGTAGTTGGCCGCGACCACGTTGTTTCGGGTCAGCGCGTTGAAA AGTGTCGACTTGCCGACGTTGGGCAGGCCCACGATCCCCAGGCTCAAGCTCACAGA Clone Rv175 :::::::::::::::Rv175SP6.seq::::::::::::::: ATACTCATGCTTGGCGCCTGGGTGGCAGCCCACCTGCCCACCACACGGACCGCGGTGCGGACGCGGCTGACGCGCCTGGTGGTCAGCATCGTGGCCGGTCTGCTGT TGTATGCCAACTTCCCGCCGCGCAACTGCTGGTGGGCGGCGGTGGTTGCGCTCGCATTGCTGGCCTGGGTGCTGACCCNCCGCNCNACAACACCGGTGGGTGGGCT GGGCTACGGCCTGCTATTCGGCCTGGTGTTCTACGTCTCGTTGTTGCCGTGGATCGGCGAGCTGGTGGGCCCCGGGCCCTGGTTGGCACTGGCGACGACGTNCGCG CTGTTCCCCGGCATCTTCGGTCTGTTCGCCGTCGTGGTACCCTGTTGCCGGGTTGGCCC :::::::::::::::Rv175T7.seq::::::::::::::: CGCCAATTCACGATATCGTTAACCGATATCCCGAGCCGATAGCTGGCGGGCTCGGGTGGTGGCCAGCGGCGCTGCGACGAAAGGTGTGACCGTCATGAAACAGACA CCACCGGCGGCCGTCGGCCGTCGTCACCTGCTCGAGATCTCAGCATCCGCAGCCGGTGTGATCGCGCTTTCGGCGTGTAGTGGGTCGCCGCCCGACCCCGGCAAAG GCCGGCCCGACACAACCCCGGAACAGGAAGTCCCGGTCACCGCGCCCGAAGNACTTGATGCGCGAACNCGGAGTGCTCCAAACGCATCCTGCTGAT Clone Rv176 :::::::::::::::Rv176SP6.seq::::::::::::::: ATACTCAAGCTTGGGCACTGACTTCGGTACCCCCTCCGCCTTTGGCCAGCAGCAGCCACAGCGCGGTTCGCGGACCGAACGTGGACATCAATAGCCCGGAATCGGT GTGTGCAAGTTGGTAAACGGTGTTGATCCCAAGCTTTGCCAGCCTTTTCGTAGTCTTGGGCCCCACACCCCACAGTGCTTCGACGGTACGGTCACCCATGATGGCC ATCCAGTTGGCATCGGTGAGCTGATAAATGCCAGCTGGTTTCGCCAACCCGGTAGCGATCTTGGCGCGCTGCTTGTTGTCACTGATACCTATCGAGCAAGACAGCC CGGTTTGCGACAAAATGACTTTTCGGATCTCTTCGGCGACTTCGATGGGGTCGTCGGGA :::::::::::::::Rv176T7.seq::::::::::::::: AAAGTCCTGTGCCGGTTCGCTAAACACCCGGCGGACACTCAGACGGTGCTGGTGGTGCGGCATGGCACCGCGGGCAGCAAAGCGCACTTCTCCGGGGGACGACAGC AAGCGACCGCTAGACAAGAGGGGTCGTGCGCAGGCAGAAACGTTGGTACACAGCTGCTGGCGTTCGGCGCCACCGATGTTTATGCCGCCGACCGGGTGCGCTGCCA CCAGACGATGGAGCCACTCGCCGCGGAACTGAACGTGACCATACACA Clone Rv177 :::::::::::::::Rv177SP6.seq::::::::::::::: ATACTCAAGCTTGGGTTCCACGCCCGCGCAGCCACGCCGTCACCTTTCCACGAGACCTCACCTGCCGATCCGAAATGGAATCGGCCGTGACGGAATTGGCGCACCG AACACCCAACGAGGTGGTGGCTTCGTCGCGAACCGTCACCCGAGTCGCGGCCACCGTGCGCACGGCGACGTTCTACACCCGCACCAAGATCCGAAAGCTGCAAGCT CCCAGCACCGATCCCGACGTCATCACCGCTGCCGCCCGGCACGTCCTTGACCTATTCGAGCTGGATCGGCCCGTCCGGTTGCTGGGAGTGCGGTTAGAACTGGCCT AGAACCGGCGGGCACACCGCNCCTGGGCGGGGCGAATTCTTGACCGCNCCGGCC :::::::::::::::Rv177T7.seq::::::::::::::: CGCGGTTGGCGTAGTTGGACGGGTCGCCCTCCGAGGCCAATGATGACGATGACCACGCCGATCACGATGGCCACCGAGAGGGACAACAACAGAAAGCTGACGAATC CCTCCTTGGCGGCCGGGGCTTTGTGGTCGCCGGTCGCGATGGGCGCGAATTTACGGCCCGCTCCCCCAGGCCGCCGCGAAGCAGGGTCCCCAGCCAGTTGGCGTAG GCGGAATTAACGATCAGCGCCACCGCGATAACCTGCCATGCCTCGGGCATATCGATGTGCGGCCAGAACAGGCCGAAC Clone Rv178 :::::::::::::::Rv178SP6.seq::::::::::::::: CCAACAAGAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGGCGCGAACGACGCCAGCGACCACATTCAGCAGATGGC CAGCGCGTGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCGTGATCGACATCGTCACCGCCGCACCACTGCCCGGCCTCGGGTTCACGCAG CCGTTGCCGCCCGCAGCGGACGATCACATCGCCGCGATCGCCCTGTTCGGGAATCCCTCGGGCCGCGCTGGCGGGCTGATGAGCGCCCTGACCCCTCAATTCGGGT CCAAGACCATCANCCTCTGCAACAACGGCGACCCGATTTCTTCNGACGGCAACCGGTGGCGAGCGCACCTAGGCTACGTGCCCGGGATGACCAACCAGGCGGCGCG TTTCGTCGCGAGCAGGATCTAACCGCGAGCCGCCCATAGATTCCCG :::::::::::::::Rv178T7.seq::::::::::::::: TAANACCCGTGTAATTTGGGATGGGCAAAAAGGCCAAGCACCGCGTGGCCACGAACGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGA ACGTACGGCGTTTCAACACGTCGCGTCNCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGGTAGCNCCCTGGCCGGGCGATGATCTGCAGCGTCGCCGCG GGTAGTCGCCGCCCGGGCGGCTACAGTCTGAAACGCGATGACCATCGATCTCTGGATGCAGCATCCGACGCAACGGTTCCTACACGGCGATATGTTCGCCTCGCTG CGCCGGTGGACCGGTGGGTCTATCCCGGAGACCGACNTCCCGATCGAAGCGACCGTCTCCTCGATGGACGCCGGCGGCGTCACCCTGGGTTTGCTCACCGCCTGGC GTGGCCCCAA Clone Rv179 :::::::::::::::Rv179SP6.seq::::::::::::::: GTCCGCAAAAGACTCAGCGGCCGACTTTGCTCGCAGCTGGCGGTACCGCGCCACCGATTCGATGCCGTGGTCGCGGAAGAATGCCTCCCGAAATCGCACGGCCGAC TCCAGTTCGGCGAGCATCCGCGATGCCAGCTGCGGCTGCGCCCTGCCGGCCACGGCACCCACATGCGGCAGTTCGTCCACCTGGGCCAGCGCCCCGCCGCCGAAGT CCAAACAATAGAACTGCACCCGGCCCGCATCGTGGGTAGCAGCCAACGCCATGATCAGCGTCCGCAGCGCGGTTGACTTGCCCGTTTGCGGTGCACCTACGACCGC GACATTGCCTGCGGCCCCGGACAAGTCGATCGTCAGCGGCACCCN :::::::::::::::Rv179T7.seq::::::::::::::: CGTGGCCACGAACGCCGGAAGGGACANTCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGAACGTACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAA CATTCGGGGATGGCAGCAACCTGGCAGCTACCTGGCCGGGCGATGATCTGCAGCGTCGCCGCGGGTAGTCGCCGCCCGGGCGGCTACAGTCTGAAACGCGATGACC ATCGATGTGTGGATGCATCATCCGACGCAACGGTTCCTACACGGCGATATGTTCNCCTCGCTGCGCCGGTGGACCGGTGGGTCTATCCC Clone Rv17 :::::::::::::::Rv17SP6.seq::::::::::::::: ATACTCAAGCTTTGCGGCGGGCGCCGAAATGTGAACGCACCAAACCCGCCCGCTGCGGGTCGGCGGGCCACTCGACCTCGAATTTCGCCGCCGTGACCATCCAGCC CGACGGCAGTTGGGCACCCGGCCCCCCGGTCGCGGCATAACTGTTGGCGTCGCCGTCATAAAGCTCGAACAGCACCGAAACCGACTCCACCACCGGCCGGTGCGCC TCAAAATCCACGCCGATCTCCACATACCGGGAAAACGTCGGTGTCCCATCGGGTTTCGGCTTGCCCGCCAGCTGCACACCACCGGTGGCCTCGGCCACCTTCGCGG CCTGAGCGCAGCTACNCATCCTGACGATCATCACCCCGCCCCCGGCTCACGCTTGGCCTCCGTGACCGCACGCATCGCCCGGTTGCGCGCACCGCGACGCCCGTAC AGCCGCGCGCAC :::::::::::::::Rv17T7.seq::::::::::::::: AGCTTGCCGGGACTGCGGAACAGAAGCGGCGGTTCCTACCGCGGTGTGCGGCCGGCGCGATATCGGCCTTTTTACTAACCGAACCCGATGTGGGCTCCGATCCGGC GCGCATGGCATCGACGGCGACGCCGATCGATGACGGCCAGGCTTACGAGCTTGAGGGTGTGAAGTTGTGGACCACCAACGGTGTGGTAGCGGACCTGCTAGTGGTT ATGGCGCGGGTACCGCGCAGTGAAGGGCACCGAGGGGGAATCAGCGCCTTTGTCGTCGAGGCTGATTCGCCCGGGATCACCGTGGAGCGGCGCAACAAGTTCATGG GACTGCGTGGCATCNAAAACGGCGTGACCCGGCTTCATCGCGTCNGGGTGCCCAAAGACAACTTGATCGGCA Clone Rv180 :::::::::::::::Rv180SP6.seq::::::::::::::: CTCAAGCTTGGCGATGCGGGCTGGCCAAAACTGGCCGGGCGGGGGTTGGCTTGTTCAATCAAGGGTGGGTTGCCG :::::::::::::::Rv180T7.seq::::::::::::::: CCGAAGGCCCGTTCCCGGGCGTTCAGCAAGCGATCGTCGGTTGGCCCACTGCGGGTCGAATCTTGCGGCCGCGCCGGTCGTGGAACGCCCAGGTCACCCGGCGGCG TACC Clone Rv181 :::::::::::::::Rv181SP6.seq::::::::::::::: ATACTCAAGCTTTTTTCTGCTCATGAAGGTTAGATGCCTGCTGCTTAAGTAATTCCTCTTTATCTGTAAAGGCTTTTTGAAGTGCATCACCTGACCGGGCAAATAG TTCACCGGGGTGAGAAAAAAGAGCAACAACTGATTTAGGCAATTTGGCGGTGTTGATACAGCGGGTAATAATCTTACGTGAAATATTTTCCGCATCAGCCAGCGCA GAAATATTTCCAGCAAATTCATTCTGCAATCGGCTTGCATAACGCTGACCACGTTCATAAGCACTTGTTGGGCGATAATCGTTACCCAATCTGGATAATGCAGCCA TCTGCTCATCATCCAGCTCGCCAACCAGAACACGATAATCACTTTCGGTAAGTGCAGCAGCTTTACGACGGCGACTCCCATCGGCAATTTCTATGACACCAGATAC TCTTCGACCGAACGCCGGTGTCGTTGACCA Clone Rv182 :::::::::::::::Rv182SP6.seq::::::::::::::: CTCAAGCTTGGTGCCGACATGGCCGGGCTGGAGCCCGCGTATGGCAAGGTTCCGCTCAATGTGGTTGTGATGCAGCAGGACTACGTTCGCCTCAATCAGCTCAAAC GTCACCCCCGTGGCGTGCTGCGCAGCATGAAGGTCGGCGCCCGCACGATGTGGGCGAAGGCAACAGGTAAAAACCTGGTCGGCATGGGTCGAGCCCTCATTGGGCC GTTGCGGATCGGGTTGCACCGCGCCGGAGTGCCGGTCGAACTCAACACCGCCTTCACCGATCTTTTCGTCAAAAATGGCGTCGTGTCCGGGGTATAC :::::::::::::::Rv182T7.seq::::::::::::::: CCGAAGCGTGGGAAATCCTGACCGAATACCGCGACGTGCTGGACACTTTGGCCGGCGAGCTGCTGGAAAAGGAGACCCTGCACCGACCCGAGCTGGAAAGCATCTT CGCTGACGTCTAAAAGCGGCCGCGGCTCACCATGTTCGACGACTTCGGTGGCCGGATCCCGTCGGACAAACCGCCCATCAAGACACCCGGGGGAGATCGCGATCGA AACGCGGCGAAACTTGGGCC :::::::::::::::Rv183SP6.seq::::::::::::::: CGACTCGACAAGCATTCTTGACAGTTGTTTTGGCTCGGCATGGTTAGCCAAGGTTCTGCGGTCCCACCAGATCATCTTGGTCCGGTAGCGCTCGTCCGGGTATGCT GCCGCCGGGATTCTCGCTGCTATTACTCCCCCCGAAAAACGCCACCGGTCCAGCGCGTGGGCCGCCGCGGTCCCCATCACAAACTGAACCCCCAAGACCCCACATG CTTAGCGGTAGGGCGCGCGCCAAGGCGGCAGCAATCGCATCACTGCGCTGCGCGTCACTATTAACCCACCCGGACTTCACTTCCACGACCCCGAATGGCGCCCGGT CATTGATCATCTTGCGCACCGCGGATAATCCGGGATTGCCAGCCCATTCGACTACCGCATGCGAGTCATCGGCTGACCGCAGCGGTCCGATTACCCGAGCGCCCCG ANTACATCTCCTCCAATATCAATGGGCGCAA Clone Rv183 :::::::::::::::Rv183T7.seq::::::::::::::: GCGGTNTAGCTTCCCGTCGTACCGGCGACCGCCAGCCGAGAAGCTCGTTTTCCCAGTGTTGCTGGGGATTCTCACGCTGCTGCTGAGTGCGTGCCAGACCGCTTCC GCTTCGGGTTACAACGAGCCGCGGGGCTACGATCGTGCGACGCTGAAGTTGGTGTTCTCCATGGACTTGGGGATGTGCCTGAACCGGTTCACCTACGACTCCAAGC TGGCGCCGTCTCGTCCGCAGGTCGTTGCTTGCGATAGCCGGGAGCCCCGGATCCGCAATGACGGATTCCATGCCAACGCTCCGAGTTGCATGCGGATCGACTACGA ATTGATCACCCAGAACCATCGGGCGTATTACTGCCTGAAGTACCTGGTGCGGGTCGGATACTGCTATCCGGCGGTGACGACCCCCGGCAAGCCGCCATCCGTGCTG CTGT Clone Rv184 :::::::::::::::Rv184SP6.seq::::::::::::::: CTCAAGCTTGGGCGTGACGGCCACCGGGGCCACTCCGCACAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCG CTCAACTTTGTGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCA ATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAAAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAA CCTGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCTACGGCGACCCGGCCTATGGTTATTCC :::::::::::::::Rv184T7.seq::::::::::::::: CGGGTGTCATTGGCCACCGGCGGCGGCTGTCCGGGAAATGGCGGGTCCCCGGTGGTTTTGCTGAGGAGTGCTGAACCGTAGTCGAAGTGGGCGGCGTCAGACTCCA CCCAGCCAGCAGGCAGCGCGAAGCTGAATCCTCCAACCGGGTTGTCGATCCGGACAGGTTGGGGTGCGTTTGGGGCAATGACAGGTGGCGGCGGTGCGTTCGGGTC GGCCGGCGGAGGTGCTGCGTTGGGATCGCCCGGCTGGGCATTCGGCGTGTTGGCGGCGGCCGGTGGTGGGGGGGCAACANGTGTCGCCGGTGCGGGTGGCGCTGCA Clone Rv185 :::::::::::::::Rv185SP6.seq::::::::::::::: NCTTGATATTGGCGTCAACGGTGTCGGCACCCGGCGTCCTGCAGTTGGTAGGCCTGCAGTTTGTCGATCAGGCCGATGCCGGGCCCTCGTGGCCACGCATGTACAG CACCACGCCGCGCCCCTCACGGGCGACCATCGCCAGCGCGGCGTCCAGCTGAGGCCCGCAATCGCAGCGGGGTGACCCAAACACATCGCCGGTCAAGCACTCCGAA TGCACCCGGACCAGCACGTCGTCACCGTCGGCGTTGGGCCCGGCGATCTCGCCGCGGACCAGCGCGACATGTTCCACGTCCTCGTAGATGCTGGTGTAGCCGATGG CGCGAAACTCCCCATGACGAGTCGGAATCCGCGCCTCGGCGACCCGCTCAATGTGCTTCTCGTGCTTGCGCCGCCATTCGATCAAGTCAGCAATGGTGATCAGCGC CAGACCGTGCTCNTCGGCG :::::::::::::::Rv185T7.seq::::::::::::::: CATAAGGGCCGGCGTACCCGGTACCGGCCGCGGGCCTACCACGTGCCGGAACTGGAAGCGCAGTAAGCCCTCAACGCGCCACCGCTTTGGCCCGCGCGCCCGGCGT AGGCGCATCGGCGGTGGCCGTGGGGCGGCGCACTGCGACCTCACCAGCGGCTTTCGAGCTTTGTTCGATCAACCGGCCAGCATGGTCGAGGATGCATTCGAGACCA TATTCGAAATTGGTTTCATCGGGGGCCCCGATCCGATGCCCCCTCCCAGTTGCGTGAGCAAGCAGCGGAGTCGTCGCGGGATCGATGGCCACGGGGTGTTCAATGG CGGATGGTCCGCTGCCCGCCGACTGGCTCTTGCGGGAGAGCCGATCTAGCACCACCGATCCGCGCACGTGGACCGAAACCGCCGAGTAGATGTCGAAAGCGT Clone Rv186 :::::::::::::::Rv186SP6.seq::::::::::::::: CGTCCTTTTCCCCAAGATAGAAAGGCAGGAGAGTGTCTTCTGCATGAATATGAAGATCTGGTACCCATCCGTGATACATTGAGGCTGTTCCCTGGGGGTCGTTACC TTCCACNAGCAAAACACGTAGCCCCTTCAGAGCCNNATCCTGAGCAANATGAACAGAAACTGAGGTTTTGTAAACGCCACCTTTATGGGCAGCAACCCCGATCACC GGTGGAAATACGTCTTCAGCACGTCGCAATCGCGTACCAAACACATCACGCATATGATTAATTTGTTCAATTGTATAACCAACACGTTGCTCAACCCGTCCTCGAA TTTCCATATCCGGGTGCG Clone Rv187 :::::::::::::::Rv187SP6.seq::::::::::::::: CTCAAGCTTCATGTCCGTACGGCTCGGGTACGCTTCCGTCGCAGTGTGCGAGTGATAAATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTC AGTTGCTCACCGGAATCCAACCGGTAGAAGGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCAGCACTC CGCAGGCTTCGTCGGGGTGGTCGCGACACGCATGGGCCACCATCGCATTCAC :::::::::::::::Rv187T7.seq::::::::::::::: NCGCCGCCAGCCACCACGCGCGGGTCGGGCGCCGGGCCCGGGCCGCCAGGCTGCTCCGCTCGGTGATGGCACGCCACCGCGACACCACCCGGCTGCGCTACGTCGA GCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCGAGGTCGAGGTCGATACCGATTTGCGCATCCGCAGCCGCACCCTGGACGAC AGAACCGTGCCCTACGANTGCTTGTCGGGCGGGGCCAAAGAACAGCTTGGCATCCTGGCGCGATTGGCCGGCGCGGCGCTGGTCTCCAAAGAAGACGCCCTTCCGG TGCTGAT Clone Rv188 :::::::::::::::Rv188SP6.seq::::::::::::::: CGCCACGTTCATGGGCAACAACCCCGATCACCGGTGGAAATACGTCTTCAGCACGTCGCAATCGCGTACCAAACACATCACGCATATGATTAATTCGTCCAATTGT ATAACCAACACGTTGCTCAACCCGTCCTCGAATTTCCATATCCGGGTGCGGTAGTCGCCCTGCTTTCTCGGCATCTCTGATAGCCTGAGAAGAAACCCCAACTAAA TCCGCTGCTTCNCCTATTCTCCAGCGCCGGG Clone Rv189 :::::::::::::::Rv189SP6.seq::::::::::::::: ATACTCAAGCTTCAACCGATTGACGCATTGTGCGAACTGACGGCGCCCGCGCATGGCCAATCCGGAAGACCATCATTGGCCAGTGGGGGGGCGCTAACAGGTTCCA GCCCCCCACCAGTGCCGCTCGAACATGCGGTGCAACCCATTCGCAGGCCGGCAGGGAAAGCACCGCGGAAGCCGCAAAGGGCTGCAGTTCCGCGCCCAATAGTGTC GTCCGCAACCAGATGCGCTCGAAAACCGCGCCGGCAGTCAGCGCACCCGACGCGAGGTCGAGAGACGTCGTCAGCGCGCCCACATGGGGTGCCAATCGGCACGGCA GGTAGGCCGCGCGCAACCCGAACGCGTGGTGCATGCCCACGGTCCGCAGGAGGCGCAGCACCCGCCAATGCCGAAGCCCACGAAACATCGGGCGCATCCACGCTTC AACCTC Clone Rv18 :::::::::::::::Rv18T7.seq::::::::::::::: AGCTTTTGGCAGGGTCTCCTTCGAATTCGGCGTGCACCGCTATGGGTTGCAGCAGCGGCTGGCGCCGCACACCCCACTGGCCCCGGGTGTTTTGCCCCGAACCCGG ATCATGGTGAGCGAAAAGGAGATTCGCCTGTTCGATGCTGGGATTCGCCACCGCGAGGCCATCGACCGATTACTCGCCACCGGGGTGCGAGAGGTGCCGCAGTCCC GCTCCGTCGACGTCTCCGACGATCCATCCGGCTTCCGCCGTCGGGTGGCGGTAGCCGTCGATGAAATCGCTGCCGGCCGCTACCACAAGGTGATTCTGTCCCGTTG TGTCGAAGTGCCTTTCGCGATCGACTTTCCGTTGACCTACCGGCTGGGGCGTCGGCACAACACCCCGGTGAGGTCGTTTTTGTTGCAGTTGGGCGGAATCCGTGCT CTGGGTTACAGCCCGAATCGTCAC Clone Rv190 :::::::::::::::Rv190SP6.seq::::::::::::::: ATACTCAAGCTTTGTCACACCAACTGTTTCCACCAGGCGCTCCATCCGGCGAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCGCGTTCA GCTCGCTTGCGGCGCTGCAGCAGCCAGTCCGGGAAATAGCTGCCCTGGCGCAGCTTGGGGATCGCGACTTCTATGGTTGCGGCACGGGTGTCGAAATCACGGTGGC GGTAGCCGTTGCGCTGATTGGACCGCTCATCGCTGCGTTCGCGGTAGCCCGCCGCGCACAGGGCGTCGGCTTCAGCCCCCATCAAGGCGGCGATGAACGTCGAGAG CAGCCCGCGCAGCAGATCCGGGCTCGCCTGTGCGAGTTGGTCAGCCAGAACCTGCTCGGTGT :::::::::::::::Rv190T7.seq::::::::::::::: CCTTAAGCCCCGCAGGGCCCGGCACGCGCGGTACCGCCCAGGTCGCCCCAACAGTCGTCGATGTTCGCGTCGTCCGCCTCGCGCACGTGGTCTGTCACCAGTCAAC GTTAACGCCGCCGCACATGTCCTGCGGCCGGGCAAAAACGTGAAAAACGAGCGGGCGACTGCAATGTCATGACACCGACGGCCGCCGATGGGCCCAGGGTCTGGCA GATTCGATCTGTGCGGCCAGTGCCAGCAGCGTCGCCTCGTCATACGGCCGGCCGACGAGTTGAACCGACATGGGCAGGCCGTCGCCGTCGAAGTCCCACGGCACCA CGGCCGCGGGCTGGCCGGTCAGATTCCAGACTTGAAAGTACGGAACCCGTGCACCACCAGCAGCAACGTCGAAACTGCACCCCGGCGTTGGTAGGCGCCGATGCCG GGACGGGCCGGTCGCGGCGCCTGGCGTCACAACTACGTCGACATCGTCGAAGATCGACTGGATCGGCTGCTCACACCACTCGGCGGCCGCAGGCCGCCATCCGCCG TC Clone Rv191 :::::::::::::::Rv191SP6.seq::::::::::::::: AGCTTTTTGAGCGTCGCGCGGGGCAGCTTCGCCGGCAATTCTACTAGCGAGAAGTCTGGCCCGATACGGATCTGACCGAAGTCGCTGCGGTGCAGCCCACCCTCAT TGGCGATGGCGCCGACGATGGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGCGACGCGGTGGGTGGTCAAGTCCGGTCTACGCTTGGGCCTTTGCGGACGGTC CCGACGCTGGTCGCGGTTGCGCCGCGAAAGCGGCGGGTCGGGTGCCATCAGGAATGCCTCACCGCCGCGGCACTGCACGGCCAGTGCCGCGGCGATGTCAGCCATC GGGACATCATGCTCGCGTTCATACTCCTCGACCAGTCGGCGGAACAGCTCGATTCCCGGACCGCCCAGCGCATTGGTGATGGAATCGGCGAACTTGGCCACCCGCT GGGTGTTGACATCCTCGACGGTGGGCAATTGCCCCCGGTAACGTTTGCCGCCT :::::::::::::::Rv191T7.seq::::::::::::::: CGGTCCGACCCTGTTCGACGGCTACCTGAATCAACCCGATGCCACCGCCGCGGCGTTCGACGCCGACAGCTGGTACCGCACCGGCGACGTCGCGGTGGTCGACGGC AGTGGGATGCACCGCATCGTGGGACGCGAGTCGGTCGACTTGATCAAGTCGGGTGGATACCGGGTCGGCGCCGGTGAAATTGAAACGGTGCTGCTCGGGCATCCGG ACGTGGCGGAGGCGGCAGTCGTCGGGGTGCCCGACGATGATCTAGGCCAGCGGATCGTTGCCTACGTAGTCGGCTCAGCGAATGTCGATGCGGACGGGCTTATCAA CTTTGTTGCCCAACAACTTTCGGTGCACAAGCGCCCGCGCGAGGTGCGTATCGTANATGCGCTGCCGCGCAACGCCTTGGGGAAAGTGCTCCAGAACATTGCTGTC AGAAGCTGANCTACGCGAATTATCGTGTTACGCTGGA Clone Rv192 :::::::::::::::Rv192SP6.seq::::::::::::::: ATACTCAAGCTTGCCGAAGTTCCGATGGGTCGCGCCGGCGAGCCCAGCGAAGTCGCTACCGTGGCCGTGTTCTTGGCTTCGGATCTATCCTCGTTCATGACCGGCA CCGTGTTGGACGTGACTGGCGGCCGGTCCATATGACACCGAGATCATTGCCACGGTACGGCAATTCGTCAAGAAGGAAATCTTTCCCAATGCACCGGCCCTCGAAC GTGGCAACAGCTACCCGCAAGAAATCGTCGATCGGCTGGGTGTTATTGGCTTGCTCGGTCGCCGGCTGCAAGGGTATCGACACCACCGAGTTCATTCTCGGGCGTG CCGGCGCATTCGAGCTGGCGGTGCGCGCTGCCCAGCACCGTCATAGGTACTTGACGATGGTCCACGTCGGACGAGCGCCTCCACGTCGCTGCCGAACGGTATGCAT GGCGGCTACGATTCTC :::::::::::::::Rv192T7.seq::::::::::::::: CGGTGTCGGCACCGGCGTCCTGCAGTTGGTAGGCCTGCAGTTTGTGCATCAGGCCGATGCCGCGGCCCTCGTGGCCACGCATGTACAGCACCACGCCGGGCCCCTC ACGGGCGACCATCGCCAGCGCGGCGTCCAGCTGAGGCCCGCAATCGCAGCGGCGTGACCCAAACACATCGCCGGTCAAGCACTCCGAATGCACCCGGACCAGCACG TCGTCACCGTCGGCGTTGGGCCCGGCGATCTCGCCGCGGACCAGCGCGACATGTTCCACGTCCTCGTAGATGCTGGTGAGCCCGATGGCGCGAAACTCCCCATGAC GAGTCGGAATCCGCGCCTCGGCGACCCGCTCAATGTGCTTCTCGTGCTTGCGCCGCCATTCGATCAAGTCAGCAATGGTGATCAGCGCCAGACCGTGCTCATCGGC GAACACCGCAATTCATCGGTGTTGCGCCATCGAGCCCTCATCTTTTGGCTGACGATCTCGCAAATCGCCCCCGCGGGTTGCAGCCGGCAT Clone Rv193 :::::::::::::::Rv193SP6.seq::::::::::::::: ATACTCAAGCTTTGGGTGAAAGCCGATCACCGGAAGCCGCATGATCAGCCACGTTTCGCGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGC GGGTAATCGCCGACGGTGCCGGTTCGCGAGCCGAAGGTGACGACGCTGATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCAGCAACGGCGCGAGCTCAACGACGT CAATCACGTTGTCGCTTTCTACGGTCACCGACCCGGTGACCGTNCTCGCCCGGTGCGCTCGGCCGATAAGTTGCACCGCCACCACCGCGACACCGTCTTGCACGCG GACCCACCCCCGGATCCGTTGTTGGCC :::::::::::::::Rv193T7.seq::::::::::::::: AGCTTGCTGGCATCCGCTCCAGTAGCGCCCCGCGCGTGGCTTCCAGCGCCCGCAGATGCTCCATGAGCCGGCCGGTCGAGTCGGCGCCGGCGTTCACCGCCACCCG CCAGGAGCTGGCGGCCAGCATCTCCGCCTTCACGCATTGCGCGATCACAGAGAGAATATACGTCTCATATTCGTTGGAGGTCGTCGCAGGCAATCGGTCGATGACG GATTTGATGGCATCGAGCTGTGCTTCGGCGTAGCCCTCCAGCACGTCGGTATCGCTGTGGCGGTCCACGACGACCGCACCGGCGCGGCGGACAGCCGTCGGGTTGG ACGMTGTGCGGCGATCAGTCCGGCCAGCTCCGCCTCGGGATCAGCGGC Clone Rv194 :::::::::::::::Rv194SP6.seq::::::::::::::: ATACTCAAGCTTGCTGCAGCTTCCTATGACTGCTCCCGAAACCTGGGGGTGTGCCTGCTGTGTATGCACGGCATACGGACATCCTTCCCCTGAGACCCGCGGTCGA ACCAGCCACGTGTCCATCATCAGGGGTCAACCCGGGCCAAGGGCGACGGCACGCCAAGTTCGCCGACCGTTAACCTAGTGCTGTTAGCTTCATTTGCTGCGAGCAA AACAGCTGGTCGGCCGTTAGGAACTGAATTGAAACTCAACCGATTTGGTGCCGCCGTAGGTGTCCTGGCTGCGGGTGCGCTGGTGTTGTCCGCGTGTGGTAACNAC NACAATGTGACCGGGGGAGGTGCAACCACTGGCCAGGCGTCGGCGAAGGTCGATTGCGGGGGGAAGAAGAACTCAAAGCCAGTGGGTCGACGCGCAGGCCAACGC :::::::::::::::Rv194T7.seq::::::::::::::: AGCTTGACGCGGAGACGGACACATTGCGAACATTGATGACAAAATAGAAATCATTGATGGTTTGAGTCACCAGGCCGATCAAGCCTTCGCCGAGCCAAATTGCAAT CAAGAGGCCCAAGCCCGTACCAATCAGCCCGGCAACGAGGGATTCCGTCATTATCAGCCAAAATAACTGCTCTCGGGTTACACCCAAACAGCGCAATATGGCGAAA AACGGTCGCCGTTGCACGACATTAAATGTCACGGTATTGTAGATTAAAAAGATACCCACCAACAAGGCAATCAAACTGAGAGCGGTTAAATTGACCGTAAAAGCGT CCGTCATCTGTTTGACGGTGTCCCGTTGGGTATCCGACGTTTCCATACGCACACCGGCCGGCAGTCTTTGTTGGATGCGTGTTGCAGTGGCCTCATCTTTGATGAT CAAATCGATGTGGCTCAGTGTTCCGGGCA Clone Rv195 :::::::::::::::Rv195SP6.seq::::::::::::::: ATACTCAAGCTTCGGCTCAGGCGGCGCTGCTGGTAAAGTCGCTGACCGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGC GCAGGCTATCGCACCCGTTATCGGCTACGAGCAAATCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAG ATCGCCGTCAAGCATGTGTGCCGCGGATTATCAGGACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGGTCGTGGTCCGCT CGGATAGCGAGGTCAGCGAATTCNCNTTGGCAGTCCAAAGGGTCCTGCCGGTGCCGGTCTTTGCGCAAACNAAGGCNCAGGTTA :::::::::::::::Rv195T7.seq::::::::::::::: TGATCGCGCATCACCTGCTTCATAAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCGGGTGCAGGTGCTCGGGCA GCTCGGCCGCGACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACGAACGACGCCAGTCCGCTACGTAACCCCTCCGCGACTGTCCATGGACAACAGCG CGTTCTCCACCGACCGGGCCCGGGTGTGGGGTGTTTCGGCGACCGGCAGCCAGGTGGTCCACACTGCCGACGGGCGCCGCGAGCCGTTCACCGACCAGGCCGCCGA GCAAGTCCGCCCGATCGCATACTCCAACCGGTTGCGGTACTGCAGGTTCAGCTGGCGTACTCCTCGTCGCGCTCGGCGAGGTCTTGCTCCAGCACGTCGCANACGG CAG Clone Rv196 :::::::::::::::Rv196SP6.seq::::::::::::::: CAAAGCGCGAACTGCTCGCGGCAGCCCACGACGTGCTGCGTCGGATTGCCGGCGGCGAAATCAATTCCAGGCAGCTCCCGGACAATGCGGCTCTGCTGGCCCGCAA CGAAGGACTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGCTTGATGCCCGGTCGGCAAGCCCGGCAGT TGCCAAACCCAGCGTGATCAGGCTCGGCTCGCGAGTTCCGGGAAGAAGTGGCTCCGCCTGATCACCTACCATCCGCCAGGATCTGCGTGTCTTCACCACGCCCGCC AAGGAGGTTGTTGTGGTGCTATCGACCGN :::::::::::::::Rv196T7.seq::::::::::::::: CCGGAAGCCGCATGATCAGCCAAGTTTCGCGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGCGGGTAATCGCCGACGGTGCCGGTTCGCGA GCCGAAGGTGACGACGCTGATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCAGCAACGGCGCGAGCTCAACGACGTCAATCACGTTGTCGCTTTCTACGGTCACC GACCCGGTGACCGTNGTCGCCCGGTGCGCTCGGCCGAAAANTTGCACCGCCACCACCGCGAAACCGTCTTGCACNCCGGAAGCCACCCCCGATCCGTTGTTGGGCC AGGTTATTGGGT Clone Rv19 :::::::::::::::Rv19SP6.seq::::::::::::::: CCGGAACCGCCGACGGCACGGTATAACGCCTCCGCATATGGGTCGACAACCAGCGGGTCGGACTTCTGGGCTTCTAGCGTTCGCGCNGTCGCGACAAACAGCGCGG TCGAACCGACACTCGTTGTGATGTCCTAGCTATCACGTTCGGTACGCACCCAATCGAGTCTAGCGCGGGTAGNTCAGCCCCGATCTCCANGCTCCGCCGAGCCAGG CGC :::::::::::::::Rv19T7.seq::::::::::::::: CTGGTTTATGTCCCGTTGAAGTTCCATCACCCGATGTGGCGGGAGCACTGCCAGGTCGATCTCAACTACCACATCCGGCCGTGGCGGTTGCGCGGGCCGGGGGGTC GGCGCGAACTCGACGAGGCGGTCGGAGAAATCGCCAGCACCCCGCTGAACCGCGACCACCCGCTGTGGGAGATGTACTTCGTTGAGGGGCTTGCCAACCACCGGAT CGCGGTGGTTGCC Clone Rv1 :::::::::::::::Rv1SP6D2.seq::::::::::::::: CCGAGCAGTTGGGAATCGCTCTGCANCAAACCAATATTCTGCGCGACGTCGCGCGACGAGCTGGACCGATTAGGCGTACGCCTCCGNCTGGACGACACCGGGGCAC TCGATGACCCCGACGCCTACGCTCGCAGGATATTGTTCGCCGGACCCCTCTCTAG :::::::::::::::Rv1T7.seq::::::::::::::: TATATAATACTCAAGCTTGCCGACGCCAACGCTCGCGCGATGTTGTTAGCCCGACCCGGCTCTTACATGGCACCGGTGCCCCACACGTCAGCCTGTGACGTCCTGC ACCGCGACTCTTTACATAGAATGTGGATTGCCGGATTGGGGATGTCCGGCATCGCTCAATCTGTAGTCCGCGTTGTCCCGCGAGGGCCATGTGGATGGGGGGAAGG ATCCGTGGCGTCCGGGATCACCATGGGG Clone Rv201 :::::::::::::::Rv201SP6.seq::::::::::::::: ATACTCAAGCTTGCCGAAGTTCCGATGGGTCGCGCCGGCGAGCCCAACGAAATCGCTAGCGTGGCCGTGTTCTTGGCTTCGGATCTATCCTCGTACATGACCGGCA CCGTGTTGGACGTGACTGGCGGCCGGTTCATATGACACCGAGATCATTGCCACGGTACGGAAATTCGTCCAGAAGGAAATCTTTCCCAATGCACCGGCCCTCGAAC GTGGCAACAGCTACCCGCAAGAAATCGTCAATCGGCTGGGTGTTATTGGCTTGCTCGGTCGCCGGCTGCGAGGGTTTCTACACCACCGAGTTCATTCTCGGGCGTG CCGGCGCATTCGAACTGGCGGTGCGCGCTG :::::::::::::::Rv201T7.seq::::::::::::::: GCACCGGCGTCCTGCAGTTGGTAGGCCTGCAGTTTGTGCATCAGGCCGATGCCGCGGCCCTCGTGGCCACGCATGTACAGCACCACGCCGCGCCCCTCACGGGCGA CCATCGCCAGCGCGGCGTCCAGCTGAGGCCCGCAATCGCAGCGGCGTGACCCAAACACATCGCCGGTCAAGCACTCCGAATGCACCCGGACCAGCACGTCTTCACC GTCGGCGTTGGGCCCGGCGATCTCGCCGCGGACCAACGCGACATGTTCCACGTCCTCGTACATGCTGGTGTAGCCGATGGCGCGAAACTCCCCANGACAAGTCGGA ATCCGCGCCTCGGCGAACCGCTCAATGTGCCTCTCGTGCTTGCGCCGCCATTC Clone Rv204 :::::::::::::::Rv204SP6.seq::::::::::::::: TGGTCCGTGTGCGCATACCAATACAACGCGCCGGGCACCTGACGCGGCGGCCGCAACCAATCGGTGGCCATCGCCATCTTCTGCTACCCGGTCAACGGACGCACCT TCTCCTGGCCGACGTAGTGCGCCCACCCGCCGCCGTTGCGTCCCATCGATCCGGTCAAC Clone Rv205 :::::::::::::::Rv205SP6.seq::::::::::::::: GGCGTGTTGGCCACCGGGGCCACTCCGCACAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTG TGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCAATACGGTCGG TCCCACGATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAAAGCCACTGGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCA ACCAAACTTGAAGGTGATTGTTTACCTGGGCTACGGCGACCCGGCCTATGGTTATTCGACCTCCCCGCCCAA :::::::::::::::Rv205T7.seq::::::::::::::: CGTCCGTGNCCCCTCAANCGCGTGNNGCCGAAGCGGCTGGTTACGACTCCCTGTTTGTGATGGACACTTCTACCAACTGCCCATGTTGGGGACGCCCGACCAGCCG ATGCTGGAGGCCTACACGGCCCTTGGTGCGCTGGCCACGGCGACCGANCGGCTGCAACTGGGCGCGTTGGTGACCGGCAATACCTACCGCAGCCCGACCCTGCTGG CAAAGATCATCACCACGCTCGACGTGGTTAGCGCCGGTCGAGCGATCCTCGGCATTGGAGCCGGTTGGTTTGAGCTGGAAACACCGCCAGCTCGGCTTCGAGTTCG GCACTTTCAGTGACCGGTTCAACCGGCTCGAAGAGGCGCTACAGATCCTCCAGCCAATGGTCAAGGGTGAGCGCCCAACGTTTTTGGGCGATTGGTACACCACCGA ATC Clone Rv207 :::::::::::::::Rv207SP6.seq::::::::::::::: CCGCTTCCGTGTAACCGAGCANNGCGAGCGANCTGGCGAGGAAGCAAAGAAGAACTGTTCTGTCAGATAGCTCTTACGCTCAGCGCAAGAAGAAATATCCACCGTG GGAAAAACTCCAGGTAGAGGTACACACGCGGATAGCCAATTCAGAGTAATAAACTGTGATAATCAACCCTCATCAATGATGACGAACTATCCCCCGATATCAGGTC ACATGACGAAGGGAAAGAGAAGGAAATCAACTGTGACAAACTGCCCTCAAATTTGGCTTCCTTAAAAATTACAGTTCAAAAAGTATGAGAAAATCCATGCAGGCTG AAGGAAACAGCAAAACTGTGACAAATTACCCTCAGTAGGTCAGAACAAATGTGACGAACCNCCCTCAAATCTGTGACAGATAACCCTCAGACTATCCTGTCGTCAT GGAAGTGATATCGCGGAAGGAAAATACGATNTGAGTCGTCTGGCGGCCTTTCTTTTTCTCAATGTATGAGAGCG Clone Rv209 :::::::::::::::Rv209SP6.seq::::::::::::::: TGACACCCAACAGAGGGCACTTAAGATGGCAATGCGGCCGCCTACCTGCACGTTTTCGCGATGTCAGAGGATGCCGAGGGAGAACAATGCGAGCACGGCCGCTGAC NTTGCTCACCGCTTTGGCGGCGGTGACATTGGTGGTGGTTGCGGGCTGCNAGGCCCGANTCNAGGCCGAAGCATATAGCGCGGCCGACCGCATTTCGTCTCGACCG CAAGCGCGACCTCAGCCGCAGCCGGTGGAGCTACTGCTGCGCGCCATCACGCC :::::::::::::::Rv209T7.seq::::::::::::::: ACGGGCGACGCTGAGGTGGGCCCGCGGCTATTCATGCTGTCGTCCACGTCCAGCGACGCACTGCGCCAGACGGCCCGCCAACTAGCCACCTGGGTGGAAGAACACC AGGACTGCGTGGCGGCCTCGGATCTGGCCTACACGCTGGCGCGTGGCCGCGCGCACCGGCCGGTGCGCACCGCGGTGGTTGCCGCCAACCTGCCGGAGCTCGTCGA GGGTTTGCGCGAGGTGGCCGACGGTGACCCCTCTATGACGCGGCGGTGGGACACTGTGATCTAAGACCGGTCTGGGTCTTCTCCGGGCAAGGGTCTCAGTGGGCGG CGATGGGCACCCAATTGCTCGCCAGCGAACCAGTGTTCGCGGCCACCATCG Clone Rv20 :::::::::::::::Rv205SP6.seq::::::::::::::: ATACTCAAGCTTCGCGAGATCCGGATGGCACTCACGCTGGACAAGACCTTCACAAAATCTGAAATCCTGACCCGATACTTGAACCTGGTCTCGTTCGGCAATAACT CGTTCGGCGTGCAGGACGCGGCGCAAACGTACTTCGGCATCAACGCGTCCGACCTGAATTGGCAGCAAGCGGCGCTGCTGGCCGGCATGGTGCAATCGACCAGCAC GCTCAACCCGTACACCAACCCCGACGGCGCGCTGGCCCGGCGGAACGTGGTCCTCGACACCATGATCNAAAACTTCCCGGGGAGGCGGAGGCGTTGCGTGCCGCCC AGGGCGAACCGCTGGGGGTTCTGCCGCAGCCCAATGATTGCCGCGCGGCTGCATCGCGGGCGGCGACCGCCATTCTTCTGCGAATACGTCCAGGAGTACTGTCTCG GGGC :::::::::::::::Rv20T7.seq::::::::::::::: AGCTTATGTGGCCGCCCACCTACCTTATCTAGCCTAGCTAACTAAATCCAGTGCCGACAGTGCGCGGCTGGCCACCCAGCATGAGGTTATGACCACGGCATATGCC AGCGCGCTGGCGGCGATGCCGACGCTGACCGAGTTGGCCGCTAATCACACCAGCCATGCGGTGTTGCTGGGAACGAATTTCTTTGGAATCAATACGATCCCGATCG CGCTCAATGAGGCCGACTATGCGCGGATGTGGATTCAGGCGGCCACCACGATGAGTATCTATGAGGGCACCTCCGATGCGGCGCTGGCGTCNGCACCGCAAACCAC ACCGGCTCCGGTACTGTTCAACGGCGGTGCTGGCGTTTGCCAGCGCCTGCCGGCGATCTC Clone Rv214 :::::::::::::::Rv214SP6.seq::::::::::::::: ATACTCAAGCTTGCCACCCATGCCGAGCAAGGTCGACTCAGCGATGACGAATTGTTCTTCTTCGCGGTGTTGCTGCTGGTTGCGGGCTATGAGAGCACTGCTCATA TGATTAGCACNTTGTTTCTGACGCTGGCCGACTATCCAGATCAGCTGACACTCCTTGCGCAGCAACCAGACCTGATCCCGTCGGCGATCGAGGAGCACCTCCGCTT TATATCGCAATCCAAAACATCTGCCGCACAACGCGCGTCGACTATTCGGTCGGTCAAGCGGTCATCCCGGGA :::::::::::::::Rv214T7.seq::::::::::::::: CCGGGGTAGAACGATGCGATCTGGGCCATGTCGACATCGGTGGTACAGGTAAACCGCGCCGTGTGCGCGGTCTCGGAGATCAGAACGTGGTCGCAGTTGACACCGC GGGCTTTCAGCCAGTCGCGATAATCGGCGAAGTCGGCGCCTGCCGCCCCAACTAGCGCGACCTCGCCACCTAGCACACCGATGGCGAAGGCCATGTTTCCGGCCAC GCCGCCGCGGTGCATCATCAACTC Clone Rv215 :::::::::::::::Rv215SP6.seq::::::::::::::: ATACTCAAGCTTGGCGGCAACGCCACTACCGGGCTCACCAGGTCCTGTGCCGCCACCGCCGGCGCCGAAAGCACCATCAGGTCGTAGTTGTCTGGACGTTCGACAC CGTAAGCGAACACAATGCCGCCGCCCATGCTGTGCCCGAGCACGATGCGCTTGCACCCGGGATATTCCCGGGTGGCGATCCCAACGAGGGTGTCGAAGTCAGCGGT GTATCTGAGATGTCTCTCACTATCATCCGTTTGGCACCCGAGCGGGCATGCCCGCGGGGGGTCAAC :::::::::::::::Rv215T7.seq::::::::::::::: GTCGACGGCATCAAGGTCCGCAGTGATGGTGTTCATCTCACCCAGGAAGGCGTGAAGTGGCTGATACCGTGGCTTGAGGATTCGGTGCGGGTCGCCAGTTAATCCG CCGTGTGCTCCGGATGAGCGCGACGGTAACCCTGGAATTGTGCTGTGTGCTGGCTGTGTCGTTGTGATGAGCCTGTCTAAGTGGTGCGTAACCGTTTGACGAGCCG CGGCCTCGCTGCAAACATTGAAGCCCGCACGTCTGGGTTTGTATTTACACAACGAGGGCGCTCCCCGATCTGGCGCGCGCAACGAGGTGCNCACTATCCATTCGAG GTGAACTGGACTCCTTGATGCTCATGCCGGTGCGGTTTTGTC Clone Rv217 :::::::::::::::Rv217SP6.seq::::::::::::::: ATACTCAAGCTTGCGTTCGATGAAGTAGTCGTCGGTCAGCGCCGCCTCTTCGAGCTCCTTGGCGATGCCCAGCAAGGAGTCATCGCCGCCGAGCTTGGCCAGGATC TTGTCGGCCTGTTCCTTGACGATGCGGGCCCGCGGATCGTAGTTCTTGTAGACACGATGACCGAAACCCATCAATTTGACCCCGGCCTCGCGGTTCTTGACCTTGC GTTACAAACTCGCTGACGTCGTCGCCGCTGTCGCGAATGCCCTC :::::::::::::::Rv217T7.seq::::::::::::::: NGTCAAGCCGAGCATGCGCGAGGNAACGACGAACCCAACAAGCCATGGTGGTTGGCGCCGTCGAGAGGTCGGCGGTCGCCACAACGGGAAGATCGCCTTGAGCGTC GCTCGACCGCCGCCTCGAGTTGGGTCATAACGAAGTAGCTGATGCCGATCATGTCGACGTTTCCGTCGCATCAGCGTGCAGCGGCGACCCACTCGACGAGGTCTCG GTGCCGCCGCGGCCAGGGCACCAGCAGTGACGATTCCAGGCGCCGTCGGG Clone Rv218 :::::::::::::::Rv218SP6.seq::::::::::::::: CGATAATCGCTTCCGGTAAGTGCAGCAGCTTTACGACGGCGACTCCCATCGGCAATTTCTATGACACCAGATACTCTTCGACCGAACGCCGGTGTCTGTTGACCAG TCAGTAGAAAAGAAGGGATGAGATCTCCCCGTGCGTCCTCAGTAAGCAGCTCCTGGTCGCGTTCATTACCTGACCATACCCGAGAGGTCTTCTCAACACTATCACC CCGGAGCACTTCTAGAGTAAACTTCCCATCCCGACCACATATAGGCTAAGGTAATGGGCATTACCGCGAGCCATTACTCCTACGCGCGCAATTAACGAATCCACCA TCGGGGCCGCTGGTGTCN Clone Rv219 :::::::::::::::Rv219SP6.seq::::::::::::::: NAATAGTCAAGCTTTCTCGTGATTACCACCCGTGTAATTTGGGATGGGCAAAAAGGCGAATCACCGCGTGGCCACAAACGCCGGGAGGGACAATCTCGGGCGGCTA GGGCTTCTCGCGGGAAGGCCCGAACGTACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGGTATCACCCTGGCCGGG CAATGATCTGCAGCGTCGCCGCGGGTAGTGNCCGCCCGGGCGGCTAC :::::::::::::::Rv219T7.seq::::::::::::::: CCAACTAGAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGGCGCGAACGACGCCAGCGACCACATTCAGCAGATGGC CAGCGCGTGCCGGGCCACGATGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCGTGATCGACATCGTCACCGCCGCACCACTGCCCGGTCTCGGGTTCACGCAG CCGTTGCCGCCCGCAGCGGACGATCACATCGCCGCGATCGCCCTGTTCGGGAATCCCTCGGGGCCGCGCTGGCGGGCTGATGATCGCCCTGACCCCTCAATTCGGG TCCAAGA Clone Rv21 :::::::::::::::Rv21SP6.seq::::::::::::::: ATACTCAAGCTTGCTGCAGCTTCCTGTGACTGCTCCCGAAACCTGGGGGTGTGCCTGCTGTGTATGCACGGCATACGGACATCCTTCCCCTGAGACCCGCGGTCGA ACCAGCCACGTGTCCATCATCAGGGGTCAACCCCGGCCAAGGGCGACGGCACGCCAAGTTCGCCGACCGTTAACCTAGTGCTGTTAGCTTCATTTGCTGCGAGCAA AACAGCTGGTCGGCCGTTAGGAACTGAATTGAAACTCAACCGATTTGGTGCCGCCCGTAAGTGTCCTGGCTGCCGGTGCGCTGGTGTT :::::::::::::::Rv21T7.seq::::::::::::::: AGCTTGCGCGGCGTGGCGATCGCGGTTCAAGGCGCGCTCTTCGAGCACAACGAGCGAAGACAGCTCGGCGACGGAGCCTTTATCGACATCCGTTCGGGCTGGCTGA CCGGCGGCGAAGAACTGCTGGACGCGTTGTTGTCGACGGTGCCGTGGCGAGCCGAGCGCCGTCAGATGTACGACCGGGTGGTCGATGTGCCGCGGCTGGTGAGTTT TCACGACCTGACCATCGAAGATCCGCCGCATCCGCAGCTGGCGCGGATGCGCC Clone Rv220 :::::::::::::::Rv220SP6.seq::::::::::::::: AATACTCAAGCTTGCGCACGACCAGGACGTCGAGTGGCGCTTGCAGTGACTTGGCGACCTCAAAGGCCACCGGTACCCCGCCGCGCGGCAAGCCAAGGACNACNAC GGCCTTGCCGGATAGCTGCGCCAGGCGTTGCGCCAACTGGCGTCCAGCGTCGCCACTGATCGTCAAAGAGCTTCATCTGCCGAGTGTGCGCCATCTCATGGCTCCA AATATGGAATTAGGTCCCTGGGCCGACTGACGACAGTCCCTCAGCGACCGGATTGCGCATCCCGCCTTGTACGCTGCTCCGCAAATCCCGGGCTTGCGTCCGCGGA AGCGAACTCGGCGGCGCTACGGTGGTGGCTCAACTTCGGCCGTGC :::::::::::::::Rv220T7.seq::::::::::::::: GGTTGGTGCGGTCCACCTTCGCGGCGGCGGCGCGATATGCCTTGCTGGTCTTGCTCATTTGATATCCAATCTATGGGTCGTGGTTACTCAGCGGGCCGAAGCTGGC CCTCCCACGGGTAGGGCCCTATTCGACGGTGATGCCCATCGACCGAGCGGTACCGGCGATGATCTTGGCCGCAGCGTCGACGTCGTTGGCGTTGAGGTCCGTCTTC TTGGTCTCGGCGATTTCGCGGACTTGATCCCAGGTGACTTTGGCGACCTTGGTCTTGTGCGGCTCCGCCGAACCCTTCGCCACACCAGCGGCCTTAAGCAGCAGCT TGGCGGCGGGCGGCGTCTTCAGCGTGAAAGTGAAGCTACGGTCTTCATAAACGGTGATCTCCACCGGGATGACGTTGCCGCGCTGGTTCTCCGTCGCGGCGTTGTA CGCCTTGCAGAACTCCATGATGTTGACCCGTGCTGACCGAACGCGGGGCCCACTGGCGGGGC Clone Rv221 :::::::::::::::Rv221SP6.seq::::::::::::::: ATACTCAAGCTTTTCGACCCGCAAGCCGGCGGTGCCCCTCCTCGTTCCGCTGCCCGGTCTTCTCGATCGGTTCGGGGTCGCCGCGCTAGGCCCAATTGCCCGGCTC CTCCTCGGGCCGTTCCACAACCCGCATCGTCGCCGGGCTAGGTTCAAGCCATGCCGGTAAACCCCAGGACGCCAGTGCTGATCGGCTATGGACAGGTCAACCACCG AGGCGACATCGACGCCNAAAATCAGTCCATCGAACCCGTCGACCTGATGGCCNCCGCGGCCCGGAAAGCCGCCGAGTCCACCGTGCTCGAAGCGGTGGATTCCATC CGTGTGGTGCACATGCTGTCGGCGCATTACCGGAATTCCCGGGCGTCTCCTCGGC :::::::::::::::Rv221T7.seq::::::::::::::: NCCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCGGGTGCAGGTGCTCGGGCAGCTCGGCCGCGA CAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACGAACGACGCCAGTCCGCTACGTAACCCCTCCGCGACTGTCCATGGACAACAGCGCGTTCTCCACCG ACCGGGGCCGGGTGTTGGGGTGTTCGGCAACGGCAACCAAGTTGGTCCACACTGCCGACGGGGGCCGCAAATCCGTTCACCGAACCAGGCCGCCNAAACAATTCCG CCCGATCCCATAT Clone Rv222 :::::::::::::::Rv222SP6.seq::::::::::::::: ATACTCAAGCTTGTCGGGATCAATCTCGAGGGCATCCACGCACGAAAAGTAAACTCTATCAAGCTTTTTGACGACACCCACGGACGCCCCATATATGTTCGGGTGG GCAAGAACGGTCCCTACCTGGAACGTTTGGTGGCCGGCGACACCGGTGAGCCCACGCCGCAGCGGGCCAACCTCAGCGACTCGATTACCCCGGACGAACTGACTCT ACAGGTGGCCGAAGAGCTCTTTGCCACACCGCAACAGGGACGGACTTTGGGCTTGGACCCAGAAACCGGCCACGAAATCTTTGCCAGGGGAAGGCCGGTTTGGGCC TTATGTTACCTATATCCTGCCGGAACCTGCGGCTGATGCGGCCGCGGCCGCTCAGGGAN :::::::::::::::Rv221T7.seq::::::::::::::: AGCAGCTAGCCGCGCTCGCCGCGCTGGTCGGTGCGTGCATGCTCGCAGCCGGATGCACCAACGTGGTCGACGGGACCGCCGTGGCTGCCGACAAATCCGGACCACT GCATCAGGATCCGATACCGGTTTCAGCGCTTGAAGGGCTGCTTCTCGACTTGAGCCAGATCAATGCCGCGCTGGGTGCGACATCGATGAAGGTGTGGTTCAACGCC AAGGCAATGTGGGACTGGAGCAAGAGCGTGGCCGACAAGAATTGCCTGGGCTATCGACGGTCCAGCACAGGAAAAGGTCTATGCCGGCACCGGGTGGACCGCTATG CGCGGCCAACGGCTGGATGACAGCATCGATGACTCCAAGAAACGCGACCACTACGCCATTCAAGCGGTCGTCGGCTTCCCGACCGCACATGATGCCGAAGAATTCT ACAGCTCCTCCG Clone Rv223 :::::::::::::::Rv223IS1081N1400.seq::::::::::::::: CGCGACTGGCTCCCCGGNCGGCTGCTCGGGTCCGCCGATAGAGACCGGGATGTCGCCCGACGACGGGCAGCCGGGTTGCGTGGGACGGGGCGGGGGTCGGGCAGCC CAAGCAACGGGCTAGTCCCCGAATCCTACGGAGCCGTCACCTACGCCTACGTAATAGTAGCTATCAATAACAGTTGACATACGCAACGATCTGTGAGATCAATATT GCCTGACGCATGTCAAGACAGGCGTCAAGACAGGTGTCAATAATTCGCTCCGCTGGTGACGGTAACCGGTCGTGCGGGTGTGTGACGCCTAAGGAAGGAGTGTGGG TGGTGACGCTGAGAGTGGTTCCTGAGGGTTTGGCGGCCGCCAGTGCGGCGGTGGAGGCGTTGACCGCACGGCTGGCCGCCGCACACGCTGGCGCGGCGCCGGCGAT TACGGCGGTGGTGGCGCCCGCGGCGGATCCGGTGTCGTTGCAGAATGCGGTGGGGTTTAGCGCCTTAAGTAGCCAGCATGCCGCGATCGCCGGCGAAAGGGTCCAA GAACTGGGT :::::::::::::::Rv223SP6.seq::::::::::::::: ATACTCAAGCTTATTGAACCGCGGGTCGCAGGCAAAGTGGACCTCATAACGACTCGGGTCCAGCGACCGCGCCAACACGAACGGCCGGACGACGTGGGCCAGGGTC GCGGCCTCCCCTACAAACAGGATCCGTTGCCTGCGAACGACAGGCTCCGGTGCGGCGTTGGGCGCCGTGCTCGTCCCAGCGTCCGGTCCCGGGTCGCCGGCGACGC TTGTTTCCTCCATACTCGCCCCCTAATCTCGAGGCAGCCCGTACCCGCAGGCAACCTCCCAAAAATGCAATCCCGCAAAATGCAATGCGTCNAGCTATTTCTCACA CCGACCGCTAGTTGCGGATCAGAAATCCGTTGGGCGCGGAAGTCCAGCCGAATTTGTTCTCCCGCTCCGCATCATGCTTGTAATCGTTTGGAAATTCATCCTCATA TGCCTCGATCGCTTCATAGGGTCCAGGCCCAAACCCGGGCAGGACTGGGTGGCCGTTGATGTTGGAATCCTCCACTACTAGGTATTCACCGGC :::::::::::::::Rv223T7.seq::::::::::::::: GTCTCGATCATGGCCAAAGAGCTCGACGAAGCCGTAGAGGCGTTTCGGACCCGCCCGCTCGATGCCGGCCCGTATACCTTCCTCGCCGCCGACGCCCTGGTGCTCA AGGTGCGCGAGGCAGGCCGCGTCGTCGGGGTGCACACCTTGATCGCCACCGGCGTCAACGCCGAGGGCTACCGAGAGATCCTGGGCATCCAGGTCACCTCCGCCGA GGACGGGGCCGGCTGGCTGGCGTTCTTCCGCGACCTGGTCGCCCGCGGCCTGTCCGGGGTCGCGCTGGTCACCGGCGACGCCCACGCCGGCCTGGTGGCCGCGATC GGCGCCACCCTGCCCGCAGCGGCCTGGCAGCGCTGCAGAACCCACTACGCAGCCAATCTGATGGCAGCCACCCCGAAGCCCTCCTGGCCGTGGGTGCGCACCCTGC TGCACTCCATCTACGACCAGCCCGACGCCGAATCAGTTGTTGCCAATATGATCGGGTTCTCGAC Clone Rv224 :::::::::::::::Rv224SP6.seq::::::::::::::: ATACTCAAGCTTTCGTCAGTTCATGGCGCCAGCAGACCAACAAGAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGG CGCGAACGACGCCAGCGACCACATTCAGCAAATGGCCAGCGCGTGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCGTGATCAAGATCTTC ACCGCCGCACCACTGCCCGGCCTCGGGTTCACGCATCCGTTTGGCCGCCGCC :::::::::::::::Rv224T7.seq::::::::::::::: GCCCCGTGTAATTTGGGATGGGCAAAAAGCGAAGCACCGCGTGGCCACGAACGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGAACGT ACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGGTAGCACCCTGGCCGGGCGATGATCTGCAGCGTCGCCGCGGGTA GTCTCCGCCCGGGCCGC Clone Rv225 :::::::::::::::Rv225SP6.seq::::::::::::::: ATACTCAAGCTTCCTTTGACCGAACGCGTCCACCGCACCGTGAGATTGGTGGCGCCATTCGTCGTGGTGTAGCTGCTGTTGGCGGCGTCGCCGTATTGTGCGGGCC AGCCTTGTGCGGGGGCCGCTTCTACCCACAAGTCGGCACTTCCGCAACCGCCCAGCTCGACCGCGAATTACGGCGGCCGCAACGGCCGCCGGAAGGCGTCACGCAA TCGCTTATCCTTTCCAGGTTCCCAAATCCTCCGCTTACTTGGGTCCTTCATCGG :::::::::::::::Rv225T7.seq::::::::::::::: GGCAGCGGCGACAACCGGAACGTCCGCACGGTGCTCAATCACGGGTGCACGGTGTGCATCAGAATGGCGGGGGTTCGTTGTCGCGGTGAGGCGTTCGGCGAGGAGG TAGTGTCTACCCCTTGCCCGCGGGTTCGTGCGGACTGAAAGGGATTTCATTGGGAACCCACGGCTGCGTATCGCAGGGCCTCGGTGACGTCTGCTTCCTCNAGCTC AGGAAGTTCGGCGAGAATCTCGGTGGATGTTATTTGGTCCGCCTAC Clone Rv226 :::::::::::::::Rv226SP6.seq::::::::::::::: ATACTCAAGCTTTCTCGGCTTCTCTGATAGCCTGAGAAGAAACCCCAAGTTAATCCGCTGCTTCACCTATTCTCCAGCGCCGGGTTATTTTCCTCGCTTCCGGGCT GTCATCATTAAACTGTGCAATGGCGATAGCCTTCGTCATTTCATGACCAGCGTTTATGCACTGGTTAAGTGTTTCCATGAGTTTCATTCTGAACATCCTTTATTCA TTGTTTTGCGTT Clone Rv227 :::::::::::::::Rv227SP6.seq::::::::::::::: ATACTCAAGCTTGGTGACCGGCACCGCGATACGTTGCGGCAGGCATCTGGGCTGGCGGTGGTTCGCCGCTCCGAAGCCGTCGAACACCATCGCCAGCGCGGCTTCC ACATCAACGACCATTTCGGCCAGCTTGCGGCGCATCAGCGGCTTGTCGATGAGCGCCCCACCGAATGCCCGCCGCTGCCCGGCGTATCACATCGATTCGACCATCG CGCGGCGCGCGTTGCCGAGGGCGAACGAGGCGGTGCCCAACCGCAATCTGTTTGGTCAGCTCCCTCATGCGGGTTGATTCCTTGCCGTCCGGACGGGCCCGCGTCA TGCGCTCGGTTCGCC :::::::::::::::Rv227T6.seq::::::::::::::: CCGTTGCGCAGCGTGAGCCGATAGTTGACATCCGGCTCGGTGAAGGTGAAATCGATGGCCAGGTCGAGGTCCCATGCGCGTGGGCCATTGATGCTGATCGCCAGGA CGTCAAAGATTTGGTCCGGCGTCAGCTGGGCGAAAAACGTGGGCGCCGGGACTTGCCCGGAGCTGCCCGGGTTCCCGTCGCGCAGCTCGGCGGCCCCGGTCAGAAA GAAATTGCGCCAGGTCGCACACTCCGCGCCGTAGGCCAGCTGCTCCAGGGTGTCGGCATAGAGCCCGCGGGCCGCAGCGTGCTCGCTGTCGGCGAACACCGCATGG TCGAGAAGCGTTGCCGCCCAACGGGAAATCACCTGCGTCGAAAGCTTCGCGGGCCAGCTCCAGCACTCGGTCGATGCCACCCAACGCGT Clone Rv228 :::::::::::::::Rv228SP6.seq::::::::::::::: ATACTCAAGCTTGCGGATGTTACCCCTGACAGCGTGAACTATGTCNAAACACACGGCACCGGAACGGTGTTGGGGGACCCCATCGAGTTCGAGTCGCTGGCGGCCA CTTATGGCCTGGGTAAAGGCCAGGGCGAGAGCCCGTGCGCATTGGGGTCGGTCAAAACCAACATCGGCCACCTGGAGGCGGCCGCCGGTGTGGCTGGATTCATCAA GGCGGTGCTGGCGGTGCAACGTGGGCACATTCCCCGCAACTTGCACTTCACCCGGTGGAACCCGGCCATCAACACGTCGGCGACGCGGCTGTTCGTGCCGACCGAA AGCGCCCCGTGGCCGGCGGCTGCCGGTCCACGCAGGGCTGCGGTGTCATCGTTCGGCCTCAGCGGGACCAA :::::::::::::::Rv228T7.seq::::::::::::::: CCGGTAACCAGATCAGCTCGTCGACCTCACTGCCGGGGGTGAATTCCCCACCGGTGCTGCGCGCTGCCCAGTAGTGCACCTTCTTGACGCCTCGAAAAGGGGAGTC GGTCGGGTAGGTCACCGTCAGGAGCCGCCTACCCAGGTTGGCGCGGTGACCGGTCTCCTCGAGTATCTCCCGCACCGCCCCCACCGGTGCGGTCTCGGCCGGATCC ACTTTGCCCTTGGGCAGCGACCAGTCGTCGTAACGGGGGCGGTGAATGACAGCGATCTCGACCGGCCCTTCCGAATCGGCACTGCCGGGTCGCCAGAACACCGCAC CGGCGGCGTACACAATCCGGCCCGCCGAGCGCCGGCGGGCGGACGANTTCTGGATCGACACCTCAACTCCTGCAGGTCAATTCGGCCAAGCTGCTCGCGGTCGTGG ATGTGGTC Clone Rv229 :::::::::::::::Rv229SP6.seq::::::::::::::: ATACTCAAGCTTGATGCCGCCGAAACCGAGCGTGAGCACGCCGCCACCCACCACGCGCGGGTCGGGCGCCGGGCCCGGGCCGCCAGGCTGCTCCGCTCGGTGATGG CACGCCACCGCGACACCACCCGGCTGCGCTACGTCGAGCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCGAGGTCGAGGTCTA TACCGATTTGCGCATCCGCAGCCGCACCCTGGTCGTCTCGTACCGTGCCCTACCTCTGCTTGTCGGGCGGGGCCA :::::::::::::::Rv229T7.seq::::::::::::::: TCCGTACGGCCCGGGTACGCTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTCAGTTGCTCACCGG AATCCAACCGGTAGAAGGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCAGCACTCCGCAGGCTTCGTC GGGGTGGTCGCGACGCGCATGGGCCACCATCCATCCACCAGGTCTGCGCGAATCACCCGC Clone Rv22 :::::::::::::::Rv22SP6.seq::::::::::::::: GGACACATTGCGAACATTGATGACAAAATAGAAATCATTGATGGTTTGAGTCACCAGGCCGATCAAGCCTTCGCCGAGCCAAATTCCAATCAAGAGGCCCAAGCCC GTACCAATCAGCCCGGCAACGAGGGATTCCGTCATTATCAGCCAAAATAACTGCTCTCGGGTTACACCCAAACAGCGCAATATGGCGAAAAACGGTCGCCGTTGCA CGACATTAAATGTCACGGTATTGTAAATTAAAAAGATACCCACCAACAAGGCAATCAAACTGAGAGCGGTTAAATTGACCGTAAAAGCGTCCGTCATCTGTTTGAC GGTGTCCCGTTGGGTNTCCGACGTTTCCATACGCACACCGGCCGGCAGTCTTTGTTGGATGCGTGTTGCAGTGGCCTCATCTTTGATGATCA :::::::::::::::Rv22T7.seq::::::::::::::: GCCTGGCCCAGGTGAAGGCCGACCTCGACGCCAAAGCCGCTGATCCGGCACATGAGTCGGTGGACTGGGACTTGAAGTCGCTGCGATGGGCGTGGAACCGAGCCAA AGATGACGTGGCGCCGTGGTGGGCCGAGAATTCCAAGGAGTGCTACTCGTCGGGGTTGGCCGATCTGGCCCAGGGCCTGGCTAATTGGAAAGCTGGCAAGAACGGG ACCCGCAAAGGCCGGCGGGTGGGCTTCCCGCGATTCAAATCCGGGCGGCGTGATCCTGGCAGGGTGCGGTTCACCACCGGCACCATGCGCATAGAGGATGACCGGC GCACGATCACGGTCCCGGTGATCGGGCCGCTGCGGGCCAAGGAGAACACCCGCCGGGTGCAACGCCACCTCGTGAGCGGGCGCGCGCAGATCCTGAACATGACCTT GTCGCAGCGGTGGGG Clone Rv230 :::::::::::::::Rv230SP6.seq::::::::::::::: TAACTCAAGCTTCAAGTCCGCNGTCCGACCCTGTTCGACGGCTACCTGAATCAACCCGATGCCCCGCCGCGGCGTTCGACCCGACAGCTGGTACCGCACCGGCGAC GTCGCGGTGGTCGACGGCAGTGGGATGCACCGCATCGTGGGACGCGAGTCGGTCGACTTGATCAAGTCGGGTGGATACCGGGTCGGCGCCGGTGAAATTGAAACGG TGCTGCTCGGGCATCCGGACGTGGCGGANGCGGCAGTCGTCGGGGTGCTCGACTATTATCTAGGCCAGCGGATCGTTGCCTACGTAGTCGGCTCAGCGAATGTCGA TGCGGACGGGCTTATCAACTTTGTTGCCCAACAACTTT :::::::::::::::Rv230T7.seq::::::::::::::: CCATGTCGCCCCAACATATCGTCGATGTTCGCGTCGTCCGCCTCGCGCACGTGGTCTGTCACCAGTCAACGTTAACGCCGCCGCACATGTCCTGCGGCCGGGCAAA ACGTGAAAAACGAGCGGGCGACTGCAATGTCATGACACCGACGCCGCCGATGGGCCCAGGGTCTGGCAGATTCGATCTGTGCGGCCAGTGCCAGCAGCGTCGCCTC GTCATACGGCCGGCCGACGAGTTGAACCGACATGGGCATGCCGTCGCCGTCGAAGTCCCACCGCACCACGGCCGCGGGCTGGCCGGTCAGATTCCANACTTGAAAG TACTGAAGCCGCTGCACCACCAG Clone Rv231 :::::::::::::::Rv231SP6.seq::::::::::::::: CGAAAGCGTGAAACAGCTCGCGGCAGCCCCCGACGTGCTGCGTCGGATAGCCGGCGGGCGAAGATCAATTCCAGGCAGCTCCCGGACAATGCGGCTCTGCTGGCCC GCAACGAAGGACTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGCTTGATGCCCGGTCGGCAAGCCCGG CAGTTGCCAAACCCAGCGTGATCNTGCTCNGCTCTNTANTTCGGCGAAGAAGTGGCTCGCCTGATCACCTACCATCGGCCAGGATCTGCGTGTCATCACAACGCTC GCCAAGGAGGTTGTTGTG :::::::::::::::Rv231T7.seq::::::::::::::: TCCGCCACGCTTCGCGCCGCCCGGCATACGGCGCGTACCGATCTCCCGCGTCATACACCGCGGGTAATCGCCGACGGTGCGGTTCGGGAGCCGAAGGTGACGACGC TGATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCAGCAACGGCGCGAGCTCAACGACGTCAATCACGTTGTCGCTTTCTACGGTCACCGACCCGGTGACCGTAGT CGCCCGGTGCGCTCGGCCGAGAAGCTGCACCGCCACCACCGCGACACCGTCTTGCACGCGGACCCACCCCGGATCGGTTGTTGGCCAAGGTAATTGGGTCATTCCA TTTGACGGGACGCCGACCC Clone Rv232 :::::::::::::::Rv232SP6.seq::::::::::::::: CATTCTTTAACAGTTGTTTTGGGCTCGGCATGGTTAGCCAACGTTCTGCGGTCCACCATATCATCTTGGTCCGGTAGCGCTCGTCCGGGGTATGCTGCCGCCGGGA TTCTCGCTGCTATTACTCCCCCCGAAGAACCGCCACCGGTCCAGCGCGTGGGCCGNCGCGGTCCCATCACAAACTGAACCCCCAACAGGGACATGCTTATCGGTAG GGCGCGCGCCAAGGCGGCAGCAATCGCATCACTGCGCTCTGCGCGTCACTATTAACCCACCCGGACTTCACTTCCACCACCCCGAATGGCGCCCGGTCATTGATCA TCTGGCGCACCGCGGATAA :::::::::::::::Rv232T7.seq::::::::::::::: CGGTGTCCTGCAGTTGGTAGGCCTGCAGTTTGTGCATCATGCCGATGCCGCGGCCTCGTGGCCACGCATGTACAGCACCACGCCGCGCCCCTCACGGGCGAACATC GCCAGCGCGGCGTCCAGCTGAAGCCCGCAATCGCAGCGGCGTGACCAAACACATCGCCGGTCAAGCACTCCGAATGCACCGGACCAGCACGTCGTCACCGTCGGCG TTGGGCCCGGCGATCTCGCCGCGGACCATGCGCGACATGTTCCACGTCCTCGTANATGCTGGTGTAGCCGATGGCGCGAAACTCCCCATGACGAGTCGGAATCCGC GCCTCGGCGACCCGCTCAATGTGCT Clone Rv233 :::::::::::::::Rv233SP6.seq::::::::::::::: CGGCATCTGGCGGCTGAACCTGTTCTTGGGCAACATGCCGAGGATCGCCTCTTCCACCACGCGGTCGGGGTGGCGTTGCATTACCTCACCGATGGTGCGCTTGTGC AGGCCGCCGGGATACCCCGAGTGCCGGTAAACCATCTTGTGCTGCAGTTTGTCGCCGCTGATGGCGACCTTGTCGGCGTTGATCACGATNACNAATCACCGCCANC GACATTGGGGGCGAACGTCGGCTCGTGCTTGCCGCGCAGCAGGCTGGCCGCCGCGACGCAAGGCGCCAACCACCACGTCCGTGGCGTCGATGACGTACCACCATCG CGTGGTGTCACCCGCCTTGGGC :::::::::::::::Rv233T7.seq::::::::::::::: GCGGCAAAAATTGAAGCACTCNTGGCCACTNCCGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGAACGTACTGCGTTTCAACACGTCG CGTCGCCCTCCGACCGCGAACATTCTGGGATGGCAGCAACCTGTTAGCACCCTGGCCGGGCGATGATCTGCAGCGTCGCCGCGGGTAGTCGCCCCCGGGCGGCTAC AGTCTGAAACGCGATGACCATCGATGTGTGGACGCCGCATCCGACNCAACGGTTCCTACACTGTGATATGTTCGCCTCGCTGCGCCGGTGGACGGTGGGTCTATCC CGGA Clone Rv234 :::::::::::::::Rv234SP6.seq::::::::::::::: CGCGTTGAACTGAAGGGGTGCCGCCCGGCTCGAGCAGGCAAGCCATTTGTTCGATGCGGTTACCGAAGATCTCTTCGGTGACTGCCCGCCGCCGGCCAGCTCGGCT CAGTGTCCGGCGTTGGTCGCCGCGGCGACAATCTTGGCGTCCACGGTGGTCGGGGTCATGCCCGCGAGCAGGATTGGCGAGCGGNCGGTCAGCCGGGTGAACTTCG TCAAGAGCTGACGCTGCGGTTGGGGAGGCGAATCATGGTCGGTGCGTAGCCTCGACTAGGCCCGGG :::::::::::::::Rv234T7.seq::::::::::::::: TGACAACGCGGCGGCGATTACCCCGCTACCGCAGCAGCATGACGCGGTAGCGAACACCGCCGGATGCAGCGCAGGTGCGTCGATGTGCTCACGGAATCGCCCCGGC ACCGCGATCTCGAGGATCACCAGTGCCACCCCCTGCAGCGCGACACCGACGATTCCGTACACCGCCACGCCGATCAGGCCCTGGGCCAGCTGATTGGAGCTGGCGT ATATGGCGGCGATGGTGACGATGGTCATCGCCTCTTACATTGTGGCGGCCAGAACCACGGCGTTGGGGCGGCGGTCGATGAACACTAGGCGACCANATCCCCGGGG TCAACAGGTTGACCATCC Clone Rv235 :::::::::::::::Rv235SP6.seq::::::::::::::: CGCGGACATCCCGAACGAGGACACGCGACCGCTTCGGTGTGTGATCTATCAGGGCTCGCACCACGCGCAACCGCTTCCGGCTACCTAGACGCGGT :::::::::::::::Rv235T7.seq::::::::::::::: GCATGCGGGTGATGCCGTTCTCAGTGCGCAACAGCGTTCGACGCGGCATACCCAGCCGCACATGCCGTGCACGCCCGAGCCGGGGCGGGAATCT Clone Rv237 :::::::::::::::Rv237SP6.seq::::::::::::::: CTCAAGCTTCAGNCCNTCTAAGCGGTCTGCGCGGCGATCGCAAAGATCGCCCTTTGCCGGCGTTGGGGGCTTCTGCTCGGGGGTGTTGTACACCTTCTCGAACACC TCGGCACCGACACCACCACCGTCGGCTTGAACACCGCCAACATCGGCAGCANATCTTGATGTCCTGGTGAATCCACGGTGACTTTGGAGTGGAAGGCGGCCATACT GATCGCGCGCGCCACCACATGAGCTAGCGGCAGGAAAACCAGCAGCCGCTCACCCTTGCGCAGCAGCGTCGGGTGATATGCCTGGCGCCC :::::::::::::::Rv237T7.seq::::::::::::::: AGTCGAANGTCAGTCCGGTCTCCTCTCCGACTACGGCCAAGAACTGGGGCGACGGTGTCAGTGCAGAACAGCGGAAACTGGTGGCGCCCTAGGCGAGCGAACGCTC ACAAACGGCGGTGACCGCTTCTGGTCGTGCACCATCGAGCCGTGCCCAGCCCGGCCGCGTGCCGTCAGCCGCATCCACTGGATGCCCTTCTCGGCGGTTTCAATCA NGTACAGGCGACGTTCGCCACCATCGTGCCGGGGCACGTTAGCGAGAAACGCCGACTTCACCGATTGCCTCGGTGATGxxxxx Clone Rv23 :::::::::::::::Rv23T7.seq::::::::::::::: AGCTTCGCGGCGTGGCGATCGCGGTTCAAGGCGCGCTCTTCGAGCACAACGAGCGAAGACAGCTCGGCGACGGAGCCTTTATCGACATCCGTTCGGGCTGGCTGAC CGGCGGCGAAGAACTGCTGGACGCGTTGTTGTCGACGGTGCCGTGGCGAGCCGAGCGCCGTCAGATGTNCGACCGGGTGGTCGATGTGCCGCGGCTGGTGAGTTTT CACGAGGTGACCATCGAAGATCCGCCGCATCCGCAGCTGGCGCGGATGCGCCGGCGGCTCAACGACATCTACGGCGGCGAACTGGGTGAGCCCTTCACCACCGCCG GGCTGTGCTACTACCGCGACGGCTCTGACAGGGTCGCCTGGCATGGCGACACCATTGGTCGCGGCAGCACTGAGGACACTATGGTGGCGATCGTCAGCCTCGGCGC CACCCGCGTCTTCGCGCTGCGGCCGCGTGG Clone Rv240 :::::::::::::::Rv240SP6.seq::::::::::::::: AGCTTCAGCTGATACTCGACCAGCCCCACTCGGGCCAATACGTGAATGTCTAGCATCTTCACCCGTTCACGGGCTANTCGAGTAGTAGACATTGATTAGCCTGAAC GTACCTCCGACGCCAGCTGACGAACGGGTATGCGGATGGATTTCGTGGTGTCGCGCCCGAAGGTCAATTCGTTACGGATGTATCTCGGGGCCGGATCGGGGCCGAT GTTGGCGGCCGCGGCGGCCTGGGACGGACTATCCGACGAACTGGCGGTGGCGGCGTCGTGGTTTGGGTCGGTGACCTCGGGGCCTGGCGGATGCGGCGTGCGCGGC CCGCGGCGGTTGCGATGGCNCGCGCGGT :::::::::::::::Rv240T7.seq::::::::::::::: CTGGTCATGGACGTTGCTCCGGTAGTGGCTCACTGCCGATCCTCCTCGTTGAGAGTGCCACCTCAGGGTTGGGTAGGGTTGGGTACTCGAAACCAAGTTACCCACC AGTAACACCGTCAAAATATATCCGTTGCATAGGTCAATGCAAGTTGATGTGAGCTACATTGCACCAACTAACTAACCAACCGGTTGGGTTAGCGGTGATCCTGGCC GTGTCGGTCCTCTCACCTGCGGTGATAGCGATCAAATGAAGAATATGCGGAGTCTAGGGCGGCAGCGCCTGGCANCGTAGATCATCGGCTCACGCGGATGCGGCCT CTTGGTACGGACATGCGCGCG Clone Rv241 :::::::::::::::Rv241SP6.seq::::::::::::::: CTCGTGAGTAGCACCCCTGTAATTTGGGATCGGCAAAAAGGCGAATCACCGCGTGGCCACGACACGCCGGGAGGGACNATCTCGGGCGGCTAGGGCTTCTCGCGGG AAGGCCCGAACGTACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGG :::::::::::::::Rv241T7.seq::::::::::::::: GGATCAACTACCGGCCAACGGTGATTCTTGGGCGCCGCTGACGCGCAACGACCCAGCGACACATTCAGCAGATTGGCCAGCGCGTGCCGGGCCACGATGTTGGTGC TCGGCGGCTACTCCCATGGTGCGGCNCGTGATCGACATCGTCACCGCCGCACCACTGCCGGCCTCGGGTTCACGCAGCCGTTGCCGCCCGCAGCGGACGATCACAT C Clone Rv243 :::::::::::::::Rv243SP6.seq::::::::::::::: AGGACCGTCAGCACGGCGACGTGCTACTCGCCGAGCAGTGGGAATCGCTCTGCAGCAAACCATTACTCTGCGCGACGTTCGAGATGACCTTCTGAATGGACGGATC TACCTGCCGCGCGACGACCTGGACCGCGTATGCGTCCGCCTCCGCCTGGACGACACCGGGGCACTCTATGACCCCGACGGACGGCTCGCGGTACTGCTGCGGTTCA CCGCCGAGCCCCGCACGGTACGCGTCGGGACTGCGCTGAGTCCANCCTCGACGCCGTAGCGCTGCTGCTGTGCGGCCATGTCTGGCATCTACCGCCGTCGCTCCCT TGA :::::::::::::::Rv243T7.seq::::::::::::::: CGACTCTGTTGGCCACTGCGGGTCGATCTTGCGGCCGCCCCGGTCGTGGAACGCCCAGGTCACCCGGCGGCGCACCGCGGTCAGCGCGTCGTTGGCCAGCGTGGTC ACATGGAAGTGGTCGACGACGAGCTTGGCGTTGGGCAGCAGCCCGGGCGTGCGGATCGCCGAGGCGTATGCAGCGGCGGGGTCGATGGCCACCGTACTGGATGCTC TCCCGGAACTGCGGTGTGCGCGCTTGCAGCCATGCCAGCACCGCCGCGCCGCCGCGGCCTTCATGCTGCCCATAAACCCTGATACCGGCCAGGTCGACNAACCNGT ATCCCACGGTCAACCC Clone Rv244 :::::::::::::::Rv244SP6.seq::::::::::::::: CACACGGACGGCGGTGCGGACGCAGCTGACGCGCATGGTGGTCAGCATCGCGGCCGGTCTGCTGTTGTATGCCTACTTCGCGCCGCGCAAATGCTGGTGGGCGGCG GTGGTGGCGCTCGCATGGCTGGGCTGGGTGCTGACCCAACTCTCGAACCACACCCGGTGGGTGGGCTGGGCTATGGCCTGCCATATCGGCCTGGTGTTCTACN :::::::::::::::Rv244T7.seq::::::::::::::: CCGATATCCGAGCCGATAGCTGGCGGGCTCGGGTGGTNGCCAGCGGCGCTGCGACGAAAGTGTGACCGTCATGAAACAGACACCACCGGCGGCCGTCGGCCGTCGT CACCTGCTCGAGATCTCAGCATCCGCAGCCGGTGTGATCGCGCTTTCGGCGTGTAGTGGGTCGCCGCCCGAGCCCGGCAAACGCCGGCCCGACACAACCCCGGAAC AGGAAGTCCGGTCACCGCGCC Clone Rv245 :::::::::::::::Rv245SP6.seq::::::::::::::: GCTTCAGGACAAATTGNATCCCTATGCACCCGTTGTCACGCCGATGAGTGAAGACTGCACCGCAATCGCCGGAATCCGGCAAACCCTGCACAAGCGAAATCAACCG GAGGCTGACAAGGCAACGTCGGTGATCCGTACCGCCTGGTTGGACAAACGGCAGAAGGCGCCTCGTCCGGTCCATCTACGCCGAGCACACTGGTGATAGCGCCATC GGCATCGGTGCGGCCACGGTGGAGACGAACGTCCGCNGGCGTCTGGGTCAGTAACCCGCCGACCAGTTCTCGGGCAAGCTGGTCAACATCGGGCGCCACGTCTCCA AC :::::::::::::::Rv245T7.seq::::::::::::::: GTTTGGCGGCCTTATTGCACTGAGGTCGTCAATTGACCCACAGCGGAAATGCCGACTATTCGCAGGCCTCCTTGGCCTTGGCTGCCGGAGATGGGCTCCGCGGGAA CCGCATGCAGGTATATGACCTCGGTTTCTCGGGTGCTACCGCGTGCCTTGTCGAGGATGAACTCGGCGTTGGAATTGTCCAGCCGGCCCAATTCATCGAGCGCAGA TTCGTACACATGGCCGGCGGCGACATACCTTCACCGTGGATCTGCTCCACACGGACCGCCCTGTCGGGATCTGCTCACGGGTAAAGGAATTA Clone Rv246 :::::::::::::::Rv246SP6.seq::::::::::::::: GCGCACTCCTCCTTATCGCTCCGCTCTGCATCGTCGCGGCGCGGTCAGGTGCAAACGCCTTCGGGGGTGGGGGTCCTGCGGAGCACACCGGATACGGAGCGCAACG CGTCGCGTTGTGCGGGCAAACAAGTGTGCAGGNNCCAATGCCATGTCCAGCAGCTTATCAGTGTCGAACGTGCGAACGTCGCGCCTTCGCCGGTGCCTGAATCTCT ACAAG :::::::::::::::Rv246T7.seq::::::::::::::: CGCTGAAAGCCACCATTCGCCGGGTCGGCGCCGGGCTCGGGCCGCCAGGCTGCTCCGCTCGGTGATGGCACGCCACCGCGACACCACCCGGCTGCGCTACGTCGAG CCATACCGGGCGGAGCTACATCGGCTCGGCCGCCTAGTGTTCGGGNCCTCTTTCGAGGTCGAGGTCGA Clone Rv247 :::::::::::::::Rv247SP6.seq::::::::::::::: TGTAATTTGGGATGGGCAAAAAGCAAANCACCGCGTGGCCACAAACGCGGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGCCCGAAACGTACGGCG TTTCAACACGTCGCGTCGCCTCCGACGCCGAAATTCGGG :::::::::::::::Rv247T7.seq::::::::::::::: CTTGGGCAACATGCTGAGGATCGCCTTTTCACCACGCGGTCGGGGTGGCGTTGCATTAGCTCACCGATGGTGCGCTTGTTGCAGGCCGCCGGGATACCCGAGTGCC GGTAAACCATCTTGTGCTGCAGTTTGTCCCGCTGATGGCGACCTTGTCGCGTTGATCACGATGACGAAGTCACCGCCATCGACATTGGGGGCGAACTCGGCTTGTG CTTG Clone Rv249 :::::::::::::::Rv249SP6.seq::::::::::::::: GCATGCTTCATTATCTAATCTCCAGCCGTGGTTTAATCAGACGATCGAAAATTCATGCAGACGGTCCCAAATAGAAAGACATTCTCCAGGCACCAGTTGAAGAGGT TGATCAATGGTCTGTTCAAAAACAAGTTCTCATCCGGATTGAACTTTACCAACTTCATCCGTTTCATGTACAACATTTTTAGAANCATGCTTC Clone Rv24 :::::::::::::::Rv24SP6.seq::::::::::::::: ATACTCAAGCCTGATGCCGCCGAAACCGAGCGTGAGCACGCCGCCAGCCACCACGCGCGGGTCGGGCGCCGGGCCCGGGCCGCCAGGCTGCTCCGCTCGGTGATGG CACGCCACCGCGACACCACCCGGCTGCGCTACGTCTATCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCATTGTTCNGGCCCTCTTTCGAGGTCGAGGTCTA TACCGATTTGCGCATCCG :::::::::::::::Rv24T7.seq::::::::::::::: TCCGTACTGGTCGGGTACGCTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTCAGTTGCTCACCGG AATCCAACCGGTAGAAGGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAACCTCGGGTCCG Clone Rv251 :::::::::::::::Rv251SP6.seq::::::::::::::: GTTCTCGCACGATTTCGGATTAGCGGGATGGTCTCAATTGGGTATGCGGGGAAGGCGCTGACATTCGCCGCGATTAGCTGTTTGATGGACCGGGGGTGATTTTTGA TCACGGAAATGGGTGTTTATNCAGGTCGCACGCTTTCATCCGGGGCGGAACG :::::::::::::::Rv251T7.seq::::::::::::::: GGGTGTGCCTGCTGTGTATGCACGGCATACGGACATCCTTCCCCTGAAGACCCGCGGTCGAACAGCCACGTGTCCATCATCANGGGGTCAACCCCGGCCAAGGGCG ACGGCACGCCAAGTTCGCCGACCGTTAACCTAGTGCTGTTAGCTTCATTTGCTGCGAGCAAAACAGCTGGTCGGNCGTTAGGAATGAATTGAAACTCAACCGATTT GGTGCCGCCGTAGGTGTCCTGGCTG Clone Rv252 :::::::::::::::Rv252T7.seq::::::::::::::: ACTACCCGGCCAACGGTGATNTCTTGGCCGCCGCTGACNGCGCGAACGACGCCAGCGACCACATTCAGCAGATGGCCAGCGCGTGCCGGGCCACGANGTTGGTGCT CGGCGGCTACTCCCANGGTGCGGNCGTGATCGACATCNTCACCGCCGCACCACTGCCCGGCCTCGGGTTCACCAGCCGTTGCCGCCCGCAGCGGACGATCACATCG CTTTTATTTNNTNTTCNGGAATCCCTCGGGCCGCGCTGGCGGGCTGATGA Clone Rv253 :::::::::::::::Rv253SP6.seq::::::::::::::: ACGTCGGGANACTGTTCGCGTTCATCCTCGTCTCGGCGGATTGGTCTGCTGCGCCGGACCGACCGATCTTCAGCGGGGGGTCACGCTCCGTGGGGTGCCGTTACTT CCGATCGCCCAGTGTGCGCGTGCTGTGGCTGATGCTGAACCTCACCGCGTTGANTTGGATCGGTTCGGGATCTGGCTGGTGGCCGGAACGCNATTTATGTCGCTAC GGGCGCCGGC :::::::::::::::Rv253T7.seq::::::::::::::: GCTCAAAGGCACTACTGGCACCAAGGCCCACACGTCACCTGTGACTCCTGCGCCGACCCGCCCGAGGTCTGGCCGTTACACCGAACGGGCGAGCCGGGAGTTGGTA CCATCGAACAAGACAAGGTGCATGGGCGGAGTTGTTCCGCCACTTCGTCGATGACGGGTC Clone Rv254 :::::::::::::::Rv254SP6.seq::::::::::::::: CGATACCGGCTGCTTACCGAGACATCCACCATGCCACCCGAATCACCGCACGCGCCGAAATCGCACAACAGCTTGACGCCTTGCAGGTTCCGCGATTGGAATTGCC GACGGTCTCTGACGGCGTCGACCTTGGCAGCCTCTACGAGCTCTCGGAATCACTTGCCCAGCAGGGGGTTCGATGAGTGTCACACCGAAGACCTCGATATGGGCGC AATCCTGGCCGACACATCCAACCGGGTGGTTGTGTGCTGCGGCGCCGGTGGGGTCNGCAANACACTACCGCGGCCGCGCTGGCGTTGCGCGCGGCCGAATATGGCC GCACTGTGGTCG :::::::::::::::Rv254T7.seq::::::::::::::: CGTCGTCGTCGTGGTATGCGATAGCCATCCCGTCGGGCTACTCGCCATCACCGATCAGCTTCGCCCCGAAGCCGCCGCGGCGATTTCCGCTGCGACCAAACTGACC GGGGCCAAACCGGTATTGCTTACCGGCGACAACCGGGCCACCGCCGATCGGCTCGGTGTACANGTTGGCATCGACGACGTACGGGCCGGGCTACTGCCGACGACAA NGTCGCAGCCGTGCNGCNGCTGCAAGCTGGAGGTGCCAGATTGACCGTGGTCGGTGACGGTATCAACGACCTCCGGCCTTAGCGGCCGCGCATGTCGCATCGCCAT GGGCAGCGCCCGAC Clone Rv255 :::::::::::::::Rv255SP6.seq::::::::::::::: GCACGCAATCGAAGTCACCCAAACCGGGCGGGCCAGGCGTCTNACGCCACGTCNACCAGCCGCAACCTCAACCCGGCCACGGCGAGCTCCTGATCAAGGCCGAGGC CATCGGTGTCTACTTCATCGACACCTACTTCCGCTCCGGGCAATATCCGCGCGAACTCCCGTTCGTCATCTGCTCCGAAGTATGCGGCACGGTGGANGCCGTCGGC CAGGGGTTAC :::::::::::::::Rv255T7.seq::::::::::::::: TCGACTGTGTGGCCACAGATCACGCCCCGCATGCCGAGCACGAGAAATGCGTCGAATTCGCCGCGGGCCGGCCGGCATGCTCGGGTTGCAGACGGCATTGTCGGTG GTGGTGCATACAATGGTGGCGCCGGCTTGTTGANTTNGGCGCGATATCGCGCGGGTGATGAGTGANAACCGGCGTGCA Clone Rv257 :::::::::::::::Rv257SP6.seq::::::::::::::: GAACCTGACACCCTGGTCACGGGTGAGCACGGACTTGATTTCTTCNCTATTGGTCGGCGCTGTTGAGCACACCACGCCGCTGACGGCCGTCGCGTCCTCGCTGTGC TCGGTCTGGTGGAGCGCGCTGCCCGCGGCCNAACATCNTAAATCAAGCGTATTCGTCAACAGATATCATCAATGTCGGCGCTGGACTATTCAAATCATCGATATAC TGGTGACCTGGTCCTTCGCCATCGATCAATGGCGATAGTCACGCAAATCGTCACGGACATCGTCGGCGTCCCAGCTGGCCCGTGCCAACAGATGCTGCAACCCATC GGGGTGGTATCACCGCGGTGCTCGGCGATGGTCCACAATTCTTGCGGTCCAAGCCCNAAACATCCCGGGCATGAATTCACCGGCATGCGCN :::::::::::::::Rv257T.seq::::::::::::::: CTATCGTACCCGCGCCGGTCACCTTCTGGATATCGCCGGCCTGGTCAAGGGGGCGTCCGAGGGAGCCGGGCTGGGTNACAAGTTCCTGGCTCATATCCGCGAATGC GACGCCATTTGTCAGGTGGTGCGGGTGTTCGTCGACGACGACGTGACTCATGTCACCGGACGGGTCGATCCCCAGTCCGACATTGAGGTCGTCGAGACCGAGCTGA TCCTGGCAGATCTGCAAACCCTGGAGCGGGCCACGGGCCGGCTGGAGAATGAAGCGCGCACCAACAAGGCGCGCAAGCCGGTCTACGAAGCGGCACTGCGTGCCCA GCANGTGCTCGACGCCGGGCAAGACGCTGTTCGCCGCGGGGGTGGATGCCGCCGCGTTGCGCGACTGAAACTGCTGACCACCAAGCCCTTCCTGT Clone Rv258 :::::::::::::::Rv258SP6.seq::::::::::::::: TACTCAAGCTTCAGGCCGCCACGTCCGCCGTCCGTCGGCGACGTGACCTCGAGCGCCGAGTTCGACTCGACATCGCCGCCGGCGCATGCCGACATGAACGCGGCAC TCACCGCAAGCCCGTCGGACGTCAGGTCGATCGACTCCGCTTCAAGCACCGGATCGTCCGGGCAACTCGCGGCCTCGGCCTGTGCGAACGGCACACCCGTCGTGGC GGCNCCCCGCGCGGAACTGGGCTCATCACGGTCGTTGCGAGCCGGTCGCGTCACCGCGTACCGACGCCGTC :::::::::::::::Rv258T7.seq::::::::::::::: CCGACATCGAGTGGGCTCGCAGTGACTTGGCGACCTCCAAGCCACCGGTACCCGCCGCGCGGCAAGCCAAGGACGACGACGGCCTTGCCGGATAGCTGCGCCAGGC GTTGCGCCAACTGGCGTCCAGCGTCGCCACGATCGTCAAAGAGCTTCATCTGCCGAGTGTGTCGCCATCTCATGGCTCCAAATATGGAATTAGGTCCCTGGGCCGA CTGACGACAGTCCCTCAGCGACCGGATTGCGCATCCCGCCTTGTACGCTACTCCGCAAATCCCGGGCTTGCGTCCGCGGAAGCGAACTCGGCGGCGCTACGTGGTG GTTCACTTCGGCCGTGCGCACTCGGATCGACGGGCCGATGGTGGCCGGGCCCGCGCGCTTCTTGGTCATCCGATTGAGT Clone Rv259 :::::::::::::::Rv259SP6.seq::::::::::::::: ATACTCAAGCTTGTCGCGGTAAACCGCACGCAGGGCGGTGGGTGCGGTGTCAAAGACACCCACACTTCTTTGCGGTTCGGTGATCTCGACACCGGCCGCGAGCCGA CCACCATGCGCGCGTAGATCGGCGATCAGCGCGTCGGCTATCGCCTGGGTGCCGCCCACCGGAATCGGCCAGCCGACCGAATGGGCCAGCGTTGCCAGCATCAGTC CGGCGCCGGCCGACACCAGTGACGGCAACGGTGAAATCGCGTGGGCGGCAACGCCGGTGAACAACGCGCGGGCATCCTCGCCCGCCAACGACCGCCACCGAGGGTG CCTGGGCCATCATCCGCAGCCCGA :::::::::::::::Rv259T7.seq::::::::::::::: TGGACTCATAACGATCGGGTCAGCGACGCGCCAACACGAACGGCCGGACGAGTGGGCCAGGGTCGCGCCTCCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAG GCTCCGGTGCGGCGTTGGGCGCCGTGCTCGTCCCAGCGTCCGGTCCCGGGTCGCCGGCGACGCTTGTTTCCTCCATACTCGCCCCCTAATCTCGAGGCAGCCCGTA CCCGCAGGCAACCTCCCAAAAATGCAATCCCCCAAAATGCAATGCGTCGAGCTATTTCTCACACCGACCGCTAGTTGCGGATCAGAAATCCGTTGGGCGCGGAAGT CCAGCCGAATTTGTTCTCCCGCTCCGCATCATGCTTGTAATCGTTTGGAAATCATCCTCATATGCCTCGATCGCTTCATAGGTCAAGGCCAAACCCGGCAGGATGG GTGGCC Clone Rv25 :::::::::::::::Rv25SP6.seq::::::::::::::: CTTTACACTTTATGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTG ACACTATAGAATACTCAAGCTTAGTGGTTGCGCACGTAAATTCGTCAGGTGACCGATCCCCTGCTGTCTCACTCGCCTCACAGCGACCACCACGGCTGGCGCTCAA GGCGGGCACGTGCGGAGCAGATGAGGAATGTGCGACGTCTTGATGCAGCCTGTCAGAACACCGAGACCCTCGACGAACTTACGATCGAAACCGCTTAGGCCAACCG GTGACGGGGGTGTCTTTCCGCGGCTAGGGCGCCTTATCGTCCGAAGGCCGTGGGTGGTGATCGCCTTCTGGGTCGCGCTTGCGGGTCTGCTTGCGCCGACGGTGCC GTCCCTGGACCGATCTCCCAGCGGCATCCAGTGGCGATTCTGCCATCGG :::::::::::::::Rv25T7.seq::::::::::::::: CAGGCATGCAAGCTTGCGATGTATCAACACGCCGTTGCGCAGCGTGAGCCGATAGTTGACATCCGGCTCGGTGAAGGTGAAATCGATGGCCAGGTCGAGGTCCCAT GCGCGTGGGCCATTGATGCTGATCGCCAGGACGTCAAAGATTTGGTCCGGCGTCAGCTGGGCGAAAAACGTGGGCGCCGGGACTTGCCCGGAGCTGCCCGGGTTCC CGTCGCGCAGCTCGGCGGCCCCGGTCAGAAAGAAATTGCGCCAGGTCGCACACTCCGCGCCGTAGGCCAGCTGCTCCACGGTGTCGGCATATAGCCCGCCGGCCGC AGCGTGCTCGCTGTCGGCGAACACCGCATGGTCGAGAAGCGTTGCCGCCCAACGGAAATCACTGCGTCAAAGCTTCGCCGGGCCACTCCAGCACTCCGTC Clone Rv260 :::::::::::::::Rv260SP6.seq::::::::::::::: ATACTCAAGCTTGACCGACGCTGATCGCACCGCACGCGGGAACCTCAAGGGCACTACTGGCACAAGGGCCCACACGTCAACCTGTTAACTCCTGCGCCGACCCCGG CCGAAGTCCTTGGCGTTAACACCGAACGGGCCAACCCGGGAATTTGGGTTCCATCAAAACAAATAGCAGGTGCCTGGGCGGAGTGTTC :::::::::::::::Rv260T7.seq::::::::::::::: GTCGTCGTGTGCTGGGGCGTCCGTATCAGCACGCCCACGAAATGGGGCACAAGAAGGATTCCTGGAACGGTGGCTGTCCAAGATCACCCTCGCCCAAAACTGCTAC GGGCACTTCTACATCGAGCACAACCGTGGCCATCACGTCCGCGGTGTCCACACCGGGAGG Clone Rv261 :::::::::::::::Rv261SP6w.seq::::::::::::::: ATATGCCTTGCTGAGCTTTTCGGATCGCAGCGAGTCGTACCCGCGCCGGTCACCTTCGTGGATATCGCCGGCCTGGTCAAGGGGGCGTCCGAGGGAGCCGGGCTGG GTAACAAGTTCCTGGCTCATATCCGCGAATGCGACGCCATTTGTCAGGTGGTGCGGGTGTTCGTCGACAACGACGTGACTCATGTCACCGGACGGGTCGATCCCCA GTCCGACATTGAGGTCGTCGAGACCGAGCTGATCCTGGCAGATCTGCAAGCCCTGGAGCGGGCCACGGGGCGGCTNGAA :::::::::::::::Rv261T7.seq::::::::::::::: GACACCCTGGTCACGGGTGAGCAGGACTCGATTTCTTCGCTATTGGTCGGCGCTGTTGAGGCACAGCACGCCGCTGAGGCCGTCGCGTCCTCGCTGTGCTCGGTCT GGTGGAGCGCGCTGCCCGCGGCCGAACATCGTAAATCAAGCGTATTCGTCAACAGATATCATCAATGTCGGCGCTGGACTATTCAAATCATCGATATACTGGTGAC CTGGTCCTTCGGCCATCGATCAATGGCGATAGTCACGCAGATCGTCACGGCATCGTCTGCGTCCCAGCTGGCCCGTGCCAACAGATGCTGCACCCCATCGGGGTGG TATCNCCGCGGTGCTCGGCGATGGTCCAACAATTCTTGCGGTCCAAGCCCGAAACCATCCGGCCATGAGTTCACCGGCATGGCGCAACGGCTGGTGCCGGGCAAAA CGCGGCGCGATCGAATTC Clone Rv262 :::::::::::::::Rv262SP6.seq::::::::::::::: TGTAGAAGGTGGGTCCCGTCCAACTTCGCGGCGGCGGCGCGATATGCCTTGCTGGTCTTGCTCATTTGATATCCAATCTATGGGTCGTGGTTACTCAACGGGCCGA AGCTGGCCCTCCCACGGGTAGGGTCCTATTCGACGGTGATGTCC :::::::::::::::Rv262T7.seq::::::::::::::: CCCGAATCCGGTGGCCGGCAGGGGGCCTGGCGACGTGGACACCTTCTAACTTGTCTTTACCGGTCACTGTTGCACCCCAACACCTTTAACGACGTGGACGGACGTT ACATCGGATTCGACGGTGTCATCCACAGCGTTGCCATTGGGCACACCCACTACGCCAATTTCTCCGACTGGGACACCTACCGCAGCCTCGCCCCACTGCAGGGACT GTTGTTCCCGCAACGGGCCATCGACATGATCCAGTCGTTGGTGACCGACGCGGAGCAGACTGGTGCGTATCCGCGTTGGGCGCTGGCGAAATTCCGCCACCGGCAT GAT Clone Rv263 :::::::::::::::Rv263SP6.seq::::::::::::::: TTGAGATGCTGGTCGGGATGCCGATGGTTGGAACATGGTCCCCTGGCGTCGAATACGCGCGAGCGCATGAGCTCACCGGTTCGGAACAACGTATCGAAGAACTCGC ACTGCTGGCAGATGGTATCTCCGATGTGGTTGTAATTTGTATCCCAACTCTAACTGTGCTATCGGATCTGCGTGAATA :::::::::::::::Rv263T7.seq::::::::::::::: CGTAATCACGATCCCGCTGAGACACTTGACCTTACGGCCGAAGTGACTTCGCTGCTGCTATGCCGACACCCGATTTCCATACGCTGCTGTACACGACGGCCGGGCC GGTGGCCTCCATCACGCTCAACCGCCCGGAACAGCTCAACACCATCGTCCCGCCCATGCCCGACGAGATCGAGGCCGCTATCGGGTTGGTCGAACGCGACCAGGAC ATCAAGGTCATCNTNCTGCGCGGTGGCGGGCGCGCCTTCTCCGGCGG Clone Rv264 :::::::::::::::Rv264SP6.seq::::::::::::::: CAAGCTTAAGCTGGTTCCGGCCACTCCATGAGCCGTAGTGCAATGGTTCGTGCACGGCGAGGCCGAACTTGCCATAAACATCCCTGACGAAAGTCTCCGGCAAGCC GATTGCTTCTTCGGGCCGCTTCTTGTGGATTGTCCGATAACCCGGTCCCTCATGCTGGAAGTTGTGCGCACTCTTTCCTTCCGCGATGTGGGCTAACGACTCGTCA TTGAGCAAGAAGTACGTGCACAGGCATCGTCCGCCGGGCTTCAGCACGCGGGAGATCTCGTCCAGATAGTGCTCCACGTCCGGNGGGAAACATGTGGGTGAACACC GAGGTNAGAAACACCNCATCCAACGACGCATCCGGGATATGGAAAGCGAAA :::::::::::::::Rv264T7.seq::::::::::::::: TATGGTCTTCGTCGACCAGTACGTCGTAGGCGCCATGAGCCAGCGACTGAAGCCGCGCCATGCCTGCACGGCCCGCTCATCCAGCGAGGCGGCCATCTCCCGCAGA TAGCCTGCCGCCTCGGCGCGCACGCTGTCCGGATCGCGTCCGAGCTCGTCGGCCAGCGCACGCAGCCGCTCGTCATACCATCGGGCATCCAGCAGTTGGGTAACCT CAACGGGGTCGGTCGCTAGCGGCGTCATTGATTCAGCAACAATACCGATGCGCTGCAGCAACTTTCGCAGTCCGATGCGGCCCACCTCCCGTGCAGTCACTGGCTA GCCCCCGTCATGCCGGTTGTGTCGATGGCACGGCAGCGGGCTCGTAAACCTGCGGTCTCAGCTCGCTGG Clone Rv265 :::::::::::::::Rv265SP6.seq::::::::::::::: GCTTAGCGGTCTTGCTCGAACCGACATTGCGTGCCACTCATGAGCGGGTGGCGGTCGCGGTGCTTACACATCT :::::::::::::::Rv265T7.seq::::::::::::::: GTATCTGGCGCCTCTCGAATATCCTTGAACGTCCCGCGGTGCCACCCAGATAGATCGCAGCGCCCTGCAATGGAGTTCCCTTTATGGCCTCTCTAGCCTCCCGCTT GATCGGCTCGACCCGAGAGATGCCCTCGGGCGTTGCGGGATCTCCCTCCA Clone Rv266 :::::::::::::::Rv266SP6.seq::::::::::::::: CTTCACGCCGATCCGCGACCGCGAACGCGACGGTGACGGTGGCGACAAGGTTCGGTTGGTCGCCGCGGCGCTGGGCGATATCAGCTCACCCGGTTTCGAAGGTGTT CGGCGACCGGACGGTGCTGCAGACATTCTTGAGCGTCCTCGACCGGCCCGATTCGGCCTTCAACATCGTGACGCCGTATTTCGGCGGTACCGCTCGGCGCCGAGTC GAAGGCGGCCTGAGCTAAAGCCGGGCATTGCGCGAGTGGTAAACAAGTTCGGTGACTTCGGTTGACCGACTCGACGGGCTCGATCTGGGCGCGCTGGACCGGTATC TGCGTTCGCTGGGGATCGGGCCNACCGCNANTTGCGTTGCGANCTGATTCCGGTGGAGCTCCAATCTGACTTCCGG :::::::::::::::Rv266T7.seq::::::::::::::: GCAGCTACCGACCCTAGCGACGAGTGTGTTCGCAGCGTCGAATGTGAACGTTCGGCGTGATTCGGCGCGCGGGTTCCCGCTCTCAGCGCACGTTCGGCGCCGAGGN GGCTAGTCCCTGGTTAAGCAATGTCTCGGTCGCCGCCAGCAGCGCGCATGTCGCCAACCCGTCNACCGCGTTGCGCATGTCCGGTACCGACGGAAACGACGGCGCG ATCCGGATGTTCTTGTCGTCCGGATCCTTTCGATACGGGAACGACCCCCCGCCTCGGTCACCGCGATACCAACGTCCTTAGCCAANGCTACNGTCCGGCGCGCGGT CCCGGGCAACACGTCGAAGCTGATGAANTAACCACCCTTGGGCTCGGTCCAAGANGCGATCTTGGACTCCTTAACCGCTGATNCAA Clone Rv267 :::::::::::::::Rv267IS1081N60.seq::::::::::::::: TCCCCATCGGCGCCGGACCGTTTGAAAGTCCAAGCACGGGTGGGATGGAATCGACGACAGTTGAGCGCCGTCGGTGGCCGTGGTCAGCAGCTGTTCGCGAACGCAC CAGGTCACATCCCTTCGACATCTCACCGACGTGGCACGGGCGACATCAACAGGAAGATTGACGAATCCCTCGCAGGCGCGGCACGTCCGCAGGCCAACGCCAACTA CGGGGCCACCAGCGATCCTCCGCTCACGCACCAGCCCAAGCCAGGCTCANCCACCCAAGTCGGCCCGCGCTCTCCCTGGCCCCCTGGTCTCCGGGGCCTTGTTAAA CAACTACCGGAAGTCCACCAATCCTCGCTGCATCTCGACACCGTCCGCCTCACTCCCTTCCTCCCGCCCCTCTCCACACNACACACCTCTTGCATTAAGGTCACGG AGCGGTCACTTTTCGTCGGACGAAATTCGCAATCCGGCCGCTCGCCGCCAGAGAT :::::::::::::::Rv267SP6.seq::::::::::::::: CGGAAAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCGCGTTCAGCTCGCTTGCGGCGCTGCAGCAGCCAGTCCGGGAAATAGCTGCCCT GGCGCAGCTTGGGGATCGCGACGTCGATGGTTGCGGCACGGGTGTCGCAAATCACGGTGGCGGTAGCCGTTGCGCTGATTGGACCGCTCATCGCTGCGTTCGCGGT AGCCCGCCCCGCACAGGGCGTCGGCTTCAGCCCCCATCAGGCGGCGA :::::::::::::::Rv267T7.seq::::::::::::::: GGCCGAGTCCAGCACTTCGCACTATGTGCAGACCAAANACCCGGTGGTCGCCGCGCTGCGGCAGCGGCTGGCAACGGCGCCGGTGATCACCGAGTGGTGCGNAGTT GCCGACCGGCAGTTCGCCGCGGGCTTACTACGAGAAGGGCCTGCGCGACGTCATCAGGTATCACGTGTCGATGACGTCGAGCGTTAACTTCCCCGACCAGACGGCG ACCTCGCCGATGGACCCCGCGTTGTACCTGGTGTGGGCGCAAGCTAACGCCGCCGCANGCTATCGGTACTCGGTCGAAGCGCAGCCGGGGTCGCAAGCGCTAGCGG GCAAGGTCGCGACGATCTCGGTCACCTGGACCAACTACGGCGCTGCTGCCGCCACCGAATAGTGNGTGCCCGGCTACCGGCTGGTGGATTCCACGGGACATGTGGT TCGGACCTGCCGGCAGCGGTGGAACTGAAGANGCTGGTCT Clone Rv268 :::::::::::::::Rv268SP6.seq::::::::::::::: AGCTTCAAGGACATCGTCATCGCGACCAAAACCGCGAGCTAGGTCGGCATCCGGGAAGCATCGCGACACCGTGGCGCCGAGCGCCGCTGCCGGCAGGCCGATTAGG CGGGCAGATTAGCCCGCCCGCGGCTCCCGGCTCCGATTACGGCGCCCCGAATGGCGTCACCGGCTGGTAACCACGCTTGCGCGCCTGGCGGCGGCCTGCCGGATCA GGTGGTATATGCCGACAAAGCCTGCGTGATCGGTCATCACCAACGGTGACAGCAGCCGGTTGTGCACCATCGCNAACGCCACCCCGGTCTCCGGGTCTGTCAN :::::::::::::::Rv268T7.seq::::::::::::::: GCTCGCGGTCCAGCAGCAGACGTGTCTGACCCCGACGCCCGGCCGCCGGTACCGAAACCGGATCGGCCCGCCGATGGCCGCGGCCACGGCGTCTGCCTTACCCGGC CCGGATACCAGCAGCCACACCTCGCGGGAACGCTGAATCGCCGGCAGGGTCAAGGTGATTCGGCGTGGCGGCGGTTTCGCGAATCGTCCACCGCCACCACCATGCG GGTGCTCTCGAAGACGCGGGGCTGTGCGGGAACAGCGAGTTAATGTGGCCCTCGGGCCCCATGCCCAGCAGGTGGACGTCGAAATTCGGCCCGGGTCACCTGGTGC GGCACTGGCGGCC Clone Rv269 :::::::::::::::Rv269SP6.seq::::::::::::::: AGCTTGTCGATCGTCCGGCAGCGTCCGGCGAGTCAAGTCGAAGCCAGTCCGGTCTCCTCTCCGACTACGGCCAAGAACTGGGCGACGGTGTCAGTGCATACCAGCG GANACTGGTGGCGCCCTAGGCGAGCGACCGCCTCACAAACGGCGGTGACCGCGTTCTGGTCGTGCACCATCGAGCCGTGCCCATCCCGGCCGCGTGCCGTCAGCCG CATCCACTGGATGCCCTTCTCGGCGGTTTCAATCAGGTACAGGCGACGTTCGCCANCATCGTGCCGGGGCANGG :::::::::::::::Rv269T7.seq::::::::::::::: TTGGTGATCATCGNCCCAACGACCCCGAGGCGATGTTCTTGCACACCGAGGAGTGTCGCAAGCTGGGGCTGGCCTTCGCCGCCGATCCGTCTCAGCAGCTGGCGAA GCTGTCGGGGTGAGGAAATTCGCAGGCTCGTCAACGGTGCTGCTTACTTGTTCACCAACGACTACTAATGGGATCTGCTGCTGTCCAAGACCGGCTGGTCAGANGC CGATGTGATGGCGCAGATCGACCTGCGGGTGACCACATTGGGTCCTAAGGGTGTCGATTTGGTAGAACCTGACGCACCACCATCCACGTCGGCGTTGGTCCCCGAA ACAGCCAGACCGA Clone Rv26 :::::::::::::::Rv26SP6.seq::::::::::::::: GGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCAAG CTTGATTTTGATCATCATGATGATCATCACCCGAAGTGTGGTAGCCGCAGTGGTTATCGTGGGTACCGTCGTGCTTTCCATGGGCGCCTCTTTGGGGCTTTGCGTA TTGGTCTGGCAGGACATTCTGGGTATCGAGTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCCTGGCGGTGGGATCCGACTACAATCTGCTGCTGATTT CCCGGTTGAAAGAGGAAATTGGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGGAGTGGTGACGGCTGCCGGCATGGTGTTCGCCGTTAC CATGTCGTTGTTTGTGTTCAGCGATTTGCGAATT :::::::::::::::Rv26T7.seq::::::::::::::: CAGGCATGCAAGCTTGGCGTGCCGTTCCAACCCGAATTGGCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACGACGAGGTCGTCCGCGGGACACACC TCGATGCTGCCGCCATGGACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCG GATCGCGGTGATCGTCGATGACGGCATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCNCCCGGGCGCACG Clone Rv270 :::::::::::::::Rv270SP6.seq::::::::::::::: GGCATCTTGGCCGCCATGTTAGCCACACTGCCACCGGCTATAGAAGCGATGCGCACCGTCCTGCCAGCACATTGCGGCGCTCCTCCCTGGAAAGCAAGATAACCAA GCTCATGCCGTGGTTGTGGGTGGCGTGGTTTGGTTTGGGTAACTTTGG :::::::::::::::Rv270T7.seq::::::::::::::: TCGGCTAATAATCGTCGACGCCGGCCTCCTCTGCAATCGCCTTGGCGGTCGCCGGGTTGTCACCGGTGATCATCACGGTGCGGATGCTCATTCGGCGCATTTCGTC GAATCGTTCCCGTATGCCCACCTTGACGATGTCCTTCAGATGGACGACGCCGATGGCCCGCGCGCTGCTGTTATCGGTCCATTCCGCAACGACTAGGGGTGTCCCC CGCCGGAGCTGATGCCGTCGACAATGGCACCCACCTCCTCGGTGGGGTGGGCACCGTGATCGCGAACCCACTTCATCACCGCAGCCGCGGCACCTTGCGGATTCGA CGGATG Clone Rv271 :::::::::::::::Rv271SP6.seq::::::::::::::: CTCAAGCTTGGAGGCGTGGCGATCGCGGTCCAAGGCGCGCTCTCCGAGCACAACGAGCGAAGACNGCTCGGCGACGGAGCCTTTATCGACNTCCGTTCGGGCTGGC TGACGGCGGCNAAATAATGCTGGACTCGTTGTTGTCGACGGTGCCGTGGCGAGCCGAGCGCCGTCAGATGTACGACCGGGTGGTCTATGTGCCGCGGTTGGTGAGT TTCCACGACCTGACCATCGAAGATCCGCCGCATCCGCTGCTGGCGCGGATGCGCCGGTGGCTCAACTAATTCTACGGCGGCGAACTGGGTNATCCCTTCNCCACCG TCGG :::::::::::::::Rv271T7.seq::::::::::::::: CCTAGGTCAACCGTACCGTCATCGGATCGGGGTCGACCGCACAGATGGACTGGAGCTTCGGCGAGGTCATCGCCTATGCCTCGCGGGGGGTGACGCTGACCCCGGG TGACGTGTTCGGCTCGGGCACGGTGCCCACCTGCACGCTCGTCGAAGCACCTCAGGCCACCGGAAATCATTCCCGGGCTGGCTGCACGACTGCGACGTGGTCACCC TCCAGGTCGAAGGGCTGGGCGAGACGATGCAGCCGTCCGGACGAGCGGCACTCCTTTTCCGTTGGCTCTTTCGGCCGAATCCGGACGCCGAACCCGACCGGCGCGG GGTCAACCCGGCACCGACGCGGGTGCCGTTTACCCGCGGGCTGCACAAATCCCGACGGGTATGGGCTTTGACCTGCCGACGGGGGA Clone Rv272 :::::::::::::::Rv272SP6.seq::::::::::::::: AGCTTGGCGTGACACCAACACAGGGCACTTAAGATGGCAATGCGCCGCCTACCTGCACGTTTTCGCGATGTCAGAGGATGCCGAGGGGAGAACAATGCGAGCACGG CCGCTGACGTTGCTCACCGCTTTGGCGGCGGTGACATTGGTGGTGGTTGCGGGCTGCGAGGCCCGAGTCTAGGCCGAAGCATATAGCGCGGCCGACCGCATTTCGT CTCGACCGCAAGCGCGACCTCAGCCGCAGCCGGTGGAGCTACTGCTGCGCGCCATCACGCCGCCTAGGGCTCCGGCGGCGTCGCCGAACGTCGGGTTTGGCGAACT GCCTACCCGGGTCCGGCAGGCAACCGAT :::::::::::::::Rv272T7.seq::::::::::::::: TCATGCCGTTGGACCGACCATCGGAGTTAGTTGCCGAACCGCGGGACCACCGCAAGCACCCGGTCCTGGTCGCGCACCGCGTCGGCCAACCGCTTGAGCACCACCA CGCCGCAGCCCTCGCCGCGCACGAATCCATCCGCGTTGGCGTCGAAGCTGTTGCATCGGCCGGTCGGTGACAGCGCCGACCACTTGGACAGCGCGATGGCGGTGAA CGGTGACAAGGTGAGCTGCACCCCGCCCGCCAATGCCACGTCGGTTTCACGCAGGCGAAGCTCTGACACGCCAAGTGAATTGCCACCAGCGACGACGAACAAGCGG TATCTACGGCGATGG Clone Rv273 :::::::::::::::Rv273SP6.seq::::::::::::::: GGGTCGACTTTCTGCAAGGCGAGGCTACACCGTCGTCGTCGTGGTATGCGATAGCCATCCCGTCGGGCTACTCGCCATCACCGATCAGCTTCGCCCCGAAGCCGCC GTGGTGATTTCCGCTGCGACCAAACTGAACGGGGCCAAACCGGTATTGCTTACCGGCGACAACCGGGCCACCGCCGATCGGCTCGGTGTTCAGGTTGGCAT :::::::::::::::Rv273T7.seq::::::::::::::: AATCCGAAATCCTGACCGATACTTGAACCTGGTCTCGTTCGGCAATAACTCGTCGGCGTGCAGGACGCGGCGCAAACGTACTTCGGCATCAACGCGTCCGACCTGA ATTGGCAGCAAGCGGCGCTGCTGGCCGGCATGGTGCAATCTAACAGCACGCTCTTCCCGTACACCAACCCCGACGGCGCGCTGGCCCGGGCGGAACGTGGTCCTCG ACACCATGATCGAAAAACCTTCCCGGGGAGGCGGATGC Clone Rv274 :::::::::::::::Rv274SP6.seq::::::::::::::: TTCCGAATTTCGGGTCCNGGTCATATGACCCTCATGGAAGAAGAAGCGGCCGCCCCGCGCCCGTGCGACGGCGAATGAAAACCCTCACCCAGGCCGCATTGAACGC CGACAAGACGGTGGAGCAGGTCGAAGACGTCCTGGACGGTCTGGGTAAGACCATGGCCGAGCTGAACAGCTCGCTGTCACAGCTGAACAGCACCGTGGAGCGCTTG GAGGACGGTCTGGACCATCTCGAAGGTACCCTGCACAGCCTGGACGATCTCGCGAAACGGCTCATCGTGTTGGTCGAGCCGGTGGAAGCCATCGTCGATCGGATCG ACTACATCGTGAGCCTCGGCGAAACGGTGATGTCACCGCTGTCGGTC :::::::::::::::Rv274T7.seq::::::::::::::: NCTCGATCTTGGGGTACGTTCGATGAGGCTGCTGACCAACAACCCGGCCAAGCGGGTGGGACTGGATGGATACGGATTGCACATCATCGAGCGCGTGCCGCTGCCG GTGCGGGCCAACGCGGAAGAACATCCGTTACCTGATGACCAAGCGTGACAAATTGGGGCACGACTTGGCTGGGTTGGACGATTTTCACGAATCCGTGCATCTGCCC GGAGAATTCGGCGGTGCCTTGTGAAGGTGGCGCCGGGGTGCCGGATCTGCCGTCGCTGGATCGTCTGGTGTGCGGCTGGCGATTGTCGCCAGCAGCTGGCACGGAA AGATCTGCGACGCGCTGTTGGACGGCGCCCGCAAGTGGCCGCCGGTGTGGCCTCGATGACCGACTGTGGTCTCGGGTGCTCCGCGCGATCGATAT Clone Rv275 :::::::::::::::Rv275SP6.seq::::::::::::::: TCATCCCGACCAAAACGCGAGCTAGGTCGGCATCCGGGAAGCATCGCGACACCGTGGCGCCGAGCGCGCTGCCGGCAGGCCGATTAGGCGGGCATATTATCCCGCC GCGGCTCCCGGCTCCGAGTACGGCGCCCCGAATGGCGTCACCGGCTGGTAACCGCTCTTGCGCGCCTGGGCGGCGGCCTGCCGGATCAGGTGGTAGATGCCNACAA AGCCTGCGTGATCGGTCATCACCAACGGTGACAGCAGCCGGTTGTGCACCAAGCGCGAACGCCACCCCGGTCTCCGGGTCTGTCCAACCGATCGACCGCCCAAGCC CACATGAACAAACCCCGGCATCACGTTGCCGATCGGCATACCGTGA :::::::::::::::Rv275T7.seq::::::::::::::: TTGGCGGGTTGGCCCAGCAGCCCGCCGGTGACGGCGACGATGCTGGGCTGGTTGCGGCCCTGCGCCACCGCGGCTTGCATGCTGGTTGGCTGTCTTGGGACGATCC CGAAATAGTCCACGCGGATCTGGTGATTTTGCGGGCTACCCGCGATTACCCCGCGCGGCTCGACGAGTTTTTGGCCTGGACTACCCGCGTGGCCAATCTGCTGAAC TCGCGGCCGGTGGTGGCCTGGAATGTCGAGCGCCGTTACCTACGTGACCTGATGGATCGGGGGGTGCCGACCGTGCCCGGCGATGTGTATGTGCCGGGANAGCCGG TCCGGTTGCCACGCAAAGGCCATGTCTTCGTCGGTCCGACCATCGGTACCGGGACACGGCGCTGTATTGCCCGGTTCGCTGCCGAGTTCGTCGCGCAACTGCACGC NGGCGGGCCAGCGGTGCTCGTTCANCCCGGAGGTTCCGGTGACGATGATCGTGTTGGTCTCCCT Clone Rv276 :::::::::::::::Rv276SP6.seq::::::::::::::: GTAGGAGAGAACAAAGACCGTCGATAGGACACGTGTTACGCCGGTAGCTGTCATTGGTATGGGGTGCCGCTGCCGGGGGGCATCTACTCACCCGATCGGTTGTGGG AGGCGTTGCTGCGGGGCGACAATCTGGTCACCGAGATCCCCGCCGACCGCTGGGACATCTACGAGTACTACGACCCCGAACCCGGCGTGCCCGGACGCACCGACTG CAAATGGGGCGCGTACCTCGATAACGTCGGCGACTTTGATCCCGAGTTCTTCGGGATCGGGGAGAAAGAAACGATAGCGATCGATCCGCAGCACCGCTTGTTGCTG GAAACCTCCTGGGAAGCCATGGAACACGGCGGGCTAACACCGAACCATATGCCTCCCGACAMGGGTTTTCGTGGGGTT :::::::::::::::Rv276T7.seq::::::::::::::: CGAACTGAGCCCATAGAAAGGCAGCGACTAATTCGCTGGGCAAATAGGAAGACCCTTTGTCCTGCCACGTATATTTGTCGACCTCGTTGCGAAGGAAGCGGCTGCG ATTGGTGCCCTTTTCCCTGGAGAATCTCTGCCCGGAGCAGGAAGTCTTATGAGTTGACAAGCAGGGGCGCCGCCTTCGCCGGAAATCACATTCTTGGTCTCGTGAA ATGAGAGCGCTCCCAGGTCGCCGATGCTGCCGAGCGCCCGCCCACGATACGACGCCATCGCGCCTTGGGCCGCGTCTTCGACCACCGCCAGGTTGTGGTGCGTGGC GATCTTCATGATCGCGTCCATCTCGCAGGCCACCCGGCATAGTGAACGGGGACCATGGCCTCGGTTCGCGGGTGAA Clone Rv277 :::::::::::::::Rv277SP6.seq::::::::::::::: CTTAGACGCCACCTCCGGGCCGAGCTCCACGGGGTGGATAAGTACGGCCGGATGTGGCCGCAATGGGAAGTTGTTGCCCGCTTGACTGTCCGGGTTAACGCCGGAT TCCACCACATCCCCTTGCGAAAGGCCGTTGGGTT :::::::::::::::Rv277T7.seq::::::::::::::: GATCGCGATCGTCGATGTGGCCATCCGGCTTGGCGTCGACCCGCGTAAGGCAGACCAGATGGTTCGCGGCACGGTCAACCTGCCACACGCACTGGTAAGACTGCCC GCGTCGCGGTATTCGCGGTTGGTGAAAAGGCCGATGCTGCCGTTGCCGCGGGGGCTGATGCTGTCGGATCGACGATCTGATCGAGAGGATCAGGGCGGCTGGCTGG AATTCGATGCCGCGATCGCGATACCGGATT Clone Rv278 :::::::::::::::Rv278SP6.seq::::::::::::::: AGCTTACGCCGCTTTCGCTTCNGATTTGGGACGCCGCATCGAAAGCGCAGTTGGAAGCGCGGCGCCCGGCTGGTCGAGCTGCTCAAGCAGCCGCAATCCCAGCCCA TGCCCGTTGAGGAGCAAGTGGTTTCGATCTTCCTGGGCACCGGCGGTCACCTGGACTCGGTGCCCGTCAAGGATGTCGGCGGTTCGAAACCGAATTACTGGACCAC ATGCGGGC :::::::::::::::Rv278T7.seq::::::::::::::: CGACGGGACCTCGTCGCATCTTCCATAGCCCGCCACACCTTCAGTTGCTCACCGGAATCCAACCGGTATAAGGTCGGCGAAGCGCTCGGCATTGGTCATCGGGATA TGCCGCTCGGGACGGTCAGATGCCCTCGGGTCCNGCCAGCACTCCTCAGGCTTCGTCGGGGTGGTCGCGACCGCATGGGCCACATCGCATTCACCAGGTCTGCGCG AATCACCAGCACGTANACGGTTCCTTTCCTAAGCAACACCGAAATTTCAGGACCCGAATGCTCCGGGAAAACATGTCACGGTAAGTCCGGTATTCCGGGTACCGGT TGAGCATTGA Clone Rv279 :::::::::::::::Rv279SP6.seq::::::::::::::: CGGCATCGGTTTGGGCTGTCACCAGCAGTTGGTACTTCTTCACTACTGTTGTTCGAGCGTCGAGCCGCCGCGCGTGTCGAGGTCGCCGGACGCGTACCCGCCAGGC CGGTCAGGGTGCCCTTCCAGTCCACGCNGCTGTGGTCGGCTAACCGCTTATCTTCAATCGAGACNATCGCCAGCTTCATCGTGTTGGCGATCTTGTCCGAGGGCAC CTCGAACCGGCGCTGCGANTACAGCCACGCGATCGTGTTGCCCTTCGCGTCGACCATCGTCGATACCGCAGGCACTTGCCCCTCGAGCAGCTGGGCCGATCCGTTG GCAACGACCTCAGAGGCACGATTGGACATCAGCCCTAGCCCGCCTGCG :::::::::::::::Rv279T7.seq::::::::::::::: CCGTCGANGCCGCCGACTTGGCTTGACCGACACCAACATGGCCTGAGGGTGTTCAACAAGACCGTGGCCGACGGGCTGAACATCACCATGAGCGGCATGAGCCACG CCACCGAGTTCATCATGTTGATCGCCGAAAACCATTGGCGGGTAGCGGAAGAACGGTCGAGGTGCTCTACACCCGAGTATTCGAAGTCGAAAGGCCAACCGTGCTC AACGGCGTCAACATCATTTTCGACGGGTTTCTGCGAGGGAGGATGCCACGATGAACTGGATCCAGGTGCTGTTGATCGCGTCGATCATCGGGTTGCTGTTCTACCT GTTGCGGTCGCGCCGAAGCGCGCGGTCCGTGCCTGGGTCAAGGTGGGCTATGTCTTGTTCGTGCTCCCGGCATCTATGCCGTGCTGAGA Clone Rv27 :::::::::::::::Rv27SP6.seq::::::::::::::: TTACACGNCCTGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGAC ACTATAGAATACTCAAGCTTTTTGAGCGTCGCGCGGGGCAGCTTCGCCGGCAATTCTACTAGCGAGAAGTCTGGCCCGATNCGGATCTGACCGAAGTCGCTGCGGT GCAGCCCACCCTCATTGGCGATGGCGCCGACNATGGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGNGACGCGGTANGTGGTCAAGTCCGGTCTACNCTTGGG CCTTTGCGGACGGTCCCGACGCTGGTCGCGGTTGCGCGGCGGAAAGCGGCGGGTCGGGTGCCATCAGGAATGCCTCACCGCCGCGGCACTGNACGGCCAGTGCCGC GGCGATGTCNGCCATCGGGACATCATGCTCGCGTTCATACTCCTCGACC :::::::::::::::Rv27T.seq::::::::::::::: CAGGCATGCAAGCTTTGTCACACCAAGTGTTTCGACCAGGCGCTCCATCCGGCGAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCGCGT TCAGCTCGCTTGCGGCGCTGCAGCAGCCAGTCCGGGAAATAGCTGCCCTGGCGCAGCTTGGGGATCGCGACGTCGATGGTTGCGGCACGGGTGTCGAAATCACGGT GGCGGTAGCCGTTGCGCTGATTGGACCGCTCATCGCTGCGTTCGCGGTAGCCCGCCCCGCACAGGGCGTCGGCTTCAGCCCCCATCAAGGCGG Clone Rv280 :::::::::::::::Rv280SP6.seq::::::::::::::: AGCTTAGCCAGTTTTTCTACTCTTGGGCCCACACCCACAGTGCTTCGACGGTACGGTCACCCATGATGGCCATCCAGTTGGCATCGGTGAGCTGATAAATGCCAGC TGGTTTCGCCAACCCGGTAGCGATCTTGGCGCGCTGCTTGTTGTCACTGATACCTATCGAGCAAGACAGCCCGGTTTGCGACAAGATGACTTTTCGGATCTCTTCG GCGACTTCGATGGGGTCGTCGGGAGTCCCGGGCGCCACCGCGAGGTAAGCCTCGTCCCAGCCCCATACCTCGACCGGGTATCCCAGGTCGCGCAATAACGCCACCA CCTCCTCGGACGCCGCGTTGTAGGCGGCTGGGTTCGACGGCAAGAAGTGGCCTCAGGGCATCGTCGGCGCGGTCCCAACGGCNTGCCGGCGCGCACACCGTAGGCG CGGGGCTC :::::::::::::::Rv280T7.seq::::::::::::::: CCGGCGGAACTCAGACGTGCTGGTGGTGCGGCATGGCACCGCGGGCAGCAAAGCGCACTTCTCGGGGGACGACAGCAAGCGACCGCTAGACAAGAGGGGTCGTGCG CAGGCAGAAGCGTTGGTACCACAGCTGCTGGCGTTCGGCGCCACCGATGTTTATGCCGCCGACCGGGTGCGCTGCCACCAGACGATGGAGCCACTCGCCGCGGAAC TGAACGTGACCATACACAACGAGCCCACCCTGACCGAAGAGTCCTACGCCAACAACCCCAAACGCGGCCGACACCGAGTGCTGCAGATCGTCGAGCAAGTAGGCAC ACCCGTGATCTGCACGCAGGGCAAGGTCATTCCCGATCTGATCACGTGGTGGTGCGAGCGCGACCGTGTGCCCCCGACAGTCCCGCAATCGCAAAGGCAGCACGTT GGTGT Clone Rv281 :::::::::::::::Rv281SP6.seq::::::::::::::: GTATGGTCAGCTGTCCATCCGGCGCTGTCGGCCGAGCTGCCAGATCTCGTCAGCCGTAACCGGTTGCGGGATCCACGCGTGCGGGTTGTCTAC :::::::::::::::Rv281T7.seq::::::::::::::: CCGACTTTCCGCGGGTACCCGCTCAACTTTGTGTCNACCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGA CGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATC GTGGGGACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCTACGCGACCCGGCCTATGGTTATTCGACCTCGGCCGCCCAATGTTGC GACTCCGTTCGGTTGTTCCAGAANGTCAGCCCG Clone Rv282 :::::::::::::::Rv282SP6.seq::::::::::::::: GCACCGATGTCGGCGAGCACTTCGTCAACTTCCAGGGGTGCCCGCACCAAGTATTTCGACGAGTATTTCCGTCGGGCCGCCGCCGCCGGTGCGCGGCAGGTGGTCA TCCTGGCGGCGGGGCTGGGACTCGCGCGCGTACCGGCTGCCTCGGC :::::::::::::::Rv282T7.seq::::::::::::::: TGCACCCAACTTACTGAGCATGCTAACGCTGGTCGTGCGGGTCTTGTTCCCGCGTGTCGGCAGGGCACACGCTCGGGGCGTAGCTGGGAGAGGCCCCGGTCAAGCC CGGAGAGCAGTGCTCAGTCCGCCAGCTTGACCGACTTTCGATGAGAACGCGCTTCTCGCCGTATTGAACTGGCGTGCTGACGGTCGCTGAGCAGCGCTCGCCGAGT GCGGCCGCTGATTCTTTCATCGAGCCAGGACGCGCATTCGTGTTCGGCCGC Clone Rv283 :::::::::::::::Rv283SP6.seq::::::::::::::: AGCTTACGGCCGGTCGACGCGACGAGTGGTTCATGACACCACAAACCGTCAACGCCTACTACAACCCGGGGATGAACGAAATCGTCTTCCCGCAGCGATTTTACAG CCACCATTTTTCGATCCGCAGGCCGACGAGGCCGCCAACTACGGCGGGATCGGGGCGCGTGATCGGGCACGATGATCGGGCACGGTTTCGACGATAGGGCGCCAAA TACGANGGCGACGCAATCTGGTCNATTGGTGGATCGA :::::::::::::::Rv283T7.seq::::::::::::::: ATGCGTCACGTCACCACAATCGCGAGGACCCAATCATGCCGCCCAGGGCGGCCAACCCAATGGTGGCCGCGAAGCGGCAGCTCGATCGCAGCGCCGGAGGTGCCGG CCGCCAGTTGATTCACGAACAGGGTGAGGTCATAGGCGGGCAGGATAGTGACGAACGCAAGACCTATATCTGCCGTCGGAGTAAGAATCGAGTAGCCGGTCGACCA ACGGAAGCGAAAGTGTCCGCGATGTTGATGAGCGTCGCCGGTTGTGGCGGCGGTGGC Clone Rv284 :::::::::::::::Rv284SP6.seq::::::::::::::: AGCTTCACCAGCGTGCCGATGCTGTTCGCNACACCTCCCTACTATGCGCAATTCGCCGACACGGGTGGCATCAACACGGGCGATAAGGTGGACATCGCTGGGGTGA ACGTCGGGCTGGTGCGCTCGCTGGCAATCCGCGGCAACCGCGTGTTGATCGGATTCTCGTTGCCCGGCAAGACAATCGGGATGCAAAGCCGGGCAGCAATTGGCAC CGACACCATTCTTGGCCGTAAGAACCTGGAAATCGAACCCCGCGGTTCGGAGCCGTTGAAACCCAACGGTTTCCTGCCGTTGGCGCAGAACACTACGCCATACCAA ATCTATGACGCGTTCGTC :::::::::::::::Rv284T7.seq::::::::::::::: CTGCCGCGGTGGCGGTCAGCGCCTGGCAAGTCACCGCACCGCCGTCCGGTTCATCGGCAGGCTCCCCCGAAAAGGGCCCTGGCAACAGAAGGTGATCAATGAGCTC CCGCAGACCTTCGCCGATCTGGGACCGACATACGTGAAGTTCGGCCAGATCATCGCGTCCAGCCCGGGAGCATTCGGTGAGTCGCTGTCGCGGGGAATTCCGCGGC CTGCTCGACCGGGTGCCGCCCGCAAAAACCGACGAGGTGCACAAGCTCTTCGTCGAGGAACTCGGCGACGAGCCGGCCCGGCTGTTCGCCTCCTTCGAGGAAGAAC CGTTCGCGTCTGCGTCCATCGCCCAAGTGCACTACGCGACCTGCGCAGCGGCGAAGAAGTGTGGTCAACATCCACGGCCGGGCATCCGCCGCCGCGTTT Clone Rv285 :::::::::::::::Rv285SP6.seq::::::::::::::: GATCGTGCCGGCCCCCCGGCGGCAGTAGCAGATCAGCTCGTCGAAATCGCGGCAACCAGTCCAGTCGATTTCCATACGGGCGCCGTCAATCAACTCTGCGAAGATC GCGATCGGCACCGGAAACCGGCGAGCCGCGTCAGCCAGCGCAACCAGCACCGGGATCGGATGAATCATCAATATTATCAAGTGATTTCCTGATGGCATCGAGCTCG GTGATCTTGGTCTCGGGGGCCAGCTCGCCGTCGGCGACGTGCGTCGATCCGGCGGCCGAGCGCATAGCCGCAAATAGTGCCGCTCGCTTTTCGCGCGGCAAGAGTC GGATGCCGTAATATANGTTTCTGGCGGCCGTGCGCGTGATCNACTCGGTGATTCGATACGCCTGTTCATCTCGGTCATGCCGTCCTC :::::::::::::::Rv285T7.seq::::::::::::::: GGTGGCGCAATGACCGAAACCACCCCAGCCCCGCAAACCCCGGCGGCCCCGGCCGGGCCCGCACAATCGTTCGTGTTGGAGCGGCCCATCCAGACCGTTGGGCGCC GTAAGGAGGCCGTGGTACGAGTGCGGCTGGTGCCCGGCACCGGCAAGTTCGACCTCAACGGCCGCAGCTTGGAGGACTACTTCCCAAACAAGGTGCACCAGCAGTT GATCAAGGCACCCCTGGTCACCGTGGATCGGGTGGAAAGTTTCGACATCTTTGCCCACCTGGGCGGCGGCGGCCCGTCGGGTCATGGCCGGCGCGCTGCGCCTGGG TATCGCCCGGGCATTGATTCTNGTATCGCCGGATGACCGGCCCGCGCTGAATAANGCCGGCTTCTTGACCGTGATCCACGCGCCACCGAACGCAAA Clone Rv286 :::::::::::::::Rv286SP6.seq::::::::::::::: CACAATAGATTACTCAAGCTTCGAACCAGCGGCCTTATCACGTATCCCCGCTGAGACCTTGACCCTTAGGGCCGAAGTGACTTCGCTGCTGCTATGCCGACACCCG ATTTCCAGACGCTGCTGTTACACGACGGCCGGGCCGGTGGCCACCATCACGCTCAACCGCCCGGAACAGCTCAACACCATCGTCCCGCCCATGCCCGACGAGATCG AGGCCGCTATCGGGTTGGCCGAGCGCGACCAGGACATCAAGGTCATCGTGCTGCGCGGTGCCGGCCGCGCCTTCTCCGGCGGTTACAACTTCGGCGGCGGGTTCCA ACATTGGGGGCAT :::::::::::::::Rv286T7.seq::::::::::::::: TCAGGACGCTTATGGTTGGCAGATGGTCGCCCTGGCGTCGAATACGCGCGAGCGCATGAGCTCACCGGTTCGGAACAACGTATCGAAGAACGTCGCACTGCTGGCA GATGGTATCTCCGATGTGGTTGTAATTTGTATCCCAACTCTAACTGTGCTATCGGATCAGCGTGAATATCGAGATATTGCGAATGCGATGACAGGCCGCCATTCGG TTTATTCGCTTACGCTTCCCGGGTTCGATTCGTCTGATGCACTGCCGCAAAACGCGGATATGATTGTTGAAACCGTATCTAACGCAATTATTGATGTGGTAGGCGG CAGCTGCCGTTTTGTGCTGTCGGGCTATTCATCGGGTGGGGGTGTTTGGCTATGCCCTCTGCTCCCAT Clone Rv287 :::::::::::::::Rv287SP6.seq::::::::::::::: CGCAGCTGTCGCCGATCTGGTCCGGAATACCAGCTCCAGGTTCTGAGTGGAAGATGAGTGCGGGCCATCGAAGTGTTGTCAATGTACTCCAGGATGTCAGGTGCCG GCCGCTGGCGAGGATCTTGGGCACCGCCGCCATGACTTGGTCGAAGTCGGCGAACGGGGCGAGCACGCTGGCGTCGTGGTC :::::::::::::::Rv287T7.seq::::::::::::::: GTAGTTCGTTCATCCAAACACAGTGCGGTACCGGCTCAAGCGGATCACCGACTTCACCGGGCGCGATCCCACCCAGCCACGCGATGCCTATGTCCTTCGGGTGGCG GCCACCGTGGGTCAACTCAACTATCCGACGCCGCACTGAAGCATCGACAGCAATGCCGTGTCATAGATTCCCTCGCCGGTCAGAGGGGGTCCAGCAGGGGCCCCGG AAAAGATACCAGGGGCGCCGTCGGACCGA Clone Rv288 :::::::::::::::Rv288SP6.seq::::::::::::::: TCCGCTCGCTTCTCCGAGAGGTTGAGTGCCAACGCTCTGCCGATGCCCGAAGCCGGCCCCGGTGATGACGGCGACCTTGCCTTCGAATGAGCTCATTTGACTACTC CCCGTGGTTGTCCCTGCGATTGGTGGAGGTGGCCGCGCAGCCTTGCCCCGAGGTCGGCGATCGCGTCTCGGGCTTCGGGGAGCAGACTGACCTGCAGATGGAAGTC GTGCCACATGCCCGCGAACCGGCGATGCTCGATGCTTGTTTTCGAAGCGGCGCAGGCGGTTTCGATCTTGTCCGCGTCAACACNGATCGGATCGTCGCCCGCGGTC TGCATGACGAATGGGCG :::::::::::::::Rv288T7.seq::::::::::::::: ATGGGAGGCCACCGATTACCATCTTGCACACACCGATTCCGGGCTATTGATGTCCACGTTCGGTCCGCGAACCGCGCTGTGGCTGCTGCTGGCCAAAGGCGGAGGC GATACCGAAGTCAGTGCCCAAGCTTGGGTTCCACGCTCGCGCAGCCACGCCGTCACCTTTCCACGAGACCTCACCTGCCGATCCGAAATGGAATCGGCCGTGACGG AATTGGCGCAGCGAACACTCAACGAGGTGGTGGCTTCGTCGCGAACCGTCACCCGAGTCGCGGTCACCGTGCGCACGGCGACGTTCTACACCCGCACCAAGATCCG AAAGCTGCAAGCTCCCAGCACCGATCCCGACGTCATCACCGCTGCCGCCCGGCACGTTCTTGAACCTATTCGAGCTGGAATCGGCCGTCCGGTTGCTGGGAATTGC NGTTAAGAACTGGGCCT Clone Rv289 :::::::::::::::Rv289SP6.seq::::::::::::::: GCTTTGCGCGCTTCTCCGAGAGGTTGGAGTGCCAACGCTCTGCCGATGCCCGAGCCGGCCCCGGTGATGACGGCGACCTTGCCTTCGAATGAGCTCATTTGACTAC TCCCCGTGGTTGTCCCTGCGATTGGTGGAGGTGGCCGCGCAGCCTTGCCCCGAGGTCGGCGATCGCGTCGCGGGCTTCGGGGAGCAAACTGACCTGCAGATGGAAG TCGTGCCACATGCCCGCGAACCGGCGATGCTCGATGCTTGTTTTCGAAGCGGCGCAGGCGGTTCGATCTTGTCCGCGTCAACGCAGATCGGATCGTCGCCCGCGGG TCTGCATGAAGAAT :::::::::::::::Rv289T7.seq::::::::::::::: CTCACGCAGCCACGCCGTCACCTTTCCACGAAGACCTCACCTGCCGATCCGAAATGGAATCGGCCGTGACGGAAATTGGCGCAGCGAAACACTCAACGAGGTGGTG GCTTCGTCGCGAACCGTCACCCGAGTCGCGGTCACCGTGCGCACGGCGACGTTCTACACCCGCACCAACATCCGAAAGCTGCAAGCTCCCAGCACCGATCCCGACG TCATCACCGCTGCCGCCCGGCACGTTCTTGACCTATTCGAGCTGGATCGGCCCGTCCGGTTGCTGGGAGTGCGGTTAGAAACTGGCCTAGAAACCGGCGGGCACAC CGCACCTGGGCGGGGN Clone Rv28 :::::::::::::::Rv28SP6.seq::::::::::::::: TGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAAT ACTCAAGCTTGATGCCGCCGAAACCGAGCGTGAGCACGCCGCCAGCCACCACNCGCGGGTCGGGCGCCGGGCCCGGGTCGCCANGCTGCTCCGCTCGGTGATGGCA CGCCACCGCGACACCACCCGGCTGCGCTACGTCGAGCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCGAAGTCGAAGTCGATA CCGATTGCGCATCCGCNGCCGCA :::::::::::::::Rv28T7.seq::::::::::::::: CAGGCATGCAAGCTTCACGTCCGTACGGCTCGGGTACGCTTCGGTCGCAGTGTGCAGTGATAGATGACGACCGGGAACCTCGTCTGCATCTTCCATAGCCCGCCAC ACCTTCAGTTGCTCACCGGAATCCAACCGGTAGAAGGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAACCCTCGGGTCCGGCCA GCACTCCGCAGGCTTCGTCGGGGTGGTCGCGACGCGCATGGGCCACC Clone Rv290 :::::::::::::::Rv290SP6.seq::::::::::::::: GCTTGTCTATCGTCCCGGCCAGGTCCGGCCAGTCAAGGTCGAAGGCCAGTCCGGTCTCCTCTCCGACTACGGCCAAGAACTGGGCGACGGTGTCAGTGCAGACCAG CGGAAACTGGTGGCGCCCTAGGCGAGCGACCGCCTCACAAACGGCGGTGACCGCGTTCTGGTCGTGCACCATCGAGCCGTGCCCAGCCCGGCCGCGTGCCGTCAGC CGCATCCACTGGATGCCCTTCTCGGCGGTTTCAATCAGGTACAGGCGACGTTCGCCACCATCGTGCCGGGGCACGGTTAGCGAGAAACCGCCGACTTCACGATTGC CTCGGTGATGCCGTCGAAACAGATCGGGCCT :::::::::::::::Rv290T7.seq::::::::::::::: GCGCGCCATGTTGAGGTTGTCCGACGGTGACGACGGTGAACCACAACTGTTTGACCTGTCCGCACACACCGTGTGGATCGGCGAGCGGACCCGACAAATCGATGGC GCGCACATCGCGTTTGCCCAGGTGATTGCTAATCCGGTCGGGGTCAAGTTGGGCCCCAACATGACCCCGGAACTGGCCGTGGAGTACGTCGAGCGGCTCGACCCGC ACAATAAGCCGGGCCGGCTGACTTGGTGAGCAGGATGGGCAACCACAAGGTCCGCGATCTGTTGCCACCGATCGTGGAGAACGTCCATGCCACCGGGCATCAGGTC ATCGGC Clone Rv291 :::::::::::::::Rv291SP6.seq::::::::::::::: TTGCCTTCCATGCCGAGCAAGGTCGACTCAGCGATGACGAATTGTTCTTCTTCGCGGGTGTTGCTGCTGGTTGCGGGCTATGAGAGCACTGCTCATATGATTAGCA CATTGTTTCTGACGCTGGCCGACTATCCAGATCAGCTGACACTCCTTGCGCAGCAACCAGACCTGATCCCGCCGGCGATCGAGGA :::::::::::::::Rv291T7.seq::::::::::::::: CGACGCTGGGCCCAACTGCGACCACCAGGTCCTGGTATGGCAGGACATGGCCGGGTTCAGCGGCGCCAATACCG Clone Rv292 :::::::::::::::Rv292SP6.seq::::::::::::::: TAACGACTCGGGTCCAGCGACCGCGCCAACACNAACGGCCGGACNACGTGGGCCAGGGTCGCGGCCTCCCCTACAAACAGGATCCGTTGCCTGCGAACGACAGGCT CCGGTGCGGCGTTGGGCGCCGTGCTCGTCCCAGCGTCCGGTCCCGGGTCGCCGGCGACGCTTGTTTCCTCCATACTCGCCCCCTAATCTCGAGGCAGCCCGTACCC GCAGGCAACCTCCCAAAAATGCAATCCCCCAAAATGCAATGCGTCNAGCTATTTCTCACACCGACCGCTAGTTGCGGATCANAAATCCGTTGGGCGCGGA :::::::::::::::Rv292T7.seq::::::::::::::: CNTGGCGGTGGGTGCGGTGTCGAACACGACCACACTTCTTTGCGGTTCGGTGATCTCGACACCGGCCGCGAGCCGACCACCATGCGCGCGTAGATCGGCGATCAGC GCGTCGGCTATCGCCTGGGTGCCGCCCACCGGAATCGGCCAGCCGACCGAATGGGCCAGCGTTGCCATCATCAGTCCGGCGCCGGCCGACACCAGTGACGGCAACG GTGAAATCNCGTGGGCGGCAACGCCGGTGAACAACGCGCGGGCATCCTCGCCCGCCAGCGACCGCCAGGCAGGGGTGCCCTGGGCCAGCATCCGCAGCCCGAGACN CAGGACCGANCCCAGTG Clone Rv293 :::::::::::::::Rv293SP6.seq::::::::::::::: GCTTTTCNGATCGCAGCGAGTCGTACCCGCGCCGGTCACCTTCGTGGATATCGCCGGCCTGGTCAAGGGGGCGTCCGAGGGAGCCGGGCTGGGTAACAAGTTCCTG GCTCATATCCGCGAATGCNACGCCATTTGTCAGGTGGTGCGGGTGTTCGTCAACAACNACTTGACTCATGTCACCGGACGGGTCGATCCCCANTCCGACATTGAGG TCGTCGANACCGAGCTGATCCTGGCANATCTGCAAACCCTGGAGCGGGCCACGGGCCGGCTGGAGAAGGAANCGCGCACCAACAAGGCGCGCAAGCCGGTCTACGA CGCGGCACTGCGTGCCCAGCAGGTGCTCGACGCCGGCAANACGCTGTTCGCCGCGGGGGTGGATGCCG :::::::::::::::Rv293T7.seq::::::::::::::: GTCGTACGCCATTNGTCGGTGTGCGCATACCAGTACGACGCGCCGGGCACCTGACGCGGCGGCCGCGACCAGTCGGTGGCCATCGCCATCGTCTGCCACCCGGTCA ACGGACGCACCTTCTCCTGGCCGACGTAGTGCGCCCACCCGCCGCCGTTGCGTCCCATCNATCCGGTCAACATGAGCAGCGCCAACACCGAGCGGTACATGACATC GCTGTGGAACCAGTGACAGATTCCGCCGCCCATGATGATCATCGACCGTCCTCCGGATTCGGTCGCGTTGCGGGCGAAATTCCTTGGCAAACCGGATTGCCTGCGC GGCCGGCACACCGGTGATCGACTCCTGCCAGGCCGGGGTGTTCTGCTGGGTTCGGTCGTGGTACCGGT Clone Rv294 :::::::::::::::Rv294SP6.seq::::::::::::::: GCGAGGCGGTATCGCTTCCCGTCGTACCGGCGACCGCCAGCCGAGAAGCTCGTTTTCCCAGTGTTGCTGGGGATTCTCACGCTGCTGCTGANTGCGTGCCANACCG CTTCCGCTTCGGGTTACAACGAGCCGCGGGGCTACGATCGTGCGACGCTGAANTTGGTGTTCTCCATGGACTTGGGGATGTGCCTGAACCGGTTCACCTACNACTC CAAGCTGGCGCCGTCTCGTCCGCAGGTCGTTGCTTGCGATAGCCGGGAGGCCCGGATCCGCAATGACGGATTCCATGCCAACGCTCCGAGTTGCATGCGGATCGAA TACNAATTGATCACCCA :::::::::::::::Rv294T7.seq::::::::::::::: TGGGTCTTGCCGGCGAGCCCAGCGAAGTCGCTAGCGTGGCCGTGTTTCTTGGCTTCGGATCTATCCTCGTTACATGACCGGCACCGTGTTGGACGTGACTGGCGGC CGGTTCATATGACACCGAGATCATTGCCACGGTACGGCAATTCGTCAAGAAGGAAATCTTTCCCNATGCACCGGCCCTCGAACGTGGCAACAGCTACCCGCAAGAA ATCGTCGATCGGCTGGGTGTTATGGCTTGCTCGGTCGCCGGCTGCAAGGGTATCGACACCACCGAGTTCATTCTCGGGCGTGCCGGCCGCATTCGAGCTGCCGGTG CGCGCTGCCCAGCACCGTCATAAGTACTTGANGATGGTCAAACGTCGGACGAACCGCCACCACGTCGCTGCCGAACGG Clone Rv295 :::::::::::::::Rv295SP6.seq::::::::::::::: TAGATGCCCAAGCTTGCCNTTANAGACCTCGTCGACCAAGCACGGACGCGACCGTCGAAGGTGGCGAATCCGGGCTTGGCGTCNACCCGCGTAAGGCAGACCAGAT GGTTCGCGGCACGGTCAACCTGCCACACGGCACTGGTAAGACTGCCCGCGTCGCGGTATTCGCGGTTGGTGAAAAGGCCGATGCTGCCGTTGCCGCGGGGGCGGAT GTTGTCGGGAGTGACGATCTGATCGAGAGGATTCAGGGCGGCTGGCTGGA :::::::::::::::Rv295T7.seq::::::::::::::: TCTCCACGGCGTGGATCAAGGTACCGGCCGGGATGTTGCGCAATGGCAGGTTGTTGCCCGGCTTGATGTCTGCGTTAGCGCCGGATTCCACCACATCCCCTTGCGA AAAGTCCGTTGGGTGCAATGATGTAGCGCTTCTCCCCATCGAGATAGTGGAGCAACGCAATCCGTGCGGTACGGTTCGGGTCGTACTCGATGTGCGCGACCTTGGC GTTGACACCATCTTTGTCATTGCGGCGAAAGTCGATCATCCGGTAAGCGCGCTTATGACCGCCGCCTTTGTGCCGGGTNGGTAATCCGGCC Clone Rv296 :::::::::::::::Rv296SP6.seq::::::::::::::: GCCCGGTTCGATCGGGCATGTCCGCAGTCGTCGTTACCGGAGGCGGTCGTGGCCGCGCTAATCGGCGTCGGCGCCGACAAGATGTGGGATATCCGCAATCGGGGCG TCATCCCTGCGGGCGCGCTCCCCCGCGTCCGAGCCTTCGTCGACGCAATCGAGGCAAGTCACGACGCGGATGAGGGGCAGCAGTGAATTACAGCGAGGTCGAGCTG TTGAGTCGCGCTCATCAACTGTTCGCCGGAAACAGTCGGCGACCGGGGTTGGATGCGGGCACCACACCCTACGGGGGATCTGCTGTCTCGGGCTGCCGACCTGAAT GTNGGTGCGGGCANCGCCGGTATCNACTCCCGTGGAACACAGCCGGGGC :::::::::::::::Rv296T7.seq::::::::::::::: CTCGGCGTGGATATCGGTGTAGCCGGCGCCGGTGAANGTCGGCTCCTTACGTCCACTCGACAACAGCTCATAGCGATCCAACCAGTANGCAACCGCCTTCAGCAGT ACAACCGCGCCGGCGAACACTGCGAGTTGAACGCGAGCTGCCTGGGTCAGCATGCCTCTGCCGGTTGTCAGCCGAAGGCCGCCGAACAGGTAATGCGTCAACAGGC TCGCTAGAAACGCCAGAACCACGGCCACGAACAGCCAGTTCAGCACCGACCGGTAGAACGGCAGATCGAAGACGAAAAAACCCAATGTCATAGCCGAATTCGGGGT CCACGATGCCAAAGGTGCCCCCCGTGTACAACAACTGAACTTCACCCA Clone Rv29 :::::::::::::::Rv29SP6.seq::::::::::::::: TCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTC AAGCTTCACGTCCGTACGGCTCGGGTACGCTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTCAGT TGCTCACCGGAATCCAACCGGTAGAAGGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCAGCACTCCGC AGGCTTCGTCGGGGTGGTCGCGACGCGCATGGGCCACCATCGCATTCACCAGGTCTGCGCGAATCACCAGCACGTAGACGGTTCCTTTCCTAAGCAACACCGAAGT TTCAGGACCGAATGCTCCGGGAAACATGTCA :::::::::::::::Rv29T7.seq::::::::::::::: CAGGCATGCAAGCTTGATGCCGCCGAAACCGAGCGTGAGCACGCCGCCAGCCACCACGCCCGGGTCGGGCGCCGGGCCCGGGCCGCCAGGCTGCTCCGCTCGGTGA TGGCACGCCACCGCGACACCACCCGGCTGCGCTACGTCGAGCCATACCGGGCGGAGCTCCATCCGCTCGGCCGCCAGTGTCCGGGCCCTC Clone Rv2 :::::::::::::::Rv2SP6.seq::::::::::::::: CCTGCATCCGGCTCGTATGTTGTGTGGAATTGTGANCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGA ATACTCAAGCTTCCAATCCCCCTGCCCTGATACGCGTCGGCAACCGTGAACGCGATCTCGGCGACCGTCGGATCGGTTTCATCCCGCACAAAACGCGCGTCGGCTA CGGGGTCGCTTCCGTCGGTCACCACCCAGACGAAGTGGTCGACGTAGTCGACTTCCGACAGGTAGTGCATCAACGCCGGACTGGGAACACNAGCCGACTGAACCCG TCGATACAGCGTCTCNCCGGAGAACTGGATGTGTCCGTGCACGGTCCGCTCGCGGTCACCGGGCAGCACGGGGCGTAACATCAGTTGAGTCCCGTCGGCAAGCCGT ACCGGAATCGGGGAGACGA :::::::::::::::Rv2T7.seq::::::::::::::: CAAGATGATCGCCGGTGCCACCCCGATCCGTGCCTCGGTCAGCGCGAACGTGCTTTCCGGTCCGGCGACCACCATGTCGCACGCACCGACCAGGCCGAACCCGCCG GCCCGCACATGCCCGTTGATGGCGCCGACCACCGGCAGCGGCGACTCGACGATGGCGCGCAACAGCGCCGTCATTTCCCGCGCCCGCGCCACCGCCATCCGGTACG GATCACCACCACCACCGCCGGCCTCGCTGAGGTCCGCGCCGGCGCAGAACGTTCCGCCGGTATGCCCCAGCACGACCAGCCGCACCGCCGGATCTGCTTCGGCCGC ACTCAGCCCTTGATGTAGTTGGCTGACCAGCGTGCTCGACAGCGCGTTGCGGTTGTGCGGAGAGTTCAGTGTCAGCCTGGCGAAGGGGCCGCCGCAGGCGGCCGGG CCAGCGTAGTCGACGGGGCTG Clone Rv301 :::::::::::::::Rv301SP6.seq::::::::::::::: CTCAAGCTTCGATCGACAGTACTCCCGCCTTGGGTCTGGTCTTCGAGCTGGTCGGTCATGGTCGGACCTGCTGGTAGTGGGGATCTAACGCAACATGGTCGGGATT CATCATGGTGTACCCGTGATACCCATTCGCAGCTGCCGGTGAAACCCCGCGATGCCGGGATTTCCAGCCGACTAGGATGTCTAGCCGGCCAGCCGCTGCCGCCCGG ACTTCGGGATGTTCGGTATACCACCGATCGGCAATCTTGCNTATCCGCCGATGCTCGAACGCTAGCCACCCCAAACCAACCACTGTGACNACAATC :::::::::::::::Rv301T7.seq::::::::::::::: TGAATTTCCCGATCCCACAATCTCGGTTCAGATACAGGTCGCCATACCCCTTACTTCGGCAACGCTGGGCGGATTGGCCCTGCCGCTGCAGCAGACCATCGACGCC ATCGAATTGCCGGCAATCTCGTTCAGCCAATCCATACCCATCGACATTCCGCCGATCGACATCCCGGCCTCCACTATCAACGGAATTTCGATGTCGGAGGTCGTGC CGATCGATGTGTCCGTCGACATTCCGG Clone Rv302 :::::::::::::::Rv302SP6.seq::::::::::::::: TACTCAAGCTTGAACGCTGCGAGCGAGCCCATGTAGAGCGTTTGGTACCAAACCGATCGGTGGGCCAACTTGCCATGGGCTCACAGCGGCTATCGCGAGCGTGTAG CCGATCATCGGCCAGGCGACGGTGGCCTGAGCGGCAGGGGTTGCCTTATCCATCCTCTTGCGGCATGGTTGCCGCAGGGAGTGCCGGTAAGTCTGGTCGGCAACCT GGCCCGCTGCGGGTTGGGTTCGGATTCCCTCGGCTAGTAAGGTGCTCGCCTGGTGTTACAACGAATCGCTAGACAGCTCTTATCGGGAGTGGCCGTCGCGATCGTT GCGCTGCCGCTGGCGATCGCGTTCGGCNTTACCGCCACCGGAACGTCCCAAGGTGCGCTCATCGGGCTCTACGGCGCCATCTTCGCCGGATTCTTCCCNGCCGTGT TCGGTGG :::::::::::::::Rv302T7.seq::::::::::::::: GCGGTGTCTGAACTTCGCCCGTTCCCTCCAGCGCATTGAGCTTCAGCCCGACCGGCAGGTAGGGAGTCGGCATGCGGTCCTTCGCCCCGAGCCCGCTGGCTAAATA GCCACCCCCGAGCGCGGTCACGGTCTTTGCACCGGGACGACGGCATACCGGCAGCGCGAACATCGCCGCGGGCTGCAGCGTGAACGTCGAATACGAGTCGAACAGT GTCGGCGCGTAAAAACCCGAGCCGGCGGTCGCTTCGGTAATCAACGGCTCCTGCGCAACCAGCTGCAANTCNCCGGTGCCACCGGCGTTGACAATCTTGATNTCGG CGACCTCGCGCACCAN Clone Rv303 :::::::::::::::Rv303SP6.seq::::::::::::::: TACTCAGCTTCGGCTCAGGTGGTGCTGCTGGTAAAGTTCNCTGAACGGTGCAAGGTTTCGACAATGTGGTGCCGGTTCGGCGGGTACTGCCATCGAGACACTGGCG AGGCTATCGCACCCGTTATCGGCTACAAACAAATCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGAT CGCCGTCAAGCNTGTGTGCCGCGGATTATCAGGACTGACCTCCTGGCTGACCGGCNTGTTTGGTCNCGATGCCTGGCGCCCGGCCGGCGT :::::::::::::::Rv303T7.seq::::::::::::::: CATCACCTGGTTCATGAAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCGGGTGCAGGTGCTCGGGCAGCTCGGC CGCGACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACGAACGACGCCAGTCCGCTACGTAACCCCTCCGCGACTGTCCATGGACAACANCGCGTTCTC CACCGACCGGGCCCGGGTGTGGGGTGTT Clone Rv304 :::::::::::::::Rv304SP6.seq::::::::::::::: CTCAAGCTTCCCGGCGGCCAGTACCGAAAGCGCGAACAGCTCGCGGCAGCCCACAACNTGCTGCGTCGGATTGCCGGCGGCGANATCAATTCCAGGCAGCTCCCGG ACAATGCGGCTCTGCTGGCCCGCAACGAAGGACTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGCTTG ATGCCCGGTCGGCAAGCCCCGGCAGTTGCCAAACCCAGCGTGATCAGGCTCGGCTCGCGAGTTCGGCGAAGAAGTGGCTCGCCTGATCACCTACCATCGGCCAGGT CTGCGTGTCATCACNACGCTCGCCAAGGAAGGTTGTTGTGGTGCT :::::::::::::::Rv304T7.seq::::::::::::::: GCCACGTTTCGCGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGCGGGTAATCGCCGACGGTGCCGGTTCGCGAGCCGAAGGTGACGACGCT GATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCAGCAACGGCGCGAGCTCAACGACGTCAATCACGTTGTCGCTTTCTACGGTCACCGACCCGGTGACCGTAGTC GCCCGGTGCGCTCGGCCGAGAAGTTGCACCGCCACCACCGCGACACCGTCTTGCACGCGGACGCCACCCCCCGGATCGGTTGTTGGCCAAGGTAATTGGGTCATCC ATTTGACGGGACGCCGACCCCGCAGCCCCAGTACCGCCCACGACCACGCCGGCTGACCCCACCACTGTACGAACACCAAGGCGACGCCGACCA Clone Rv306 :::::::::::::::Rv306SP6.seq::::::::::::::: CTCAAGCTTGATGCCGCCTAAACCGAAGCGTGAGCACGCCGCCACCCACCACGCGCGGGTCGGGCGCGGGGCCCGGCGCCGCAGGCTGCTCCGCTCGGTGATGGCA CGCCACCGCGACACCACCCGGCTGCGCTACGTCAAGCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCGAGGTCNAGGTCNATA CCGATTTGCGCATCCGCAGCCGCACCCTGGACGACAGAACCGTGCCCTACGAGTGCTTGTCGGGCGGGGCCAAAGAACANCTTGGCATCCTGGCGCGATTGGCCGG CGCGGTCCTGGTC :::::::::::::::Rv306T7.seq::::::::::::::: CTCGGGTACGCTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTCAGTTGCTCACCGGAATCCAACC GGTANAANGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCAGCACTCCGCAGGCTTCGTCGGGGTGGTC GCGACNCGCATGGGCCACCATCGCATTCACCAGGTCTGCGCG Clone Rv307 :::::::::::::::Rv307SP6.seq::::::::::::::: CTCAAGCTTCAATTCCTCCACGACGCGTTCCCAAATGAATTTCCCGATCCCACAATCTCGGTTCAGATACAGGTCGCCATACCCCTTACTTCGGCAACGCTGGGCG GATTGGCCCTGCCGCTGCAGCAAACCATCGACGCCATCGAATTGCCGGCAATCTCGTTCAGCCAATCCATACCCATCGACATTCCGCCGATCGACATCCCGGCCTC CACTATCAACGGAATTTCGATGTCGGAGGTCGTGCCGATCGATNTNTCCGTCNACATTCCGGNGGTCACCATCACCGGCACCAGNATCGACCCGATTCCGCTGAAC TTCGACGTTCTCAGCAGCGCCGGAACCA :::::::::::::::Rv307T7.seq::::::::::::::: TTAACCCCCGTGGCCTCTACGCCGCCTNCGGGTCGAACATGCATCCCGAGCANATGCTCGAGCGCGCACCCCACTCGCCGATGGCCGGAACCGGCTGGTTACCCGG GTGGCGGCTGACGTTCGGCGGCGAGGACATCGGCTGGGAAGGGGCGCTTGCCACCGTCGTCGAAGACCCAGATTCGAAGGTGTTCGTCGTGCTCTACGACATGACC CCGGCGGACGAGAAGAACCTTGACCGGTGGGAAGGCTCCGAGTTCGGCATCCACCANAAGATCCGATGCCGCGTT Clone Rv308 :::::::::::::::Rv308SP6.seq::::::::::::::: CTCAAGCTTGATTTTGATCATCATGGATGATCATCACCCGAAGTGTGGTAGCCGCAGTGGTTATCGTGGGTACCGTCGTGCTTTCCATGGGCGCCTCTTTCGGGCT TTCCGTATTGGTCTGGCAGGACATTCTGGGTATCGAGTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCCTGGCGGTGGGATCCGACTACAATCTGCTG CTGATTTCCCGGTTGAAAAANGAAATTGGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGGAGTGGTGACGGCTGCCGGCATGGTGTTCG CCGTTACCATGTCGTTGTTTGTGTTCAGCGATTTGCGAATTATTGGTCAGAT :::::::::::::::Rv308T7.seq::::::::::::::: CGNCCAACCCGAATTGGTTTTCGGCGCCNTCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACCTCGATGCTGCCGCCATGGACGCG GTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCNCNGGCGTTACCGCATCCCGTTGACCGGGCGGATCGCGGTGATCGTCGATGACG GCATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCGATCGGCCCANACGACATCGTGGC GAGATTCGCCGG Clone Rv309 :::::::::::::::Rv309SP6.seq::::::::::::::: CGTGACTGCCACCGGGGCCACTCCGCAGAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTGTG TCNACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACNCAGCGGTTCCNCTGACCAATACGGTCGGTC CCACGATGACCCANTACTACNTCATTCGCACGGANAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCAACC AAACTTGAAGGTGATTGTTAACCTGGGG :::::::::::::::Rv309T7.seq::::::::::::::: TCGCTCAAGCGCNTGAGGCCGAANCGGCTGGTTACGACTCCCTGTTTCTGATGGACCACTTCTACCAACTGCCCATGTTGGGGACGCCCGACCAGCCGATGCTGGA GGCCTACACGGGCCCTTGGTGCGCTGGCCACGCGACCGAGCGGCTGCAACTGGGCGCGTTGGTGACCGGCAATACCTACCGCAGCCCGACCCTGCTGGCAAAGATC ATCACCACGCTCGACGTGGTTAGCGCCGGTCGAGCGATCCTCGGCATTGGAGCCGGTTGGTTTGAGCTGGAACACCGCCAGCTCGGCTTCGAGTTCGGCACTTTCA GTGACCGGTTCAACCGGCTCGAAAAGGCGCTACANAT Clone Rv30 :::::::::::::::Rv30SP6.seq::::::::::::::: ATACTCAAGCTTCCGCTGGGGCCTGTTCAACCATGGCGATCCCGTTGGTCCCGGACATCCCGAACGAGGACACCGCGACCCNCTTCGGTGTGTGATCATTACCGTT GGGCCACTGCGTAACCGCTTGCGGCACAAAGAGCCCGGTCTCGACGTCGGAAAAGCTCATCGGGCACCCGATTGAAATGCAGCAGCGGCGGCACCACCCGTGCCGC AGTGACAGAATTGCCTTGATCAGCCCGACGGTCCCCGCCGATGCCGTGCTGTGCCCCATGTTGCTCTTGGCCCGATCCAAGCGCGCAGGGGGTGCCGCGCCATACA CCCGCGCCAGGCTGCGGTACTCAATCGGGTCGCCGATTGGCGTACCGGTGCCGTGCGCCTCCACCACACCGACCGTTTCGGGCTG :::::::::::::::Rv30T7PEG.seq::::::::::::::: CAACAGCGTTCCAGCGGCATACCACCGCACATGCCGTGCACCCGGCGCCGGGCGGAGTCGCCGCATAACACANGTACACCTTGGGAATCGGTGTGCGCCAGGGATT CNACCGCGGGGTGGGGCCGGCGATCGCGCGCCAGGTCGAGTTGGCGCCGACCGTGATNTCACCGCGACGTAGTTGGCGTTGTGGTCCGCCATCCGCGCGGCGGGGC ACGGCGCGGGCCGCCACCACGATGTCACGGAAGCCGGGGGCGAACGCTCGACGACCTGGTTACCGTCTCNGTCGCNTCNANCGTGGACCCGACNGCACGTGGGCAT ATGTCCANAACGGACGNGGCCGGTTTCNTCGATGCNGCCGGGGTCCGCGACNTGCGGACNCNCNGNCACACCATCCGCCAGTCCGCGTGGCGTCCCGCCGCGACTC TGCCTCGGCCGCGCCA Clone Rv310 :::::::::::::::Rv310SP6.seq::::::::::::::: CTCAAGCTTTGNCGACGATCGGGCGATGTCGATGANAGGAAACCCCAGCGCACAACCGACNATTTTGGCGTAGCCGGCGGACNTCTGCTCGATTCCGATCACGTCG GCGCTCGCATCGAGCATGGCGCCGGCGACGGCTAGCAGCGATCCGCCGTCGTCGAGGAACACGACACGAGCCGTACGCCCGGCCGTAAGCCGCGCCCAGGATTCGG CGAAAAACCGTTCTACGTGGCGGGTGTACTGGGTGTCCAATGATTCGTGGGGTGCGTAGGCGTCGCTGCAATCGTCGACATAAATGCCGTCGGCCCGCATCGCGTC AACAACTCCCGGGTGAGTGGAATANCACTTGCCGA :::::::::::::::Rv310T7.seq::::::::::::::: TCCAACGCGGTGACAGATTTGTCTATCCTGGACCTGACGGTGAGGTCGAAGTTTTCCAGGAATTCGGCAAAATCGGTAAGAGCCTGAAGAATTCGGTATCGCCGGA CGAAATCTGCGACGCATACGGGGCAGATACGCTTCGGGTTTACGAGATGTCGATGGGGCCGCTGGAGGCTTCACGTCCATGGGCCACAAAGGATGTTGTCGGCGCG TACCGTTTTCTGCAGCGGGTGTGGCGCTTGGTCGTCGACGAGCACACCGGCGAAACTCGGGTGGCTGACGGCGTGGAACTCGACATCGATACGCTACGGGCGTTGC ACCGCACCATCGTCGGCGTGTC Clone Rv311 :::::::::::::::Rv311SP6.seq::::::::::::::: CTCGTCCTTGACTACGCCCAGTATCGAAANCCTCCTGTGCCGGTNCGCTAAACACCCGGCGGACACTCANACGGTGCTGGTGGTGCGGCATGGCACCGCGGGCAGC AAAGCGCACTTCTCCGGGGACGACAGCAAGCGACCGCTAGACAAGAGGGGTCGTGCGCAGGCAGAAGCGTTGGTACCACAGCTGCTGGCGTTCGGCGCCACCGATG TTTATGCCGCCGACCGGGTGCGCTGCCACCABACBATGGAGCCACTCGCCGCGGAACTGAACGTGACCATACACAACGAGCCCBCCCTGACCGAAGAGTCCTACGC CAACAACCCCAAACGCGGCCGACACCGAGTGCTGCAGATCTTCG :::::::::::::::Rv311T7.seq::::::::::::::: GTATCGCCTCCNCCTTTGGCCACCAGCAGCCACAGCGCGGTTCGCGGACCGAACGTGGACATCAATAGCCCGGAATCGGTGTGTGCAAGTTGGTAAACGGTGTTGA TCCCAAGCTTTGCCAGCCTTTTCGTAGTCTTGGGCCCCACACCCCACAGTGCTTCGACGGTACGGTCACCCATGATGGCCATCCAGTTGGCATCGGTGAGCTGATA GATGCCAGCTGGTTTCGCCAACCCGGTAGCGATCTTGGCGCGCTGCTTGTTGTCACTGATACCTATCGAGCAAGACAGCCCGGTTTGCGACAAGATGACTTTTCGG ATCTCTTCNGCGAACTTCCAATGGGGGTCTCCGGANT Clone Rv312 :::::::::::::::Rv312SP6.seq::::::::::::::: CTCAAGCTTTTGGTCTAGCCGGCCGAGCACGATACGGGTGTCCTTGGCCACCGGCGGCGGCTGTCCGGGAAATGGCGGGTCCCCGGTGGTTTTGCTGANGANTGCT GAACCGTAGTCGAAGTGGGCGGCGTCAGACTCCACCCAGCCAGCAGGCAGCGCGAAGCTGAATCCTCCAACCGGGTTGTCGATCCGGACAGGTTGGGTGCGTTTTG GGGCAATGACAGGTGGCGGCGGTGCGTTCGGGTCGGCCGGCGGAGGTGCTGCGTTGGGATCNCCCGGCTGGGCATTCGGCNTTNTTGGCGGCGGCCGGTGGTGGGG GGCAACANGTGTCCCGGTGCGGGTGGCGCTGC :::::::::::::::Rv312T7.seq::::::::::::::: ATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCCGCGGTACCCGCTCAACTTTCTCTCGACCCTCAACGCCATTGCGGCACCTA CTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGC ACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCT ACGGCGACCCGGCCTATGGTTATTCGACCTCGCCGCC Clone Rv313 :::::::::::::::Rv313SP6.seq::::::::::::::: CTCAAGCTTGCAATGCGGGTCGGGATGCCCATGGTTGGAANATGGTCGCCCTGGCGTCNAATACGCGCGAGCGCATGAGCTCACCGGTTCGGAACAACGTATCGAA AAACGTCGCACTGCTGGCAGATGGTATCTCCGATGTGGTTGTAATTTGTATCCCAACTCTAACTGTGCTATCGGATCAGCGTGAATATCGANATATTGCGAATGCG ATGACAGGCCGCCATTCGGTTTATTCGCTTACGCTTCCCGGGTTCGATTCGTCTGATGCACTGCCGCAAAACGCGGATATGATTGTTGAAACCGTATCTAACGCAA TTATTGATGTGGTAGGCGGCAGCTGCCGTTTTGTGCTGTCGG :::::::::::::::Rv313T7.seq::::::::::::::: CAAATACACGCCGGACGCACAGGCGGACATCGCCATCCCGAGCACACCCAAAACGGGATACAGGATGGAGGCCAACGCCACGGCCGCGCCCAGGATCACCAACCAC ACCGGCTTGGTCAGCTTGTCGGCGGCGGTATAGGCATCGGGCCGCTGCAACGCAGCATGCACAAACGCGTACACCGCTGTCACCAAGACGGCGAGCAGCAATACCA GCATGACGGTACCCACGAGGTGGCTCACGCATTCAGACTATGCGGTTTGCATCCAACACG Clone Rv314 :::::::::::::::Rv314SP6.seq::::::::::::::: CTCGTCCTTCGGCCTCGCTGCAGGAGTGGGAGCCGCAGGGCTGGAAATCCGAAAAACGAGCCGGTGATCGCACTGTCGCCGATCGGCGCCGCACCTGGTTGGTGTT ACGGATGAATCCGCAGCGAAATGTGGCTGCGGTGGCGTGTCGTGACTCGTTGGCGTCGACGCTGGTGGCAGCCACCGAGCGGTTGGTCCAGGATCTGGATGGGCAA AGTTGTGCGGCCCGGCCGGTGACGGCCGATGAGCTGACCGAGGTCGACAGCGCCGTGTTGGCTGACTTGGAACCGACATGGAGTCGCCCCGGTT :::::::::::::::Rv314T7.seq::::::::::::::: GTCTAGNCCGCCGAACACGATACGGGTGTCATTGGCCACCGGCGGCGGCTGTCCGGGAAATGCGCGGGTCCCCGGTGGTTTGCTGAAGANTGCTGAACCGTAGTCG AAGTGGGCGGCGTCAGACTCCACCCAGCCAGCAGGCAGCGCGAAGCTGAATCCTCCAACCGGGTTGTCGATCCGGACAGGTTGGGGTGCGTTTGGGGCAATGACAG GTGGCGGCGGTGCGTTCGGGTCGGCCGGCGGAAGTGCTGCGTTGGATCGCCCGGCTGGGCATTCGGCGTGTTGGCGGCGGCCGGTGG Clone Rv315 :::::::::::::::Rv315SP6.seq::::::::::::::: ATCAAGCTTGAGATTGGGCGTCAACGGGTGTCGGCACCGGCGTCCTGCAGTTGGTAGGCCTGCAGTTTGTGCATCAGGCCGATGCCGCGGCCCCTCGTGCCACGCA TGTACANCACCACGCCGCGCCCCTCACGGGCGACCATCGCCAGCGCGGCGTCCAGCTGAGGCCCCGCAATCGCAGCGGCGTGACCAAACACATCGCCGGTCAAGCA CTCCGAATGCACCCGGACCAGCACGTCG TCACCGTCGGCGTTGGGCCCGGCGATCTCGCCGCGGACCAGCGCGACATGTTCCACGTCCTGTAAATGCTGGTGTANCCGATGGCGCGAAACTCCCCCATGACAAN TCGGAATCCCGCGCCTCGGCGACCCCGCTCAATGTTGCTTCTCNTGCTTG :::::::::::::::Rv315T7.seq::::::::::::::: TCGACNAGCATTCTTGACNGTTGTTTTGGCTCGGCATGGTTAGCCAAGGTTCTGCGGTCCCACCAGATCATCTTGGTCCGGTAGCGCTCGTCCGGGTATGCTGCCG CCGGGATTCTCGCTGCTATTACTCCCCCCGAAGAACGCCACCGGTCCAGCGCGTGGCCGCCGCGGTCCCCATCACAAACTGAACCCCCAACAGGGGGACATGCTTA GCGGTAGGGCGCGCGCCAAGGCGGCAGCAATCGCATCACTGCGCTGCGCGTCACTATTAACCCAGCCGGACTTCACTTCCACGACCCCCGAATGGCGCCGGTCATT GATCATCTTGCGCACCCGCGGATAATCCGGGAT TG Clone Rv316 :::::::::::::::Rv316SP6.seq::::::::::::::: ACCGGGGCCACTCCGCACAATCTGTACCCGACCAANATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGGCGGTACCCGCTCAACTTTGTTCNACCCTCA ACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCNGCGGTTCCGCTGACCAATACGGTCGGTCCCACNATGAC CCANTACTACATCATTCGCACGGANAACCTGCCGCTGCTAAAGCCACTGCGATCGGTGCCGATCGTGGGAACCCACTGGCGAACCTGGTTCAACCCAAACTTGAAG GTNATTGTTNACCTGGGCTACGGCGANCCGGCCTNTGGTTATTCCACCTCNCCGCCCAATGTTTGCNACTCCCGTTCGGGGTTGTTCCCNAAGGTCAAACCC :::::::::::::::Rv316T7.seq::::::::::::::: CGCTCAAGCGCNTGAGGCCGAANCGGCTGGTTACGACTCCCTGTTTGTGATGGACCACTTCTACCAACTGCCCATGTTGGGGACGCCCGACCAGCCGATGCTGGAG GCCTACACGGCCCTTGGTGCGCTGGCCACGGCGACCGAGCGGCTGCAACTGGGCGCGTTGGTGACCGGCAATACCTACCGCAGCCCGACCCTGCTGGCAAAGATCA TCACCACGCTCGACGTGGTTAGCGCCGGTCGAGCGATCCTCGGCATTGGAGCGGTTGGTTTGANCTGGAACACCGCCAGCTCGGCTTCGAGTTCCGGCACTTTCAG TGACCGGTTC Clone Rv317 :::::::::::::::Rv317SP6.seq::::::::::::::: CTCAAGCTTGCGTTCGATGAAGTAGTCGTCGGTCAGCGCCGCCTCTTCGAGCTCCTTGGCGATGCCCAGCAAGGAGTCATCGCCGCCGAGCTTGGCCAGGATCTTG TCGGCCTGTTCCTTGACGATGCGGGCCCGCGGATCGTAGTTCTTGTAGACACGATGACCGAAACCCATCAATTTGACCCCGGCCTCGCGGTTCTTGACCTTGCGTA CAAACTCGCTGACGTCGTCGCCGCTGTCGCGAATGCCCTCGAGCATCTCCAGGACAGCCTGATTGGCGCCGCCATGAAGCCGGACCCCATAGTGCGTTGATGCC :::::::::::::::Rv317T7.seq::::::::::::::: GGTCAGGCCCGAGCAGGCGCGAGGAACGACGAACCCAACAAGCCATGGTGGTTGGCGCCGTCGAGAGGTCGGCGGTCGCACAACGGGAAGATCGCCTTGAGCGTCG CTCGACCGCCGCCTCGAGTTGGGTCATAACGAAGTAGCTGATGCCGATCATGTCGACGTTTCCGTCGCATCAGCGTGCAGCGGCGACCCACTCNACCGAGGTCTCG TGCCGCCGCGGCCAGGGCACCAGCAGTGACGAGTCCAGGCCGCCGTCGGGCCAAGCAGTCGCGGTGCCANCCGTGGTGGGTCCGGCGATGGTTGGTGTGCTCATTT CGGGAACGCCA Clone Rv318 :::::::::::::::Rv318SP6.seq::::::::::::::: CTCGAAGCTTTAACAGCATCAACCCCGCCCCGCACCAGCACCGACACNATGTCGATGCCATCGAAGGTGAATGTCGAACTGGCGCAAACCATCGCGACCGCGACCA CCGGCAACATGGGTACCGGCGATTTCCGGTGCCAATGCCGACCCGACGGGCCGCTCTCACCGCAGGTGACCTCGATCACCGAGACCANCCGGCCGTTNTNNTCACG CACCCCTACCGTGTCACGCCCAAAACGGCGCTGGTGGTCGATTGCCGGAGTGCACCCCNCACCCCAGTGTGCGTCCCCGGATCC :::::::::::::::Rv318T7.seq::::::::::::::: TGATGCCGCACCCGATCGACGGTCGTTGGTCGGGGTTGACTGGCGCCCGGCGAAGCAGGGCGTCGACCGCGGCCCGGACGTCGGCGGCCGTCACCGGGTCGGCCAT TGCCCGGGCGGGAGTCGTCGAGCTGACCACGGTAGACAAGTCGGCGCTGGCCGTCGAAGACNAACGTGCGGGTGTGCAGGCCGCGGAGAAGGCGCCGGCGACNTTC TTGGGTTTCGTCGTANAGATACGGGAACGTCCAGCCGTGGCGGCGGGCCTCGGCGACCATCTGATCGGCCCGTCC Clone Rv319 :::::::::::::::Rv319SP6.seq::::::::::::::: TTTCGGGCGAGGCGGTATANCTTCCCNTCGTACCGGCGACCGCCAGCCGANAAGCTCGTTTTCCCAGTGTTGCTGGGGATTCTCACGCTGCTGCTGANTGCGTGCC AAACCGCTTCCGCTTCGGGTTACAACGAGCCGCGGGGCTACNATCGTGCGACGCTGAAGTTGGTGTTCTCCATGGACTTGGGGATGTGCCTGAACCGGTTCACCTA CNACTCCAAGCTGGCGCCGTCTCGTCCGCAGGTCGTTGCTTGCGATAGCCGGGAGGCCCGGATCCGCAATGACGGATTCCNTGCCANCGCTCCGAGTTGCNTGCGG ATCGACTACNAATTGATCACCCANAACCATCGGGCGTNTTACTGCCTGAAGTACCTGGTGCGGGTCGGATACTGCTATCCGGCGGTGACAACCCCGGCAAGC :::::::::::::::Rv319T7.seq::::::::::::::: GTTTTGGCTCGGCATGGTTAGCCAAGGTTCTGCGGTCCCACCAGTCATCTTGGTCCGGTAGCGCTCGTCCGGGATATGCTGCCGCCGGGATTCTCGCTGCTATTAC TCCCCCCCGAAGAACGCCACCGGTCCAGCGCGTGGGCCGCCGCGGTCCCCATCACAAACTGAACCCCCCAACAGGACATGCTTAGCGGTAGGCGCGCGCCAAGGCG GCAGCAATCGCATCACTGCGCTGCGCGTCACTATTAACCCACCCGGACTTCACTTCCACGACCCCGAATGGCGCCCGGTCATTGATCATCTTGCGCACCGCGGATA ATCCGGGATTGCCAGCCCATTCNACTACCGCATGCGAGTCATCGGCTGACCGCAGCGGTC Clone Rv31 :::::::::::::::Rv31SP6.seq::::::::::::::: TCGCCTAGGCGGGCTTCCCCTTCCGTCCGAGCNGTCAGAAGCTCCTATGACAATGCACTACCCGAGACNATCAACGGCCTATGCAATACCNAGCTGATCAAACCCG GCAAGCCCTGGCGGTCCATCGAGGATGTCGAGTTGGCCACCGCGCGCTGGGTCGACTGGTTCAACCATCGCCGCCTCTACCGGTACTGCGGCGACATCCCGCCGGT CTAACTCGACGCCGCCTCACTACGCTCAACGCCAGAGACCANCCGCCGGCTGACGTCTCAGATCAGAGAGTCTCCGGACTCACCGGGGCGGTTCATCCCCACTGTC GATAGCGTCTGTGGATAACTTTGTCTGCA :::::::::::::::Rv31T7.seq::::::::::::::: GCGCGTNGAACTGATAGGTGCGGCCCGGCTCGAGCANGCCGGCCATTTGTTCGATGCGGTTACCGAAGATCTCTTCGGTGACCTGCCGCCCGCCGGCCAGCTCGGC CCAGTGCCCGGCGTTGGCCGCCGCGGCGACAATCTTGGCGTCCACGGTGGTCTGGGTCA Clone Rv321 :::::::::::::::Rv321SP6.seq::::::::::::::: CTCAAGCTTCAATACAGAGTTATAAACTGTGATAATCAACCCTCATCAATGATGACNAACTAACCCCCGATATCAGGTCACATGACGAAGGGAAAGAGAAGGAAAT CAACTGTGACAAACTGCCCTCAAATTTGGCTTCCTTAAAAATTACAGTTCAAAAAGTATGAGAAAATCCATGCAGGCTGAAGGAAACAGCAATAACTGTGACAAAT TACCCTCAGTAGGTCAGAACAAATGTGACGAACCACCCTCAAATCTGTGACAGATACCCTCAGCTATCCTGTCGTCATGGAAGTGATATCGCCGGAAAGGAAAAT Clone RV322 :::::::::::::::Rv322SP6.seq::::::::::::::: CTCAAGCTTCGATCGACATTACTCCCGCCTTGGGTCTGGTCTCCGAGCTGGTCGGTCATGGTCGGACCTGCTGGTAGTGGGGATCTAACGCAACATGGTCGGGATT CATCATGGTGTACCCGTGATACCCATTCGCAGCTGCCGGTGAACCCCCGCGATGCCGGGATTTCCAGCCGCACTAGGATGTCTAGCCGGCCAGCCGCTGCCGCCGG ACTTCGGGATGTTCGGTATACCANCGATCGGCAATCTTGCGTATCCGCCGATGCTCGAACGCTANCCACGCCAAACCAACCACTGTGACNACAATCGCCACCACAC CAAAGGTCATGCCCTCGGCGTGATGTCCGGTGCCGAAAGCCGCAAGAGCTCCGACGCCGCC :::::::::::::::Rv322T7.seq::::::::::::::: CATTCCCAATTGAATTTCCCNATCCCACAATCTCGGTTCAGATACAGGTCGCCATACCCCTTACTTCGGCAACGCTGGGCGGATTGGCCCTGCCGCTGCAGCANAC CATCGACGCCATCGAATTGCCGGCAATCTCGTTCAGCCAATCCATACCCATCGACATTCCGCCGATCGACATCCCGGCCTCCACTATCAACGGAATTTCGATGTCG GAGGTCGTGCCGATCGATGTGTCCGTCGACATTCCGGCGGTCACCATCACCGGCACCAGGATCGACCCGATTCCGCTGAACTTCGACGTTCTCAGCAGCGCCGGAC CCATCAACATCTCGATCATCGACATTCCGGCGCTGCCGGGCTTTGGCAACTCGACCGAGCTGCCGTCGTCGGGCTTCTTCAACACCGGCGGCGGTGGCGGCT Clone Rv327 :::::::::::::::Rv327SP6.seq::::::::::::::: CTCAAGCTTTCGGCGGAGACGGACANNTTGCGAACATTGATGACAAAATAGAAATCATTGATGGTTTGAGTCACCAGGCCGATCAAGCCTTCGCCGAGCCAAATTC CAATCAAGAGGCCCAAGCCCGTACCAATCAGCCCGGCAACGAGGGATTCCGTCATTATCAGCCAAAATAACTGCTCTCGGGTTACACCCAAACAGCGCAATATGGC GAAAAACGGTCGCCGTTGCAGCACATTAAATGTCACGGTATTG :::::::::::::::Rv327T7.seq::::::::::::::: AGCTTAACTGCTCCCTAATACCTGGGGCTGTGCCTGCGGTGTATGCACGGCATACGGACATCCNTCCCCTGAGACCCNCGGTCTAATCAGCCACGTGTCCACCATC AGGGGTCAACCCCGGCCAAGGGCGACGGCACCCCAAGTTCGCCGACCGTTAACCTATTGCTGTGAGCTTCATTTGCTGCGAGCAAAACAGTTGGTCGGCCGTTAGG AACTGAATTGACACTCAACCGATTTGGTGCCNCCGTAGGTGTCCTGGCTGCGGGTGCGCTGGTGTTGTCCGCGTGTGGTAACGACCACAATGTGACCGGGGGAGGT GCAACCACTGGCCACGCGTCCGCGAATGCTATTGCGGGGG Clone Rv328 :::::::::::::::Rv328SP6.seq::::::::::::::: CTCAAGCTTGGGGTGGCGCTGTCGGTCGGTGTGCTTGGCGGCGTCGGTATCAACACCGCCCACGAAATGGGCACAAGAAGGATTCGCTGGAGCGGGTGGCTGTCCA AAATCACCCTCGCCCAGACCTGCTACGGGCACTTCTACATCGAGCACAACCGTGGCCATCACGTCCGGGTGTCCACACCGGAGGACCCGGCGTCGGCGCGGTTCGG CGAAACGTTGTGGGAGTTCCTGCCCCGCAGTGTTATCGGCGGCTTGCGCTCGGCCGTTCATTTGGAGGCCCAACGGCTGCGTCGGCTCGGCGTCAGCCCCCT :::::::::::::::Rv328T7.seq::::::::::::::: GCACCAAGGCCCCACACGTCACCCTGTGACCTCCTGCGCCGACCCGCCCCGAGGTCCTGGCCGTTACAACCTGAACGGGCGAGCCCGGAGTCTGGTACGCATCGAA CAAAGAGCAAGGTGCATGGGCGGAGTTGTTCCGCCACTTCGTCGATGACGGGGTCNATCCATTCGAGGTCCGTCGCCGCGTCGGTCGAGTGGCGGTCACACTCCAG GTACTCGACCTCACAGACGAGAGGACTCGATCCCATCTAGGTGTGGACGAAAACAGTCTTCTGTCCGA Clone Rv329 :::::::::::::::Rv329ST6.seq::::::::::::::: TCGCCTCCGCATATGGGTCGACGCCAAGCGGGTCCGGATTTTCTGGGCTTCATCGCTCGCGCCGTCGCGACAAACAGCGCGGTCGACCGACACTCGTTGTGATGTC CCAGCTATCACCTTCGGTACGCACCCATCGACCCTACNCGGCTATCTCAGCCGCGATCTCCAGGCTCCGCCGACGGAGGTGCATCCCGGTCCGGATCCCCACTAAC CCGGCACCATTGGCGTCN :::::::::::::::Rv329T7.seq::::::::::::::: GTCCTCGAGTGCCGCCGTCGNCACNCCCAGCGCCCGCGCGGCCACTTGGATGCGACCCGTTTCAAGTCCCTTCATCATCTGCGAAAAGCCTTGACCCATGGCTCCG CCCAGGATCGCCGAGACCGGCACCCGGAGGTTGTCGAACGACAGCTCGCAGGATTCGACGCCCTTGTAACCCAACTTCGGCAAGTCCCGCGACACCGTGAGTCCCG GCCCGGGTTCGACGAGCACGATCGACATGCCTTGGTGCCGCGGTGTGGCGTTCGGGTCGG Clone Rv32 :::::::::::::::Rv32SP6.seq::::::::::::::: GGCATACCAATGTGGACTTCTGCTCACCCACGATATCCGTGGTCTGATCCGCTGCTGCGGCGGGCTGCNACCTGCNTTCTCNGCGGCACCCGTNACTACATGCNCG CGCCGCACGCATACGTCGCGGCGGGACCCACTCCNACTGGTCGACGGTGCTGGCCGCGTGTCCGCANGTCCCNAACCCGGCCGCACCCGACGAAACCGGCCGCGTC CGTTCTGGAGGCCAACGCTCATGTGCCGTCGGGTCCATGCTCGACGCCATCGAGACCGTAACCAGCGTCCTCGAGCGGTCGCCTCCGGCTTCCGTGACATCTTCGT GGCTGCTCGCGCCGTGCCGCCGCGCGGATGGTCGACCACAACGCCAACCACCTCGGCGGTGACATCACCGTCCGCGCCACTCGACCTGCGCGCCGATCGCGGCCC :::::::::::::::Rv32T7.seq::::::::::::::: GTGAGCAGACCTACGCCNCCTGGTTGCGCCAACTCGGTACCGATCATGGCGCGCNGCCTGTCGTCACCGATACCCAGCGAACAAGACAGCCCGGTCCGCGACAAGA TGACTTTCCCGATCTCTTCGGCGACTTCCATGGGGTCGTCCGGAAGTCCCGGGCGCCACCGCGAGGTAACCCTCGTCTCAGTCCCATACGCGACCGGGTATCACGT CGCGCAACAACGCCACCACCTCCCAGACGCCNCGTTGTACGCGGCTGGGTTCCACNGCAATAAGTGGCCTCANGGCATCGTCCGGCGGCGGTCCNCAAACGCA Clone Rv330 :::::::::::::::Rv330SP6.seq::::::::::::::: CTCAAGCTTGAGGTTAACTTTGAACGGATCGAGCTGGACGTTCGAGACGGTGATCGGGCCGAACCTGAATTGTCCGGTAATGCCCAACGCAAAAAGCAGGGTGGTG GCCGGGGCGGTGAAACCGGCGTCGGCGGCACCGTCGAAATCTATGTGGATTGCCGGAATGGGATGTCCGGCACACGGCGAAACCGTAGTTCGCTTGTCCCGTGAGC CCAGGTGGATGGGGGAAAGATCCTGGTGTCCGGGATAATAATGGGCCGATGCCGCCGGTTGAAGCTCCACTGGATCGGGAATTCCGGAATCTTGATCCGACGCTTC AGGCCGAACAGGCCCCTC :::::::::::::::Rv330T7.seq::::::::::::::: CGGCGACGTCGCGATACGCCGAGCAGTTGGGAATCGCTCTGCAGCAAACCAATATTCTGCGCGACGTTCGAGAGGACTTTTTGAATGGACGGATCTACCTGCCGCG CGACGAGCTGGACCGATTAGGCGTACGCCTCCGCCTGGACGACACCGGGGCACTCGATGACCCCGACGGACGGCTCGCGGCNCTGCTGCGGTTCAGTGCCGACCGC GCCGCAGACTGGTNTTCGCTGGGACTGCGGCTGATTCCACACCTCGACCGCCGCAGCGCTGCCTGCTGTGCGGCCATGTCTGGCATCTACCGCCGTCAGCTCGCCT TGATCAGAGCATCGCCGGCGGTCGTCTA Clone Rv331 :::::::::::::::Rv331SP6.seq::::::::::::::: CTATAAAATACTCAAGCTTGATGCCGCCGAAACCGAGCGTGAGCACGCCGCCAGGCACCAGGCGCGGGTCCGGGGCCGGCCCCCCCCCGGCCCCCTGCTCCGCTCG GTGATGGCACGCCACCGCGACACCACCCGGNTGCGCTACGTCNAGCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCTCTTTCGAAGGTCN AGGTCNATACCGATTTGCGCATCCGCAGCCGCACCCTGAACNACANAACCGTGCCCTACTATTGCTTGTCNGGCGGGGCCAAAAAACAGCTTGGCATCCTGGCCCN ATTGGCCGGCGCGG :::::::::::::::Rv331T7.seq::::::::::::::: CTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCCGCACACCTTCAGTTGCTCACCGGAATCCAACCGGTAGAAGGT CGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCGGCCAGCACTCCGCAGCGCTTCGTCGGGGTGGTCCCCGAGCCCA TGGCCACCATCGCATTCACCAGGTCTGCGCGAATCNCCANCACGTANACNGTTCCTTTCCTAA Clone Rv333 :::::::::::::::Rv333SP6.seq::::::::::::::: CTGGCACCAAGGCCCCACACGTCACCCTGTGACCTCCTGCGCCGACCCCGCCCCGAGGTCCTGGCCGTTACCACCGAACGGGCGAGCCGGAGTCTGGTNCGCATCG AACAAANAGCAAGGTGCATGGGCGGAGTTGTTCCGCCACTTCGTCGATGACGGGGTCNATCCATTCGAGGTCCGTCGCCGCGTCGGTCNAGTGGCGGTCACACTCC AGTACTCGACCTCACAGACNAAAGGACTCNATCCCATCTAGGTGTGGACNAAACAGTCTTCTGTCCGACNACTACACCACCACCCAGGCCATCGCCGCCGCCCGGG CGATGCCAACTTCGACGCCGTACTGGCCCCGGCCGGGGGGTCCCCGGTTGTCAAACACTTGCCGTGTTCNTTCACGCNCTGCCCCACATCCAACCCCCAACG Clone Rv334 :::::::::::::::Rv334T7.seq::::::::::::::: GTTCTTGGCCCATGCGGAGGTATCGCCGTTTCCACCACGCGGTCGGGGTGGCGTTGCATTAGCTCACCGATGGTGCGCTTGTGCAGGCCGCCGGGATACCCCCGAG TGCCGGTAAACCATCTTGTGCTGC Clone Rv335 :::::::::::::::Rv335SP6.seq::::::::::::::: CAATACTCAAGCTTGGCGTGCCGTTCCAACCCGAATTGGCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACNACNACGTCGTCCGCGGGACACACCT CGATGCTGCCGCCATGGACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCCGGAACGTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGG ATC :::::::::::::::Rv335T7.seq::::::::::::::: CNTCATGATGATCATCACCCGAAGTGTGGTAGCCGCAGTGGTTATCGTGGGTACCGTCGTGCTTTCCATGGCGCCTCTTTCGGGCTTTCCGTATTGGCTCGGGGAG CACATTCTGGGTATCGAGTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCCTGGCGGTGGGATCCGACTACAATCTGCTGCTGATTCCCCGGTTGAAAG AGGAAATTGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGGAGTGGTGACGGCTGCCGGCATGGTGTTCGCCGTTAGCATGTCGTTGTTT TGTGTTCAGCGATTTGCGAATTATTGGTCAGATCGGTACCAC Clone Rv336 :::::::::::::::Rv336SP6.seq::::::::::::::: ATACTCAAGCTTTTACGGTGATCGCNCATCACCTGGTTCATGAACTGGAAGCAGCCCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCG GGTGCAGGTGCTCGGGCAGCTCGGCCGCNACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGANNAACGACGCCAGTCCGCTACGTNACCCCTCCCGGAC TGTCCATGGAGAACAGCGCGTTCTCCACCGACCGGGCCCGGGTGTGGGGTNTT :::::::::::::::Rv336T7.seq::::::::::::::: GCTGGTAGAGTCGCTGACCGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGCGCAGGCTATCGCACCCGTTATCGGCTAC GAGCAAATCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGATCGGCGTCAAGCATGTGTGCCCCCAAT TATCAGGACTGACCTCCGGCTGACCGGCATGTTTGGTCGCGATGCCTGGGCG Clone Rv337 :::::::::::::::Rv337SP6.seq::::::::::::::: GCTTTCCGCCGATACCCGCCATGTCNCGCACATCCAGGACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAGTGCGGATGATCGGGCCCCCGTACGTCGTG GTGTACCTCGTCGGTAACAACGAAACCGAAGCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGGCCACCGCACGGGGTGAGGGCTATGTCA CCGGTCCGGCANCACTCAATGCCGACCAGGCCGAGGCCGGANACAAAAANTATCGCTAAGGTCACCGGATCACNAGCATGGTGATCGCAGCAATGTTGCTAGTGAT CTACGCTCCGTAATTA :::::::::::::::Rv3337T7.seq::::::::::::::: CTTCCAACCCGAATTGGCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACAACCTCGATGCTGCCGCCATGGACCG GTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGGATCGCGGTGATCGTCGATGAGC GCATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCANGTCGCCCGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCGATCGGCCCCA Clone Rv338 :::::::::::::::Rv338SP6.seq::::::::::::::: TACTCAAGCTTCGCGAGATCCGGATGGCACTCACGCTGGACAAGACCTTCACAAAATCTGAAATCCTGACCCGATACTTGAACCTGGTCTCGTTCGGCAATAACTC GTTCGGCGTGCAGGACGCGGCGCAAACGTNCTTCGGCATCAACGCGTCCGANCTGAATTGGCAGCAAGCGGCGCTGCTGGCCGGCATGGTGCAATCNACCAGCACG CTCAACCCGTA :::::::::::::::Rv338T7.seq::::::::::::::: CCCACGACTTTCTCCTCGATCAGTTGGATTTGTACGAAGAGGCAACGAAAGCAGTGATCCTCGGGATGGTCGACGCCTACATCGACCCCCGTTCGCCGCCGCACAG CCTGCTAGATGCGCTGGGCGAGCAGGTCCCACAGTTCGCCGCTAAGGCACGGCGTCTGTTCCCGTCCGGATCGCCATTCGGCCTCGGCGTCCTGCTCCCATTGGAT CAATAGGGCTGGCAGCTCCGTCGGCAGGGGCCTACGCCTCACCCCGTCACG Clone Rv339 :::::::::::::::Rv339SP6.seq::::::::::::::: CTCAAGCTTATGCGCGCCGGCCGAGGTCTGCTCACGGCAACCCCTGAAGTTTAGGGGACNACCTACTCAGCGCAAAATTTCGCTAATGTGAGTCCGGCCCACCAGG GGNANATCACCCATGTCGATCATGATCTACCCCGGATACCGGATTGGCGGTAGCGCCCACGATCGTCNAAATNTCCGCCTGAATCATCGGATAGCTGATCGGGGGT CACGCGTTTTGANTTCACCGCGAACAGCCGCCAGCCGGCCCCGCANCGANCCGATCTCNTGCCCGGCCATGGGCCCCCAATCTTNTCG :::::::::::::::Rv339T7.seq::::::::::::::: GTGTGTGGTGGAACCCATCTGAGCAGTGTGCCAAACCGGGGCAGACAGCTCCCAATTGACGTGAGCCCCGCTCACTTGCTGGGTAAGCGTC Clone Rv33 :::::::::::::::Rv33SP6.seq::::::::::::::: CTTTACACTTCCTGCATCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTG ACACTATAGAATACTCAAGCTTGGCGTGACGGCCACCGGGCCACTCCGCACCATCTGTACCGACCCAAGATCTAC :::::::::::::::Rv33T7.seq::::::::::::::: CAGGCATGCAAGCTTTAGCTGCCCGAATGCGTCACCCCGATGCGCCCAGATCGGGGCTTCGCAGATAAAGCACGAACAGGCGGGCAAAACGTCNATCTCGGAGCCG GAAGGGCAATCAGCCGACCGTCGACGAACGACACCGGCGAGACCACTTAGGCAGTGACGGCCGGCCCGAACATTACGCGCTCGTTGATTAGGCGTTCGGTCTCGTC CGCGGTCATGCCGAGCAGCTTGCGGCAGATCTGAACGCTGTCCTGTCCGGGCAGCGGCGCCGGGCGTTGGGTGCCTGCCCGAATGTGACGAAACCCGGAGCCGACC CGTCTCGGCGGGCCGCGGACGGCGATCCGC Clone Rv340 :::::::::::::::Rv340SP6.seq::::::::::::::: CNCAAGCTTGCGGATGTTACCCCTGACAGCCTGAACTATGTCNAAAACACACGGCACCCGGAACGGTGTTGGGGACCCCATCGANTTCGAGTCGCTGCCGGCACTT ATGGCCTGGGTAAAGGCCAGGCNANAGCCCGTGCGCATTGGGGTCGGTCAAAACCAACATCGGCCACCTGGAGGCGGCCGCCGGTGTGGCTGGATNCATCAAGCGC GGTGCTGGCGGTGCAACGTGGGCACATTCCCCGCAACTTGCACTTCACCCGGTGGAACCCGGCCATCNACGCGTCGGCNACGCGGCTGTTCGTGCCNACCNAAAAC CCCCCGTGGCCGGCGGC :::::::::::::::Rv340T7.seq::::::::::::::: GGAACCGGTAACCAGATCAGCTCGTCGACCTCACTGCCGGGGGTGAATTCCCCACCGGTGCTGCGCGTGCCCAGTAGTGCACCTTCTTGACGCCTCGAAAAGGGGG AGTCGGTCGGGTAGGTCACCGTCAGGAGCCGCCTACCCAGGTTGGCGCNATAGCCGGTCTCCTCGAGTATCTCCCGCACCGCCCCCAGCCGTGCGGTCTCACCCAN ATCCACTTTGCCCTTGGCAGCGACCAGTCGTCGTANCNGGGGCGGTGAATGACAACGATCTCGACCGGCCCTTCCN Clone Rv341 :::::::::::::::Rv341SP6.seq::::::::::::::: TACTCAAGCTTCAGAACAGGCCTGTTGTGGGCNCACCCGGCTCGCCGAGTTCTGCACGCACCGGCCTCAAGTGCGGCCCGCACCGCCGGCATCTCCCGGTCACCAG GGCCGGGCCCGCGCCGCAGCGACGGGCGTGTTCGCGCAGTTCGCCGTCAATGATGCTGACCTGATCGGCCACCCGGGCGTTCTCGGCGTCGTCGCGTTCACTAATC GCGGTGCTCAGCAGCGTCTCGACAGCCACCACCCGAGTGGCGACCAGCTGC :::::::::::::::Rv341T7.seq::::::::::::::: TAATGTCTTGCCAACGTCACCACAATCGCGATGAATTCAATCATGCCGCCCAGGGCGGCCAACCCAATGGTGGCCGCGAGCGGCAGCTCGATCGCAGCGGGGAGGT TGCCGGCCGCCAGTTGATTCACGAACAGGGTGAGGTCATAGGCGGGCAGGATAGTGACGAAGGCAAGACCTATATCTGCCGTCGGAAGAAGAATCGAGTAGCCGGT CGACACAACGGAAGCGAAAGTGTCCGCGATGTTGATGAGCGTGCCGGTTGTGGCGGCGGTGGCGGC Clone Rv343 :::::::::::::::Rv343SP6.seq::::::::::::::: TACTCAAGCTTTCGTCAGTTCATCGCGCCAGCAGCCAACAAGAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGGCC GCGAACGACGCCAGCGACCACATTCAGCANATGGCCAGCGCGTGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCGTGATCGACATCGTCA CCGCCGCACCACTGCCGGCCTCGGGTTCACGCAGCCGTTGCCGCCCGCAGCGGANNATCACATCGCCGCGATCGCCCTGTTC :::::::::::::::Rv343T7.seq::::::::::::::: CCACCCGTGTAATTTGGGATGGGCNAAAAGGCNAAGCACCGCGTGGCCACGAACGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGGAAGGCCGAAC GTACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGGTAGCACCCTGGCCGGGCGATGATCTGCAGCGTCGCCCGCGG TAGTCGCCGCCCGGGCGGCTACAGTCTGAAACGCGATGACCATCGATGTGTGGATGCAGCATCCGACG Clone Rv344 :::::::::::::::Rv344SP6.seq::::::::::::::: TCAAGCTTTAGCTGCCCGAATCCGTCANCCCGATGCNCCCAGATCGGGGCTTCGCANATAAAGCACNAACAGGCGGGCAAAACGTCNATCTCGGAGCCGGAAGGGC AATCANCCGACCGTCNACAAACGACACCGGCGANACCACTTAGGCAGTGACGGCCGGCCCCGAACATTACNCGCTCGTTGATTAGGCGTTCGGTCTCGTCCGCCTC ATGCCGAGCAGCTTGCGGCANATCTGAACGCTGTCCTGCCGGGCAGCGGCGCCGGGCGTTGGGGTGCCTGCCGGAATGTGACNAAACGGAGCCGACCCCCTCTCGG CG :::::::::::::::Rv344T7.seq::::::::::::::: CCGGGGCCACTCCGCACAATCNGTACCNNACCAANATCTACACCATCGGAATACGACGGCGTCGCCGANTTTGCGGGTACCCGCTCAACTTTGTGTCGACCCTCAA CGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGAACAAATNGACGCNTCGGTTCCGCTGACCAATACGGTCGGTCCC Clone Rv346 :::::::::::::::Rv346SP6.seq::::::::::::::: NCTGGCCTTTGGTCCACACTAANACAATACTCAAGCTTCCCGGCCGCAGAGCCGCCAACTCACGATATCGTTAACCGATATCCCGAGCCGATAGCTGCCGGCTCGG GTGGTGGCCAGCGGCGCTGCGACNAAAGGTGTGACCGTCATGAACAGACACCACCGGCCGGCCGTCGGCCGTCGTCACCTGCTCGANATCTCAGCATCCGCAGCCG GTGTGATCGCGCTTTCGGCGTGTNGTGGGTCNCCGCCCGAGCCCGGCAAGGCCGGCCCCGACACAACCCCGGAAC :::::::::::::::Rv346T7.seq::::::::::::::: CATCTGCCCACCACACGGACCGCGGTGCGGACGCGGCTGACGCGCCTGGTGGTCAGCATCGTGGCCGGTCTGCTGTTTGTATGCCAGCTTCCCGCGCGCAACTGCT GGTGGGCGGCGGTGGTTGCGCTCGCATTGCTGGCCTGGGTGCTGACCCACCGCGCGACGACACCCGGTGGGTGGCTGGGCTACGGCCTGCTATTCGGGCTGGTGTT CTACGTCTCGTTGTTGCCGTGGATCGGCGAAGCTGGTGGCCCCGGGCCCTGGTTGGCACT Clone Rv 347 :::::::::::::::Rv347SP6.seq::::::::::::::: GACAATACTCAAGCTTGACTGGCCACCCACCGGCATGACCACCCGACAGGCCCGACTGGTCGTACCACTCGAACGCCGGGGTGTTGATGTCCCAGCCGTGAANTCG TCCTGCGCGCGCAGGCCGTCNAACAGGTACAGGGCGGGCGAATTGGCACCACCACTTTGGAATTGGACCTTGATGTCACGGCCCATCGACGGCGACGGCACCTGCA GGTACTCCACCGGCAAGCCCGGCCGGGAAAATGCCCCGCGGTCNCCGTGCCACCGACGGCGCCGANCAAACCCGACACTAGGGCCGCGCCNACGGCCCCCGACCAC NANTCNACGCGACATACCCGTGACGGCGCCACNAACCCTGTCAACA :::::::::::::::Rv347T.seq::::::::::::::: CCTCCAACTCGGCGGGGAAGCGACNCCAGCCTACCGAGCTTGGAGTCCANGACGCCAGCGGCGGCGTCGGTCGCGTCGTGGTGCCGCCGGCGGTGGCGTTGGCTGG CAACGATCTCCACCCAGCCGGTCGGGTTACCCACGATCTCGGCATANACGCGGGCCGAGGCCCGGTGCGATACCGTATTGCGTCAATTGGGACCGGTTGTGCATTC GCTAGCTCGGTTGCCACACCCGTCAGGGGTTCGACGTTGGCGGGTTCGGCGGCCCCCANCACCGCTGTCACCATGCCCGCCAAGCCGACCTGCGGCGCCCACCAAC TGCAGCACCANCATGTCGCCGTCGCGCGCCGCGATCACATGG Clone Rv348 :::::::::::::::Rv348SP6.seq::::::::::::::: CTCAAGCTTTTTGAGCGTCGCGCGGGGCANCTTCGCCGGCAATTCTACTANCGAGAANTTCTGGCCCGATACGGATCTGACCGAANTTCGCTGCGGTGCANCCACC TCATTGGCGATGGCGCCGACNATGGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGCGACGCGGTAGGTGGTCAAGTCCGGTCTACGCTTGGGCCTTTGCGGAC GGTCCCGACGCTGGTCGCGGTTGCGCCGCNAAAGCGGCGGGTCGGGTGCCATCAGGAATGCCTCNCCGCCGCGGCACTGCACGGCCAGTGCCGCGGCGA :::::::::::::::Rv348T7.seq::::::::::::::: CNCCAGCTTGATTGGTCTGGTTGCATTGGCCAGCTGCGCGAGCCTGGCTCACTTCAACTACGACGACCGCAAAACAATTGCCGCCTTCGGATCCGAGTTCGGTTGG TACGCGGCAATGGAGCACCATTTCTCGGTGAATCAGACTATTCCTGAGTACTTGATCATCCACTCTGCACACCGACCTGCGAACCCCGCGCCCCTTGCCGACCTGG AGCAGCTGGCGCAACGTGTGAGCCAGTCCCAGGCGTTGCCATGGTTCGCGGTGTGACCCGGCCAAACGGGGAAAACC Clone Rv349 :::::::::::::::Rv349SP6.seq::::::::::::::: CAATACTCAAGCTTGACTGGGCCCGCACTTCGGCGCCACCCACACCGTCAACGCCCGCGAAGTCNACGTCGTCCAGGCCATCGGCGGCCTCACGGATGGATTCGGG CGCGGACGTGGTGATCGACGCCGTCGGCCGACCGGAAACCTACCAGCAGGCCTTCTACGCCCGCGATCTCGCCGGAACCGTTGTGCTGGTGGGTGTTCCNACGCCC GACATGCGCCTGGACATGCCGCTGGTCNACTTCTTCTCTCACGG :::::::::::::::Rv349T7.seq::::::::::::::: TCGACGGTTTGGCGGCCTTAAATGCACTGAGGTCGTCATTGACCCCACAGCGGAAATGCCGACTATTCGCAGGCCTCCTTCGGCTTGGCTGCCGGAGAGGGCGCTC CGCGGGAACCGCATGCAGGTATATGACCTCGGTTTCTCGGGTGCTACCGCGTGCCTTGNTANGATNANCTCGGCGTTGGAATTGTCCAGCCGGCCCCAATTGATCG AGCGCANATTCGTACACNTGGCCGGCGGCGACATACGCTTCACCGTGGATCTGTCTCCACACGGACCGCCCTGCGGGATCCTGCTCACGGGTAANGGAACTTACGT GGCACTCGG Clone Rv34 :::::::::::::::Rv34SP6.seq::::::::::::::: GACCACGCCAGGCTAATCACGTGACGCTACCGAATACCTNCCTAGTGGTGCAGGCTCCCGCTGGAAATGGCCCTGTACCAACTCGCGCACCGGTGCCAG :::::::::::::::Rv34T7.seq::::::::::::::: CGGCACCCGACCCCTTTGAGCCGTCCGCCGTGGCCGCGGTGGAACTGCCGACGAGGGACTGATCGTGCTGGGCAAATTGGTCGATGGCACGCTGGCCCCCCGATCT GAAGGTCN Clone Rv350 :::::::::::::::Rv350SP6.seq::::::::::::::: CTCAAGCTTGCCGTTACCCCGACTTCCGGAGGGACACCATGAGCACCGCCAGCCGAGCACGAGGCCAAACTCCGCCGACGCAGGCCGGTTGGACTTGTCGTGCTGG ACAAGGGGTTTAGCCGCCGAAGCAGTGACGTACATGGGCGAAAAGCAGTTCGCCTGTCGACCGACGGNGCNNACCGTGAGGCTAGGGAAGCGAGGAGCACATGGCC GCCGACCCGCAATGTACACGCTGCAAGCAAACCATCGAACCCCGGATGGCTATNCNTCACCGCCCATCGCCGCGGT :::::::::::::::Rv350T7.seq::::::::::::::: CATGTCGCGCACATCCAGGACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAGTGCGGATGATCGGGCCCGCCTACGTCGTGGTGTACCTCGTCGGTAACA ACGAAACCGAAGCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGAACACCACACCGCCACCGCACGGGGTGAAGGCCTATGTCACCGGTCCGCAGCACTCAA TGCCGACCAGGCCGAGGCCCGGAGACAAAGTATCGCTAAGGTCACCGCGATCACGAGCATGGTGATCGCAGCAATG Clone Rv351 :::::::::::::::Rv351SP6.seq::::::::::::::: ATACTCAAGCTTCGGTACGGTGGCGGGCCGTGCTGCTGGCCGCGGTCGCGGCGTGCGCGGCCTGCGGTCTCGTTACNAGCTCGCGCTGCTGACACTGGCGCGCNAG CCTGAACGGCGGCGGGATCGTGGCCACCTCCCTGATCGTCGCGGGCTACATAGCCGCGCTGGAGCAGGCGCCTTGCTGATCAAGCCGCTACTTGCACACGCGGCCC ATCGCGTTCATCGCCGTGGAGGCGGTGCTGGGCATCATCGGCG :::::::::::::::Rv351T7.seq::::::::::::::: TGTCAAGTCCTTTCAGATCTCNTTTTTATGACATGACTGGAGATCTGTCTAGATTGCAGCTCCTGTGAGCGTGGGTACCGGATTCAAGCCGGTCGGTCACGCCCCG GTGGTACCGGCTTTGCGGCAGTGCTCGGCCTCGAGTTCGGCGATCGCGCGCGAAGTGCGTTCGCGCAGCAAGATCGCGGCCGTAATGCCGGCGATGACCGCGATGA CCAGCGCGATCCAGGAGAACCGTTCCAACCAGTGCTGGGCGGCCATCCCGGCGAAGTAGACCAGTGCAGTGGTGCC Clone Rv352 :::::::::::::::Rv352SP6.seq::::::::::::::: CAATACTCAAGCTTCAAAACAGGCCTGTTGTGGGCGCACCCGGCTCGCCGAGTTCTGCACGCACCGCCTCANTGCGGCCCGCACCGCCGGCATCTCCCCGGTCACG CAGGGCCGCGGCCCGCGCCGCANCGACGGNGTGTTCGCGCAGTTCGCCGTCAATGATGCTGACCTGATCGGCCACCCGGGCGTTCTCGGGCGTCGTCCGTTCACTA ATCGCGGTGCTC :::::::::::::::Rv352T7.seq::::::::::::::: TACGCTGGCGCTGGAGGGAGCCANNTACAACATCCACGCCAATGCTCTTGCCCCGATCGCGGCGACCAGGATGACCCAGGACATCCTGCGCCCCGAAGTACTGGAA AAGCTCACACCCGAGTTCGTCGCACCGGTGGTGGCCTACCTGTGCACCCGAGGAGTGTGCGACAACGCATCGGTGTACGCGTCGGTGGTGGCACAGGTGCAGCGAG TTGCGCTGTTTGGCAACGACGGCGCCAACTTCGACAAACCGCCGTCGGTACAAGATGTTGCGGCGCGGTGGGCCCGAGATCACGATCTGTCCGGTGCGAAAATTGC TG Clone Rv353 :::::::::::::::Rv353SP6.seq::::::::::::::: GCTTTTCCGTCCGTCNNCGCTCAACCGCGTGAGGCCGAAGCGGNTGGTTACCGACTCCCTGTTTGTGATGGACCACTTCTACCAACTGCCCATGTTGGGGACNCCC GACCAGCCGATGCTGGAGGCCTACACGGCCCTTGGTGCGCTGGCCACGGCGACCGANCGGCTGCNNTGGGCGCGTTGGTGACCGGCAATACCTACCGCAGCCCCGA CCCTGCTGGCAANATCATCACCACGCTCGACGTGGTTAGCGCCGGTCGAGCGATCCTCGGCATTGGAGCCGGTTGGTTGANCTGGAACA :::::::::::::::Rv353T7.seq::::::::::::::: CNGCTTTTTAATGGCCTTGACNTGGGCGNGCCGGCCACCGGGGCCACTCCGCACAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACT TTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGC GGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGG AACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCTACGGCGACCCGGCCTATG Clone Rv354 :::::::::::::::Rv354SP6.seq::::::::::::::: CTCAAGCTTGCCGGGAGGGTGCATGGCCGACTCGGATTTACCCACCANGGGGCGCCAACGCGGTGTCCGCGCCGTCNAGCTGAACGTTGCTGCCCGCCTGGAGAAC CTGGCGCTGCTGCGCACCCTGGTCGGCGCCATCGGCACCTTCGAGGACCTGGATTTCGACGCCGTGGCCGACCTGAGGTTGGCGGTGGACGAAGGTGCACCGCGGT TGATTCGCTCGGCCTTGCCGGATGCCACCCTGCGCCTGGTGGTCGATCCGCGAAAANACGAANTTGTGGTGGAGGCTTCTGCTGCCTGCGACACCCACNACGTGGT GGCACCGGGCAGCTTTAGCTGGCAT :::::::::::::::Rv354T7.seq::::::::::::::: CCGACGCCGTCGTGGCCACCAACACCGCGACCAGCACCGTGACCCGGACCGGGGTGCCGCGCGAACCGGTCTTGGCCAATTGCCGCGGCACCAAGCCGTCGGCGCC CATGGCGAACAGCACGCGGCATTGCCCGAGCATCAACACCATCACCACCGTGGTAAGCCCGGCCAGCGCCGACGGAGATGATGCCGCTGGGCCCAGTACACCCCCG TTGGCCTGGAACGCGGTGGCCAGTTTGCCGGCCGCGGCCCGGTACGGTCCGCAGTTGGGTGTATGGAACCATGCCCGACAGCACCACCG Clone Rv355 :::::::::::::::Rv355SP6.seq::::::::::::::: TTNACTGGCCTTTGGTCCACACTAGACAATACTCAAGCTTCCAGGACATCGTCATCGCGACCAAAACCGCGAGCTAGGTCGGCATCCGGGAAGCATCGCACCGGG TGGCGCCGAGCGCCGCTGCCGGCAGGCCGATTAGGCGGGCAATTAGCCGCCGCGGCTCCCGGCTCCGANTACGGCGCCCCCGAATGGCGTCACCCGCTGGTAACC ACGCTTGCGCGCCTGGCGGCGGCCTGCCGGATCAGGTGGTAAATGCCGACA :::::::::::::::Rv355T7.seq::::::::::::::: NGACGTCTTCCATCCGCGCGTCGTTTTGGCGGGTTGGCCACAGCAGCCCGCCGGTGACGGCGACGATGCTGGGCTGGTTGCGGCCCTGCGGCACCGCGGCTTGCAT GCTGTTGGCTGTCTTGGGACGATCCCCCGAAATAGTCCACGCGGATCTGGTGATTTTGCGGGCTACCGCGATTACCCCGCGCGGCTCGACGAGTTTTGGCCCTGGA CTACCCGCGTGGCCAATCTGCTGAACTCGCGGCCGGTGGTGGCCTGGAATGCGAGCGCCGTTACCTA Clone Rv356 :::::::::::::::Rv356SP6.seq::::::::::::::: CTTCCTCCTGAGTACCNCCCGTNTACTTTGGGATGGGTAAAAAGGCGAATCNCCGTTTGGTCACGAACGCCGGGAGGGACAATCTCGGGCGCCCGTGGGTCTCCGC GGGAANGCCCGAATGTACGGTGTCTCGACACTTCCCNTCCCCTCCG :::::::::::::::Rv356T7.seq::::::::::::::: GAGCATCGGGACNTACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGGCGCGAACGACGCCNGCGACCACATTCAGCAGATGGCCAGCGCG TGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCNTGATCNACATCGTCACCGCCGCACCACTGCCCGCCGCCTCGGGTCACGAGCCGTTGC CGCCCNCAGCGGACGATCACNTCGCCGCGATCGCC Clone Rv357 :::::::::::::::Rv357SP6.seq::::::::::::::: TACTCATGANCATCCTTTAATCANNGCTTTGCGTTTTTTTATTAAATCTTGCAATTTACTGCAAAGCAACAACAAAATCGCAAAGTCATCAAAAAACCGCAAAGTT GTTTAAAATAAGAGCANCACTACAAAAGGAGATAAGAAGAGCACATACCTCAGCACTTATTATCACTAGCGCTCGCCGCAGCCGTGTAACCGAGCATAGGGGAGCG AACTGGCGAGGAAGCAAAGAAGAACTGTTCTGTCAGATAGCTCTTACGCNCA Clone Rv358 :::::::::::::::Rv358SP6.seq::::::::::::::: CTCAAGCTTCAGGTCAATGTGCNCCAAGCCCTGACGCTGGCCGACCAGGCCACCGCCGCCGGANACNCTGCCAAGGCCACCGAATACAACAACGGCCGCCGAGGGT TCGCANCCCAGCTGGTGACCGCCGAGCANANCGTCAAAAACCTCAAGACGCTGCATGACCAGGCGCTTANCNCCGCANCTCAGGGCCAAGAAGGCGTCAAACGAAA TGCGATGGTGCTGCACCANAAGATCGCCGAGCGAACCAAGCTGCTCAGCCNG :::::::::::::::Rv358T7.seq::::::::::::::: CATGGTGGCACTGTAGCGACGTGCTGCAATCAAGGTCATGCCCGACTCTGGTCAGCTCGGANCCGCTGACACCCCGCTAAGGCTGCTCAGCTCGGTGCATTACCTC ACCGACGGCGAACTCCCCCAGCTTTACGACTATCCGGATGACGGCAGCTGGTTGCGGGCGAACTTCATCATCAGCTTGGACGGCGGCGCTACCGTCGATGGCACCA GCGGGGCGATGGCCGGGCCCGGCGACCGATTCGTCTTCAACCTGTTGCGTGAACTTGCCGACGTCATCGTGGTCGGCGTGGGCACCGTGGCATTGAGGCGCTACTC CGGCGTCCGGATGGGTGTCGTCCAGCGCCAGCAC Clone Rv359 :::::::::::::::Rv359SP6.seq::::::::::::::: TACTCAAGCTTGCGGGTGATCGCCTTGGTCAACGGCACCGTGATCGGATCGGGGTCNACCGCACAAATGGACTGGAGCTTCGGCGCAANCATCGCCTATGCCTCGC GGGGGGTGACGCTGACCCCGGTGACNTGTTCGGCTCGGGCACGGTGCCCACCTGCACGCTCGTCTATCACCTCGGCCACCGGAATCATTCCCGGGCTGG :::::::::::::::Rv359T7.seq::::::::::::::: GTTGGNGCCTCGTCGGCGAACAGTTCTCGCACGATTTCCGGATTAGCGGGACTGGTCACCAGTTGGGTATGCGGGAAGGCGCTGACGTTCGGCCGGATTAGCTGTT TGATGGACGCGGTGGTGATGTTCTGATCACGGAACTGGCTGTAATAGCCCAGGGTCGCCACGTTTCATCCGGCCCCGGACCCCGGCGCACCGAGCGTGTCGCGCAG GTATGCGACGTGATTTTCGCTGAAGTCCCCGTACCCGGAGAACT Clone Rv35 :::::::::::::::Rv35SP6.seq::::::::::::::: TGCTTCCGGCTCGTATGTTGTGTGGAATTGTGANCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAAT ACTCAAGCTCCAGGTCAATGTGCGCCAAGCCCTGACGCTGGCCGACCAGGCCACCGCCGCCGGAGACGCTGCCTTTGTCACCGAATACAACAACGCCCGCCGAGCG TTCGCAGCCCAGCTGGTGACCGCCGAGCAGAGCGTCGAAGACCTCAAGACGCTGCATGACCAGGCGCTTAGCGCCGCAGCTCAGGCCAAGAATGCCGTCGAACGAA ATGCGATGGTGCTGCGGCATAAGATCGCCGAGCGAACCAAGCTGCTCAGGCCAGCTCGAGCAGGCGAAGATGCACGAGCA :::::::::::::::Rv35T7.seq::::::::::::::: CAGGCATGCAAGCTTCGGAGGCAGACCCGTGCATGGTGGCACTGTAGCGACGTGCTGCAATCAAGGTCATGCCGACTCTGGTCAGCTCGGAGCCGCTGACACCCCC GCTAAGGCTGCTCAGCTCGGTGCATTACCTCACCGACGGCGAACTCCCCCAGCTTTACGACTATCCGGATGACGGCACCTGGTTGCGGGCGAACTTCATCAGCAGC TTGGACGGCGGCGCTACCGTCGATGGCACCAGCGGGGCGATGGCCGGGCCCGGCGACCGATTCGTCTTCAACCTGTTGCGTGAACTTGCCGACGTCATCGTGGTCG GCGTGGGCACCGTGCGCATTGAAGGCTACTCCGGCGTCCGGATGGGTGCTGTCCATCGGCCA Clone Rv360 :::::::::::::::Rv360SP6.seq::::::::::::::: TACTCAAGCTTGGGGTGGCGCTGTCGGTCGGTGTGCTTGGCGGCGTCGGTATCAACACCGCCCACGAAATGGGGCACAAGAAGGATTCGCTGGAGCGGTGGCTGTC CAAAATCACCCTCGCCCANACCTGCTACGGGCACTTCTACATCGAGCACAACCGTGGCCATCACGTCGGGGTGCCACACCGGAGGACCCCCGGCGTCGGGGGGTTC GGCANAACGTTGTGGGANTTCCTGCCCCGCANTGTTATCGGCGGCTTGCGCT :::::::::::::::Rv360T7.seq::::::::::::::: GGCCATCGCCACCGCNCCGCGGCGAACGCTCAAAGGCACCTACTGGCACCAAGGCCCCACACGTCACCCTGTGACCTCCTGGCCGACCCCCGCCCGAGGTCCTGGC CGTTACCACCGAACCGGGCGAGCCGGGAGTCTGGTACGCATCGAACAAAGAGCAAGGTGCATGGGCGGAGTTGTTCCGCCACTTCGTCGATGACGGGTCGATCCAT TCGAGGTCCGTCGCCGCGTCGGTCGAGTGGCGGTCACACTCCANGTACTCGACCTCACAGACGAGAGGACTCGATCCCATCTAGCGTGTGGACGAAACAGTCTTCT GTCCGACGACTACACCACCACCCAGGCCATCGC Clone Rv361 :::::::::::::::Rv361SP6.seq::::::::::::::: GCTTGCGGGTGATCGCCTTGGTCACGGCACCGTGATCGGATCGGGGTCNACCGCNCAGATGGACTGGANCTTCGGCGAANTCNTCGGCCTATGCCTCGCGGGGGGT GACCCTGACCCGGGTGACNTGTTCGGCTCGGGCACGGTGCCCACCTGCACGCTCGTCAAGCACCTCNGGCCACCGGAATCATTCCCCGGGCTGGCTGCACNACGGC GACNTGGTCNCCCTCCAGGTCGAAGGGCTGGGCNAAACAANGCAGACCGTCCGGACANCGGCACTCCTTTTTCCGTTGGCTCTTCGGCCGAATCCGGACGCCNAAC CCGACCGGCG :::::::::::::::Rv361T7.seq::::::::::::::: GTTCTCGCACGATTTCCGGATTAGCGGGACTGGTCACCAGTTGGGTATGCGGGAAGGCGCTGACGTTCGCCGCGATTAGCTGTTTGATGGACGCGGTGGTGATGTN CTGATCACGGAACTGGCTGTAATANCCCAGGGTCGCCNCGCTTTCATCCGGGCCCGGACCCGGCGCACCGAAGCGTGTCGCGCAGGTATGCGACGTGATTTCGCTG AAGTCCCCGTACCCGGAGAACTCGAACACGCTGAGGCGCTCGTCACCGTCGTNNCGGCGACCAAGCGCGGCGAGCAACTGCGCAAAATCGTTAAGANAGGTCGAAT CGTTGAAATTCGGCACCACCTGCACC Clone Rv363 :::::::::::::::Rv363SP6.seq::::::::::::::: CACAAGACAATACTCAAGCTTCAGGTCAATGTGCNCCAAGCCCTGACGCTGGCCGACCAGGCCACCGCCGCCGGANACGCTGCCAAGGCCACCGAATACAACAACG CCGCCGAGGCGTTCGCAGCCCAGCTGGTGACCGCCGAGCANANCGTCNAAAACCTCAAGACGCTGCATGACCAGGCGCTTANCGCCNCAGCTCAGGCCAAGAAGGC CGTCGAACGAAATGCGATGGTGCTGCAGCANAANATCGCCGANCGAACCAAGCTGCTCAGCCAGCTCGAGCAG :::::::::::::::Rv363T7.seq::::::::::::::: CCACCGTGCATGGTGGCACTGTAGCGACGTGCTGCAATCAAGGTCATGCCCGACTCTGGTCAGCTCGGAGCCGCTGACACCCCCGCTAAGGCTGCTCAGCTCGGTG CATTACCTCACCGACGGCGAACTCCCCCCAGCTTTACGACTATCCGGATGACGGCACCTGGTTGCGGGCGAACTTCATCAGCAGCTTGGACGGCGGCCTACCGTCG ATGGCACCAGCGGGGCGATGGCCGGCCCGGCGACCGATTCGTCCTTCAACCTGTTGCGTGAACGGTGCC Clone Rv364 :::::::::::::::Rv364T7.seq::::::::::::::: GCTTTCCGCCGATACCNCCATGTCCCGCACATCCAGGACTTCTGGGGGGATCCGCTGACAGCGGCGGGCATCCCAAAGTGCGGATGATCGGGCCCGCCTAGTCGTG GTGTACCTCGNCGGTAACAACGAAACCGAANCGTATGACTCNGTCCACGCGGTG :::::::::::::::Rv364T7.seq::::::::::::::: CAACCCGANTTGGCTTTCGGCGCCNTCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACCTCGATGCTGCCGCCATGGACGCGGTCG AACGCAAGCAGCTGATCGATCTACNACGCCGNGNGGAACGCTTCNGCCGCGGGCGTGACCGCNTCCCGTT Clone Rv365 :::::::::::::::Rv365SP6.seq::::::::::::::: GGGATGGGCAAAAAGGCGAAGCACCGCGTGGCCACGAACGCCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGGAAGGCCGAACGTACGGCGTTCAAC ACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGGTAGCACCCTGGCCGGGCGATGATCTGCCAGCGTCCCCGCGGGTAGTCGCCGCCCGG GCGG :::::::::::::::Rv365T7.seq::::::::::::::: CAGCAGACCAACAAGAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGGCGCGAACGACGCCAGCGACCACATTCAGC AGATGGCCAGCGCGTGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCACGGTT Clone Rv366 :::::::::::::::Rv366SP6.seq::::::::::::::: CTCAAGCTTGACTGGCCACCCACCGGCATGACCACCGACAGGCCCGACTGGTCGTACCACTCGAACGCCGGGGTGTTTGA :::::::::::::::Rv366T7.seq::::::::::::::: TTTGGTGCCCGGAATGGCGAGTCCCATTTANTCGCTGATTTGTTTGAACAGCGACGAAACCGGTGTTGAAAATGTCGCCTGGGTCGGGATTCCCTCTCCAAGCAAG AGTAACTGGCCCCCAAATAAGTTACTCGTCGTCTTGCAAAGACCGCTACCCCGATGCCATTATGTGTTCCTTACGCTCNNNNTTCCGGTGCGCCCATCATTATCTG CACCTTTGCACTGCACATTGAGCTTAGCAGCGCTCG Clone Rv367 :::::::::::::::Rv367T7.seq::::::::::::::: GAATTNGCTTTCGGCGCCATCGGCCCAGGACCGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACCTCGATGCTGCCGCCATGGACGCGGTCGAACGC AAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGGATCGCNGTGATCGTCGATGACGGCATCGCCA CCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCGGGCCCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCGATCGGCCAGCGACATCGTGCCGCCGAGATTCCG CGGGTACGCCGATGAAGTGGTGT Clone Rv368 :::::::::::::::Rv368SP6.seq::::::::::::::: TAAAGCTTTCGTCAGTTCATNGNGCCCCCGGACCAACAAAAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGGCGCN AACGACGCCAGCGACCACATTCAGCAGATGGCCAGCGCGTCCGGGCCACACGAGGTTGGTGCTCGCGGCTACTCCCAGGGTGCGGCCGTGATCNACATCGTCACCG CCGCACCACTGCCCGGCCTCGGGTTCACGCAGCCGTTGCCGCCCGCAGCGGACGATCACNTCGCCGCGATCGCCTGTTCGGGAATCCCTCGGGCCGCGCTGCCGGG GCTGATGAGCGCCCTGACCCCTCAATTCGGGTCCAANACCATCNACCTCTGCAACAACGGCGACCCCGATTGTTCGGACGGCAACCGGTGGCGANCGCACCT :::::::::::::::Rv368T7.seq::::::::::::::: CCGGGAGGGACCATCNCGGGCGGCTNCGGCTTCTCTCCGGAAGGTTCTANNGTNNGCGTTCNACNCTTCCCGTCGCCCTGCGACCGCCCGAACATTCGGGGGTATG CNNGCANCCTGTNAGCATCCNGGCCGGGGC Clone Rv369 :::::::::::::::Rv369SP6.seq::::::::::::::: CTCAAGCTTCCGCATCAGATCGCTATAGAACCGGTGCGCGTCCCACCGAGTGGCTGGTCGCCTTCCAGCACGATCGTTACCGCGTTATCGGAATCAAACTCNCCCG AACACCTGACCAACGCGCTTGATCGCCTGAATCGATGCGGCGTCGCTGGGGCTCATCGATACCGAGTGTGCTTTTCCGACCACTTCCAGTTGCGGTACGGCGAGAT TGACAAAGGCGGTGAAGCCCAGCCAGAGCAGGACGATCACCNCCGCAAACCCGGCGGATTTGCCCG :::::::::::::::Rv369T7.seq::::::::::::::: GCTTGGCAGCCTGCGGCTGGGCGCCCTNGAGCTCTTCGATCTGGATCTCCGGACTCGAGATGCTCACTTGCCCGGCCGTGGACGTACCCATTGCGGCCGGGACCCC AGCGCCCCCCAGGTGACCAGCGAGTTGGGCTGCACGCTGACCGGCCCGTCGGGTCGACGCCGGTAACGGTCAGCAGCTCCGANGTCCNCTGATCCCGACCGCAGCT GCCAATGCGCGCTGGCAGCCGACGTGGATGTGCCGGGGCCTAGATCGCGGGGCAGCAGCGAGACCCGCGTCACCGACGGTCATCACCTTGCCGAGTTTAGGCCTGC CGCAN Clone Rv36 :::::::::::::::Rv36SP6.seq::::::::::::::: GCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTNCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATCTAGGTGACACTATAGAATA CTCAAGCTTGAGCCTATCGGGCTATCAGCTGGTTGATGTCCCG :::::::::::::::Rv36T7.seq::::::::::::::: CAGGCATGCAAGCTTGTCGTCTATCACATCCGACCACCAACGCCCGACGGCTCGGCAGAACGCCTCCGCATATGGGTCGACGACCAGCGGGTCGGACTTCTGGGGC TGCCAGCGCTCGCGCCGTCGCGACAAACAGCGCGGTCGAACCGACACTCCTTGTGATGTCCCACCTATCACCTCGGTACGCACCCAATCGACGCTAGCGGGCCTAG CTCAGCCCCGATCTTCCAGAGCTCCGCCCCG Clone Rv370 :::::::::::::::Rv370SP6.seq::::::::::::::: GCTTTTTGAGCGTCGCGCGGGGCGGCTTCCCCGGCAATTCTACTAGCGAGAAGCTCGGCCCGATACGGATCTGACCGAAGTCGCTGCGGTGCAGCCCACCCGCATT GGCGATGGCGCCGACNATGGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGCGACGCGGTAGGTGGCAATTCCGGTCTACGCTTGGGCCTTTGCGGGACGGTCC CGACGCTGGTCGCGGTTG :::::::::::::::Rv370T7.seq::::::::::::::: CGANCCTGTTCGACGGCTACCTGAATCACCCCGATNCCACCGCCGCGGCGTTCGACGCCGACAGCTGGTACCGCACCGGCGACGTCGGGGTGGTCGACGGCAGTGG GATGCACCGCATCGTGGGACGCGAGTCGGTCGACTTGATCAATCGGGTGGATACCGGGTCGGCGCCGGTGAAATTGAAACGGTGCTGCTCGGGCCCATCCGACGTG GCGGAGGCGGCAGTCGTCGGGGT Clone Rv371 :::::::::::::::Rv371SP6.seq::::::::::::::: NAAGCTTTGTCACACCCAAGTGTTTCNACCAGNCGCTCCATCCGGCGAAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCCGTTCAGCTC GCTTGCGGCGCTGCAGCAGCCAGTCCGGGAAATAGCTGCCCTGGCG :::::::::::::::Rv371T7.seq::::::::::::::: CCGCTGGNCGGCGGCGCTGGGCTGCGGTAACAATTACCACAACACTTTTCGGTAGCCGAACAGCGGCGCGTACCAGCGAAATGGCACAGCCACCGCAGTCGCCGAC ATCCCGCGAAGATGGCAGTTTTCGTGCGGTCGAGCGGCGAAGGCCTAGCGTCATTGTTGCCTGGCAAGGTTGCTGGCCCCGG Clone Rv373 :::::::::::::::Rv373SP6.seq::::::::::::::: CTCAAGCTTCTTCTGCCCCTTGCCGTTNCGGATNACATCCCGCAGCGACTCGGCTTCGGCGTCGATGTCGAAGTTCTCGATCAGCTTCTGGATCGACTCCGGCGGG ATGGCACCGGTGAAGCTACTCGCCGTAGCGGTCGACNAGTTCGCGGTAGAAGTTTTCGTCNACNATCAGCTGCTTGGGCGGGANCTTGGTGAAAGTGCTCCAATGT CCTCCAACCGGTCCAGCTCACGCTGCGCGGTCACGGATCTGGCGCATCTCGCGCTCGCCGCCGTCGCGAACTTGCGCCGCCATCGGGCTTGGGGCC :::::::::::::::Rv373T7.seq::::::::::::::: GTTCACACCTACCTACTATGCCNCAATTCNCCGACACGGGTGGCATCAACACGGGCGATATAAGGTGGAAATCGCTGGGTGAACGTCGGGCTGGTGCGCTCGCTGC AATCCGCGGCAACCGCGTGTTGATCGGATTCTCGTTGCCCGGCAAGACAATCGGGATGCAAAGCCGGGCAGCAATTCNCNCCNACACCATTCTTGGCCGTAAGAAC CTGGAGATCGAACCCCGCGGTTCGGAGCCGTTGAAACCCAACGGTTTCCTGCCGTTGGCGCANACCACTACGCCATACCAAATC Clone Rv374 :::::::::::::::Rv374SP6.seq::::::::::::::: CTCAAGCTTTACGCCGACGCCGGCCTACACAACACCAAGGAAACGATTGCCTACTGCCGAATCGGGAACGGTCCTCGCACACCTGGTTCGTGTTGCGGGAAATTAC TCGGACACCAAAACGTCAAGAACTACGACGGCAGTTGGACAGAATACGGCTCCCTGGTGGGCGCCCCGATCGAGTTGGGAAGCTGATATGTGCTCTGGACCC :::::::::::::::Rv374T.seq::::::::::::::: TCCCNCATGGGATAACGGGTTTAGATTTCNACAACGGCACCGTGTTTCTCAACAAGCCGGTCATCAGCTGGGCCGGCGACAACGGTATCTACTTCACCCGCTTCCG CCCGTACAAGAAAAACCACTAGGCCACCATCGAGTCCAAGAACAACCACCTGGTCCGCAAGTACGCGTTCTACTACCGCTATGACACCGCCGAGGAACGCGGCGTG CTCAACCGGATGTGGAAGCTGGTCAACGACCGCCTCAACTACCTCACCCCGACCATCAAACCGATC Clone Rv375 :::::::::::::::Rv375SP6.seq::::::::::::::: CTCAAGCTTGGGTGTTGCCGATCACCGGAAGCCNCATGATCAGCCAGTTTCGCGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCCGGCGGTA ATCGCCGACGGTGCCGGTTCGCGAGCCGAAGGTGACAACGCTGATTGAATCNAGTTCCANGTCCAGCGGGT :::::::::::::::Rv375T7.seq::::::::::::::: TNAACAGCTCGCGGCAGCCCACGACCTGCTGCGTCGGATTGCCGGCGGCGAGATCAATTCCAGGCAGCTCCCGGACAATGCGGCTCTGCTGGCCCCGCAACGANGA CTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCGATCGCACAGGTTGGCCCACAACCGGCCGCTTGATGNNNNGTCGGCAAGCCCCGGCAGTTNGCCAA CCCAGCGTGATCANGCTCGGCTCGCGAGTTCGGCGAAANAAGTGGCTCGCCTGATCACCTACCATCGGCCANGATCTGCTGTCA Clone Rv376 :::::::::::::::Rv376SP6.seq::::::::::::::: GCCANACCGGCTTGGCGTCGACTCCCGTTCNGCACATCATACGGTCCCCGGTACTGTCCAACTGCGCCGGTGCGCTAGCCAAACGTCACGACTCTCAGTGTCCCAG TTCGTGATCCGGCCGGTGGCGCCGCTGCGGCGGGGCTNATNTACTTCGGACTNATTATCTCATCCAAAGGACACGGGGCCGGTGGCTGGAATCCCATGGTGCCGAT CGGCCACACAN :::::::::::::::Rv376T7.seq::::::::::::::: CCGACCTGGTATCTTCCGATAGCCGCGTTGATATCCGGTCTGATCTCCTGCCCTTAACGCCCGATCTCAGCAGGTCCCCATGCAAAGATCCGAAGGTGTCCCNGAT CTAGGGGTCCTCGTCCTCCAGATGATGGAGCAAGTCGGCCC Clone Rv377 :::::::::::::::Rv377SP6.seq::::::::::::::: CTCAAGCTTCGGCTCAGGCGGCGCTGCCGGTAACGTCGCTGACCGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCAAGACACTGGCGCA GGCTATCGCACCCGTTATCGGCTACAAACAAATCGCGGTATGC :::::::::::::::Rv377T7.seq::::::::::::::: CATCACCTGNTTCATGAACTGGAAGCACCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCGGGTGCAGGTGCTCGGGCAGCTCGGCC GCGACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACGAACGACGCCAGTCCGCTACGTAACCCCTCCGCGACTGTCCATGGACAACAGCGCGTTCTCC ACCGACCGGGCCCGGGTGTGGGGTGT Clone Rv378 :::::::::::::::Rv378SP6.seq::::::::::::::: AGCTTAGCTTCCCGCCCCGGCAATAGGGCTCCAGCTCATCCGGTGTGACCAGATAGGGGCCCAGGTGATACCGCTGTCTTTGCCCTTGGCCTGTCCGATGCGCCAG CTGGCCCTCCAGCATCTGCAGGTCCCGTGCGGACCAGTCGTTGAAATGGTATAGCCGATGATCGACCG :::::::::::::::Rv378T7.seq::::::::::::::: CCNGAACAGAAGCGGNGGTTCCTACCGCGGTGTGCGGCCGGCGCGATATCGGGCCTTTTTACTACCGAACCCGATGTGGGCTCCGATCCGGCGCCCATGGCATCGA CGGCGACGCCGATCGATGACCGCCAGGCTTACCACCTT Clone Rv379 :::::::::::::::Rv379SP6.seq::::::::::::::: CTCAAGCTTGCGCGACTCGACAAGCATTCTTGACAGTTGTTTTGGCTCGGCATGGTTAGCCAAGGTTCTGCGGTCCCACCAGATCATCTTGGTCCGGTAGCGCTCG TCCGGGTATGCTGCGCCGGGATTCTCGCTGCTATTACTCCCCCCCGAAGAACGCCACCGGTCCAGCGC :::::::::::::::Rv379T7.seq::::::::::::::: GCNAGGCGGTATAGCTTCCCGTCGTACCGGCGACCGCCAGCCGAGAAGCTCGTTTTCCCAGTGTTGCTGGGGATTCTCACGCTGCTGCTGAGTGCGTGCCAGACCG CTTCCGCTTCGGGTTACAACGAGCCGCGGGGCTACGATCGTGCGACGCTGAAGTTGGTGTTCTCCATGGACTTGGGGATGT Clone Rv37 :::::::::::::::Rv37SP7.seq::::::::::::::: GTGTGGAACCGTGAGCCGGATAACAATTTCACACAGGAAACAGCTNTGACCTTGATTACGCCAGCTATTTAGGTGAGGCTATATTAATACTCAAGATTGCGGTCGA GCACATCGGCCCAAGAACCGCCGAAGGCACGGCGGAACGCCTGCGGCACATGGGGCGACGACCAGCGGGTCGGACTTCTGGGCTGTCCAGCCGGATCGCGCCGTCG CGA :::::::::::::::Rv37T7.seq::::::::::::::: CACTGTCAGACATATGCGCCGCTCCTCCTCATCGCTGCGCTCGGCATCGTCGCCGGCGGTCATGGCGTCACCCTACCCAAGCCGAAACGCGAAACGAGAACGTGTT CCATTATTAGGGTGTGAGCACCAATACCAGATGCTCACCAGGAACTCACGCAGCACCGGGACGGATGTCAGCCACCACGCCCATCTGGGGTGGTAGCGGGGGAAAT ACGGCTAACGCGGCTCCGGTGCCGGCAGCCCAGCGCAGCCCTCGGCGGCGGACACGGCAAACAACGACGACCCATAGTTGTTCTTTGCCGGATGGCCCCGTGTTGC GGACATATCGGGCGGCGGCGCGGGCGCCGCCGAGGTAGTGGCTGAGGCCCATCTCGTGCCCCGCCGAATGGCCCCAGCCAAACCGTGTA Clone Rv381 :::::::::::::::Rv381SP6.seq::::::::::::::: CTCAAGCTTTTACGGTGATCGCGCATCACCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCANCCTCTCGTCGGCGGTCGGGT GCAGGTGCTCGGGCAGCTCGGCCGCGACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACNAACGAC :::::::::::::::Rv381T7.seq::::::::::::::: CTCAGAAGCCGCTAGCTGGTAGAGTCGCTGACCGGTGCACGTGGCGNCAATGTGCGCTGCCGGTTCGCG Clone Rv382 :::::::::::::::Rv382SP6.seq::::::::::::::: CTCAAGCTTGCGCTCATCAAGCGCGAACAGCAGGGCGGTCGGCTGGTCGCCATGACGGGTGACGGGACCAATGACGCACCCCGCGCTCGCGCAAGCCGATGTCGGG TGGCNATNAATACCGGCACCCAGGCGGCCCGGGAAGCCGGCAACATGGTCNATCTCCACTCC :::::::::::::::Rv382T7.seq::::::::::::::: ACTTCTATTTCGACTGGTGTGCTGTGGCGCGATCCGACTGCCGGCGTGGTCAAGGCCGGCCAGTTGTGGGATNCCACAGGCAC Clone Rv383 :::::::::::::::Rv383SP6.seq::::::::::::::: GCTTGTCGTATTCCGTGGCACTGTCAGACATATGCGCCGCTCCTCCTCATCGCTGCGCTCGGCATCGTCGCCGGCGGTCATGGCGTCACCCTACCCAAGCCGAACG CGAAACGAGAACGTGTTCCATTATTAGGGTGTGAGCACCAATACCGATTGCTCACCAGGAACTCAC :::::::::::::::Rv383T7.seq::::::::::::::: CGATATTCGTCGGCCGCGTTGTCTCGACTGGGTCGCGT Clone Rv384 :::::::::::::::Rv384SP6.seq::::::::::::::: GACCTCGGCCACCAAGCCGGACGCGACCGTCGAGGTGGCGATCCGGCTTGGCGTCGACCCGCGTAAGGCAGACCACATGGTCCGCGGCACGGCCANCCTGCCACAC GGCACTGGTAAGACTGCCCGCGTCGCGGCN :::::::::::::::RV384T7.seq::::::::::::::: CCGGAAGTCTAGGGGACGACCTACTCAGCGCAAAATGTCGCTAATGTGAGTCCGCCCCACCAGGGCAGATCAACCCATGTCGATGATGACCTACCCGGATAGGGGA TTGGCGGT Clone Rv385 :::::::::::::::Rv385SP6.seq::::::::::::::: AGCTTCAGTTCCTCCACGACGCGTTCCCAAATGATTTCCCGATCCCACAATCTCGGTTCAGATACAGGTCGCCATAGCCCTTACTTCGGNAACGCGTGGCCCGATT GGCCCTGCCGCTG :::::::::::::::Rv385T7.seq::::::::::::::: CCGCCTACGGGTCGAACATGCATCCCGAGCCGATGCTCGAGCCGCGCACCCCACTCGCCGATGGCCGGAACCGGCTGGTTACCCGGGTGCCGGCTGACC Clone Rv386 :::::::::::::::Rv386SP6.seq::::::::::::::: GCGGCTGGTTACGACTCCCTGTTTGTGATGGACCACTTCTACCAACTGCCCATGTTGGGACGCCCCGACCAGCCGATGCTGGAGGCCCTACACGGCCTTGGTGCGC TGGCCACGGCGACCGAGCGGCTGCAACTGGGCGCNTTGGTNACCGGCAATACCTACCGCAGCCCGACCTGCTGGCAAAGATCATCACCACGCTCGACGTGGGTTAG CGCCGGTCGAGCGATCCTCGGCATTGGAGCCGGTTGGTTTGAGCTGGAACACCGCCAGCTCGGCTTCGAGTTCGGCACTTTCAGTGACCGGTTCAN :::::::::::::::Rv386T7.seq::::::::::::::: GCCTTTCCGCACAATCTGTACCCCAGGACCNTCTAAAAATCGAATACGACGGCGTCGCCGACTTTGCGGGGTACCCGCTCAACTTTGTGTCGACCCTCAAGGCCCA TTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCANTNNTGTCGGTCCCACGATGACCCAGTA CTACATCATTCGCACGGAGAACCTGCCGCTGCTAGAGCCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTCAACCAAACTTGAAGGTGATT GTTAACCTGG Clone Rv387 :::::::::::::::Rv387T7.seq::::::::::::::: GCAGCCAACAAGATGCATCGGGATCATACGCCGTCAACTACCCGGCCAACGGTGATTTCTTGGCGGCCGCCCCAC Clone Rv388 :::::::::::::::Rv388SP6.seq::::::::::::::: CTCAAGCTTGCCAAAGAGACCTCGTCCACCAAGCNGGACGCGACCGTCNAGGTGGCGATCCGGCTTGGCGTCCACCCGCGTAAGGCANACCANATGGTCGGCGGCA CGGTCAACCTGCCACACGGCACTGGTAANACTGCCCGCGTCGCGGTATTCGCGGTTGGTGAAAAGGCCGATGCTGCCGTTGCCGCGGGGGGGGATGTTGTCGGGAG TGACAATCTGATCGANAGGATTCAGGCGGCTGGCTGGAATTCGATGCCGCGATCGCGACACCGGGATCAGATGGCCAAAGTCGGGTCNCATCGCTCGGGTGCTGGT C :::::::::::::::Rv388T7.seq::::::::::::::: CCACGGCGTGGATCAAGGTACCGGCCGGATGTTGCGCAATGGCAGGTTGTTGCCCGGCTTGATGTCGGCGTTAGCGCCGGATTCCACCACATCCCCCTTGCGAAAG TCCGTTGGGTGCAATGATGTAGCGCTTCTCCCCATCGAGATAGTGGAGCAAACGCAATCCGTGCGGTACGGTTCGGGTCNTACTCGATGTGCGCGACCTGGCGTTG ACACCATCTTTGTCATTGCGGCGAAAGTCGATCATCCGGTAAGCGCGCTTATGACCGCCCGCCTTTGTGCCGGGTGGTAATCCGGCCATGCGCGTTGCGTC Clone Rv389 :::::::::::::::Rv389SP6.seq::::::::::::::: GGCGGCTGCGTCGGCGAGATGATCGCCCGGTGCCACCCCGATCCGTGCCTCGGTCAGCGCCAACGTGCTTCCGGTCCGGCGACCACCATGTCGCATGCGCCCCGAC :::::::::::::::Rv389T7.seq::::::::::::::: GCAATCGCCTTGGCGGTCGCCGGTTGTCACCGGTGATCATCNCGGNGCGGATGCTCATNCGGCGCATTTCGTCNAATCGTTCCGTATGCCCACCTTGACCCGATGT CTTCATATGGACCACGCCGATGGCCCNCGCGCTNCTG Clone Rv38 :::::::::::::::Rv38SP6.seq::::::::::::::: CCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCA AGCTTCCACATCGGTATGCCAAAGCATTGCGCCGCTATCGATTTCGCGCTGGCATCGCCAAGGTGGACTTCTTGCTCAGCGACGAGATCCCGTGGTCGGATCCGCG GCTGCGGCGGGCTGCGACCCTGCATCTCGGCGGCACCCGTGACCAGATGGCGCGCGCCGAGGCAGACGTCGCGGCGGGACGCCACGCCGACTGGCCGATGGTGCTG GCCGCGTGTCCGCACGTCGCCGACCCCGGCCGCATCGACGAAACCGGCCGCCGTCCGTTCTGGACCTATGCCCACGTGCCGTCGGGGTCCACGCTCGACGCGACCG AGACCGT :::::::::::::::Rv387T7.seq::::::::::::::: CGCGTCCACCGCAGCGTGAGATTGGTGGCGCCATTCGTCGTGGTGTAGCTGCTGTTGGCGGGCGTCGCCGTATTGTGCGGGCCAGCCTTGTGCGGGGGCCGTTCTA CCCACGAGTCGGCACTTCCGCAACCGCCCAGCTCGACCCGCGATTACGGCGGCCGCAACGGCCGCCGGAAGGCGTCTCGCAAGCGCCTTATCCTTTCGCAGGTTCC AGATCCTTCCGCTACGTGGTCGCTCATCGGCGGCCCGGCCGAATGAGTACAGGTGAGGGTAACCGCTACAAATGAAGTTGGTCAGTGCTGGCCCCAACTGTGTAAT GGTTGCCCGGCTCGGGTCACCACGTACATTCTGGCAAGGCGGGCGAGATTCGGTTCCTCGCGTCCTTGGCCGGTGGCGGTTCCCGGTTGTCCGTGGGCGTGTCGTG TACGTGGTGTAAGTGTCGTGAACTCCTCAGTTTGGGCT Clone Rv390 :::::::::::::::Rv390SP6.seq::::::::::::::: CTCAAGCTTGCGCTGGATCTGGCGGCTGAGCCTGTTCTTGGCAACATGCCGAGGGATCGCCTTTTCCACCACGCGGTCGGGGTGCGTTGCATTAGCTCACCCCGAT GGTGCGCTTGTGCAGGCCGCCGGGATACCCCGAGTGCCGGTAAACCATCTTGTGCTGCAGTTTGTCGCCGCTGATGGCGACCTTGTCGGCGTTGATCACANATGAC AAGTCACCGCCATCGACATTGGGGGCGAACGTCGGCTTGTGCTGCCGCGCAGCAGGTTGCCGGCCCGCGACGGCAGGGGGGGAANCACCACGTC :::::::::::::::Rv390T7.seq::::::::::::::: TTTGGGATGCGGCAAAAAGGCGAAGCNCCGCGTGGCCACAACGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCCGAACGTACGGCGTTC AACACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGGTAGCACCCTGGCCGGGCGATGATCTGCAGCGTCGCCCGCGGGTAGTCGCCCCC GGCGGCTACAGTCTGAAACGCGATGACCATCGATGTGTGGATGCAGCATCCGACGCAACGGTTCCTACACGGCGATATGTTCGCCTCGCTGCGCCGGTGGACCGGC TGGGTCTATCCCGGA Clone Rv391 :::::::::::::::Rv391SP6.seq::::::::::::::: CTCAAGCTTCGTCATAAGACCATGGTGCGCTTTCTTTCACCCGTCCANAGTCGGGGGCATCCGCACCGGCTCGCATCGCATCATCGCTCCCACGAGCGGGGCTCAT CAGCTTGGGCCATTTCAATGTACTTGATACCCCGCGCTGCGGGTAGGCCACTGCNACAATTCAAACACGGTGTCACACGGTGAATANTGTCNANATGGGCTCTGAT CAACCGTCNCAAACCCGGTTC :::::::::::::::Rv391T7.seq::::::::::::::: GAATTCTGCGTGCACCGCTATGGGTTGCAGCAGCGGCTGGCGCCGCACACCCCACTGGCCCGGGTGTTTCGCCCCGAACCCGGATCATGGTGAGCCGAAAAGGCGA TTCGCCTGTTCGATGCTGGGATTCGCCACCGCGAGGCCATCGACCGATTACTCGCCACCGGGGTGCGAGAGGTGCCGCATGCCCCTCCCGTCGACGTCTCCGACGA TCCATCCGGCTTCCGCCGTCGGGTGGCGGTAGCCGTCGATGAAATCGCTGCCGGCCGCTACCACAAGGTGATTCTGTCCCGTTGTGTCGAAGTGCCTTTCCCGATC GACTTTCCGTTGACCTACCGGCTGGGGCGTCTGCACAACACCCCGGTGAGGTCGTTTTGTTGCAGTTGGGCGGAATCCGTGCTCTGGGTTACACCCCCCCAACTCG TCNCGGCGGTGCGCGC Clone Rv392 :::::::::::::::Rv392SP6.seq::::::::::::::: GCAGTTGGGAATCGCTCTGCAGCAAACCANTATTCTGCGCGACGTTCGAGAGGACTNTTTGAATGGACGGATCTACCTGCGCGCCGACGAGCTGGACCGATTAGGC GTACNCCTCCGCCTGGACGACTCCGGGGCACTCGATGACCCCGACGGACGGCTCGCCGGCACTGCTGCGGTTCANTGCCNACCGCGCCCGANACTGGTATTCCTGG GACTGCGGCTGATTCCACACCTCGACCGCCGCAGCGCTGCCTGCTGTGCGGCCATGTCTGGCATCTACCGCCGTCAGCTCGCCTGATCAGACCATCGCCCCCCCCT CGTCTACCATCGGCGAATCTCTCTGTTCGGGACTGAANAANAGCCCAAGTGGCGGCGGCAGCACTGGNACTCTTCGGTAACCTGCNGACCGGATTGGACCGCTACC G :::::::::::::::Rv392T7.seq::::::::::::::: TTGATCTGGACGTCTGAGCGGTGATCGGNCCGAACCTGAATTGTCCGGTAATGCCCAGCGCAGAAAGCANGGTGGTGGCCGGGGCGGTGAANCCGGCGTCGGCGCG CACCGTCGAAGTCGATGTGGATTGCCGGAATGGGGATGTCCGGCACGGCGAAGCCGTAGTTCGCTTGTCCCGTGAGGCCCANGTGGATGGGGGGAAGGATCGTGGT GTCCGGGATGATAATGGGGCCCGATGCCGCCGGTTGAAGTCCAGTGGATCGGGAATTCGGGAATCGTGATGCCGACGTTCAGGCCGAACAGGCCCTCCAAGTGCCT CGCCACNAGATGCCGTTGCTGAAGTTGCCCGACATGAGGCGCCGGTGTCCACATTGGCCCGAATTGGCGACGCCGGTGTTGGC Clone Rv393 :::::::::::::::Rv393SP6.seq::::::::::::::: CACGTAGGCGCCGTCCATAAATNACTCCGCCGCGCTTCGCACNTCCTCGTANCGATCCTTGGCGAGCAGGTCANCCGGCGCTGCCCGTCNAGGACCCCCTTTTTTG GCGTGCAGCCACTGGCCGACACCTCGGGGGTAAGCGAATCCGAGAGCAGGAGGACNAGGTCACGAANCTGCGCCAGCCCCGGTCGTACCGTCAGGGGGGTGTCCGC CGGTCCGCCACCCCGCGTACCGCCCGATCGGACACCTGTATGACCGCGGCGACNTCGACCTGGGTGACGCCGAAGGGTTTCAGGGCATCNACNATCTCGGCTGGTC GACCGCCCGGTCCAGGGTGACCGCCATCGTGGTTCCTCCGCAACTTCCGGTTCTACTACCGTAAACGCTACCG :::::::::::::::Rv393T7.seq::::::::::::::: CGGGGAACGGTCCTCGCACACCTGGTTCGTGTTGCGGGAATTACTCGGACANCAAAACGTCAAGAACTACGACGGCAGTNGGACAGAANACGGCTCCCTGGTGGGC GCCCCGATCGAGTTGGAAGCTGATATGTGCTCTGGACCCAAGCAAGGACTGACATTGCCGGCCAGCGTCGACCTGGAAAAAAGAAACGGTGATCACCGGCCGCGTA GTGGACGGTGACGGCCAGGCCGTGGGCGGCGCGTTTCGTGCGGCTGCTGGGACNCCTCCGACGAGTTCACCGCCGGGAAGGTCGTCGCGTCGGCCACGGGCGAATT TCCGGTTCTTTCGCCGCGCCCCCGGATCCTGGGACCGCNGGCGCGCGCTTGTT Clone Rv396 :::::::::::::::Rv396SP6.seq::::::::::::::: CTCAAGCTTTGTCCGACAAGCGTTCCCGGGCGGTCAGCAAGCGAACGTCGGTTGGCCCACTGCGGGTCGATATTGCCGCCAGGGA :::::::::::::::Rv396T7.seq::::::::::::::: CGTCAGCACGGCGACGTCGCGNTACGCCGAGCAGTTACACAATCGCTCTGCAGCAAACCAATATTCTGCGCGCACGTTCGAGAGGACTTCTTGATTGGACTG Clone Rv39 :::::::::::::::Rv39SP6.seq::::::::::::::: CTGCATCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAA TACTCAAGCTTCGCGCAGCGGCGGGTTGACCCGGTTCACGCCGTCATAGCTGGCCAATCTGGCCATCGTCGATCANCATGTGGTGGGGGGTGACCTCGCGGTGATC GAAATACCCTGGTCCTTATCCCATTTCAGGATTTCGACGGTGCCCGCGGCCGACGCGTGACAGTGTGCACCCGGGCGCCGGCGTCACGGGCCAGCAAGGCGGTCGC GGGACGATCGATTCCTCGGCGGCCCGGGGCCATCCCGGCCAGCCCCAGCCGCGCCGCCATGGGTCCCTCGTGCGCGCGACGGCGCCGACCGTCAGCCGCGCTCCTC GGCGTGCTGGGCGATCAGCACGCCCAAACCGGTG :::::::::::::::Rv39T7.seq::::::::::::::: CCGACGCGCACTACGTGCTGGTGTCCACCCGCGACCCGCACCGGGCACGAGCTACGCAGCTACCGCATCGTCGATGGCGCTGTCACCGAGGAACCTGTCAATGTGT CGAGCAGTACTGAACCGTTCCGAGAAAGGCCAGCATGAACGTCACCGTATCCATTCCGACCATCCTGCGGCCCCCACACCGGCGGCCAGAAGAGTGTCTGGCCAGC GGCGATACCTTGGGTGCCGTCATCAGCGACCTGGAGGCCAGCTATTCGGGCATTTCCGAGCGCCTGATGGACCCGTCTTCCCCAGGTAAGTTGCACCGCTTCGTGA ACATCTACGTCAACGACGAAGACGTGCGGTTCTCCGGCGGCTTGGCCACCGCGATCGCTGACGGTGACTCGGTCACCATCCTCCCCCGCCGTGCCGGTGGGTGAGC GGACACATGACACGATACGACTCACTGTTGCATGCCTTG Clone Rv3 :::::::::::::::Rv3SP6.seq::::::::::::::: TGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGCCATCGATTACGCCAAGCTATTTAGGTGACACTATAGAAT ACTCAAGCTTGCCGGGAGGGTGCATGGCCGACTCGGATTTACCCACCAAGGGGCGCCAACGCGGTGTCCGCGCCGTCGAGCTGAACGTTGCTGCCCGCCTGGAGAA CCTGGCGCTGCTGCGCACCCTGGTCGGCGCCATCGGCACCTTCGAGGACCTGGATTTCGACGCCGTGGCCGACCTGAGGTTGGCGGTGGACGANGTGTGCACCCGG TTGATTCGCTCGGCCTTGCCGGATGCCACCCTGCGCCTGGTGGTCGATCCGCGAAAAGACGAAGTTGTGGTGGAGGCTTCTGCTGCCTGCGACACCCACGACGTGG TGGCACGGGCAGCTTTAGCTGGCATTCCT :::::::::::::::Rv37T.seq::::::::::::::: GGAAACACCGNCGCCGTCGTGGCCACCAACACCGCGACCAGCACCGTGACCCGGACCGGGGTGCCGCGCGAACCGGTCTTGGCCAATTGCCGCGGCACCAAGCCGT CGCGCGCCATGGCGAACAGCACGCGGCATTGCCCGAGCATCAACACCATCACCACCGTGGTAAGCCCGGCCAGCGCGCCGACGGAGATGATGCCGCTGGCCCAGTA CACCCCGTTGGCCTGGAACGCGGTGGCCAGATTTGCCGGCCCGCGGCCCGGTACGGTCCGCAGTTGGGTGTATGGAACCATGCCCGACAGCACCACCGATACCGCG ACGTAGAGAAGGGTCACGACCCCAGCGACGCGAGAATCCCTCGAGGGACGTCTCGTTGAGGACGCTTGGTCTCCTCGGCCATGGTGGCCACGATGTCAAACCCCGA TAAACGCGAAGAACACGATCGATGCCCGGCCAGCACGCCGTA Clone Rv40 :::::::::::::::Rv40SP6.seq::::::::::::::: CCTGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACNCTATAGA ATACTCAAGCTTGTCCTCGGGCGTTGGCCTCGGCCAAGAAATCGTCGACGCCGGCCTCCTGTGCAATCGCCTTGGCGGTCGCCGGGTTGTCACGGTGATCATCACG GTGCGGATGCTCATTCGGCGCATTTCGTCGAAGCGTTCCCGTATGCCCACCTTGACGATGTCCTTCAGATGGACGACGCCCGATGGCCCCGCGCTGCTGTTATCGG TCCATTCCGCAACGACTAGGGGTGTCCCCCGCCGGAGCTGATGCCGTCGACAATGGCACCCAACCTCCTCAGTGGGGTGGCCACCGTGATCGCAAAACCACTTCAT CACCGCAGCCGCGGCACCTTTGCGGATCCGAACGGATGCGCTC :::::::::::::::Rv40T7.seq::::::::::::::: TTCGTTCGATGGCGCCGCCCCGGCTACGGTTTGACCTGTGGGTGTCGAATTGGGGTCAAATTCCGAGGTCGGCGCGTAAGAGTGGTCATCCTGCAGGGGGGCCGGG GCCGAACTGCGCCGGCTCACACCGCGCAACACCGACCAGCTGCTGTTCGACGGCCTGCCCTGGGTATCCCGCGCGCATCAGGAGCACGACGAATTCGCCGAGCTGC TGGCTTCCCGCGGTGCGGAAGTGCTGTTGCTGTCGGACCTGTTGACTGAGGCACTACATCACAGCGGGGCCGCCCGCATGCAGGGGATCGCCGCTGCCGTCGACGC ACCGCGCTGGGACTGCCGCTGGCGCAAGAACTTTCGGCCCTACCTGCGTATCTCGACCCAAGCANGTTGGCGCATGTGCTGACGCCGGCATGACTTCAACGAACTC CCNTCCGACACGCCGAACGAAGTGTCGTTGGTGTTGCGTATGC Clone Rv412 :::::::::::::::Rv412SP6.seq::::::::::::::: GCGGCGAGTGTGGTGGGTGCCGAACACGAATCCAACGACGCACTGGCGGAGAGATACCACTTGCTGTACTGGAAGCAGTGCTGATGATCTCCCGTGGAATGTGCCC TCGCCGCCGTCTATCGAAAACAGTGGCATGCTGCG :::::::::::::::Rv412T7.seq::::::::::::::: CAACCGCGCTCGGCGCGTCTGGGCCTTCCGCCGGCTCCGCCGACAATTCTATCTCTGGATCAGCGGGGCTCTCCGGGCCGGCCTCCGCGAACTCAACAGGCCGCGC CTTCCGGCCGAAACATTCCCTAGCCATATATGATCGCACCTCGATACACGATCTGGCGGCAACACCGCAAAGCGTCCGACGGGCCCCAACCTCCGCAATTCAGTAT CCGGG Clone Rv413 :::::::::::::::Rv413SP6.seq::::::::::::::: GAAGGTCGGCGAAGGTGTGGCTGGNTGCCGATCACGAATCCAATGATGCAGTGGTCGGAAGATATTAGCCACTTGCTGTTCTGGAGACAGGTGCTGATGATCTCCC GTGGAATCTCCCTCGACTCCGTCTATCGAAATCGTGAACA :::::::::::::::Rv413T7.seq::::::::::::::: TCCTGCGCTCTGGGCCATTCTCGGGTCTGCCGACAATTCTATCTCTGGATCTGTGGGGCTCTCTTGGCCGGCCTCNGCGATCTCTCTTCANGGCGCGCCTTCCCGG AAACATTCCCTATCCATATATGATCGCACCTCTATACACCGTTGGCGGCAACACCGCAAAGTGTCTGTCG Clone Rv414 :::::::::::::::Rv414SP6.seq::::::::::::::: AGCTTTACGCTGGCGTATCAGCGTTGGGGCCGCTGCCATTTCGGTCGCCCAACGCGTTGCCAGCTCCCTGCGCTGTCAGGGGCTTGCGGCAAACTGGCCACCCCCA ACAAACTTGGCTGAGCTTGATC :::::::::::::::Rv414T7.seq::::::::::::::: CTCTATCTGGCGTCACATTCGCAATCTTTAGATTGCAGATATCGATAAAATCACCCGCGCGACAAGACCGCCCATGTCATCCTTCGATGTTATTTCGCCGGCCTGG GGAAAGCGCAACGACGTTGCCTACACGTTCCGCCGT Clone Rv415 :::::::::::::::Rv415SP6.seq::::::::::::::: AGCTTTNCCTTGCATCTGCACCCCGATCCACGTCAGCCACGTCGGCGTTCTCCACCAAGAAGTTGCGGGCATTCTCCTTGCCCTGCCGAGCTGCTCGCCCTCCGTA GGTGAACCAGGCACCCGACTTGCGGATGAGGCCCTGATCCACACCCATGTCGATCAGCGAGCCCTCCCTGCTGATCCCTGCCGTAGAGGATGTCGAACTCGGCCCC TGCTTGAAGGGGGGCGAACAGTTGTGCACGACAACCCTTCGGCGACGAGGGTGTGCAGTTCCTCGACCTCGAGGTCGAACGTTCGTGCCCCGCCGTTGGCAGCCCA CTTCTCGGATCACGGAATAGCGGANTTCTTCCGCCAGCATGTCGTGCAGGAATTTGTCATCCAGGGCATCCGCGAGCGCCTGCACGCCG :::::::::::::::Rv415T7.seq::::::::::::::: ACTGTCNAGGGAATGCTTCGCAGCATCTACCTGCAGTCGCTTGTGCATAAGCGGACGGCCCNAACCTGTTCGTGTTCCGGGGACACCAGACGGGGGGAGCAGCAGT ACGGCGAAAGGTTTGAGCGGAAAGGAGTTGCGCAAATCGGGCGCCCCCAACACCCGTCCGCAAGACGCGGTCAACGAACCTGTTCAGGGATCAGGGTCAGGCGACT ACCTGCACTGAGAACAAGCGATCTGCTGATCTGCCAGAAGATGGACATGAATGTCCACGGCAAGCCTGATGGCCTGCCGCTCTTCCGGGAATGTTTGGC Clone Rv416 :::::::::::::::Rv416SP6.seq::::::::::::::: TGAATTATGATCCCGACACAACTGCATCANTTTAGCCGCGTCGNGATGCTATCCGCCGACGGTTTGGANCNGGTCCGTGTCGTTCGTGTTGATCTCACCCGAAGTT CTGTCCGCCGCCGCCGGGGATCTAGCGAACGTGGGATCGACAATCAGCGCCGCCAACAAGGCGGCAGCGGCTGCGACCACGCAGGTGCTGGCGGGGGGGGCGGATN AGGTGTCAGCGCGCATCGCGGCGCTGTTTGGTATGTACGGCCTGNAATATCCGGCGATCAGTGCGCAAGTTGCCGCGTATCACCANCAGTGCCGTGCAG :::::::::::::::Rv416T7.seq::::::::::::::: AACGGGGACCNCAAGAAACCATTCAANAACGAGGGGTCGTCACCAACGTCGAAACCGACGGTTGCCAGCCGGCCCACGATATTGCGTGCTCGAGGGTCCGCTGTAC CCTCACCGAACGTGAGTCCCACACCGCGGAGGCGGGCGACTCTGGCGTCGTTAGCAGCCCGAGCTCAAGGTGTCCCGCACCACTGTCGGAATGCTTTTAACCGACC GGATCAGCTCTCCGCCGATCTACGTGAACGAGTGCTTGCCACGGCCAAGCGACTGGGCTATGCCGGACCGGATCGGTGGCGCGATCGTTGCGGACCCCGCCCCGCC GGTGCGGT Clone Rv417 :::::::::::::::Rv417SP6.seq::::::::::::::: AGCTTTGGAGCCNCNCCGANCCNCCGGTACGCCCCGCCACCGCCGTACCCGGCACCCGACCCCTTTGAGCCGTTCGCCGTGGCCGCGGTGGANCTGGCGACGAGGG GACGATCGTGCTGGCAAAGTGGTCGATGGCACGCTGGCCGCCGATCTGAAGGTCGGCATGGAGATGGAGCTGACGACCATGCCGCTGTTCGCCGACNACGACGGGG TGTGCAGCGCATCGTCTACGCGTGGCGGATCCCATCGCGCGCCGGCGACNATGCANAGCGCANCGATGCTGAGGAGCGGGGGGATGAGGATGAGCCCCCCGGGCAC CCGTTTACMTCCTGGGTGCCGGTATGCACCCGTGGGGAAATGGGTAATGACTTC :::::::::::::::Rv417T7.seq::::::::::::::: TTCTCNCATCGTTCGTACTNNGATGGACGCTGCTGCCCCGAGGCGATCCTGGCCAACCGGCCTCTCGCCCCCCCGACCTTCGGGGGGAACCTGAACTTCTTTTTTC CGATGGGCGCTTGGGCCAAACGTACCGGGGCTATCTTCATTCGGCGTCAGACGAAGATATTCCCGTCTACCGCTTCGTATTACGTGCTTACGCCCCCCCAGCTGGT GCAAAACCATGTCAACCTCACCTGGTCGATCGAAGGGGTCGGACCAGAACGGGCAAGCTACGGCCACCGGTGTTCGGGATCCTGCGTTACATCACCGATGCGCGTC GACGAAATCGACGGTCCCGAAGTGTATTGGTCCCCACCTCGATCGTGTACGAACAGCTGCACGAAGTGGAAGCCATGACCACCGAAGCCTATGGCCGGTGAA Clone Rv418 :::::::::::::::Rv418SP6.seq::::::::::::::: TTCTTCCGGGTACCGCTGATCGGCGGCACCATCACGCACCCCGGTGCAGGGCGAGGCGGCCCGCCGGTGTGGTGTTGCTACGGCCGGCCAGCCCGTACCGGTGTGA TCGCCGGTGGTGCGGCCCGCGCGGTGCTGGAATGTGCGGGGTGCACGACATCTTGGCCAAGTCGCTGGGCAGTGACAACGCGATCAATGTGGTGCACGCCACCCGT GGCCGCGCTCAAGCTGCTGCACCGTCCGGAGGAGGTGGCCGGCGCGCCGCGGTTTGCCAATAGAAGACGTCCCCCCCGGCCGGGATGCTG :::::::::::::::Rv418T7.seq::::::::::::::: GTCGAAAGTGACCATCTCTACCTTGAGTGCCATACCGCCCCGACCCTATGCCTCGGATAGCTCGGCGGAAAGAAACGCTTGCAGTGCCGCCCGAATAGGCCTACGT CGTGAGCGCCCATCAACTCTCGCGCGGAGTGCATCGCCAGCTGGGCGGCGCCGACGTCGACCGTGGGATTCCGGTGCGCGCCGCGGCCAACGGCCCCGATCGTCGA CCCGCACCGGCAGATCGGCGCGATGTTCGTAACGCTGCATAGGCACTCCCGCGCGCTGGCAGGCCAGTTGCGAAACGCCCCCCGCGGTGCCTTCCGTCGGTTGGCT TTACCGCAAATTTGGGGTTGCCCCT Clone Rv419 :::::::::::::::Rv419SP6.seq::::::::::::::: AAAGCCACGGAAACGATTGCCTACTGCCGAATCGGGGAACGGTCCTCGCACACCTGGTTCGTGTTGCGGGAATTACTCGGACACCAAAACGTCAAGAACTACGACG GCAGTTGGACAGAATACGGCTCCCTGGTGGGCGCCCCGATCGAGTTGGGAAACTGATATGTGCTCTGGACCCAAGCAAGGACTGACATTGCCGGCCAGCGTCTACC TGGAAAA :::::::::::::::Rv419T7.seq::::::::::::::: TTTCGCCACCGCNAGGTCGTGCGCGTTCCAGAAAAGCGTGGTTCGGCCGGGCGCGAGGATTGGACGGTCCAANCTGACCAGCCGGTCCGGCCACCCGTTAGGCAGA TCGCGGTGTGTATATGTTCGGCCCTCGGCATAAACGCCATTGCTGCGGTGAAAATCGGACATCTCGCCGATTGCCAGTCTACATGATCCGCCTTGTCCCCCCCCCG GTCGTTGACAAACGCGATGTCNGCCTCCTGGGAAGCGGTGGC Clone Rv41 :::::::::::::::Rv41SP6.seq::::::::::::::: TCGCCAAGTGGATTCGTGCTCACCNACGAGATCCGTGGTCGGATCCGCNGCTGCGCGGGCTGCGACCCTGCATCTCGGCGGCACCCGTGACCAAATGGCCGCGCCG CGAAGCAGACGTCTCGGCGGGAGCGGACGCCGACTGGGCGATGGTGCTGGCCGCGTGTCCCNGTCNCCCGACCCCCCCCATCNACCAAAACCGGGGGGGGGTCCCG TTCTGGACCTATCCCACGTGCCNTCGGGGTCCACGCTCGACGCGACCGANAACGTAACCAGCGTCCTCGANCGGTCGCCCCCCCCCTTCCGTGACATGCTGGTGGC GGCCGCGCCGT :::::::::::::::Rv41T7.seq::::::::::::::: GTACCGTCACCATGATCGCCCCCCATCGGCATCGGTGAGCTGATAGATCCCAGCCGGTTTCGCCAACCCCCGAGCGATCTTGGCGGCTGCTNGTNGTCGNTGANAC NTAGCCACCAACAGAGCCCGGTGTGCGACAAGNGACTGATCGGATCTCTCCGGACACNTTCGAGGGGGGTCNTCAGGAGNCCGGGCGCCACCCCGAGGTAACCTCC GCCCAGCCTCACACCGCGACCGGGTATCNCAAGTCGCGCAATANCCCACCACCTCCTCGGACCCCCACGTTGTATGCGGCTGGT Clone Rv42 :::::::::::::::Rv42SP6.seq::::::::::::::: ATACTCAAGCTTAGACCTCACTGATGTGGCGGGACGCGGGAGATAACCGCGGTTCGAGCCGTTCAACAGTGGTGTTCCCACACCAGTTGTTGCCTTTGCCCGAAGT AAAGCGATTCGATTTGCTCGAAAAGAGGGCTGGCTGCTCGTGAGGGACATCCATGGCCGATACCTCAGCGATCTCAACGGTCAAGCGACTGCATGTTTGGCGCAAG GTATCGCTAAGCATAGGTTCGTGACGGATTTGACAGCAAGAGCTTTCCAAAGATTGCTGTCCACATANTGATCGCATCTCTACACCTCTTCGCCGGTCGCTGTCAA GAGCCATTCGAATCAGTTATCTCGCTCGTGCTTGGAAAAAATTTCCAGCCTGCGTTGGACAAACCGCGTCGCCAAAGCGGT :::::::::::::::Rv42T7.seq::::::::::::::: AGCTTCCCGAGAAACAGTGCATTCCCAAGCAGCCCGTTGTCACGCCGATGAGTGAAGAGTGCACGCAATCGCCGGAATCCGGCAAAGCCCCTGCACAAGCGAAATC AACCCGGAGGCTGACAAGGCAACGTCGGTGATCCGTACCGCCTGGTTGGACAAACGGCAGAAGGCGGCCTCGTCCGGTCCATCTACGCCGAGCACACTGGTGATAG CGCGCATCGGCATCGGTGCGGCCAGCCTGGAGACGACGTCCGCGGGCGTCTGGGTCAGTAACCCCCCCACCAGTTCTCGGGGGCAAGCTCCTCGAACCATCGGGGA CGTCTCCAACGCGCCACGCGCCATACCTGGTGCCAGTTGCTTGCGCATCCGGGTGTGCGGCCGGATCGGACGTCGCAGAAACGCAGCCACCCCCCCGTGAGAGTGA CCCACGGCGCTGGACACGTGTCTGGTTAC Clone Rv43 :::::::::::::::Rv43SP6.seq::::::::::::::: CGGCCGGGATGTGCGCAATGGCAGGTTGTCGCCCGGCTTGATGTCGGCGTTAGCGCCGGATTCCACCACATCCCTGCGAAAGTCCGTTGGCGGTGCAATGATGTAN CGCTTCTCCCCATCGAGATAGTGGAGCAACGCAATCCGTGCGGTACGGTTCGGGTCGTACTCGATGTGCGCGACCTTGGCGTTGACACCATCTTTGTCATGGGGGC GAAAGTCGATCATCCGGTAAGCGCGCTTATGACCGCCGCCTTTGTGCCNGGTGGTAATCCGGCCATGCGCGTTGCGTCCACCGCGACCGTGCAGCCCCCCACCCAG CGACNTCTCCGGGGTTGACCGGGTGATCTCGGCGAAATCAGATACGCTGGCGCCGCGACGACCAGGCGTCGTGGCTTGTACTTGCGAAATTGCCATGGCTCTTTCA GGTCTTTCTCTCACCTCTCGTCGCCGGGCTAGGGCGCATTGCCTGCTCCT :::::::::::::::Rv43T7.seq::::::::::::::: TAGCGGTGTAACCAACTCCCGGTCACCACCCGCAAACCTCTTGCGGCAACAGCACCGTCGACGCGTCAACCGGGCTGCCCGGAATCCTGTGGATGGGGCATCGAGT GCATGGTCACGACGTCCCCGACGCGGCCGGTGGCAACGACAAGTGGCCCCGATGCACCACAAATGACGGCCCGCACACCGGTGGGGACGGCCAGCACGAGAGCCTG TCGCCGAAGTCGACGCTAATGCCGTAGGCATTGGCCGTCACAACAGCGCGACGCCCCCGCGTACCACCGAGTCCAGGNGGTTGGCGGTCTCCTCGGCCAACCAGGC GTGAACCCGGCGGATCCGAATGCGCAAGACCCGTGGGC Clone Rv44 :::::::::::::::Rv44-2NDSP6.seq::::::::::::::: CCATTGGTCGGTGTGCGCATACCANTACNACGCGCCCGGGCACCTGACGCCGGCGGCCGCAACCATTCGGTGGCCATCGCCATCGTCTGCCACCCGGTCACCACGC ACCTTCTCCTGGCCGACCTAGTGCCGCCCACCGCCGCCGTTGCGTCCCATCGATCCGGTCAACATGAGCAGCGCCAACACCGAGCGGTACATGACATCTGCTGTGG AACCAGTGACANATTCCGCCGCCCATGATGATCNTCGACCGTCCTCCGGATTCGGTC :::::::::::::::Rv44-2NDT7.seq::::::::::::::: GCCGGCCTGGTCAAAGGGGCGTCCGAAGGANCCGGGCTGGGTAACAAGTTCCTGGCTCATATCCGCGAATGCGACGCCATTTGTCAGGTGGTGCGGGTGTTCGTCG ACGACNACGTGACTCATGTCACCGGACGGGTCGATCCCCAGTCCGACATTGAGGTCGTCGAGACCCGAGCTGATCCTGGCAGATCTGCAAACCCTGGAGCGCGGAC GGGCCGGCTGGAGAANGAAGCNGCACCAACAGGCGCGCAAGCCGGTCTACGACCCCGGC Clone Rv45 :::::::::::::::Rv45SP6.seq::::::::::::::: GATCCACTGACCACGATGACATATCGAAATGCTCGACGATTCCGATGGCGATCAAGGCCACGATGCCCTGGCGTTGGGCGGTATCTGGTGGATGGTGTACCCCCGG GTAGGTTCCCGTGATCGTGTCGACCCAGTCCACGCGATGGGCGGCGAGGTCGTCGGGCACCGCATCAGGGGGTNTGGGGGAGTGGGGGTCGAGTTGGGGGGGGGGG AGCTCTCCCCCGGTAGAACTCTCACCGTTGGTCGCCGCGATCTTCTCTANCGTCGCCGCGTGGTCAGGAGGTAANCAGCTCACCGGTTCGGGCCCCGTCGTCCCCC GGGCATGAACGCATCTGCGAATCCGGGCTGGGATGCGAACAACGGACCTGTGCCG :::::::::::::::Rv45T7.seq::::::::::::::: TCTACTGCCGAATCGGGGAACGGTCCTCGCCCACCNGGTTCGTGTTGCCGGAATTACTCAGGCACCGGAAACGTCGAGAACTACGAGCGGAGTTGGACANAATACC GCTCCCNGGTGGGCGCCCCCATCGANTTGGGAAGCNGAAATGTGCTCTGGACCCCACCCAAGAATGACATTGCCGGCCGCCCTCCAACTGGAAATAGAANCNGTGA TCACCCGCCGCGTTCTTGGAAGGAATGGCATGCCCTGGGCCGGCGTTCCTTCCGCTGCCGACTCCTCCCACCAATTCACGCCGAAGGGCGTCCGTCTGC Clone Rv46 :::::::::::::::Rv46SP6.seq::::::::::::::: ATACTCAAGCTTCTGTCACCGAAATCCCGCATGGGATAACGGGTTTAGATTTCGACAACGGGACCGTGTTTCTCAACAAGCCGTCATCAGCTGGGCCCGCGGACAA CGGTATCTACTTCACCCGCTTTCGCCCGT :::::::::::::::Rv46T7.seq::::::::::::::: CTGGCTCAAGCGCTCGGCGCGCAGGTGAACTCGGACCGGCTCGACGTCGCCGAACGCAAGCCCTGCTGGCCCACGGACCCGTCGTCATATGGGGGGAGGGGGGGGG TGCACAAGTCTACAACAACGCCGGCATCGCGTACAACGGCAACGTCGACAAGTCGGAGTTCAAGGACATCGAGCCGCATCATGCACGTCGACGTTGGGCGGTCCTC CACCGGGCCC Clone Rv47 :::::::::::::::Rv47SP6.seq::::::::::::::: CCGCCCTCCGCATTATGGGTCAAGAACCATCGGGTCGGACTTCTGGGCTTCCAACGCTCGCGCCGTCCCN :::::::::::::::Rv47T7.seq::::::::::::::: CCGTGGCACTGTCAGCATATGCGCCGCTCCTCCTCATCGCTGCGCTCGGCATGCTGCCCCCCCCTCATGGCGTCACCCTACCCCAGCCGAACCGGAAAACGAGAAC GTGTTCCATTATTAGGGTGTGAGCACCAATACCAGATTGCTCACCAGGAACTCACGGCAGCACCGGGACCGGATGTCGGGCCAGAGCCCATCTCCCCTGGTAGGGG GAAATACCGCTAACGCGGCTCCGGTGCCG Clone Rv48 :::::::::::::::Rv48SP6.seq::::::::::::::: TACTCAAGCTTGTCCAAATATCGAAGCGTCGGGTCGCGAGGCTCGGTCGGCAGCTCCAGCAAAACCCGCTCCACCCCTAGATGCCCGGTATCCTCAAGGTCTTTAT CCGCCGCTTCACCCCACTGGCACACGGTCACCGGCACGTCGCCCCCGGCCATGGCGCAACCGCTGAAGCGGACCCCGACAGCCCCTGCCCTGATGGACTGATCGGG GATCCACCCCGGCATTGAGCCGGGCTATCCGCGGGAAGTTCGCCGGTCCCCCCGCCCACATACAGCGGAGGATAGGGCTTGTCACCGGCTCGGCAGCAGTAGTCCC GGATCGAAGTCCACATATGTCCCATGGAATTCCGCCTGCTCCTGCGTTCAGATCTCGATTATCGCGCGCAACCGCTCATCGATCACACTGCCCCCACCCCCAGGGT CCACACCATGGTTGGCGACTTCTTCGCGCAACCAGCCACACCCACGCCGAAACGAAACCGTCCCTGCG :::::::::::::::Rv48T7.seq::::::::::::::: CAGCCATGCAAGCTTGGCCAACTCCTCATCGGACTTGAAGGTGCCGTCCTCGTTGGCGGCCCTGCTCCACGGCAGTTGATGGCACCAGGAATGTGTCCGGGGGGGG TGGCTTTGTTCCTGCGGCAGGTGCGCGGGGGCCAGGATCTTGCCGAGAACTCGTCGGGAGAGCGCAGTCGATGAGGTTCTTGAGCTTGATGGCCCCCCCCCCACCT CGTCGCGGAATGCCCGAATCGTGTTATCCGGCGGGANGCGGTGTAGGAAGTCACCGGCCGGCTGACCGGGTCGCTGGACAGGCCGGCTCCGTCGAGCTCC Clone Rv49 :::::::::::::::Rv49SP6.seq::::::::::::::: ATACTCAAGCTTCAAAACAGGCCTGTTGTGGGCGACCCGGCTCGCCGAGTTCTCGACGCAACCCCCTCAACTGCCCCCCACCCCCCCCCATCTCCCCGGTCACGCA GGGGCCGCGGCCCGCGCCGCAGCGACGGCGTGTTCGCGCAGTTCGCCGTCAATGATGCTGACCTGATCGGGCCACCCCCCCTCTCCCCCTCGTCCCGTTCACTAAT CGCCGGTGCTCAGCAGCGTCTCGACAGCCACCACCCGAGTGGAGACCAGATGCNCCACCACGGACCCGCAGCGATGCCGATCACCTCACCCCGTCC :::::::::::::::Rv49T7.seq::::::::::::::: CAGGCATGCAAGCTTTGCAGTTGCTGAGTAATGTCGGCCAACGTCACCACAATCGCGATGAATTCAATCATGCCGCCCAGGCGGGCCAACCCAATGGTGGCCGGGA GCGGCAGCTCGATCGCAGCGCGGAGGTTGCCGGCCGCCAGTTGATTCACGAACAGGGTGAGGTCATAGGCGGGCAGGATAGTGACGAAGGCAAGACCTAGATCTGC CGTCGGAAGAAGAATCGAGTATCCGGTCGACACAACGGAAGCGAAAGTGCCGCGATGTTGATGAGCGTCGCCGGTTGTGGCGGCGGTGGCGGCGGTAGCACCGGTC CGCACATACCGCGGGCAACGCGGGCATCCGAATTTGGGGCAGGGTGTTCAAGGCGGCTGGCAACTCACCATGAATCT Clone Rv4 :::::::::::::::Rv4SP6.seq::::::::::::::: CCGGCTCGTATGTTGTGTGGAATTGTGACCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCA AGCTTGGCCGCAGGGCCGAGTCGATTGGTCGCGGTCGCCTCGACAGTTAGCTTATGCAATGCTAACTTCGGGGCAAGTTCAGGCGGATCGGCCGATGGCGGGGCGT AGGTGAAGGAGACAGCGGAGGCGTGGAGCGTGATGACATTGGCATGGTGGCCGCTTCCCCCGTCGCGTCTCGGGTAAATGGCAAGGTAGCGCTGAGCTCGGGGGGT CGATTTGCCACCTGCTGCCGTGCCTGGGCATCGCGGTTTACCAGCGTAAACGTCCGCCGGACCTGGCTGCCGCCCGGTCTGGTTTCGCCGGCGTGACCCCCGGTCG CCATGACAGTGCGACCCTGNACCGGGCTGGCC :::::::::::::::Rv4T7.seq::::::::::::::: GTGTGCTGTCAATTCAGAGCTGAGCCTGATGCACTCAACTTACTGAGCATGCTAACGCTGGTCGTGCGGGTCTTGTTCCCGCGTGTCGGCAGGGCACACGCTCGGG GCGTAGCTGGGAGAGGCCCCGGTCAAGCCCGAGAGCAGTGCTCAGTCCGCCAGCTTGACCGACTTTCGATGAGAACGCGTTCTCGCCGTATTGAAGGGGGCGTTCG TGAGCCTGCGCGAGCAGCGCTCGCCGAGTGCGGCCGCTGATTCTTTCATCGAGCCAGGAGGCGCATTCGTGCTCGGGGGTGGGGGTGGGGGGGGGATCGTCGACGC GATCCGTCACCCACTCCTCGATCAGGTCTGCCTCATCGAACGGGCCAACGGTGCTGTCGGAGTAAGTGTGCGTGGGCACCGAGCCCCTGCTGTGGTACACCCCCAC CGTTGCATGAACAA Clone Rv50 :::::::::::::::Rv50SP6.seq::::::::::::::: ATACTCAAGCTTCACCAGGCGCCCGGCGGGCGGGGGGGGAAGCCAGGCAGCCCCCTCGGGGGGTCGGGGGGTTGGGGGGGTCCCCCCCAGCAGTTCGATCTCTGGA TCGGCGGGGCTCTCCGGGCCGGCCTCGGCGACCTCAGCGGCCCGCGCTTCCCCCCCAACCAATTCCTAAGGGATAGATAACCCCCTCAAATGCAGGTTGGGGGGGG CAACCCGG :::::::::::::::Rv50T7.seq::::::::::::::: AGCTTCCGTCACGACCCGCCCTCGCCGGTGCCGGCGCCATCGGTCATCGGATCTCATGACGACGTCACGTAGGGCCCCCTAGCGGGGGGGGGGGGGGTCAACTGGC GAGGCGGCGGCGACGTGACTGAGCTGGCCGAGCTGGACCGGTTCACCCCGAACTACCGTTCTCGTCGACGACTTTCAGCAGGGGGGTTGCAGCCCCCTGGAAGGCG CCGGCCACGGTGTTGCTGGTGTGCGCGCCGACCGGCGCTGGCAAGACGGTGGTCG Clone Rv51 :::::::::::::::Rv51SP6.seq::::::::::::::: ATACTCAAGCTTGCCGGGACCGCGGAACAGAACCGGCGGTTCCTACCGCGGTGTGCGGCCGGCGGATATCGGGCTCCCCCATAACCGAACCCCGATGTGGCGCTCC :::::::::::::::Rv51T7.seq::::::::::::::: ACGTTGGCTCTGCCGGAACGTATTTCCAGCGGCACGCATTCGGCGTGGGTGCCGGGCGGGATTGCGTCGCTGGGATCACCAGCAGTCCCCCCCCCCCCCTCCCCTC GGGCTATGAATTGCACCGAGCCGGAAAATCCNCAC Clone Rv52 :::::::::::::::Rv52SP6.seq::::::::::::::: ATACTCAAGCTTGTCGTATTCCGTGGCACTGTCAGACATATGCGCCGCTCCTCCTCATCGCTGCGCTCGGCATCGTCGCCGGCGGTCATGGCGTCACCCTACCCAA GCCGAACGCGAAACGAGAACGTGTTCCATTATTAGGGTGTGAGCCAAATACCGATTGCTGAGGGGGGTCAGGGGGGGTTGTGCCCCCCCCCCCCCACCCCCCCCCC CCATCTGGGGTGGTAGCGGGGGA :::::::::::::::Rv52T7.seq::::::::::::::: CGTTGGTAGCCCGATATGCATAGTGTATCTTACTGAACATGATTTTCCATTATGGAGCCCGGGTGCCCCACCCCAGGTGCCCCCTCAGCCCCCCCCCCCCCCCACT GACCAGGTGTTGCGGGCGAACATCGGCCCCGGCTTCGGATTCCGGTCCGGGTACCGGGCGACCCACCGCTTCGAAGGTA Clone Rv53 :::::::::::::::Rv53SP6.seq::::::::::::::: ATACTCAAGCTTGGCCAACTCCTCATCGGACTTGAAGGTGCCGTCCTCGTTGGCGGCCCTGCTCCACGGGCAGTTGATGGCACCCGGGTTGTTCCCGGGGCGGTGG CTTTTGTTCCTGCGGCAGGTGCGCGGGGGGCCATGATCTTGCCGGAAAACTCGTCGGAGAGCGCACGTCGATGAGGCTTCTTGACGTTGATGGCCCAGGACCTCGT CGCGGAATGCCCGAATCGTGTTATCCGCGGGGAGGCGGTGTATGAGGTCACCGGCCGGCTGACCGGGTCCCTGGACAGCGGGCGTCCGTCCAGCTCCCCACTTCTT GCGGGCGCCGTCCAACNACTTGACTTCTCCTGG :::::::::::::::Rv53T7.seq::::::::::::::: ATATCTTAAGCGTCGGGTCCCGAGGCTCGGTCGGCAGCTCCAGCAAAACCGCTCCACCCCTAGATGCCGGTATCCCTCAAGGTCTTTAGCGGGGTTCACCCCCCCA CTGGCACACCGGTCACCGGCACGTCGCCCCGGCATGGCGCAACCGCTGAAGCGCAACCCCGACAGCCCCCCTGCGGTGATGGACTGATGGGTCCCCCCCCCCCTTG AGCCGGGCTATCCGCGGGAAGTTCGCCGGTCCCCCGCCCACATACAGCGGAGGATAGGCTTTGTCACCGGCTTCGGCCAGCAGTAGATCGGATCGAAGTCCCACAT ATGTCCCATGGAATTCCGCCTGCTCCTGCGTCCAGATCTCGATTATCGCGCGCAACCGCTCATCGATCACACGTCCGCCACCCGAAATCCCACCCCACATGGTGGC GACTTCTTCGCGCA Clone Rv54 :::::::::::::::Rv54SP6.seq::::::::::::::: ATACTCAAGCTTGTCGCGGTAAACCCGCGAGCAGGGCGGTGGGTGCGGTGCAAAACAACCACACTTCTTTGCGGGTCGGTGATCTGCAGGGGGAGGGGGGGGGGGA CCACCATGCGCGCTAAATCGGCGATCAGCGCGTCGGCTATCGCCTGGTGCCGCCCACCGGAATCGGCCAGCCGACCGAATGGCCAGCGTTGCCAGCCCCATCAGTC CGGCGCCGGCCGACACCAGTGACGGCAACGGTGAAATCGCGTGGGCGGCAACGCCGGTGAACAACGCGCGGGGCATCCTGGCCCCCAGCGACCCCCAGGGTTTGGT GCCCTGGGGCCAGCATCCGCAGCCCGAGACGCAGGACCGAGCCCAGTGCAGTAGGCAAAGACCGCTTGTCGGAGACATGAACTCCACGACCGT :::::::::::::::Rv54T7.seq::::::::::::::: AGCTTATTGAACCGCGGGTCGCAGGCAAAGTGGACCTCATAACGACTCGGGTCCAGCGACCGCGCCCAACACGAACGGCCGGAACGACGTGGGGAGGGGTGCCCCT CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CTCCATACTCGCCCCTAATCTCGAGGCAGCCCGTACCCGCAGGCAACCTCCAAAAAATGCAATCCCCAAAATTCAATGCGTCGAGCTATTTCTCACACCGACCCCG CTAGTTGCGGATCAGAAATCCGTTGGGCGCGGAAGTCCAGCCGATTTGTTCTCCCGCTCCGCATCATGCTTGTAATCGTTGGAAATTCATCCTCATATGCCCCTGC ATCGCTTCATAGGGTCCAGGCCAAACCGGGCA Clone Rv55 :::::::::::::::Rv55SP6.seq::::::::::::::: CTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGGGAAGCTATTTAGTGACACTATAGAATAC TCAAGCTTGGCCACTCCGCGGTGTGTGGTGGACCCATCTGAGCATGTGCCAAAACCGGGGCAGACAGTCCCAATTGACGTGAGCCCCCCCTCACTTGCTGGGGTAG CGTCG :::::::::::::::Rv55T7.seq::::::::::::::: TAGCGCCCCTCCCGGGCCGGAGCTCCACGGCGTGGATCAAGGTACCGGCCCGGGATGTTGCCATGGAGTTGTTGCCCCTTGATGTCCCCTTACCCCCCCCCCCCCA TTCCACCACATCCCCTTGCGAAAGTCCGTTGGGTGCAATGATGTAGCGCTTCTCCCATCGAGATAGTGGAGCAACGCAATCCGTCCCCTACCCCTTCGGGGTCTAC TCCCCCGATGTGCCGCACCTTGGCGTTGACACCATCTTGTCATTGCGGCAGGGGGATCATCCGGGTAAAATTATGAGGGGGGGTTGTGCCCCTATTAACCCCCCCC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC ACCAAGCGTCGTGGGCTTGTTCTTGCGAAATTGCATGTCTAATCAGGTCTTTCTC Clone Rv56 :::::::::::::::Rv 56SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TTCCGGGTTGACAAGCAGGCCAACCTGCACTTCTC :::::::::::::::Rv56T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TTGTACTTGCGAATTGCCATGTCTAATCAGGTCTTTCTC Clone Rv57 :::::::::::::::Rv57SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC AAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC :::::::::::::::Rv57T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CACCACCACCTCCGCCGGCCCTCGCTGAGGTCC Clone Rv58 :::::::::::::::Rv58SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CGCGCTGCTGTTCGCGCTGTCGGCCAGCTCGCAGGACGCGCTGCGGCAAACCGCCGCGCCCGTGGGATTGGGTCT :::::::::::::::Rv58T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CTCGCGGCCGGTGGTGGCCTGGAATGTCCANCGCCGTTCACCTACGTGACCTGATGGATCCGGGGGGNT Clone Rv59 :::::::::::::::Rv59SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC ACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC :::::::::::::::Rv59T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CGTGACGGGTACTTGGCGCGATAACGTGGTG Clone Rv5 :::::::::::::::Rv5SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GTCGCGGGCGCCACCGAGGTCGTTGACCACGA :::::::::::::::Rv5T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TCCGATCCCCGCGGCTTCAGG Clone Rv60 :::::::::::::::Rv60SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GATGCCGACCGAAATACGACCCACATGGCTCTTGTTGCNCAGTGTTGGCGGCATCAAATACCCTCAGTGCCGTCCGAC :::::::::::::::Rv60T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TCGCGCACTTCGCGATCGCGTGACTGGTCCTCGCGATGCCCCTGCGTAGC Clone Rv61 :::::::::::::::Rv61SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC :::::::::::::::Rv61T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC ATAGCTCGACCGGATCGGAGAGAATCTGGTTCTCGT Clone Rv62 :::::::::::::::Rv62SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCGAACGGTTGCCAGCCCCGGC :::::::::::::::Rv62T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC ACCGATCTTTTCGTCGAAAATGGCGGTCGTGTCGGGGGTATACGTCCGACATCCCCAGCCCCTCCCGCTGAGGTGA Clone Rv63 :::::::::::::::Rv63SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GGGCGGGCAACCGTCCGCTCAAGTCGCTTTCCGATCTGCTCA :::::::::::::::Rv63T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC AATCAGAAACCTGGCGCGCGACACAGCGTGTACTTGC Clone Rv64 :::::::::::::::Rv64ZP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CGGGAGTTGCTCGTCGGCCGACCGACCCGGCCAGCCGGGGCAAAACCGGGGAGATTCAGGGGTGGGTAGGGGTCTGGGGGGGGTGG :::::::::::::::Rv64T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TCTCTCGATGCGGTCTCCACCACCGAACAG Clone Rv65 :::::::::::::::Rv65SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GGTCCACTCACGGTACCGGGTATTTTATCGTCGACGAGGGGCACATGGT :::::::::::::::Rv65T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GCAGCCCAATGAGTTGCCGCGCGGGCTGCATCGCGGCCGGACGAGG Clone Rv66 :::::::::::::::Rv66SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC ATTGCTCGTCGGCCGACCGACCGGCCCAGCCGGGGCGGCAAAACCCCGGAAGA :::::::::::::::Rv66T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CAATCGCGGCTCACTTGNGCGATNGTCNAACAACCAACGCGNCCTGGTCACCCTCAAAGAAAATGGGTGT Clone Rv67 :::::::::::::::Rv67SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCGGCGGGGCT :::::::::::::::Rv67T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GCTGAGCCGCAGCTGATCCGGGCTCGCCGCGGCGTGATCCTGGCCTGTGGTGGTTTCGAGCATAACGAGCAGATGCGAAT Clone Rv68 :::::::::::::::Rv68SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CATTTCAGCCCCCACACCCCCAGACTTGCTCTCGATGNCCCCG :::::::::::::::Rv68T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TTTGGACCGAACGGGATTCATACTCCGCAGGCCGGGGCCCCTCCGAAAATCGGCACATGTCCTTTGATCGTTCGCAACAN Clone Rv69 :::::::::::::::Rv69T7D3.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CGATCGTCACAAAAAATCTCCGTCCT Clone Rv6 :::::::::::::::Rv6SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CGGTAGGCACCCCAATCGACCCCTACCCCGGCTATCTCACCCCCGATCTCCAGGCTCCGCCGATCCATGCGCATCCGGTCCGGATCCC :::::::::::::::Rv6T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TTGTTCTTTTGCCGGATGGCCGTGTTTGCTGACATATCGGCGCGCCGCCCCCCCCCCCC Clone Rv70 :::::::::::::::Rv70SP6D2.seq::::::::::::::: NCTACGCTGCTGAATGTTGTGCGCCGGAGGANCTCAAGACCCACGCGGTTGTACGCCGGACNTGGCGACTGGTCAGGGGGGA :::::::::::::::Rv70T7D3.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC C Clone Rv71 :::::::::::::::Rv71SP6.seq::::::::::::::: CTAAGCTTTCGGGTCCGCCGCCACTAGTACCGCGTTGCCGGCCCCCCGCCGACCTAGAATGTTCCGCCCCATTGCCGTTCCTCCCCGCCCCCCGGTT :::::::::::::::Rv71T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TGTTCCGCATACGATT Clone Rv72 :::::::::::::::Rv72SP6D2.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC :::::::::::::::Rv72TD3.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TTGCGCTGGG Clone Rv73 :::::::::::::::Rv73SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GCCACAAACGCGCCCCCGGTATAC :::::::::::::::Rv73T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CGCACCGCGATCGGTCTGTCGCGGGCATGTCCAAACAACTGAAATCCCGTCAACATGGTCGAC Clone Rv74 :::::::::::::::Rv74SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC ACGTACCTCCGACGGCCAGCTGACGAACGGGTTTTGACGGA :::::::::::::::Rv74T7D3.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GGNACACTNCGGTTCACGTTAATCANCATCGCGANTTNCTNCGTNTTCGATTANTTCTGCTAACGNNTCNNNNGTCCCCTGGGGTAGAG Clone Rv75 :::::::::::::::Rv74SP6D2.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC :::::::::::::::Rv75T7D3.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC ACTGGTCTAGCCACACCGGGGAGAATNCNCGACCCGGNGCTATCGACCCNATCACGGCTTGTCGNAAMGATAGNCAGCC Clone Rv76 :::::::::::::::Rv76SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GGCGCCCCGCGAGTTCTAGCACAGCAACGCCGCGGCCACCACAGGGGGCG :::::::::::::::Rv76T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCC Clone Rv77 :::::::::::::::Rv77SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TTGGCGCCCCAACGCCCCCGGCAGCATCGACGTGGGTAGAGCTGGATGCCGCCAGCCACGGGGGGTGGGACAACCCCCCGAGCTGCGGGGGACCCCCCCG :::::::::::::::Rv77T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC ACCCCGAAGGGCCGCTGGCCCGGCGGAACCTTGTCCTCCA Clone Rv78 :::::::::::::::Rv78SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TGNTNGGATCNGCCGACGTGCANCTGAANGANTATCCCCGGGCTGTNCCACNAGGTGTTCAACGAACCGGANCGCAACCAAGTG :::::::::::::::Rv78T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TGACA Clone Rv79 :::::::::::::::Rv79SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GCCGTCCTTGAAGAAACCGGTGGCGGNGGCAACCC :::::::::::::::Rv79T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC AACGGCACCANGCGCAACCGAAGGGCCAATCCGACATCGG Clone Rv7 :::::::::::::::Rv7SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCTGTTGGCCGACAATCTCGGTGACTTCGCGGTCAAGTCACCCGGGCCGTTGCGGGTGTCCGCAGCCTTGTCCAGCCCCCTCGCTTACTCCA :::::::::::::::Rv7T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TTCAGCCATCGGGGACATCATGCTCGCTTCATACTCCTCGACCAGTCGGCGGAACAGCTCGATTCCCGGAACGCCCACGCATGGTG Clone Rv80 :::::::::::::::Rv80SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TCATCACCACCATCGCTAGC :::::::::::::::Rv80T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TTCGCCGCCGACG Clone 81 :::::::::::::::Rv81SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC :::::::::::::::Rv61T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCACAACCCGTCGCGATCCAGCTCAGCCACGATCTCCACAATGCGCCCATCAATCGCATTGCGCTGAACGGGCAACTCCGCCAACTCCTCCAA Clone Rv82 :::::::::::::::Rv82SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GTTATTTTCCTCGCTTCCGGGCTGTCATCATTAAACTGTGCAA Clone Rv83 :::::::::::::::Rv83SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GANTTCTCCNGGGTTGAACCGGTNATCT :::::::::::::::Rv83T7.seq::::::::::::::: TGTGTGTGGTGGTAACCCATCTGAGCAGTGTGCCAAACCGGGGCAGCCAGCTCCCCAATTGACGTGAGCCCCGCTCACTTGCTGGGTAAGCGTCG Clone Rv84 :::::::::::::::Rv84SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCGACNAACGGCACTCCTTTTTTCCNTTTGCTCTTTC :::::::::::::::Rv84T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GCCGTGGAAATATCAGCAATGATA Clone Rv85 :::::::::::::::Rv85SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC AACACTCCGGCGGCGGCAGCGTGATCAACATCAGCTCCACCATGGGCCGGCTGGCGGCGGGGGGTTTC :::::::::::::::Rv85T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC AGATCGCGCTGACCACACTCAACGCCCGGACGGCTGTCCCTACCGGCGATCCAACCGGAGT Clone Rv86 :::::::::::::::Rv86SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCGAAATGCTGCGCAACATGCTCTAC :::::::::::::::Rv86T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CGGGTCCGGCAGCNAACCCGCCCGCGCCGATACCCGCTGCCCCGCGTGCGTGATTGACCGCCGCGCGCACGCTGGCCANGGATCAAACGGGCT Clone Rv87 :::::::::::::::Rv87SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TAGAATCTTTCCGCGGGCGGGTGAATCTCTGCNGGATCGGGGCNGGCGC :::::::::::::::Rv87T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GATGGGCAGTCGCCGCTCGGCATCGTCAGCCTCGCCGC Clone Rv88 :::::::::::::::Rv88SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC AGGGCTTCGTGCGGACCATCAACATCAAGTTCCAAGACGCCTACAACGCCNGTGGCGGCCCACAACCGCTGTTCGACTTCCCGG :::::::::::::::Rv88T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TCCAGCACTCGGTCGATG Clone Rv89 :::::::::::::::Rv89SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GATATTCNGCCNTCCCANCTCGAGCCTGACNCTNGATATCGTCGANNCTCACCATCNCGATCNGCTGTGCCGGTNTTGCTCGGACTN :::::::::::::::Rv89T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC ATCGGCANACTCNCGTCGATGTGCCGCGGCGCAACCATCCCCCACAATGATCNGGTGCGTCTGATCAGGCN Clone Rv8 :::::::::::::::Rv8SP6D.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TTGTGCGACCCTCAACGCCATTGCCGGC :::::::::::::::Rv8T7D4.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GACACCGGCGAGACCACTTAGGCAGTGACGGCCT Clone Rv90 :::::::::::::::Rv90SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TCGCCNATGGCTCCNGCGNNTCGCNCAACGTNTGGTTTGGTNANCTGCCTACCTGGTCNT :::::::::::::::Rv90T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GTACCNTCATGTCGGTCTGCGCNCGATATTGACGATCGTGTTCCCACGANNNNNNGANCCTCATCACGCCGGTTCGAGTGCCG Clone Rv91 :::::::::::::::Rv91T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC AANCGGCGCTNANNANATNCGCGNGAATGNCCGTCCACNANTGCATGG :::::::::::::::Rv91T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TGCCAGCTCGACCTGACGCTGGAAATCG Clone Rv92 :::::::::::::::Rv92SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GANCCCGAGCNATNCNANGTCCGTCAATC :::::::::::::::Rv92T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CACATAAGACGCAAACTGCTCTATTGTCAANTCCCANCGTGGTGTGGCNCATGAAGATGTTTGG Clone Rv94 :::::::::::::::Rv94SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GTTGGCANTNACCTCNGAGCCCCATTGGACATCANCCCANCCCGCCTGCGAACGGGAACGTCAGCNCNCTGGCGACAACCTGGCCAACAN :::::::::::::::Rv94T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GCATGGCCGTCTGGGGTCANCTCNACNATTTCANCCGTTGACCCGGGGTCACA Clone Rv95 :::::::::::::::Rv95SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GGCTCTACGCGCCATCTTCCCCGGATTCTTCGCGGCNGNGTTNCCGNGGGACCCCCGGACTGTGACNGGCCAACGGGCTCATCATCG :::::::::::::::Rv95T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC TGTCTGCGANCTCGCGCACCAGCTCGACGGCCCGGGCA Clone Rv96 :::::::::::::::Rv96SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GTAAGCAAAATACGT Clone Rv9 :::::::::::::::Rv9SP6.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CGCCGCACCCGACCGCGG :::::::::::::::Rv9T7.seq::::::::::::::: CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGCGCCCGTGCTCGTCCCAGCGTCCGGTCCCCCTCGGGGGACGCCCCTTGTTTC GGCCGGCGCCGGCTGGTCGGCAAGGAAGACCCGTTCCGGTGCTGAT

TABLE 4 End sequences of the polynucleotide inserts cloned in the named recombinant BAG vectors contained in the I-XXXX M. bovis strain Pasteur genomic DNA libraiy. RvXXXSP6 corresponds to the SP6 endsequence of the clone RvXXX; RvXXXT7 corresponds to the T7 endsequence of the clone RvXXX. RvXXXIS 1081 corresponds to a region located close to a copy of the IS1081 repetitive sequence (Insertion element) The character << - >> denotes an uncertain base residue. Clone X0001 ::::::::::::::::X0001SP6.seq:::::::::::::::: AAG- TCGGGTTTCCACACGCGCGGTTTGACCCTAGTCATATGTAATCATGTGTACCATGTGCGGGGCGCTTTTCGACGGC CGCGAAGGACCGGA-ATTTCCTGTGATTTCACTGCATGCGTACCATCTGGCACAATTGAGCA-TTGTCT-TCGCGG TGGTCGG-CGGGTTGCGTGCCGCCTGCTGCGA-ATGCACCA-TAAGCCCGAACCCACCGGCTTGGTGACCACCCGC ACGCTGCGTGTGGGGGGTAACCACTCCGCGACCCCAAGGATGGTCATTTCCAATGAACCGGCTGGACTTCGTCC A—A ::::::::::::::::X001T7.seq:::::::::::::::: GTCGCGGTTCGATCGACCCGATCTTCACCTCGTAACCTCGATGCTTAGCAGGATCCAGCTTGACCGCGTTTGGCT CTACCCACTCTTTGAGTGGCGCCGTCGCCTGTGCCCCATCGGTGTTCATGACGAACGCTTCGAAAGACTTCCTCT TGTGAGCCGGAATGTCTGCGTAAAGAAGTTCCATGTCCGGGAAGTAGACCCGGTCGCCCTCCACGTGGTACTCC TTCGAGGTCCGCTTCTCGCCGGATCCGATAAACACCGGCCCCAGGCACCGCAGCGTGAGTTCGAACGGCTTCAG GTAGGTGTTCATGCGGCGGACTCCGGGAGTGCGAGAAATAGCGGTCGCGCGTAGCTGTAGACCGGATGGTTTCC GCCCAGGCTGACGTCGAAGATGCCTCCTTGGAAGGGGCGCGA Clone X00002 ::::::::::::::::X0002SP6.seq:::::::::::::::: AACTCAAGTTTTTACGGTGATCGCGCATCACCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCG CAACATGAGCCAGCCTCTCGTCGGCGGTCGGGTGCAGGTGCTCGGGCAGCTCGGCCGCGACAGCCGCCTGACC CTGAAACCAGCTTCCATATCCCGCGAC- AACGACGCCAGTCCGCTACGTAACCCCTCCGCGACTGTCCATGGACAACAGCGCGTTTCTCCACCGACCGGGCCC GGGTGT ::::::::::::::::X0002T7.seq:::::::::::::::: GTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGCGCA-GCTATCGCACCC GTTATCGGCTGCGAGCAAATCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCA CGACGGAAAGACGCAGATCGCCGTCAAGCATGTGTGCCGCGGATTATCAGGACTGACCTCCTGGCTGACCGGCA TGTTTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGGTCGTGGTCGGCTCGGATAGCGAGGTCAGCGAATTCTCG TGGCAGCTCGAAAGGGTCCTGCCGGTGCCGGT Clone X0003 ::::::::::::::::X0003SP6.seq:::::::::::::::: TTCGAGTCATGCGCCCGCCTCGACCACGAA-ATGCACGTCG-GGTTCGATCGACCCGATCTTCACCTCGTAACCTC GATGCTTAGCAGGATCCAGCTTGACCGCGTTTGGCTCTACCCACTCTTTGAGTGGCGCCGTCGCCTGTGCCCCAT CGGTGTTCATGACGAACGCTTCGAAAGACTTCCTCTTGTGAGCCGGAATGTCTGCGTAAAGAAGTTCCATGTCC GGGAAGTAGACCCGGTCGCCCTCCACGTGGTACTCCTTCGAGGTCCGCTTCTC ::::::::::::::::X0003T7.seq:::::::::::::::: GTCATGTGTACCATTTGCGGGCGCTTTTCGACGGCCGCGAAACACCGGAGATTTCCTGTGATTTCACTGCATGCG TACCGTCTGGCACAATTGAGCAGTTGTCTGTCGCGGTGGTCGGCCGGGTTGCGTGCCGCCTGCTGCGAGATGCA CCAATAAGCCCGAACCCACCGGCTTGGTGACCACCGCACCGCTGCGTGTGGGGGGTAACCACGCCGCGACCCCA AGGATGGTCATTTCCAATGAACCGGCTGGACTTC-TCAACAA Clone X0004 ::::::::::::::::X0004T7.seq:::::::::::::::: AACAGCGCGGTTGAACTGATAGGTGCGGCCCGGCTCGAGCAGGCCGGGCCATTGTTCGATGCGGTTACCGAAA GATCTCTTCGGTGACCTGCCCGCCGCCGGCCAGCTCGGCCCAGTGCCCGGCGTTGGCCGCCGCGGCGACGATCT TGGCGTCCACGGTGGTCGGGG Clone X0006 ::::::::::::::::X0006T7.seq:::::::::::::::: GCATCTGGGCTGGCGGTGGTTCGCCGCTCCGAAGCCGTCGAACACCATCGCCAGCGCGGCTTCCACATCAACGA CCATTTCGGCCAGCTTGCGGCGCATCAGCGGCTTGTCGATGAGCGCCCCACCGAATGCCCGCCGCTGCCCGGCG TA-CACAGCGATTCGACCAGCGCGCGGCGCGCGTTGCCGAGGGCGAACGAAGCGGTGCCCAACCGCAATCTGTT GGTCAGCTCCATCATGCGGGTGAGTCCCTTGCCG Clone X0007 ::::::::::::::::X0007SP6.seq:::::::::::::::: ATCGGTTTCCAGCAACAGCCGATCGACGGCTTCGCCCA-GGCCGCTCCCGGGCGACCCGACCATTGCGTGCGCC GCGTAACGCCATCACGGATGACGCGCAGTTCGTCGCTGTCTAGCTCCACCATCGCCTGCACACCGGCGGCCAG- ACCCATTGGCCGTCGCACTCGTA- AGCAGGTAATCCTCGTCGACGGACTCGGTAACCACCGCCGCCAGCTCCGCTGCCAGGTCGGCGGGGTTGACACC GGCGGGCATCGGGATGGACGACGACGCGGTGCTGACGGCGCCTGTC ::::::::::::::::X007T7.seq:::::::::::::::: AGCGGTTTCCCA-GCGGGATGTGCTGTGAGCGCCGCACCACCAGCGCCGACGCTAAGGATGGAACGCACGGCAT CTTCTGACGCGTAACCGCGTTGTGATCGCGAGCTGAGGAGACGGTATGGGGGAGGGTTCTCGGAGGCCATCTGG GATGTTGATGTCTGTCGATCTTGAGCCGGTGCAACTCGTCGGCCCGGACGGTACGCCGACGGCCGAACGCCGCT ACCACCGTGACCTTCCTGAGGAAACGCTGCGTTGGCTCTACGAGATGATGGTGGTCACCCGCGAGCTGGATACC GAATTCGTCAATCTGCACG Clone X0008 ::::::::::::::::X0008SP6.seq:::::::::::::::: CAAGCTTCCACAGGTAGGGATCGAGGAACAGCGCGTTGAACTGATAGGTGCGGCCCGGCTCGAGCAGGCCGGC CATTTGTTCGATGCGGTTACCGAAAATCTCTTCGGTGACCTGCCCGCCGCCGGCCAGCTCGGCCCAGTGCCCGG CGTTGGCCGCCGCGGCAACGATCTTGGCGTCCACGGTGGTCGGGGTCATGCCCGCGAGCAGGATCGGCGAGCG GCCGGTCAGCCGGGTGAACTTCGTCGAAAGCTTGACCCTGCCGTCGGGGAGGCGAACCACGGTCGGTGCGTAN CTCCACCAAGCCCGGGCAACCTCGGGGGTGGCGCC ::::::::::::::::X0008T7.seq:::::::::::::::: TGGACCTCATGACAACGCGGCGGCGATTACCCCCGCTACCGCCAGCAGCATGACGGCGGTAGCGAACACCGCC GGATGCAGCGCAGGTGCGTCGATGTGCTCACGGAATCGCCCCGGCACCGCGATCTCGAGGATCACCAGTGCCAC CCCCTGCAGCGCGACACCGACGATTCCGTACACCGCCACGCCGATCAGGCCCTGGGCCAGCTGGCGTATATGGC GGCGATGGTGACGATGGCCAGCGCCACATACATTGTGGCGGCCAGAACCACGGCGTTGGGGCGGCGGTCGATG AACACTAGGCGACGCAGATCGCCCGGGGTCAACAGGTTGACCATCAGAAAGCCTGCGA Clone X0009 ::::::::::::::::X0009SP6.seq:::::::::::::::: TTTGGTGCGGCCGGCAATCAACTTC- GCTC-CAGCGGTTTCCCAGGCGGGATGTGCTGTGAGCGCCGCACCACCAGCGCCGACGCTAAGGATGGAACGCA CGGCATCTTCTGACGCGTAACCGCGTTGTGATCGCGAGCTGAGGAGACGGTATGGGGGAGGGTTCTCGGAGGC CATCTGGGATGTTGATGTCTGTCGATCTTGAGCCGGTGCAACTCGTCGGCCCGGACGGTACGCCGACGGCCGAA CGCCGCTACCACCGTGACCTTCCTGAGGAAACGCTGCGTTGGCTCTACGATATGATGGTGGTCACCCG ::::::::::::::::X0009T7.seq:::::::::::::::: CGCCCAGGGCCGCTCCCGGGCGACCCGACCATTGCTGTCGCCGCGTAACGCCATCACGGATGACGCGCAGTTCG TCGCTGTCTAGCTCCACCATCGCCTGCACACCGGCGGCCAGGACCCATTGGCCGTCGCACTCGTAGAGCAGGTA ATCCTCGTCGACGGACTCGGTAACCACCGCCGCCAGCTCCGCTGCCAGGTCGGCGGGGTTGACACCGGCGGGC ATCGGGATGGACGACGACGCGGTGCTGACGGCGCCTGTCGCGACGCTGAGCTCGGACACAGCTAGTAAATGTA GCCTAACCTACTTAATGGGTCGCAGCCCCCCGGGGTCGTCGCATGTCCAACGTTGCTCGACTGGAAGAAAATGC TCGTCGGGGAGCAAATGGCACC Clone X0010 ::::::::::::::::X0010SP6.seq:::::::::::::::: AATACTCAATCTTGATCGGTTTCCAGCAACAGCCGATCGACGGCTTCGCCCAGGGCCGCTCCCGGGCGACCCGA CCATTGCTGTCGCCGCGTAACGCCATCACGGATGACGCGCAGTTCGTCGCTGTCTAGCTCCACCATCGCCTGCA CACCGGCGGCCAGGACCCATTGGCCGTCGCACTCGTAGAGCAGGTAATCCTCGTCGACGGACTCGGTAACCACC GCCGCCAGCTCCGCTGCCAGGTCGGCGGGGTTGACACCGGCGGGCATCGGGATGGACGACGACGCGGTGCTGA CGGCGCCTGTCGCGACTCTGAGCTCGG ::::::::::::::::X0010T7.seq:::::::::::::::: GGATGTGCTGTGAGCGCCGCACCACCAGCGCCGACGCTAAGGATGGAACGCACGGCATCTTCTGACGCGTAACC GCGTTGTGATCGCGAGCTGAGGAGACGGTATGGGGGAGGGTTCTCGGAGGCCATCTGGGATGTTGATGTCTGTC GATCTTGAGCCGGTGCAACGCGTCGGCCCGGACGGTACGCCGACGGCCGAACGCCGCTACCACCGTGACCTTCC TGAGGAAACGCTGCGTTGGCTCTACGAGATGATGGTGGTCACCCGCGAGCTGGATACCGAATTCGTCAATCTGC AGCGCCAGGGGGAAGCTGGCGTTGTACACGCCCTGTCGCGGGCAGGAAGCCGCGCAGGTGGGTGCGGCGGCTT GCCTACGCAAAACCGACTGGTTGTTCCCC Clone X0012 ::::::::::::::::X0012SP6.seq:::::::::::::::: ATCACGACAACAGCGACGGTGTGTCGGATCAGCGGCCCCCGTTGCCGGGCAATGTTGAGGCGTTTCTGCGTCTG GTTGAGGCCGGCTGGGAC- CCGAGGTGGCTCGTCGGCCACATGGGCAGCACACCACCGTGGTGATGCATCTAGACGTGCAGGACCGTGCCGCT GGCCTGCA ::::::::::::::::X0012T7.seq:::::::::::::::: GCGGCTACGTGCCATCGAGACACTGGCGCAGGCTATCGCACCCGTTATCGGCTGCGAGCAAATCGCGGTATGCG TTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGATCGCCGTCAAGCAT GTGTGCCGCGGATTATCAGGACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTG Clone X00013 ::::::::::::::::X0013T7.seq:::::::::::::::: TACAAGCGGCACCTCGCCGGTGAACTGACCGTTCGCACGCTGCGCACCGCCGCCGGGCGCGTGCTCGGCGCGC CGGCGGCCCCCGAGGCCTGAGAGGGGAACCAACCATGCAGGTGAACATGACGGTAAACGGCGAGCCCGTCACC GCCGAGGTCGAACCCCGGATGCTGCTGGTCCATTTTCTCCGTGATCAGCTGCGGCTCACCGGAACTCACTGGGG CTGTGATACCAGCAACTGCGGGACATGCGTGGTGGAGGTCGACGGCGTGCCGGTGAAATCCTGCACGATGCTCG CCGTGATGGCCTCCGGGC Clone X0014 ::::::::::::::::X0014T7.seq:::::::::::::::: AGCGGCTGGTTACGACTCCCTGTTTGTGATGGACCACTTCTACCAACTGCCCATGTTGGGGACGCCCG- CC-TCCGATGCTGGAAGCCTACACTGCCCTTGGTGCGCTGGCC-C-GCGACCGAGCGGCTGCAACTGGGCGC- TTGGTGACC-GCAATACCTACCGCACCCC-ACCCTGCTGG-CAAA- ATCATCACCACGCTCGACTTGGTTAGCGCCGGTCGA-CGATCCTCGGCATTGGAACCGGTTGGTTT- Clone X0015 ::::::::::::::::X0015SP6.seq:::::::::::::::: ACGCGCGCCGATCATATCTGCTATGGATGTACAATTCAGCTCTTGCTGTTATACCAGTATATGGTGTACTATTTG ATCTATGCTGACGTGTGAGATGCGGGAATCGGCCCTGGCTCGACTCGGCCGGGCTCTGGCTGATCCGACGCGGT GCCGGATTCTGGTGGCGTTGCTGGATGGCGTTTGCTATCCCGGCCAGCTAGCTGCGCACCTCGGGTTGACCCGA TCGAATGTGTCCAACCATCTGTCGTGTTTGCGGGGCTGCGGGCTGGTA- TCCCAACCTATGAGGGCCGGCAGGTTCGGTAT ::::::::::::::::X0015T7.seq:::::::::::::::: CCGCGCTGCTGCTGACGTCGGTCGAACGTGCGACACGTCTGCGAATACCGGCCGAACGCTGGGTTTATCCACAG GCTGGCACCGACGCCCACGACACACCGGCCGTCGCCGACCGCCACCGACTGCATCGGTCGACGGCCATTCGGAT CGCCGGTGCCCGGGCGCTGGAACTGGCTGGGCTGGGGCTCGATGACATCGAATACGTCGACCTGTATTCGTGCT TTCCCTCCGCTGTCCAAGTCGCCGCAATCGAACTCGGCCTGGACACCGACGATCCTGCCCGCCCGCTGACCGTC ACCGGGGGCCTGACCTTCGCCGGCGGGCCGTGGAGCAATTACGTCACGCACTCCAT Clone X0016 ::::::::::::::::X0016SP6.seq:::::::::::::::: CAGGCGTGCAATGACCTGCACTGCGCCGGA-A-TCCCTAACCCACTAAACCGGGGCCGCTCACAAGCCGTGCAGC TCGGTCAGCGTCAGGTGCGCGACCAGGAA- TAAATGAGCAGACCCGTGCCGTCAACGATGGTGGCGATCATCGGCCCCGAAACGATGGCCGGGTC- ATGCGCAACTTCTTCAGCAGCGGCGGAAGGACGGCA-CCACCAGCGAC-ACCACACCACGAT ::::::::::::::::X0016T7.seq:::::::::::::::: GCGAA-CACTTCGTCAACTTCCAGGGCTGCCCGCACCAAGTATTTCGACGAGTATTTCCGTCGGGCCGCCGCCGC CGGCGCGCGGCAGGTGGTCATCCTGGCGGCGGGGCTGGACTCGCGCGCGTACCGGCTGCCTTGGCCCGACGGG ACCACGGTTTTTGAGCTGGACCGCCCGCAGGTCCTTGATTTCAAGCGCGAGGTGCTCGCCAGCCACGGTGCCCA ACCGCGCGCCCTGCGCCGCGAGATCGCCGTCGACCTGCGTGACGATTGGCCACAAGCCTTGCGGGACAGTGGTT TCGATGCGGCTGCACCGTCGGCATGGATTGCCGAAGGGCT Clone X0017 ::::::::::::::::X0017SP6.seq:::::::::::::::: TTGGGC-TTGCCC-CAAATA-GGCCCCAATCAAAAGCCGAGCAGGTGGAACCTA-CGATTCGCCTC-TCGT-TGTGC ACCCGAGCCATCGCACGCGCGGGGAATTCCCGGAT-TC-CCGTATTCTCCGGCGGCCGGGCTAACCCATCCCA-GCC GAACGGTTGGCTC-TGCCGTGGGTCCCGTGTTGGCCGATCGGGGCGTCACCGGGGTGCTCGGGTGCGG- TGACCATGGC-AACTGCCCC-ATGGGCCGACCCTGGTGCAGATAAACCTG ::::::::::::::::X0017T7.seq:::::::::::::::: TGGTGGAGGTCCCCACCAA-ACCCGGCCGTAACTCTGCTCACGGAAATGCGG-CAGGCCGCGCGTAGCACGTGGT ATCCGCCATAAAGGTGCACCTTAAGCACGGCGTCCCAATTCTCGAACGACATCTTGTGGAAGGTGCCGTCGCGC AAGATCCCGGCGTTGCTCACCACACCGTGCACGGCGCCGAATTCGTCAAGCGCGGTCTTGATGATGTTCGCTGC GCCGTCCTCGGTGGCGACGCTGTCGGTA-TTGGCGACCGCCCGGCCCCCCTTGTCGCGAAATCTCGGCGACGAC CTCATCGGCCATCGCCGAACCGGGCGCCCG Clone X0018 ::::::::::::::::X0018SP6.seq:::::::::::::::: GCCGGCCAAACTGGCCGGCGGGGTTGCTGTC-TCAAGGTGGGTTCCGCCACCAA-ACC- CACTCAAGGATCGCAAGGAAAGC- TCAAGGATGCGGTCGCGGCCGCCAAGGCCGCGGTCAAGGAGGGCATCGTCCCTGGTGGGGGA-CCTCCCTCATC CACCAGGCCCGCAAGGCGCTGACCGAACTGC-TGCGTC-C-GACCGGTGACAA-GTCCTCGGTGTCCACGTGT-CTC CGAAGCCCTTGCCGCTCCGTTGTTCTGGATC-CC-CCAAC-CTGGCTTGGACGGCTC- GTGGTGGTCAACAAGGTCAGCGAGCTACCCGCCGGGCATGGGCTGAACGTGA Clone X0018 ::::::::::::::::X0018T7.seq:::::::::::::::: CGACCT- AATTGTCCTGTAATGCCCAGCTCACCAA-GCATGGCTGGTGGCCGGGGCGGTGAAGCCGGCGTCTGCGGCACCG TCCAACTC-ATGTGGAT-GCCGGAATGGGGATGTCCGG-ACGGCGAATCCGTA- TTCGCTTGTCCCGTGAGGCCCAGGTGGATGGGGGGAAGGATC-TGGTGTCCGGGATGAT- ATGGGGCCGATGCCGCCGGTTGAAGTCCACTGGATCGGGAATTCGGGAATCGTGAT- CCGACGTTCAGGCCGAAC Clone X0019 ::::::::::::::::X0019SP6.seq:::::::::::::::: CTAACGGAATGAAAGCCCTGGTGGCCGT-TCGGCGGTGGCCGTCGTCGCACTGCTCGGTGTATCTTCCGCCCAAG CTGATCCCGAGGCGGATCCCGGCGCAGGTGAGGCCAACTATGGTGGCCCCCCAAGTTCCCCACGTCTTGTCGAT CACACCGAATGGG-CGCA- TGGGGAATTCTGCCCAGCCTCCGGGTCTACCCGTCCCAAGTTGGGCGTACA-CCTCCCGCCGCCTCGGGATGGCC GCTGCCGACCCGGCCTGGGCC-AGGTTCTCGCGCTGTCACCGGAAGCCGACACTGCCGGC ::::::::::::::::X0019T7.seq:::::::::::::::: CCGCGGGACAC-CCTC-ATGCTGCCGCCATGGACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCG CGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGGATCGCGGTGATCGTCGATGACGGCATC GCCACCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCG GTCCCGATCGGCCCA-ACGACATCGTGGCGAAGATTCGCCGGGTACGCCGATGATGTGGTGTGTTTGGCGACGC CGGCGTTGT Clone X0020 ::::::::::::::::X0020T7.seq:::::::::::::::: CTCTGGGACCGGCCACGGTGCC-CCGGCGTTCCCGGACGTGCTGCGCCAGGTGTCCGGCGGCCGCGTGCATGGT GTTCCCGGATCGGCCGCTGGCCAGAGCCCACCGGTGAATCTGGCGCCTGGCCGACCACCGTGCGCCGTAGGCTT GCGATCGTGCAGCGCTGGCGTGGCCAGGACGAGATCCCGACGGATTGGGGCAGATGCGTGCTCACCATCGGGG TATTTGACGGCGTGCACCGCGGGCACGCCGAACTGATCGCGCACGCGGTCAAAGGCGGC Clone X0021 ::::::::::::::::X0021SP6.seq:::::::::::::::: AATACTCAAGCTTTCGTCAGTTCATTGCGCCAGCAGACCAACAA-AGCATCGGGACATACGGA-TCAACTACCCG GCCAACGGTGATTTCTTGGCCGCCGCTGACGGCGCGAACGACGCCAGCGACCAC-TTCAGCAAATGGCCA-CGCG TGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCGTGATC-ACATC-TCACCGCCGCACCA CTGCCCGGCCTCGGGTTCACGCAGCCGTTGCCGCCCGCAGCGGAC- ATCACATCGCCGCGATCGCCCTGTTCGGGAATCCCTC-GGCCGCGCTGGCGGGCTGATTAAC ::::::::::::::::X0021T7.seq:::::::::::::::: TGCCGCGGATTTGGCTGGCTGCCCAATATTCAGAATCGGGCCTTTCTTTTTGCGCGACAATAAGGTCACAGTAAA CCCTCGTTTTGTGAGATGCGGGGCGGGCCGGGCGAA-TCGACCTCGAGTGAATGGATCTCGAGTGAATGGACAG GGCATCGCCTACGAGTCGCATCCCCATCCAACAGACCGGTGCTCTTGCATCGGACCCTGAAGGTCCCGCACGGA GGGTGTGGTTGCCGGCGCGGGGTCACGGTGCGGTAGCGACGTAGTGTTTGAACGAATTTCTTGATGCTCCAACC TGTTTGGTGTTCAATCCAGTTCT Clone X0175 .....X0175SP6..... AA-CTTGCGCGCTCGGCCGGGTC-AGCATCCAGCTGCTCGGCAAGGAGGCCAGCTAC-C-TCGCTGCGTATGCCCA GCGGTGAGATCCGCCGGGTC-ACGTCCGCTGCCGCGCGACCGTCGGCGAAGTGGGCAATGCCGAGCAGGCAAAC ATCAACTGGGGCAAGGCCGGTCGGATGCGGTGGAAGGGCAAGCGCCCGTCGGTCCGGGGCGTGGTGAT-AACC CGGTC-ACCACCCGCACGGCGGTGGTGAGGGTAAAACCTCCGGCGGCCGTCACCCGGTTAGCCCGTGGGGCAA .....X0175T7..... A-TCGAAAGTGACCATCTCTACCTTGAGTGCCATACCGCCCGACCCTATGCCTCGGATAGCTCGGCGGAAAGAAA CGCTTGCAGTGCCGCCGAATAGGCGGCTACGTCGTGAGCGCCCATCAACTCTCGCGCGGAGTGCATCGCCAGCT GGGCGGCGCCGACGTCGACCGTGGGGATTCCGGTGCGCGCCGCGGCCAACGGCCCGATCGTCGACCCGCACGG CAGATCGGCGCGATGTTCGTAACGCTGCATAGGCACTCCCGCGCGCTGGCAGGCCAGTGCGAACGCCGCCGCG GTGCGTCCG

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1-41. (canceled)
 42. A method of detecting Mycobacterium tuberculosis in a sample, comprising: (a) contacting the sample with a first nucleic acid, wherein the first nucleic acid is a polynucleotide sequence comprising SEQ ID NO:2, a fragment of SEQ ID NO:2 comprising at least 8 consecutive nucleotides of SEQ ID NO:2, or a polynucleotide whose sequence is complementary to SEQ ID NO:2 or to the fragment of SEQ ID NO:2; and (b) detecting hybridization between the first nucleic acid and a second nucleic acid in the sample, wherein detecting hybridization between the first and second nucleic acids indicates the presence of Mycobacterium tuberculosis in the sample.
 43. A method of detecting Mycobacterium tuberculosis in a sample, comprising: (a) contacting the sample with a first nucleic acid, wherein the first nucleic acid is a polynucleotide sequence comprising SEQ ID NO:3, a fragment of SEQ ID NO:3 comprising at least 8 consecutive nucleotides of SEQ ID NO:3, or a polynucleotide whose sequence is complementary to SEQ ID NO:3 or to the fragment of SEQ ID NO:3; and (b) detecting hybridization between the first nucleic acid and a second nucleic acid in the sample, wherein detecting hybridization between the first and second nucleic acids indicates the presence of Mycobacterium tuberculosis in the sample.
 44. The method of any one of claims 42 or 43, wherein the first nucleic acid hybridizes to the genome of Mycobacterium tuberculosis but not to the genome of Mycobacterium bovis under stringent hybridization conditions.
 45. The method of claim 44, wherein the stringent hybridization conditions comprise hybridizing at 65° C. in 6×SSC, followed by washing at 65° C. in 2×SSC. 